MX2018014256A - Metodos de terapia genica para enfermedades y condiciones relacionadas con la edad. - Google Patents
Metodos de terapia genica para enfermedades y condiciones relacionadas con la edad.Info
- Publication number
- MX2018014256A MX2018014256A MX2018014256A MX2018014256A MX2018014256A MX 2018014256 A MX2018014256 A MX 2018014256A MX 2018014256 A MX2018014256 A MX 2018014256A MX 2018014256 A MX2018014256 A MX 2018014256A MX 2018014256 A MX2018014256 A MX 2018014256A
- Authority
- MX
- Mexico
- Prior art keywords
- conditions
- age
- related diseases
- gene therapy
- therapy methods
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 238000001415 gene therapy Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Obesity (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662339182P | 2016-05-20 | 2016-05-20 | |
| US201662421665P | 2016-11-14 | 2016-11-14 | |
| PCT/US2017/033815 WO2017201527A2 (en) | 2016-05-20 | 2017-05-22 | Gene therapy methods for age-related diseases and conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018014256A true MX2018014256A (es) | 2019-08-16 |
Family
ID=60326179
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014256A MX2018014256A (es) | 2016-05-20 | 2017-05-22 | Metodos de terapia genica para enfermedades y condiciones relacionadas con la edad. |
| MX2022000085A MX2022000085A (es) | 2016-05-20 | 2018-11-20 | Metodos de terapia genica para enfermedades y condiciones relacionadas con la edad. |
| MX2025014039A MX2025014039A (es) | 2016-05-20 | 2018-11-20 | Metodos de terapia genica para enfermedades y condiciones relacionadas con la edad |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022000085A MX2022000085A (es) | 2016-05-20 | 2018-11-20 | Metodos de terapia genica para enfermedades y condiciones relacionadas con la edad. |
| MX2025014039A MX2025014039A (es) | 2016-05-20 | 2018-11-20 | Metodos de terapia genica para enfermedades y condiciones relacionadas con la edad |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12281154B2 (enExample) |
| EP (1) | EP3458585A4 (enExample) |
| JP (4) | JP7632835B2 (enExample) |
| CN (2) | CN109844124B (enExample) |
| AU (2) | AU2017268469C1 (enExample) |
| BR (1) | BR112018073861A2 (enExample) |
| CA (1) | CA3025020A1 (enExample) |
| MX (3) | MX2018014256A (enExample) |
| WO (1) | WO2017201527A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11208443B2 (en) * | 2017-02-14 | 2021-12-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | NAF-1 derived peptides and uses thereof |
| EP4653536A3 (en) * | 2017-03-17 | 2026-02-25 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression |
| CN110913886A (zh) * | 2017-05-24 | 2020-03-24 | 巴塞罗那自治大学 | 包含成纤维细胞生长因子21(fgf21)编码序列的病毒表达构建体 |
| KR102765034B1 (ko) | 2017-05-24 | 2025-02-11 | 유니버시타트 아우토노마 데 바르셀로나 | 섬유아세포 성장 인자 21 (ｆｇｆ21) 코딩 서열을 포함하는 바이러스 발현 컨스트럭트 |
| CA3071337A1 (en) | 2017-08-15 | 2019-02-21 | Kindred Biosciences, Inc. | Igg fc variants for veterinary use |
| CN111491657A (zh) * | 2017-10-20 | 2020-08-04 | 哈佛学院院长及董事 | 用于异源蛋白质生产的人工分泌肽 |
| US11807850B2 (en) | 2017-12-06 | 2023-11-07 | Klogenix Llc | Compositions and methods for modulating gene expression |
| SG11202101819QA (en) * | 2018-08-30 | 2021-03-30 | Res Inst Nationwide Childrens Hospital | Gene therapy for the treatment of galactosemia |
| US20210388053A1 (en) * | 2018-10-18 | 2021-12-16 | Kindred Biosciences, Inc. | Fc Variants with Altered Binding to Neonatal Fc Receptor (FCRN) for Veterinary Use |
| US12134772B2 (en) | 2018-11-21 | 2024-11-05 | Advantage Therapeutics, Inc. | Increasing gene expression |
| MX2021005824A (es) * | 2018-11-26 | 2021-10-13 | UNIV AUTòNOMA DE BARCELONA | Genoterapia con factor 21 de crecimiento de fibroblastos (fgf21). |
| CN114127291A (zh) | 2019-05-23 | 2022-03-01 | 克里斯蒂安娜保健服务公司 | 用于治疗癌症的nrf2基因敲除 |
| WO2020237208A1 (en) | 2019-05-23 | 2020-11-26 | Christiana Care Health Services, Inc. | Gene knockout of variant nrf2 for treatment of cancer |
| US20230038502A1 (en) | 2019-06-11 | 2023-02-09 | Shire Human Genetic Therapies, Inc. | Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein |
| US10653731B1 (en) * | 2019-07-15 | 2020-05-19 | Vigene Biosciences Inc. | Recombinantly-modified adeno-associated virus (rAAV) having improved packaging efficiency |
| KR102281858B1 (ko) * | 2019-09-11 | 2021-07-26 | 주식회사 쎌바이오텍 | 유산균 유래 p8 단백질의 발현 컨스트럭트를 포함하는 대장 질환의 치료 또는 예방용 조성물 |
| KR20220079857A (ko) * | 2019-09-13 | 2022-06-14 | 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 | Aav-상용성 라미닌-링커 중합 단백질 |
| EP4048800A1 (en) | 2019-10-23 | 2022-08-31 | Shire Human Genetic Therapies, Inc. | Adeno-associated virus vectors based gene therapy for hereditary angioedema |
| CN110894508B (zh) * | 2019-10-31 | 2021-08-06 | 内蒙古大学 | 一种调控白色脂肪棕色化的基因Adra1a的应用 |
| CN115515645A (zh) * | 2019-12-05 | 2022-12-23 | 哈佛学院董事及会员团体 | 治疗骨关节炎的方法 |
| JP7588466B2 (ja) * | 2020-01-22 | 2024-11-22 | 旭化成メディカル株式会社 | パルボウイルスの生産方法 |
| EP4142758A4 (en) * | 2020-04-28 | 2025-02-26 | President and Fellows of Harvard College | High efficiency gene delivery system |
| CA3182915A1 (en) * | 2020-05-13 | 2021-11-18 | Lysogene | Compositions and methods for treating gm1 gangliosidosis and other disorders |
| MX2022014754A (es) * | 2020-05-26 | 2023-01-16 | UNIV AUTòNOMA DE BARCELONA | Terapia genica del factor de crecimiento de fibroblastos 21 (fgf21) para trastornos del sistema nervioso central. |
| CN114181944B (zh) * | 2020-09-14 | 2023-10-03 | 中国科学院动物研究所 | 突变基因及构建短肢性侏儒症小型猪模型的方法和用途 |
| WO2022115739A2 (en) * | 2020-11-30 | 2022-06-02 | Cellular Longevity, Inc. | Lnp and liposome compositions for longevity in mammals and methods of using the same |
| US20220186252A1 (en) | 2020-12-16 | 2022-06-16 | Takeda Pharmaceutical Company Limited | Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein |
| KR102590276B1 (ko) * | 2021-01-04 | 2023-10-16 | 부산대학교 산학협력단 | 조직 특이적 발현을 위한 융합 프로모터 및 이의 용도 |
| CN113444730A (zh) * | 2021-03-17 | 2021-09-28 | 昆明市延安医院 | 一种原发性肝细胞klotho基因转导干细胞筛选构建方法 |
| CN113088531B (zh) * | 2021-03-25 | 2023-10-17 | 四川省药品检验研究院(四川省医疗器械检测中心) | 牛源性成分定量分析标准质粒、制备及检测方法及应用 |
| US20240124541A1 (en) * | 2021-04-12 | 2024-04-18 | University of Florida Research Foundation, Incorprated | Compositions and methods for treating obesity |
| JP2022169389A (ja) * | 2021-04-27 | 2022-11-09 | 国立大学法人北海道大学 | イヌＴＧＦ－β受容体ＩＩ |
| US12564646B2 (en) * | 2021-06-16 | 2026-03-03 | BioViva USA, Inc. | Treatment of age-related cognitive decline using genetically modified viral vectors |
| US20230018934A1 (en) * | 2021-07-16 | 2023-01-19 | Genflow Biosciences Srl | Method of in vivo administration of the coding sequence of the sirt6 gene via adeno-associated virus |
| EP4408482A4 (en) * | 2021-09-29 | 2025-11-12 | Sirt6 Ltd | METHOD OF TREATING A DISEASE |
| CN114921480A (zh) * | 2022-06-09 | 2022-08-19 | 国科宁波生命与健康产业研究院 | 一种骨细胞Terc基因敲除小鼠模型的构建方法 |
| WO2024064785A2 (en) * | 2022-09-21 | 2024-03-28 | Rejuvenate Bio | Gene therapy methods for familial partial lipodystrophy |
| WO2024064796A2 (en) * | 2022-09-21 | 2024-03-28 | Rejuvenate Bio | Gene therapy methods for arrhythmogenic cardiomyopathy |
| JP2025531584A (ja) * | 2022-09-21 | 2025-09-19 | レジュヴェネイト バイオ インコーポレイテッド | 僧帽弁疾患を治療するための遺伝子治療方法 |
| CN116790610B (zh) * | 2023-05-18 | 2024-09-20 | 四川大学 | 一种治疗骨科疾病的基因及以aav为载体的基因治疗药物 |
| EP4566618A1 (en) * | 2023-12-06 | 2025-06-11 | ADvantage Therapeutics, Inc. | Nucleic acid encoding klotho for use in therapeutic and non-therapeutic methods for reducing body weight |
| WO2025109173A1 (en) | 2023-11-22 | 2025-05-30 | Advantage Therapeutics, Inc. | Nucleic acid encoding klotho for use in therapeutic and non-therapeutic methods for reducing body weight |
| WO2026002276A1 (zh) * | 2024-06-28 | 2026-01-02 | 艾码生物科技(南京)有限公司 | 靶向tgfb的rna干扰方法、核酸及其应用 |
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| WO2013111081A1 (en) | 2012-01-24 | 2013-08-01 | Bar-Ilan University | Treatment of disease by modulation of sirt6 |
| CN103665166A (zh) * | 2012-09-03 | 2014-03-26 | 福又达生物科技股份有限公司 | 犬融合干扰素 |
| US20160120959A1 (en) | 2013-03-14 | 2016-05-05 | The Board Of Regents Of The University Of Oklahoma | Use of Klotho Nucleic Acids or Proteins for Treatment of Diabetes and Diabetes-Related Conditions |
| US10227394B2 (en) * | 2014-04-08 | 2019-03-12 | University Of Southern California | Polypeptide compositions with type VII collagen fibronectin type III-like repeats and treatment methods for wound closure and healing |
| KR20150135148A (ko) * | 2014-05-23 | 2015-12-02 | 주식회사 제넥신 | Pd-l1 융합 단백질 및 이의 용도 |
| BR112017008157A2 (pt) * | 2014-10-24 | 2017-12-19 | Bristol Myers Squibb Co | polipeptídeos de fgf-21 modificados e usos dos mesmos |
| KR20160088656A (ko) * | 2015-01-16 | 2016-07-26 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| WO2017024407A1 (en) * | 2015-08-11 | 2017-02-16 | The Royal Institution For The Advancement Of Learning/Mcgill University | Peptidic tgf-beta antagonists |
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2017
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- 2017-05-22 EP EP17800329.9A patent/EP3458585A4/en active Pending
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- 2017-05-22 CN CN202311189446.9A patent/CN117535350A/zh active Pending
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2018
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2017268469C1 (en) | 2025-01-02 |
| US20190345224A1 (en) | 2019-11-14 |
| JP2022033855A (ja) | 2022-03-02 |
| JP2019519221A (ja) | 2019-07-11 |
| BR112018073861A2 (pt) | 2019-02-26 |
| US12281154B2 (en) | 2025-04-22 |
| AU2024219991A1 (en) | 2024-10-10 |
| AU2017268469B2 (en) | 2024-07-25 |
| CN117535350A (zh) | 2024-02-09 |
| MX2025014039A (es) | 2026-01-07 |
| MX2022000085A (es) | 2022-02-10 |
| JP2023078338A (ja) | 2023-06-06 |
| JP7315284B2 (ja) | 2023-07-26 |
| US20250122267A1 (en) | 2025-04-17 |
| JP2025078652A (ja) | 2025-05-20 |
| JP7632835B2 (ja) | 2025-02-19 |
| WO2017201527A3 (en) | 2018-02-08 |
| CA3025020A1 (en) | 2017-11-23 |
| CN109844124B (zh) | 2023-10-03 |
| EP3458585A2 (en) | 2019-03-27 |
| WO2017201527A2 (en) | 2017-11-23 |
| CN109844124A (zh) | 2019-06-04 |
| AU2017268469A1 (en) | 2019-01-03 |
| EP3458585A4 (en) | 2019-10-30 |
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