MX2017014577A - Derivados de azetidina novedosos útiles como moduladores de neurotransmisión catecolaminérgica cortical. - Google Patents
Derivados de azetidina novedosos útiles como moduladores de neurotransmisión catecolaminérgica cortical.Info
- Publication number
- MX2017014577A MX2017014577A MX2017014577A MX2017014577A MX2017014577A MX 2017014577 A MX2017014577 A MX 2017014577A MX 2017014577 A MX2017014577 A MX 2017014577A MX 2017014577 A MX2017014577 A MX 2017014577A MX 2017014577 A MX2017014577 A MX 2017014577A
- Authority
- MX
- Mexico
- Prior art keywords
- cathecolaminergic
- neurotransmission
- cortical
- modulators
- derivatives useful
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente exposición se relaciona con ciertos compuestos novedosos de la Formula (I) y su utilidad en la modulación de niveles de monoaminas, dopamina, norepinefrina y serotonina en zonas corticales del cerebro y más específicamente para el tratamiento de trastornos del sistema nervioso central.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15168373 | 2015-05-20 | ||
| SE1650485 | 2016-04-11 | ||
| PCT/EP2016/061479 WO2016185032A1 (en) | 2015-05-20 | 2016-05-20 | Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017014577A true MX2017014577A (es) | 2018-06-11 |
| MX365283B MX365283B (es) | 2019-05-29 |
Family
ID=56026881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017014577A MX365283B (es) | 2015-05-20 | 2016-05-20 | Derivados de azetidina novedosos útiles como moduladores de neurotransmisión catecolaminérgica cortical. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10087142B2 (es) |
| EP (1) | EP3297987B1 (es) |
| JP (1) | JP6679621B2 (es) |
| KR (1) | KR102595892B1 (es) |
| CN (1) | CN107646031B (es) |
| AU (1) | AU2016263510B2 (es) |
| CA (1) | CA2985710C (es) |
| DK (1) | DK3297987T3 (es) |
| ES (1) | ES2730890T3 (es) |
| HK (1) | HK1245251B (es) |
| IL (1) | IL255618B (es) |
| MX (1) | MX365283B (es) |
| NZ (1) | NZ737451A (es) |
| PL (1) | PL3297987T3 (es) |
| PT (1) | PT3297987T (es) |
| RU (1) | RU2716814C2 (es) |
| WO (1) | WO2016185032A1 (es) |
| ZA (1) | ZA201707936B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107646031B (zh) * | 2015-05-20 | 2020-11-17 | 综合研究实验室瑞典股份公司 | 用作皮质儿茶酚胺能神经传递调节剂的氮杂环丁烷衍生物 |
| PT3541784T (pt) | 2016-11-18 | 2023-11-22 | Integrative Res Laboratories Sweden Ab | Novos derivados de azetidina úteis como moduladores da neurotransmissão catecolaminérgica cortical |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1512969A1 (ru) * | 1988-02-01 | 1989-10-07 | Институт нефтехимического синтеза им.А.В.Топчиева | Способ получени N-алкилазетидинов |
| FR2805818B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant |
| US20070021404A1 (en) | 2003-06-24 | 2007-01-25 | Dan Peters | Novel aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN101808987A (zh) * | 2007-06-05 | 2010-08-18 | Nsab神经研究瑞典公司分公司 | 作为皮层儿茶酚胺能神经传递调节剂的二取代的苯基吡咯烷 |
| JP5716202B2 (ja) * | 2008-11-24 | 2015-05-13 | インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー | 皮質のカテコールアミン作動性神経伝達のモジュレーターとしての３−フェニル−３−メトキシピロリジン誘導体 |
| CN102224135A (zh) * | 2008-11-24 | 2011-10-19 | Nsab神经研究瑞典公司分公司 | 用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物 |
| WO2010058020A1 (en) * | 2008-11-24 | 2010-05-27 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Novel 1 -alkyl- 3 -hydroxy- 3 -phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
| KR101273566B1 (ko) * | 2011-09-05 | 2013-06-11 | 한국과학기술연구원 | 신규한 아제티딘 유도체 및 이를 함유하는 항우울제 조성물 |
| CN107646031B (zh) * | 2015-05-20 | 2020-11-17 | 综合研究实验室瑞典股份公司 | 用作皮质儿茶酚胺能神经传递调节剂的氮杂环丁烷衍生物 |
-
2016
- 2016-05-20 CN CN201680027679.0A patent/CN107646031B/zh active Active
- 2016-05-20 ES ES16724046T patent/ES2730890T3/es active Active
- 2016-05-20 MX MX2017014577A patent/MX365283B/es active IP Right Grant
- 2016-05-20 AU AU2016263510A patent/AU2016263510B2/en active Active
- 2016-05-20 DK DK16724046.4T patent/DK3297987T3/da active
- 2016-05-20 PT PT16724046T patent/PT3297987T/pt unknown
- 2016-05-20 WO PCT/EP2016/061479 patent/WO2016185032A1/en active Application Filing
- 2016-05-20 RU RU2017140419A patent/RU2716814C2/ru active
- 2016-05-20 US US15/574,796 patent/US10087142B2/en active Active
- 2016-05-20 PL PL16724046T patent/PL3297987T3/pl unknown
- 2016-05-20 KR KR1020177033560A patent/KR102595892B1/ko active IP Right Grant
- 2016-05-20 CA CA2985710A patent/CA2985710C/en active Active
- 2016-05-20 NZ NZ737451A patent/NZ737451A/en unknown
- 2016-05-20 EP EP16724046.4A patent/EP3297987B1/en active Active
- 2016-05-20 JP JP2017560182A patent/JP6679621B2/ja active Active
-
2017
- 2017-11-13 IL IL255618A patent/IL255618B/en active IP Right Grant
- 2017-11-22 ZA ZA2017/07936A patent/ZA201707936B/en unknown
-
2018
- 2018-04-04 HK HK18104487.2A patent/HK1245251B/zh unknown
- 2018-09-27 US US16/144,076 patent/US10287247B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017140419A3 (es) | 2019-07-26 |
| PT3297987T (pt) | 2019-06-19 |
| IL255618B (en) | 2020-02-27 |
| CN107646031A (zh) | 2018-01-30 |
| RU2716814C2 (ru) | 2020-03-17 |
| JP6679621B2 (ja) | 2020-04-15 |
| CA2985710A1 (en) | 2016-11-24 |
| US20190031606A1 (en) | 2019-01-31 |
| KR102595892B1 (ko) | 2023-10-31 |
| RU2017140419A (ru) | 2019-06-20 |
| ES2730890T3 (es) | 2019-11-13 |
| PL3297987T3 (pl) | 2019-10-31 |
| US20180141903A1 (en) | 2018-05-24 |
| HK1245251B (zh) | 2020-04-24 |
| AU2016263510A1 (en) | 2017-12-07 |
| MX365283B (es) | 2019-05-29 |
| IL255618A (en) | 2018-01-31 |
| KR20180004742A (ko) | 2018-01-12 |
| CN107646031B (zh) | 2020-11-17 |
| EP3297987B1 (en) | 2019-05-15 |
| JP2018520100A (ja) | 2018-07-26 |
| DK3297987T3 (da) | 2019-06-17 |
| NZ737451A (en) | 2022-01-28 |
| WO2016185032A1 (en) | 2016-11-24 |
| EP3297987A1 (en) | 2018-03-28 |
| AU2016263510B2 (en) | 2020-03-12 |
| US10087142B2 (en) | 2018-10-02 |
| US10287247B2 (en) | 2019-05-14 |
| ZA201707936B (en) | 2020-01-29 |
| CA2985710C (en) | 2023-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |