MX2018001502A - Receptor de antigeno quimerico y celulas t en las cuales se expresa el receptor de antigeno quimerico. - Google Patents

Receptor de antigeno quimerico y celulas t en las cuales se expresa el receptor de antigeno quimerico.

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Publication number
MX2018001502A
MX2018001502A MX2018001502A MX2018001502A MX2018001502A MX 2018001502 A MX2018001502 A MX 2018001502A MX 2018001502 A MX2018001502 A MX 2018001502A MX 2018001502 A MX2018001502 A MX 2018001502A MX 2018001502 A MX2018001502 A MX 2018001502A
Authority
MX
Mexico
Prior art keywords
antigen receptor
chimeric antigen
expressed
cells
domain
Prior art date
Application number
MX2018001502A
Other languages
English (en)
Inventor
Kong Seogkyoung
Original Assignee
Yoo Young Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoo Young Pharm Co Ltd filed Critical Yoo Young Pharm Co Ltd
Publication of MX2018001502A publication Critical patent/MX2018001502A/es

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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Abstract

Se describe un receptor de antígeno quimérico que comprende: un dominio de unión a antígeno; una región de gozne; un dominio transmembrana; un dominio coestimulatorio; y dominio de señalización citoplásmica.
MX2018001502A 2015-08-05 2016-08-05 Receptor de antigeno quimerico y celulas t en las cuales se expresa el receptor de antigeno quimerico. MX2018001502A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150110788 2015-08-05
PCT/KR2016/008632 WO2017023138A1 (ko) 2015-08-05 2016-08-05 키메라 항원 수용체 및 키메라 항원 수용체가 발현된 t 세포

Publications (1)

Publication Number Publication Date
MX2018001502A true MX2018001502A (es) 2018-08-01

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MX2018001502A MX2018001502A (es) 2015-08-05 2016-08-05 Receptor de antigeno quimerico y celulas t en las cuales se expresa el receptor de antigeno quimerico.

Country Status (13)

Country Link
US (1) US10975148B2 (es)
EP (2) EP3575403A1 (es)
JP (1) JP6751493B2 (es)
KR (1) KR102011789B1 (es)
CN (1) CN108026534B (es)
AU (1) AU2016301932B2 (es)
CA (1) CA2994797C (es)
ES (1) ES2877090T3 (es)
IL (1) IL257295B (es)
MX (1) MX2018001502A (es)
RU (1) RU2724738C2 (es)
SG (2) SG11201800872QA (es)
WO (1) WO2017023138A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021004289A2 (pt) * 2018-09-05 2021-08-03 Seogkyoung Kong receptores de antígeno quiméricos e células t que expressam o receptor de antígeno quimérico para tumores sólidos
EP4081552A4 (en) * 2020-02-17 2024-01-24 University of Virginia Patent Foundation CAR-T CELLS AGAINST THE INTEGRIN ALPHAV-BETA3 WITH ROBUST ANTI-TUMOR RESPONSE AGAINST GLIOMAS AND OTHER SOLID TUMORS
CN113402612A (zh) 2020-03-17 2021-09-17 西比曼生物科技（香港）有限公司 靶向cd19和cd20的联合嵌合抗原受体及其应用
CN116178562A (zh) * 2021-11-29 2023-05-30 四川大学华西医院 基于efna1构建的嵌合抗原受体免疫细胞制备及其应用
CN114573711A (zh) * 2022-03-04 2022-06-03 陕西师范大学 一种TanCAR的构建及其应用
KR20230148435A (ko) * 2022-04-14 2023-10-25 주식회사 셀랩메드 키메릭 항원 수용체 및 hgf 결합 억제 물질의 조합 요법
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