CN117535350A - 年龄相关疾病和病症的基因治疗方法 - Google Patents

年龄相关疾病和病症的基因治疗方法 Download PDF

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CN117535350A
CN117535350A CN202311189446.9A CN202311189446A CN117535350A CN 117535350 A CN117535350 A CN 117535350A CN 202311189446 A CN202311189446 A CN 202311189446A CN 117535350 A CN117535350 A CN 117535350A
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N·戴维森
G·M·丘奇
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Harvard University
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K2319/00Fusion polypeptide
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14132Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
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  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
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CN202311189446.9A 2016-05-20 2017-05-22 年龄相关疾病和病症的基因治疗方法 Pending CN117535350A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662339182P 2016-05-20 2016-05-20
US62/339,182 2016-05-20
US201662421665P 2016-11-14 2016-11-14
US62/421,665 2016-11-14
PCT/US2017/033815 WO2017201527A2 (en) 2016-05-20 2017-05-22 Gene therapy methods for age-related diseases and conditions
CN201780058862.1A CN109844124B (zh) 2016-05-20 2017-05-22 年龄相关疾病和病症的基因治疗方法

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US (2) US12281154B2 (enExample)
EP (1) EP3458585A4 (enExample)
JP (4) JP7632835B2 (enExample)
CN (2) CN109844124B (enExample)
AU (2) AU2017268469C1 (enExample)
BR (1) BR112018073861A2 (enExample)
CA (1) CA3025020A1 (enExample)
MX (2) MX2018014256A (enExample)
WO (1) WO2017201527A2 (enExample)

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CA3025020A1 (en) 2017-11-23
JP7315284B2 (ja) 2023-07-26
JP2022033855A (ja) 2022-03-02
JP2023078338A (ja) 2023-06-06
US12281154B2 (en) 2025-04-22
JP7632835B2 (ja) 2025-02-19
MX2022000085A (es) 2022-02-10
CN109844124B (zh) 2023-10-03
CN109844124A (zh) 2019-06-04
US20250122267A1 (en) 2025-04-17
AU2017268469A1 (en) 2019-01-03
EP3458585A2 (en) 2019-03-27
MX2018014256A (es) 2019-08-16
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WO2017201527A2 (en) 2017-11-23
AU2024219991A1 (en) 2024-10-10
AU2017268469C1 (en) 2025-01-02
JP2025078652A (ja) 2025-05-20
US20190345224A1 (en) 2019-11-14
EP3458585A4 (en) 2019-10-30
AU2017268469B2 (en) 2024-07-25
JP2019519221A (ja) 2019-07-11

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