MX2018000940A - Formulaciones efervescentes de aspartato de ornitina. - Google Patents
Formulaciones efervescentes de aspartato de ornitina.Info
- Publication number
- MX2018000940A MX2018000940A MX2018000940A MX2018000940A MX2018000940A MX 2018000940 A MX2018000940 A MX 2018000940A MX 2018000940 A MX2018000940 A MX 2018000940A MX 2018000940 A MX2018000940 A MX 2018000940A MX 2018000940 A MX2018000940 A MX 2018000940A
- Authority
- MX
- Mexico
- Prior art keywords
- ornithine aspartate
- formulations
- ornithine
- aspartate
- effervescent
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 238000009472 formulation Methods 0.000 title abstract 6
- IXUZXIMQZIMPSQ-ZBRNBAAYSA-N [(4s)-4-amino-4-carboxybutyl]azanium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound OC(=O)[C@@H](N)CCC[NH3+].[O-]C(=O)[C@@H](N)CC(O)=O IXUZXIMQZIMPSQ-ZBRNBAAYSA-N 0.000 title abstract 5
- 108010049063 ornithylaspartate Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 239000002417 nutraceutical Substances 0.000 abstract 1
- 235000021436 nutraceutical agent Nutrition 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
La presente invención se refiere al campo de formulaciones farmacéuticas y nutracéuticas y, más específicamente, a formulaciones efervescentes de aspartato de ornitina, así como a los procedimientos para su fabricación. Las formulaciones de aspartato de ornitina de acuerdo con la presente invención comprenden un componente generador de gas, así como un componente ácido que libera dióxido de carbono al contacto con agua. La invención proporciona un proceso simple para la fabricación de tales formulaciones, las cuales son químicamente puras y estables y que exhiben altos niveles de efervescencia. El proceso comprende los siguientes pasos: granulación de una mezcla de aspartato de ornitina, la cual comprende aspartato de ornitina y un componente generador de gas, dando así gránulos G. Al mezclar los componentes de una mezcla final que comprende gránulos G y un componente ácido, se produce una formulación efervescente de aspartato de ornitina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3814CH2015 | 2015-07-24 | ||
EP15186592 | 2015-09-24 | ||
PCT/EP2016/067163 WO2017016930A1 (en) | 2015-07-24 | 2016-07-19 | Effervescent formulations of ornithine aspartate |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018000940A true MX2018000940A (es) | 2018-11-09 |
Family
ID=56550217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018000940A MX2018000940A (es) | 2015-07-24 | 2016-07-19 | Formulaciones efervescentes de aspartato de ornitina. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20180214372A1 (es) |
EP (1) | EP3324947B1 (es) |
JP (1) | JP6851330B2 (es) |
KR (1) | KR20180030909A (es) |
CN (1) | CN108024968B (es) |
AU (1) | AU2016299246B2 (es) |
BR (1) | BR112018001410A2 (es) |
CA (1) | CA2991004A1 (es) |
DK (1) | DK3324947T3 (es) |
ES (1) | ES2831179T3 (es) |
HK (1) | HK1254722A1 (es) |
MX (1) | MX2018000940A (es) |
PL (1) | PL3324947T3 (es) |
RU (1) | RU2734417C2 (es) |
WO (1) | WO2017016930A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022161485A1 (zh) * | 2021-01-29 | 2022-08-04 | 张曼 | 一种包含n-乙酰氨基葡萄糖的组合物及其制备方法和应用 |
WO2023182904A1 (ru) * | 2022-03-21 | 2023-09-28 | Акционерное Общество "Производственная Фармацевтическая Компания Обновление" | Шипучий лекарственный препарат для приготовления раствора, способ его изготовления |
CN114965746B (zh) * | 2022-04-24 | 2023-10-03 | 扬子江药业集团广州海瑞药业有限公司 | 门冬氨酸鸟氨酸注射液杂质分析检测方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3241977A (en) * | 1962-01-02 | 1966-03-22 | Gen Foods Corp | Effervescent beverage powders |
GB965637A (en) * | 1962-04-23 | 1964-08-06 | Tanabe Seiyaku Co | L-ornithine l-aspartate |
US4093710A (en) * | 1976-07-07 | 1978-06-06 | Sandoz, Inc. | Rapid dissolving effervescent granules |
GB8820327D0 (en) * | 1988-08-26 | 1988-09-28 | May & Baker Ltd | New compositions of matter |
RU2189228C1 (ru) * | 2001-05-24 | 2002-09-20 | Общество с ограниченной ответственностью "Сантэфарм" | Фармацевтическая композиция в форме шипучих растворимых таблеток и способ ее получения |
US7785640B2 (en) * | 2004-01-16 | 2010-08-31 | Amerilab Technologies, Inc. | Effervescent composition including cranberry extract |
JP2011511797A (ja) * | 2008-02-08 | 2011-04-14 | コルゲート・パーモリブ・カンパニー | 発泡性組成物 |
CN102274166A (zh) * | 2011-07-13 | 2011-12-14 | 辽宁科泰生物基因制药股份有限公司 | 含有门冬氨酸鸟氨酸的药物组合物 |
CN103860517A (zh) * | 2012-12-18 | 2014-06-18 | 北大方正集团有限公司 | 一种门冬氨酸鸟氨酸泡腾片及其制备工艺 |
CN103239434A (zh) * | 2012-12-26 | 2013-08-14 | 辽宁亿灵科创生物医药科技有限公司 | 门冬氨酸鸟氨酸组合物 |
CN103960731B (zh) * | 2013-01-30 | 2016-04-27 | 王玮 | 一种含门冬氨酸鸟氨酸的饮品及其制备方法 |
WO2014139469A1 (en) * | 2013-03-15 | 2014-09-18 | Wuhan Qr Science And Technology Development Co. | Ornithine- or aspartate-containing compositions and the uses thereof |
-
2016
- 2016-07-19 KR KR1020187005346A patent/KR20180030909A/ko not_active Application Discontinuation
- 2016-07-19 PL PL16742240T patent/PL3324947T3/pl unknown
- 2016-07-19 ES ES16742240T patent/ES2831179T3/es active Active
- 2016-07-19 JP JP2017566655A patent/JP6851330B2/ja active Active
- 2016-07-19 WO PCT/EP2016/067163 patent/WO2017016930A1/en active Application Filing
- 2016-07-19 EP EP16742240.1A patent/EP3324947B1/en active Active
- 2016-07-19 MX MX2018000940A patent/MX2018000940A/es unknown
- 2016-07-19 CN CN201680043480.7A patent/CN108024968B/zh active Active
- 2016-07-19 BR BR112018001410A patent/BR112018001410A2/pt not_active IP Right Cessation
- 2016-07-19 DK DK16742240.1T patent/DK3324947T3/da active
- 2016-07-19 CA CA2991004A patent/CA2991004A1/en not_active Abandoned
- 2016-07-19 RU RU2018101200A patent/RU2734417C2/ru active
- 2016-07-19 AU AU2016299246A patent/AU2016299246B2/en not_active Ceased
- 2016-07-19 US US15/746,989 patent/US20180214372A1/en not_active Abandoned
-
2018
- 2018-10-26 HK HK18113733.5A patent/HK1254722A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2991004A1 (en) | 2017-02-02 |
HK1254722A1 (zh) | 2019-07-26 |
PL3324947T3 (pl) | 2021-04-06 |
ES2831179T3 (es) | 2021-06-07 |
AU2016299246B2 (en) | 2021-10-21 |
CN108024968A (zh) | 2018-05-11 |
JP2018525338A (ja) | 2018-09-06 |
US20180214372A1 (en) | 2018-08-02 |
AU2016299246A1 (en) | 2018-01-18 |
DK3324947T3 (da) | 2020-12-14 |
RU2734417C2 (ru) | 2020-10-16 |
WO2017016930A1 (en) | 2017-02-02 |
EP3324947B1 (en) | 2020-09-30 |
KR20180030909A (ko) | 2018-03-26 |
EP3324947A1 (en) | 2018-05-30 |
BR112018001410A2 (pt) | 2018-09-11 |
RU2018101200A (ru) | 2019-07-15 |
JP6851330B2 (ja) | 2021-03-31 |
CN108024968B (zh) | 2022-07-05 |
RU2018101200A3 (es) | 2019-12-23 |
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