MX2019009612A - Metodos de elaboracion de perfiles especificos al tipo celular para identificar objetivos de farmacos. - Google Patents

Metodos de elaboracion de perfiles especificos al tipo celular para identificar objetivos de farmacos.

Info

Publication number
MX2019009612A
MX2019009612A MX2019009612A MX2019009612A MX2019009612A MX 2019009612 A MX2019009612 A MX 2019009612A MX 2019009612 A MX2019009612 A MX 2019009612A MX 2019009612 A MX2019009612 A MX 2019009612A MX 2019009612 A MX2019009612 A MX 2019009612A
Authority
MX
Mexico
Prior art keywords
cell
methods
type specific
drug targets
identify drug
Prior art date
Application number
MX2019009612A
Other languages
English (en)
Inventor
Xu Xiao
Heintz Nathaniel
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of MX2019009612A publication Critical patent/MX2019009612A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención proporciona métodos para elaborar perfiles de expresión génica y de proteína de múltiples núcleos de un único tipo celular y comparar los perfiles para determinar la variabilidad entre las poblaciones celulares, las muestras de diferentes sujetos y las células que expresan un fenotipo de enfermedad.
MX2019009612A 2017-02-10 2018-02-09 Metodos de elaboracion de perfiles especificos al tipo celular para identificar objetivos de farmacos. MX2019009612A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762457420P 2017-02-10 2017-02-10
US201762558396P 2017-09-14 2017-09-14
PCT/US2018/017556 WO2018148501A1 (en) 2017-02-10 2018-02-09 Methods for cell-type specific profiling to identify drug targets

Publications (1)

Publication Number Publication Date
MX2019009612A true MX2019009612A (es) 2019-11-12

Family

ID=63107837

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019009612A MX2019009612A (es) 2017-02-10 2018-02-09 Metodos de elaboracion de perfiles especificos al tipo celular para identificar objetivos de farmacos.

Country Status (9)

Country Link
EP (1) EP3580338A4 (es)
JP (2) JP7229538B2 (es)
CN (2) CN110582578B (es)
AU (1) AU2018219308A1 (es)
CA (1) CA3052290A1 (es)
IL (1) IL268417A (es)
MX (1) MX2019009612A (es)
SG (1) SG11201907162TA (es)
WO (1) WO2018148501A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202043256A (zh) 2019-01-10 2020-12-01 美商健生生物科技公司 前列腺新抗原及其用途
WO2021030447A1 (en) * 2019-08-12 2021-02-18 Mission Bio, Inc. Method, system and apparatus for multi-omic simultaneous detection of protein expression, single nucleotide variations, and copy number variations in the same single cells
CA3152504A1 (en) * 2019-09-06 2021-03-11 Keio University Method for producing cell aggregate including glial progenitor cells
EP4045061A4 (en) 2019-10-14 2024-04-17 ARO Biotherapeutics Company FIBRONECTIN TYPE III DOMAINS BINDING TO CD137
WO2021076574A2 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Fn3 domain-sirna conjugates and uses thereof
CN110699362B (zh) * 2019-11-15 2023-03-24 兰州理工大学 Afp5基因及其应用
CN111312330A (zh) * 2020-02-13 2020-06-19 兰州理工大学 一种基于蛋白质节点特性的关键蛋白质识别方法及系统
EP4146831A4 (en) * 2020-05-06 2024-05-15 Dignity Health SYSTEMS AND METHODS FOR TREATING LEVODOPA DYSKINESIA, IMPROVING MOTOR BENEFIT AND DELAYING DISEASE PROGRESSION
CN112538480B (zh) * 2020-12-24 2022-09-27 广州市妇女儿童医疗中心（广州市妇幼保健院、广州市儿童医院、广州市妇婴医院、广州市妇幼保健计划生育服务中心） 精子鞭毛多发形态异常疾病动物模型的构建方法和应用
CN112522425B (zh) * 2020-12-25 2023-11-28 武汉睿健医药科技有限公司 Dpc细胞鉴定分类用标记物基因、筛选方法及应用
CN112481273B (zh) * 2020-12-29 2023-11-24 南通大学附属医院 结直肠癌抑癌基因及其启动子区高dna甲基化的验证方法
KR20240031947A (ko) * 2021-04-14 2024-03-08 에이알오 바이오테라퓨틱스 컴패니 Fn3 도메인-시르나 접합체 및 이의 용도
CN113558011B (zh) * 2021-07-23 2022-05-10 深圳市中医院 基于γ-分泌酶激活蛋白基因的干燥综合征动物模型的建立方法
CN113893892B (zh) * 2021-11-10 2023-02-10 大连海事大学 一种基于微流控芯片的纳米孔及其制备方法
CN114276993A (zh) * 2021-11-11 2022-04-05 上海昆盟生物科技有限公司 一种用于分离大鼠下丘脑弓状核神经元的方法
CN114457075B (zh) * 2021-12-15 2023-05-02 徐州市中心医院 一种敲低PXYLP1基因表达的shRNA、慢病毒载体及其构建方法和应用
CN114751990B (zh) * 2022-04-01 2023-10-20 中国科学技术大学 酰胺高丝氨酸内酯受体-增强绿色荧光融合蛋白及其制备方法与应用
WO2023215805A1 (en) * 2022-05-05 2023-11-09 Alnylam Pharmaceuticals, Inc. ACTIN-BINDING LIM PROTEIN 3 (ABLIM3) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
CN115083522B (zh) * 2022-08-18 2022-10-28 天津诺禾致源生物信息科技有限公司 细胞类型的预测方法、装置及服务器

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011508598A (ja) * 2008-01-04 2011-03-17 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィク 乳癌のインビトロ分子診断
EP3369827B1 (en) * 2008-03-12 2020-12-23 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
WO2012105854A2 (en) * 2011-01-31 2012-08-09 Curonz Holdings Company Limited Compositions for administration to the eye
EP3031929A1 (en) * 2014-12-11 2016-06-15 Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch Genome architecture mapping

Also Published As

Publication number Publication date
CN110582578B (zh) 2024-02-02
AU2018219308A1 (en) 2019-08-22
SG11201907162TA (en) 2019-09-27
JP2023058610A (ja) 2023-04-25
CA3052290A1 (en) 2018-08-16
CN117965689A (zh) 2024-05-03
JP2020508652A (ja) 2020-03-26
JP7229538B2 (ja) 2023-03-01
EP3580338A4 (en) 2021-05-26
EP3580338A1 (en) 2019-12-18
CN110582578A (zh) 2019-12-17
IL268417A (en) 2019-09-26
WO2018148501A1 (en) 2018-08-16

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