JP6959327B2 - 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ - Google Patents

濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ Download PDF

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JP6959327B2
JP6959327B2 JP2019508809A JP2019508809A JP6959327B2 JP 6959327 B2 JP6959327 B2 JP 6959327B2 JP 2019508809 A JP2019508809 A JP 2019508809A JP 2019508809 A JP2019508809 A JP 2019508809A JP 6959327 B2 JP6959327 B2 JP 6959327B2
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protein
concentration
salt
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proteins
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JP2019532267A (ja
JP2019532267A5 (enExample
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マイケル マーロウ
マイケル セネット
マイケル シュナイダー
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Regeneron Pharmaceuticals Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N2021/258—Surface plasmon spectroscopy, e.g. micro- or nanoparticles in suspension

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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
JP2019508809A 2016-08-18 2017-08-18 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ Active JP6959327B2 (ja)

Priority Applications (2)

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JP2021165510A JP7321227B2 (ja) 2016-08-18 2021-10-07 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ
JP2023120438A JP2023139189A (ja) 2016-08-18 2023-07-25 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662376788P 2016-08-18 2016-08-18
US62/376,788 2016-08-18
PCT/US2017/047630 WO2018035470A1 (en) 2016-08-18 2017-08-18 Assay for determining potential to self-association of a protein using concentration-dependent self-interaction nanoparticle spectroscopy

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JP2021165510A Division JP7321227B2 (ja) 2016-08-18 2021-10-07 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ

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JP2019532267A JP2019532267A (ja) 2019-11-07
JP2019532267A5 JP2019532267A5 (enExample) 2020-07-16
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JP2019508809A Active JP6959327B2 (ja) 2016-08-18 2017-08-18 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ
JP2021165510A Active JP7321227B2 (ja) 2016-08-18 2021-10-07 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ
JP2023120438A Pending JP2023139189A (ja) 2016-08-18 2023-07-25 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ

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JP2023120438A Pending JP2023139189A (ja) 2016-08-18 2023-07-25 濃度依存性自己相互作用ナノ粒子分光法を用いて、タンパク質が自己会合する可能性を決定するアッセイ

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CN (2) CN115468919A (enExample)
AU (2) AU2017313150B2 (enExample)
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HUE052805T2 (hu) 2016-08-18 2021-05-28 Regeneron Pharma Fehérje önasszociációs képességének meghatározására szolgáló assay koncentrációfüggõ öninterakciós nanorészecske-spektroszkópia segítségével
PT4364724T (pt) 2018-05-10 2025-12-16 Regeneron Pharma Formulações contendo uma proteína de fusão do recetor do vegf de concentração elevada
CN113588582B (zh) * 2020-04-30 2024-05-14 上海药明生物技术有限公司 蛋白质样品浓度测定方式选择法及测定方法
WO2023095154A1 (en) * 2021-11-24 2023-06-01 Sensoville Biotech Pvt Ltd Method for determining changes in a protein's structure
WO2023141319A1 (en) * 2022-01-24 2023-07-27 Amgen Inc. Methods for detecting antibody self-association
CN119832975A (zh) * 2024-12-24 2025-04-15 上海药明生物技术有限公司 一种蛋白质共处方制剂的稳定性预测方法

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ES2352509T3 (es) * 2005-05-02 2011-02-21 Baseclick Gmbh Nuevas estrategias de marcaje para la detección sensible de analitos.
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JP2010506839A (ja) 2006-10-12 2010-03-04 ワイス エルエルシー 乳光の低減を伴う方法および組成物
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JP6099108B2 (ja) 2013-05-30 2017-03-29 公立大学法人大阪府立大学 被検出物質の検出装置および方法
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DK3500856T3 (da) 2020-12-14
JP2023139189A (ja) 2023-10-03
EP3761035A1 (en) 2021-01-06
KR102441221B1 (ko) 2022-09-07
KR102717462B1 (ko) 2024-10-16
CA3032361C (en) 2025-07-08
MX2023013583A (es) 2023-11-30
IL264640B1 (en) 2023-11-01
HUE066064T2 (hu) 2024-07-28
ES2837093T3 (es) 2021-06-29
US20190187149A1 (en) 2019-06-20
KR20190039185A (ko) 2019-04-10
US20240280582A1 (en) 2024-08-22
CN109661577A (zh) 2019-04-19
CN109661577B (zh) 2022-09-27
AU2017313150A1 (en) 2019-02-21
SG11201900895QA (en) 2019-02-27
IL264640B2 (en) 2024-03-01
JP2019532267A (ja) 2019-11-07
MX2019001930A (es) 2019-07-04
US20220357335A1 (en) 2022-11-10
KR20220126801A (ko) 2022-09-16
IL264640A (enExample) 2019-04-30
BR112019003175A2 (pt) 2019-06-18
ES2974961T3 (es) 2024-07-02
JP2022008959A (ja) 2022-01-14
JP7321227B2 (ja) 2023-08-04
EP3500856B1 (en) 2020-10-07
WO2018035470A9 (en) 2018-07-05
AU2023274236A1 (en) 2023-12-21
US11988668B2 (en) 2024-05-21
KR102534506B1 (ko) 2023-05-30
IL307435A (en) 2023-12-01
CA3032361A1 (en) 2018-02-22
WO2018035470A1 (en) 2018-02-22
EA201990316A1 (ru) 2019-07-31
CA3254460A1 (en) 2025-07-03
FI3761035T3 (fi) 2024-03-18
KR20230074614A (ko) 2023-05-30
EP3761035B1 (en) 2024-02-14
EP3500856A1 (en) 2019-06-26
PL3500856T3 (pl) 2021-04-19
AU2017313150B2 (en) 2023-09-14
ZA201901035B (en) 2024-06-26
DK3761035T3 (da) 2024-03-11
CA3254461A1 (en) 2025-07-03
HUE052805T2 (hu) 2021-05-28
CN115468919A (zh) 2022-12-13
US11428695B2 (en) 2022-08-30
PL3761035T3 (pl) 2024-06-24

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