MX2019013331A - Sistemas de produccion recombinante para policetidos prenilados de la familia de los cannabinoides. - Google Patents

Sistemas de produccion recombinante para policetidos prenilados de la familia de los cannabinoides.

Info

Publication number
MX2019013331A
MX2019013331A MX2019013331A MX2019013331A MX2019013331A MX 2019013331 A MX2019013331 A MX 2019013331A MX 2019013331 A MX2019013331 A MX 2019013331A MX 2019013331 A MX2019013331 A MX 2019013331A MX 2019013331 A MX2019013331 A MX 2019013331A
Authority
MX
Mexico
Prior art keywords
recombinant production
production systems
cannabinoid
cannabinoid family
prenylated polyketides
Prior art date
Application number
MX2019013331A
Other languages
English (en)
Inventor
Philip J Barr
Charles K Marlowe
Jianping Sun
Original Assignee
Baymedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baymedica Inc filed Critical Baymedica Inc
Publication of MX2019013331A publication Critical patent/MX2019013331A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y404/00—Carbon-sulfur lyases (4.4)
    • C12Y404/01—Carbon-sulfur lyases (4.4.1)
    • C12Y404/01026—Olivetolic acid cyclase (4.4.1.26)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)

Abstract

La presente invención se refiere generalmente a métodos de producción, enzimas y cepas de levadura recombinantes para la biosíntesis de policétidos prenilados clínicamente importantes de la familia de los cannabinoides. Utilizando materiales de inicio fácilmente disponibles, se utilizan enzimas heterólogas para dirigir la biosíntesis de cannabinoides en levadura.
MX2019013331A 2017-05-10 2018-05-10 Sistemas de produccion recombinante para policetidos prenilados de la familia de los cannabinoides. MX2019013331A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762504456P 2017-05-10 2017-05-10
PCT/US2018/032155 WO2018209143A1 (en) 2017-05-10 2018-05-10 Recombinant production systems for prenylated polyketides of the cannabinoid family

Publications (1)

Publication Number Publication Date
MX2019013331A true MX2019013331A (es) 2020-07-27

Family

ID=64105111

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019013331A MX2019013331A (es) 2017-05-10 2018-05-10 Sistemas de produccion recombinante para policetidos prenilados de la familia de los cannabinoides.

Country Status (7)

Country Link
US (2) US10837031B2 (es)
EP (1) EP3622059A4 (es)
CN (1) CN110869496A (es)
AU (1) AU2018265408A1 (es)
CA (1) CA3062645A1 (es)
MX (1) MX2019013331A (es)
WO (1) WO2018209143A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11180781B2 (en) * 2016-08-21 2021-11-23 Insectergy, Llc Biosynthetic cannabinoid production methods
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
MX2019013331A (es) 2017-05-10 2020-07-27 Baymedica Inc Sistemas de produccion recombinante para policetidos prenilados de la familia de los cannabinoides.
WO2019152736A1 (en) 2018-01-31 2019-08-08 Canopy Holdings, LLC Hemp powder
WO2019190945A1 (en) * 2018-03-29 2019-10-03 William Marsh Rice University Biosynthesis of olivetolic acid
WO2019209885A2 (en) 2018-04-23 2019-10-31 Renew Biopharma, Inc. Enzyme engineering to alter the functional repertoire of cannabinoid synthases
US11034980B2 (en) * 2018-05-29 2021-06-15 Massachusetts Institute Of Technology Microbial engineering for the production of isoprenoids
WO2020060948A1 (en) 2018-09-17 2020-03-26 Levadura Biotechnology, Inc. Production of cannabinoids in yeast using a fatty acid feedstock
EP3864000A4 (en) 2018-10-10 2022-08-10 Treehouse Biosciences, Inc. CANNABIGEROL SYNTHESIS
US20220127649A1 (en) * 2019-01-30 2022-04-28 Genomatica, Inc. Engineered cells for improved production of cannabinoids
CA3129577A1 (en) * 2019-02-10 2020-08-13 Dyadic International (Usa), Inc. Production of cannabinoids in filamentous fungi
EP3750989A1 (en) * 2019-02-20 2020-12-16 Synbionik GmbH Production of plant-based active substances (e.g. cannabinoids) by recombinant microorganisms
CA3130763A1 (en) * 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
US20220186267A1 (en) * 2019-03-27 2022-06-16 Rynetech Bio, Inc. Biosynthetic Cannabidiol Production In Engineered Microorganisms
US20230029027A1 (en) * 2019-04-12 2023-01-26 Renew Biopharma, Inc. Compositions and methods for using genetically modified enzymes
WO2020214951A1 (en) * 2019-04-19 2020-10-22 Genomatica, Inc. Olivetol synthase variants and methods for production of olivetolic acid and its analog compounds
WO2021042057A1 (en) * 2019-08-30 2021-03-04 Lygos, Inc. Systems and methods for preparing cannabinoids and derivatives
US11041002B1 (en) 2019-09-03 2021-06-22 Cb Therapeutics, Inc. Malonate transporters
EP4041875A1 (en) * 2019-10-11 2022-08-17 National University of Singapore Biosynthesis of cannabinoid precursors using novel aromatic prenyl transferases
JP2022552953A (ja) * 2019-10-11 2022-12-21 ナショナル ユニヴァーシティ オブ シンガポール サッカロマイセス・セレビシエを用いた簡単な前駆体原料からのカンナビノイドの持続可能な生成
WO2021081246A1 (en) * 2019-10-23 2021-04-29 Renew Biopharma, Inc. Enzyme engineering to alter the functional repertoire of cannabinoid synthases
WO2021183448A1 (en) * 2020-03-09 2021-09-16 Demetrix, Inc. Optimized olivetolic acid cyclase polypeptides
CA3172499A1 (en) 2020-03-27 2021-09-30 Mathias Schuetz Compositions and methods for recombinant biosynthesis of cannabinoids
WO2021222288A1 (en) 2020-04-29 2021-11-04 Willow Biosciences, Inc. Compositions and methods for enhancing recombinant biosynthesis of cannabinoids
EP4146809A1 (en) * 2020-05-08 2023-03-15 Lygos, Inc. Large scale production of olivetol, olivetolic acid and other alkyl resorcinols by fermentation
EP4149916A1 (en) 2020-05-12 2023-03-22 Canopy Growth Corporation Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof
US20230304049A1 (en) * 2020-08-19 2023-09-28 Amyris, Inc. Microbial production of cannabinoids
US11427840B2 (en) * 2020-11-20 2022-08-30 Hyasynth Biologicals Inc. Olivetolic acid cyclase variants with improved activity for use in production of phytocannabinoids
WO2022125960A1 (en) 2020-12-11 2022-06-16 Willow Biosciences, Inc. Recombinant acyl activating enzyme (aae) genes for enhanced biosynthesis of cannabinoids and cannabinoid precursors
EP4347800A1 (en) 2021-05-26 2024-04-10 Invizyne Technologies, Inc. Prenyltransferase variants with increased thermostability
WO2023006699A1 (en) * 2021-07-30 2023-02-02 Københavns Universitet Cells and method for producing isoprenoid molecules with canonical and non-canonical structures
CA3227215A1 (en) 2021-07-30 2023-02-02 Trish Choudhary Recombinant prenyltransferase polypeptides engineered for enhanced biosynthesis of cannabinoids
WO2023023621A1 (en) 2021-08-19 2023-02-23 Willow Biosciences, Inc. Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids
WO2023028212A2 (en) * 2021-08-26 2023-03-02 Lygos, Inc. Large scale production of divarin, divarinic acid and other alkyl resorcinols by fermentation
WO2023069921A1 (en) 2021-10-19 2023-04-27 Epimeron Usa, Inc. Recombinant thca synthase polypeptides engineered for enhanced biosynthesis of cannabinoids
CN114410675A (zh) * 2021-12-07 2022-04-29 深圳先进技术研究院 含有烯醇激酶基因和异戊烯基磷酸激酶基因的重组菌株及其在萜类化合物生产中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919322A (en) 1969-01-22 1975-11-11 Hoffmann La Roche 3-Substituted -5-alkyl-2-cyclohexen-1-ones
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
AU723619B2 (en) * 1995-04-24 2000-08-31 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
US6228647B1 (en) 1998-01-15 2001-05-08 Iowa State University Research Foundation, Inc. Transposable element protein that directs DNA integration to specific chromosomal sites
EP2305825B1 (en) 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
WO2006081537A2 (en) 2005-01-28 2006-08-03 The Salk Institute For Biological Studies Novel aromatic prenyltransferases, nucleic acids encoding same and uses therefor
BRPI0918936A2 (pt) 2008-09-15 2019-09-24 Danisco Us Inc conversão de derivados de prenila em isopreno
WO2011017798A1 (en) 2009-08-12 2011-02-17 National Research Council Of Canada Aromatic prenyltransferase from cannabis
CA3130705A1 (en) 2010-04-15 2011-10-20 National Research Council Of Canada Genes and proteins for aromatic polyketide synthesis
JP6297489B2 (ja) 2011-06-23 2018-03-20 ロー リニューアブルズ， インコーポレイテッド 芳香族分子の組換え生成系
CN103842509B (zh) * 2011-07-13 2016-06-08 加拿大国家研究委员会 用于烷酰基辅酶a合成的基因和蛋白质
JP6440497B2 (ja) 2011-10-19 2018-12-19 サイエンティスト・オブ・フォーチュン・ソシエテ・アノニム ブタジエンの酵素的製造のための方法
ES2547354T3 (es) 2013-09-03 2015-10-05 Symrise Ag Mezclas de compuestos cannabinoides, su preparación y uso
US9822384B2 (en) 2014-07-14 2017-11-21 Librede Inc. Production of cannabinoids in yeast
US10006057B2 (en) 2014-09-10 2018-06-26 Wisconsin Alumni Research Foundation Recombinant yeast having enhanced gamma valerolactone tolerance and methods of use
EP3067058A1 (en) * 2015-03-13 2016-09-14 Farmagens Health Care Srl Biological composition based on engineered lactobacillus paracasei subsp. paracasei f19 for the biosynthesis of cannabinoids
WO2017139496A1 (en) * 2016-02-09 2017-08-17 Cevolva Biotech, Inc. Microbial engineering for the production of cannabinoids and cannabinoid precursors
US11046978B2 (en) 2016-03-16 2021-06-29 William Marsh Rice University Synthesis of isoprenoids and derivatives
BR112019022500A2 (pt) 2017-04-27 2020-06-16 Regents Of The University Of California Microrganismos e métodos para produzir canabinoides e derivados canabinoides
MX2019013331A (es) 2017-05-10 2020-07-27 Baymedica Inc Sistemas de produccion recombinante para policetidos prenilados de la familia de los cannabinoides.
MA50632A (fr) 2017-10-05 2021-06-02 Eleszto Genetika Inc Micro-organismes et procédés pour la fermentation de cannabinoïdes

Also Published As

Publication number Publication date
US11555211B2 (en) 2023-01-17
AU2018265408A1 (en) 2020-01-02
CN110869496A (zh) 2020-03-06
WO2018209143A1 (en) 2018-11-15
US10837031B2 (en) 2020-11-17
US20210040512A1 (en) 2021-02-11
EP3622059A1 (en) 2020-03-18
EP3622059A4 (en) 2021-03-10
US20180334692A1 (en) 2018-11-22
CA3062645A1 (en) 2018-11-15

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