WO2018199530A3 - 대사체 분석을 이용한 베체트병의 진단방법 - Google Patents

대사체 분석을 이용한 베체트병의 진단방법 Download PDF

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Publication number
WO2018199530A3
WO2018199530A3 PCT/KR2018/004417 KR2018004417W WO2018199530A3 WO 2018199530 A3 WO2018199530 A3 WO 2018199530A3 KR 2018004417 W KR2018004417 W KR 2018004417W WO 2018199530 A3 WO2018199530 A3 WO 2018199530A3
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Prior art keywords
behcet
disease
diagnostic method
metabolome analysis
metabolome
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PCT/KR2018/004417
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English (en)
French (fr)
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WO2018199530A2 (ko
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김경헌
차훈석
김정연
안중경
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고려대학교 산학협력단
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Priority to CN201880027141.9A priority Critical patent/CN110546505A/zh
Priority to JP2019557367A priority patent/JP7179356B2/ja
Publication of WO2018199530A2 publication Critical patent/WO2018199530A2/ko
Publication of WO2018199530A3 publication Critical patent/WO2018199530A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7206—Mass spectrometers interfaced to gas chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/328—Vasculitis, i.e. inflammation of blood vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
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  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

본 발명은 대사체 분석을 이용한 베체트병 진단방법에 관한 것으로, 대사체학을 이용하여 베체트병을 효과적으로 진단할 수 있는 바이오마커를 제공하며, 이는 베체트병 치료제 개발에도 적용할 수 있다.
PCT/KR2018/004417 2017-04-25 2018-04-17 대사체 분석을 이용한 베체트병의 진단방법 WO2018199530A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201880027141.9A CN110546505A (zh) 2017-04-25 2018-04-17 利用代谢组分析诊断白塞氏病的方法
JP2019557367A JP7179356B2 (ja) 2017-04-25 2018-04-17 代謝物分析を利用したベーチェット病の診断方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0052665 2017-04-25
KR1020170052665A KR101946884B1 (ko) 2017-04-25 2017-04-25 대사체 분석을 이용한 베체트병의 진단방법

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WO2018199530A2 WO2018199530A2 (ko) 2018-11-01
WO2018199530A3 true WO2018199530A3 (ko) 2019-01-10

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PCT/KR2018/004417 WO2018199530A2 (ko) 2017-04-25 2018-04-17 대사체 분석을 이용한 베체트병의 진단방법

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JP (1) JP7179356B2 (ko)
KR (1) KR101946884B1 (ko)
CN (1) CN110546505A (ko)
WO (1) WO2018199530A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102094802B1 (ko) * 2017-10-24 2020-03-31 고려대학교 산학협력단 소변 대사체 분석을 이용한 베체트병의 진단방법
KR102150837B1 (ko) * 2019-02-22 2020-09-03 고려대학교 산학협력단 소변의 대사체 분석을 위한 소변 샘플 처리 방법
KR102355568B1 (ko) * 2020-07-20 2022-02-07 연세대학교 산학협력단 베체트 장염의 진단용 바이오마커
CN112881668B (zh) * 2021-01-18 2022-04-12 江苏省中医院 两种血清代谢物单独或联合用于制备诊断干燥综合征的试剂盒的用途
CN113539478B (zh) * 2021-06-24 2023-04-07 山西医科大学 基于代谢组学的深静脉血栓形成预测模型的建立方法

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KR101516086B1 (ko) * 2013-10-25 2015-05-07 고려대학교 산학협력단 대사체 분석을 이용한 류마티스 관절염 진단방법
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KR20160141140A (ko) * 2015-05-28 2016-12-08 고려대학교 산학협력단 대사체 분석을 이용한 베체트병 관절염의 진단방법
KR20160148807A (ko) * 2015-06-16 2016-12-27 연세대학교 산학협력단 장 베체트병 진단용 바이오마커 및 이의 용도

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KR100448488B1 (ko) 2001-09-03 2004-09-13 (주)프로테옴텍 베체트병의 질병 표시인자로서의 아포리포프로테인에이-1을 이용한 진단 시스템
PL213925B1 (pl) 2002-07-19 2013-05-31 Abbott Biotech Ltd Przeciwcialo anty-TNFα lub jego czesc wiazaca antygen, ich zastosowanie oraz zestaw
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Also Published As

Publication number Publication date
JP7179356B2 (ja) 2022-11-29
JP2020517935A (ja) 2020-06-18
CN110546505A (zh) 2019-12-06
WO2018199530A2 (ko) 2018-11-01
KR20180119717A (ko) 2018-11-05
KR101946884B1 (ko) 2019-02-13

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