MX2019001930A - Ensayo para determinar el potencial para la autoasociacion de una proteina usando espectroscopia de nanoparticulas de autointeraccion dependiente de la concentracion. - Google Patents

Ensayo para determinar el potencial para la autoasociacion de una proteina usando espectroscopia de nanoparticulas de autointeraccion dependiente de la concentracion.

Info

Publication number
MX2019001930A
MX2019001930A MX2019001930A MX2019001930A MX2019001930A MX 2019001930 A MX2019001930 A MX 2019001930A MX 2019001930 A MX2019001930 A MX 2019001930A MX 2019001930 A MX2019001930 A MX 2019001930A MX 2019001930 A MX2019001930 A MX 2019001930A
Authority
MX
Mexico
Prior art keywords
self
protein
association
potential
test
Prior art date
Application number
MX2019001930A
Other languages
English (en)
Spanish (es)
Inventor
Marlow Michael
Sennett Michael
Schneider Michael
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2019001930A publication Critical patent/MX2019001930A/es

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N2021/258Surface plasmon spectroscopy, e.g. micro- or nanoparticles in suspension

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
MX2019001930A 2016-08-18 2017-08-18 Ensayo para determinar el potencial para la autoasociacion de una proteina usando espectroscopia de nanoparticulas de autointeraccion dependiente de la concentracion. MX2019001930A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662376788P 2016-08-18 2016-08-18
PCT/US2017/047630 WO2018035470A1 (en) 2016-08-18 2017-08-18 Assay for determining potential to self-association of a protein using concentration-dependent self-interaction nanoparticle spectroscopy

Publications (1)

Publication Number Publication Date
MX2019001930A true MX2019001930A (es) 2019-07-04

Family

ID=59746357

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019001930A MX2019001930A (es) 2016-08-18 2017-08-18 Ensayo para determinar el potencial para la autoasociacion de una proteina usando espectroscopia de nanoparticulas de autointeraccion dependiente de la concentracion.
MX2023013583A MX2023013583A (es) 2016-08-18 2019-02-15 Ensayo para determinar el potencial para la autoasociacion de una proteina usando espectroscopia de nanoparticulas de autointeraccion dependiente de la concentracion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023013583A MX2023013583A (es) 2016-08-18 2019-02-15 Ensayo para determinar el potencial para la autoasociacion de una proteina usando espectroscopia de nanoparticulas de autointeraccion dependiente de la concentracion.

Country Status (19)

Country Link
US (3) US11428695B2 (enExample)
EP (2) EP3500856B1 (enExample)
JP (3) JP6959327B2 (enExample)
KR (3) KR102717462B1 (enExample)
CN (2) CN115468919A (enExample)
AU (2) AU2017313150B2 (enExample)
BR (1) BR112019003175A2 (enExample)
CA (3) CA3254461A1 (enExample)
DK (2) DK3500856T3 (enExample)
EA (1) EA201990316A1 (enExample)
ES (2) ES2974961T3 (enExample)
FI (1) FI3761035T3 (enExample)
HU (2) HUE052805T2 (enExample)
IL (2) IL264640B2 (enExample)
MX (2) MX2019001930A (enExample)
PL (2) PL3500856T3 (enExample)
SG (1) SG11201900895QA (enExample)
WO (1) WO2018035470A1 (enExample)
ZA (1) ZA201901035B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11428695B2 (en) 2016-08-18 2022-08-30 Regeneron Pharmaceuticals, Inc. Concentration-dependent self-interaction assay

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT4364724T (pt) 2018-05-10 2025-12-16 Regeneron Pharma Formulações contendo uma proteína de fusão do recetor do vegf de concentração elevada
CN113588582B (zh) * 2020-04-30 2024-05-14 上海药明生物技术有限公司 蛋白质样品浓度测定方式选择法及测定方法
WO2023095154A1 (en) * 2021-11-24 2023-06-01 Sensoville Biotech Pvt Ltd Method for determining changes in a protein's structure
WO2023141319A1 (en) * 2022-01-24 2023-07-27 Amgen Inc. Methods for detecting antibody self-association
CN119832975A (zh) * 2024-12-24 2025-04-15 上海药明生物技术有限公司 一种蛋白质共处方制剂的稳定性预测方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US771997A (en) 1903-11-21 1904-10-11 Alfred Palm Lathe attachment.
US4254102A (en) * 1975-09-08 1981-03-03 Plough, Inc. Substantive PABA compositions
US4080264A (en) 1976-03-01 1978-03-21 Massachusetts Institute Of Technology Immunoassay by light scattering spectroscopy
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US20050214356A1 (en) * 2004-03-24 2005-09-29 Joyce Timothy H Self assembling activation agents targeted using active drug release
US20050221507A1 (en) * 2004-03-30 2005-10-06 Intel Corporation Method to detect molecular binding by surface-enhanced Raman spectroscopy
US7514938B2 (en) 2004-05-11 2009-04-07 Board Of Regents Of The University And College System Of Nevada, On Behalf Of The University Of Nevada, Reno Dielectric relaxation spectroscopy apparatus and methods of use
TW200621282A (en) 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
ES2352509T3 (es) * 2005-05-02 2011-02-21 Baseclick Gmbh Nuevas estrategias de marcaje para la detección sensible de analitos.
US20070291265A1 (en) 2006-04-13 2007-12-20 Mississippi State University Optical apparatus for simultaneously measuring the scattering and concentration of signals of macromolecules in a flow cell
JP2010506839A (ja) 2006-10-12 2010-03-04 ワイス エルエルシー 乳光の低減を伴う方法および組成物
GB0621050D0 (en) * 2006-10-23 2006-11-29 Univ Strathclyde Functionalised polymers for labelling metal surfaces
EP2150617B1 (en) 2007-06-04 2014-10-22 Regeneron Pharmaceuticals, Inc. Enhanced expression and stability regions
WO2009039502A1 (en) * 2007-09-21 2009-03-26 Cytimmune Sciences, Inc. Nanotherapeutic colloidal metal compositions and methods
US20110305765A1 (en) 2008-11-21 2011-12-15 Board Of Regents, The University Of Texas System Preparation and methodology of silk fibroin nanoparticles
US20140024024A1 (en) * 2012-07-17 2014-01-23 General Electric Company Methods of detecting dna, rna and protein in biological samples
JP6099108B2 (ja) 2013-05-30 2017-03-29 公立大学法人大阪府立大学 被検出物質の検出装置および方法
IL312865B2 (en) * 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
EP2902503A1 (en) * 2014-01-31 2015-08-05 Fundación Imdea Nanociencia Functionalized metal nanoparticles and uses thereof for detecting nucleic acids
US20160074515A1 (en) * 2014-06-20 2016-03-17 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
CN104062287B (zh) 2014-07-01 2017-08-08 福建工程学院 一种基于纳米金催化的化学发光分析检测铁蛋白的方法
MA40861A (fr) * 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
WO2016115475A1 (en) * 2015-01-18 2016-07-21 Biogen Ma Inc. Anti-cd40 antibody formulations
HUE052805T2 (hu) 2016-08-18 2021-05-28 Regeneron Pharma Fehérje önasszociációs képességének meghatározására szolgáló assay koncentrációfüggõ öninterakciós nanorészecske-spektroszkópia segítségével

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11428695B2 (en) 2016-08-18 2022-08-30 Regeneron Pharmaceuticals, Inc. Concentration-dependent self-interaction assay
US11988668B2 (en) 2016-08-18 2024-05-21 Regeneron Pharmaceuticals, Inc. Concentration-dependent self-interaction assay

Also Published As

Publication number Publication date
DK3500856T3 (da) 2020-12-14
JP2023139189A (ja) 2023-10-03
EP3761035A1 (en) 2021-01-06
KR102441221B1 (ko) 2022-09-07
KR102717462B1 (ko) 2024-10-16
CA3032361C (en) 2025-07-08
MX2023013583A (es) 2023-11-30
JP6959327B2 (ja) 2021-11-02
IL264640B1 (en) 2023-11-01
HUE066064T2 (hu) 2024-07-28
ES2837093T3 (es) 2021-06-29
US20190187149A1 (en) 2019-06-20
KR20190039185A (ko) 2019-04-10
US20240280582A1 (en) 2024-08-22
CN109661577A (zh) 2019-04-19
CN109661577B (zh) 2022-09-27
AU2017313150A1 (en) 2019-02-21
SG11201900895QA (en) 2019-02-27
IL264640B2 (en) 2024-03-01
JP2019532267A (ja) 2019-11-07
US20220357335A1 (en) 2022-11-10
KR20220126801A (ko) 2022-09-16
IL264640A (enExample) 2019-04-30
BR112019003175A2 (pt) 2019-06-18
ES2974961T3 (es) 2024-07-02
JP2022008959A (ja) 2022-01-14
JP7321227B2 (ja) 2023-08-04
EP3500856B1 (en) 2020-10-07
WO2018035470A9 (en) 2018-07-05
AU2023274236A1 (en) 2023-12-21
US11988668B2 (en) 2024-05-21
KR102534506B1 (ko) 2023-05-30
IL307435A (en) 2023-12-01
CA3032361A1 (en) 2018-02-22
WO2018035470A1 (en) 2018-02-22
EA201990316A1 (ru) 2019-07-31
CA3254460A1 (en) 2025-07-03
FI3761035T3 (fi) 2024-03-18
KR20230074614A (ko) 2023-05-30
EP3761035B1 (en) 2024-02-14
EP3500856A1 (en) 2019-06-26
PL3500856T3 (pl) 2021-04-19
AU2017313150B2 (en) 2023-09-14
ZA201901035B (en) 2024-06-26
DK3761035T3 (da) 2024-03-11
CA3254461A1 (en) 2025-07-03
HUE052805T2 (hu) 2021-05-28
CN115468919A (zh) 2022-12-13
US11428695B2 (en) 2022-08-30
PL3761035T3 (pl) 2024-06-24

Similar Documents

Publication Publication Date Title
MX2019001930A (es) Ensayo para determinar el potencial para la autoasociacion de una proteina usando espectroscopia de nanoparticulas de autointeraccion dependiente de la concentracion.
CY1125697T1 (el) Σταθερες, υδατικες φαρμακοτεχνικες μορφες αντισωματων
CO2018005932A2 (es) Moléculas biespecíficas que tienen inmunorreactividad con pd-1 y ctla-4, y métodos de uso de las mismas
MY198335A (en) Urinalysis Device and Dry Reagent for Quantitative Urinalysis
WO2014141152A3 (en) Low concentration antibody formulations
CL2016002116A1 (es) Anticuerpos anti-fap y métodos de utilización (divisional sol. n°369-13).
MX362514B (es) Kits y ensayos de diagnostico para la deteccion del receptor 1 de folato.
GB2569252A (en) Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
EA201592302A1 (ru) Способы снижения уровня остаточного холестерина и других фракций липопротеинов путем введения ингибитора пропротеиновой конвертазы субтилизин-кексинового типа 9 (pcsk9)
PE20200479A1 (es) Ensayos de diagnostico para detectar, cuantificar y/o rastrear microbios y otros analitos
UY34995A (es) Formulaciones de anticuerpo y proteína
CL2018000232A1 (es) Mezcla de péptidos (divisional solicitud 201601405)
BR112016014022A2 (pt) anticorpos anti-cd3, ácido nucleico isolado, vetor, célula hospedeira, método de produção do anticorpo anti-cd3, imunoconjugado, composição, uso do anticorpo anti-cd3, métodos de tratamento, métodos de intensificação da função imune e kit
MX2016008472A (es) Anticuero monoclonal neutralizador de anti-il-33-humana.
MX388858B (es) Reducción de la viscosidad de formulaciones farmacéuticas
BR112019006853A2 (pt) composição farmacêutica líquida
BR112016014756A8 (pt) formulação de selante compreendendo fibrinogênio e zimogênios, seu método de fabricação, recipiente e uso
EA201690731A1 (ru) Анализ igfbp7, имеющий улучшенную характеристику в биологических образцах
BR112015013540A2 (pt) formulação em solução, métodos para tratar uma doença autoimune, doença inflamatória ou distúrbio proliferativo e psoríase, e, uso de uma formulação em solução
MX351127B (es) Proteínas de unión al antígeno del receptor de oncostatina m.
MX380642B (es) Ceramidas y su uso en el diagnostico de enfermedad cardiovascular (ecv).
BR112014026440A8 (pt) análises, métodos e aparelhos para avaliação de disrupção de rna.
EA201692402A1 (ru) Лекарственные формы для местного применения и их использование
CL2018002548A1 (es) Regulación del metabolismo de ornitina para aumentar el contenido de glicoformas ricas en manosa de proteínas recombinantes.(divisional solicitud 201601786)
BR112016028838A2 (pt) anticorpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, métodos de detecção de lgr5 humano em uma amostra biológica, de detecção de um câncer, de identificação de um paciente com câncer, de seleção de um paciente com câncer para tratamento com um imunoconjugado e de tratamento de um paciente com câncer