MX2017008737A - Poblaciones de celulas rpe y metodos para generar las mismas. - Google Patents

Poblaciones de celulas rpe y metodos para generar las mismas.

Info

Publication number
MX2017008737A
MX2017008737A MX2017008737A MX2017008737A MX2017008737A MX 2017008737 A MX2017008737 A MX 2017008737A MX 2017008737 A MX2017008737 A MX 2017008737A MX 2017008737 A MX2017008737 A MX 2017008737A MX 2017008737 A MX2017008737 A MX 2017008737A
Authority
MX
Mexico
Prior art keywords
methods
cell populations
generating same
rpe cell
cells
Prior art date
Application number
MX2017008737A
Other languages
English (en)
Spanish (es)
Inventor
BOHANA-KASHTAN Osnat
Wiser Ofer
Ann Rosenberg Belmaker Lior
Original Assignee
Cell Cure Neurosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Cure Neurosciences Ltd filed Critical Cell Cure Neurosciences Ltd
Publication of MX2017008737A publication Critical patent/MX2017008737A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0621Eye cells, e.g. cornea, iris pigmented cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/02Atmosphere, e.g. low oxygen conditions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/38Vitamins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/52Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MX2017008737A 2014-12-30 2015-12-30 Poblaciones de celulas rpe y metodos para generar las mismas. MX2017008737A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462097753P 2014-12-30 2014-12-30
US201562116972P 2015-02-17 2015-02-17
US201562195309P 2015-07-22 2015-07-22
PCT/IL2015/051269 WO2016108239A1 (en) 2014-12-30 2015-12-30 Rpe cell populations and methods of generating same

Publications (1)

Publication Number Publication Date
MX2017008737A true MX2017008737A (es) 2018-01-25

Family

ID=55315463

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017008737A MX2017008737A (es) 2014-12-30 2015-12-30 Poblaciones de celulas rpe y metodos para generar las mismas.

Country Status (17)

Country Link
US (6) US11891622B2 (enExample)
EP (2) EP3674397A1 (enExample)
JP (4) JP6882981B2 (enExample)
KR (1) KR20170115514A (enExample)
CN (1) CN107406830A (enExample)
AU (3) AU2015373050B2 (enExample)
BR (1) BR112017014345A2 (enExample)
CA (1) CA2972575A1 (enExample)
DK (1) DK3240892T5 (enExample)
EA (1) EA201791416A1 (enExample)
ES (1) ES2774456T3 (enExample)
HK (1) HK1246348A1 (enExample)
IL (4) IL273405B2 (enExample)
MX (1) MX2017008737A (enExample)
PH (1) PH12017501218A1 (enExample)
SG (1) SG11201705379VA (enExample)
WO (1) WO2016108239A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011063005A2 (en) 2009-11-17 2011-05-26 Advanced Cell Technology, Inc. Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells
US20180011092A1 (en) 2014-12-30 2018-01-11 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
MX2017008737A (es) 2014-12-30 2018-01-25 Cell Cure Neurosciences Ltd Poblaciones de celulas rpe y metodos para generar las mismas.
EA201791518A1 (ru) 2014-12-30 2017-10-31 Селл Кьюр Нейросайансес Лтд. Способы лечения заболеваний сетчатки
PL3331994T3 (pl) * 2015-08-05 2023-01-30 Cell Cure Neurosciences Ltd. Wytwarzanie komórek nabłonka barwnikowego siatkówki
AU2016303631B2 (en) 2015-08-05 2022-07-28 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
CN110913874A (zh) * 2017-03-16 2020-03-24 谱系细胞疗法公司 用于测量视网膜疾病疗法的疗效的方法
CN109957545A (zh) 2017-12-26 2019-07-02 江苏艾尔康生物医药科技有限公司 一种消化rpe细胞的方法
SG11202005795TA (en) * 2017-12-29 2020-07-29 Cell Cure Neurosciences Ltd Retinal pigment epithelium cell compositions
WO2020229628A1 (en) * 2019-05-15 2020-11-19 Novo Nordisk A/S Methods for obtaining eye field progenitor cells from human pluripotent stem cells
CN111972399B (zh) * 2020-08-06 2021-11-30 温州医科大学 维持肝细胞活性的保存液
MX2024001213A (es) 2021-07-28 2024-03-14 Lineage Cell Therapeutics Inc Expansion de celulas del epitelio pigmentario retiniano.
CN115840045B (zh) * 2023-02-23 2023-04-28 中国农业大学 一种猪胚胎期毛囊基板前体细胞的鉴定方法及其应用

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
SG49267A1 (en) 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US6045791A (en) 1992-03-06 2000-04-04 Photogenesis, Inc. Retinal pigment epithelium transplantation
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5405742A (en) 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
US5755785A (en) 1994-08-12 1998-05-26 The University Of South Florida Sutureless corneal transplantation method
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5854015A (en) 1995-10-31 1998-12-29 Applied Food Biotechnology, Inc. Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion
US5941250A (en) 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
GB9715584D0 (en) 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
US6632666B2 (en) 2000-01-14 2003-10-14 Biolife Solutions, Inc. Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media
GB0001930D0 (en) 2000-01-27 2000-03-22 Novartis Ag Organic compounds
PL364135A1 (en) 2001-01-31 2004-12-13 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
AU2003201745A1 (en) 2002-02-11 2003-09-04 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
US6921633B2 (en) 2002-11-18 2005-07-26 Biolife Solutions Incorporated Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
EP1799810A2 (en) 2004-10-12 2007-06-27 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
WO2006070370A2 (en) 2004-12-29 2006-07-06 Hadasit Medical Research Services & Development Limited Stem cells culture systems
US20080003676A1 (en) 2006-06-26 2008-01-03 Millipore Corporation Growth of embryonic stem cells
JP5441099B2 (ja) 2007-01-18 2014-03-12 独立行政法人理化学研究所 視細胞への分化誘導方法
ES2530370T5 (es) 2007-04-18 2018-05-28 Hadasit Medical Research Services & Development Limited Células del epitelio pigmentario de la retina derivadas de células madre
JP5484339B2 (ja) 2007-10-05 2014-05-07 ウェイン ステート ユニバーシティー 合成物の持続的な放出のためのデンドリマー
ES2764473T3 (es) 2007-10-12 2020-06-03 Astellas Inst For Regenerative Medicine Métodos mejorados para producir células RPE y composiciones de células RPE
US20090226955A1 (en) 2007-12-21 2009-09-10 University Of Miami Immortalized retinal pigmented epithelial cells
JP2009180811A (ja) 2008-01-29 2009-08-13 Canon Inc レンズ鏡筒および撮像装置
KR101025880B1 (ko) 2008-10-23 2011-03-30 공희숙 성체 줄기세포를 이용한 인슐린 분비세포로의 분화 유도방법
WO2010133686A1 (en) 2009-05-20 2010-11-25 Cardio3 Biosciences S.A. Parmaceutical composition for the treatment of heart diseases.
WO2011063005A2 (en) * 2009-11-17 2011-05-26 Advanced Cell Technology, Inc. Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells
CN103648507A (zh) 2010-12-30 2014-03-19 人类起源公司 用于冷冻保存和包封细胞的方法
US20120258451A1 (en) 2011-04-08 2012-10-11 Advanced Cell Technology, Inc. Laser isolation of viable cells
EP2702135B1 (en) 2011-04-29 2019-04-17 University of Southern California Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate
JP6223963B2 (ja) 2011-05-18 2017-11-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 網膜疾患を処置するための組成物および方法
CA2855941A1 (en) 2011-11-14 2013-05-23 Advanced Cell Technology, Inc. Pharmaceutical preparations of human rpe cells and uses thereof
US9658216B2 (en) 2012-01-31 2017-05-23 Cell Cure Neurosciences Ltd. Methods of selecting retinal pigmented epithelial cells
US9850463B2 (en) 2012-02-01 2017-12-26 The Regents Of The University Of California Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation
CN102618497B (zh) * 2012-03-15 2013-10-02 中国人民解放军第三军医大学第一附属医院 利用人骨髓间充质干细胞制备视网膜色素上皮细胞的方法
US20150079046A1 (en) 2012-04-03 2015-03-19 Reneuron Limited Stem cell microparticles
CN104640579A (zh) 2012-05-30 2015-05-20 神经技术美国有限公司 冷冻保存的可植入细胞培养装置及其用途
ES2688019T3 (es) 2012-06-05 2018-10-30 The Regents Of The University Of California Métodos y composiciones para la producción acelerada de células epiteliales pigmentadas retinianas a partir de células pluripotentes
SG11201408230VA (en) 2012-06-11 2015-01-29 Macuclear Inc Therapeutic formulation and methods of treatment
EP2925856B1 (en) 2012-12-03 2018-03-07 Biolamina AB Methods of producing rpe cells
US20150368713A1 (en) 2013-02-01 2015-12-24 THE UNITED STATES OF AMERICAN, as represented by the Secretary, Department of Health and Human Serv METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs)
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
US20150159134A1 (en) 2013-12-11 2015-06-11 Pfizer Limited Method for producing retinal pigment epithelial cells
EP3080248A1 (en) * 2013-12-11 2016-10-19 Pfizer Limited Method for producing retinal pigment epithelial cells
US9637721B2 (en) 2013-12-20 2017-05-02 Bio-Ess Laboratories, Llc. Media for cell culture
WO2015175504A1 (en) 2014-05-12 2015-11-19 The Johns Hopkins University Differentiation of human pluripotent stem cells into retinal pigment epithelium using hif1 inhibitors
CA2948820C (en) 2014-05-12 2022-03-22 Jonathan Allen Rowley Ready-to-print cells and integrated devices
EA201791518A1 (ru) 2014-12-30 2017-10-31 Селл Кьюр Нейросайансес Лтд. Способы лечения заболеваний сетчатки
MX2017008737A (es) 2014-12-30 2018-01-25 Cell Cure Neurosciences Ltd Poblaciones de celulas rpe y metodos para generar las mismas.
US20180011092A1 (en) 2014-12-30 2018-01-11 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
US11230696B2 (en) 2015-07-29 2022-01-25 Hadasit Medical Research Services And Development Ltd. Large scale production of retinal pigment epithelial cells
AU2016303631B2 (en) 2015-08-05 2022-07-28 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
PL3331994T3 (pl) 2015-08-05 2023-01-30 Cell Cure Neurosciences Ltd. Wytwarzanie komórek nabłonka barwnikowego siatkówki
AU2016308818B2 (en) 2015-08-18 2022-04-21 Astellas Institute For Regenerative Medicine Clinical formulations
CN105284787A (zh) 2015-10-23 2016-02-03 深圳爱生再生医学科技有限公司 骨髓间充质干细胞的保存试剂及其应用
JP6987769B2 (ja) 2015-10-26 2022-01-05 セル キュア ニューロサイエンシズ リミテッド 網膜色素上皮細胞の調製法
KR101982801B1 (ko) 2015-10-28 2019-05-30 서울대학교 산학협력단 망막색소상피 분화 유도용 조성물
CN110913874A (zh) 2017-03-16 2020-03-24 谱系细胞疗法公司 用于测量视网膜疾病疗法的疗效的方法
SG11202005795TA (en) 2017-12-29 2020-07-29 Cell Cure Neurosciences Ltd Retinal pigment epithelium cell compositions
EP4351334A1 (en) 2021-06-09 2024-04-17 Lineage Cell Therapeutics, Inc. Methods and compositions for treating retinal diseases and conditions

Also Published As

Publication number Publication date
WO2016108239A9 (en) 2017-08-10
IL305070A (en) 2023-10-01
ES2774456T9 (es) 2020-11-05
US20220169982A1 (en) 2022-06-02
IL253238B (en) 2020-04-30
CN107406830A (zh) 2017-11-28
US20220154141A1 (en) 2022-05-19
JP7608192B2 (ja) 2025-01-06
JP2023052646A (ja) 2023-04-11
AU2015373050B2 (en) 2022-09-29
KR20170115514A (ko) 2017-10-17
US20210332325A1 (en) 2021-10-28
US20220169981A1 (en) 2022-06-02
AU2015373050A9 (en) 2017-09-07
EP3240892A1 (en) 2017-11-08
DK3240892T3 (da) 2020-02-17
US20180016553A1 (en) 2018-01-18
US20240301351A1 (en) 2024-09-12
JP6882981B2 (ja) 2021-06-02
IL305070B1 (en) 2025-07-01
IL253238A0 (en) 2017-08-31
ES2774456T3 (es) 2020-07-21
AU2025237944A1 (en) 2025-10-16
IL321407A (en) 2025-08-01
JP2018502576A (ja) 2018-02-01
AU2022291539A1 (en) 2023-02-02
IL273405B1 (en) 2023-09-01
IL273405A (en) 2020-05-31
AU2015373050A1 (en) 2017-07-13
IL273405B2 (en) 2024-01-01
EP3240892B1 (en) 2019-11-06
US11987810B2 (en) 2024-05-21
SG11201705379VA (en) 2017-08-30
BR112017014345A2 (pt) 2018-01-02
US11891622B2 (en) 2024-02-06
EP3240892B9 (en) 2020-07-22
HK1246348A1 (zh) 2018-09-07
IL305070B2 (en) 2025-11-01
EA201791416A1 (ru) 2017-11-30
CA2972575A1 (en) 2016-07-07
JP2025111765A (ja) 2025-07-30
PH12017501218A1 (en) 2018-01-29
EP3674397A1 (en) 2020-07-01
WO2016108239A1 (en) 2016-07-07
DK3240892T5 (da) 2020-10-19
JP2021072832A (ja) 2021-05-13

Similar Documents

Publication Publication Date Title
MX2017008737A (es) Poblaciones de celulas rpe y metodos para generar las mismas.
ZA202310779B (en) Compositions and methods for enhanced gene expression
PT3506403T (pt) Coletor de corrente, placa de elétrodo associada e bateria
EP4374863A3 (en) Methods for generating stem cell-derived beta cells and uses thereof
EP3736821A4 (en) SOLID ELECTROLYTE MATERIAL, AND BATTERY
PL3509145T3 (pl) Kolektor prądu, zawierająca go płytka elektrody i bateria
SG10201810150UA (en) Compositions and methods for enhanced gene expression in cone cells
EP3346537A4 (en) Bipolar plate, cell frame and cell stack, and redox flow battery
SG10201808258SA (en) Improved methods for manufacturing adoptive cell therapies
WO2016103269A8 (en) Populations of neural progenitor cells and methods of producing and using same
IL268354A (en) Microbial cells, methods for their preparation and their uses
EP3251659A4 (en) Nanovesicles derived from cell membrane, and use thereof
EP3316376A4 (en) Bipolar plate, cell frame, cell stack and redox-flow battery
WO2017048809A8 (en) Nk cells exhibiting an adaptive phenotype and methods for preparing and for using
EP3131145A4 (en) Polymer electrolyte composition and polymer electrolyte membrane, membrane-electrolyte assembly, and solid polymer fuel cell using same
EP3644423A4 (en) ELECTROCHEMICAL CELL AND ELECTROCHEMICAL STACK
EP3595059A4 (en) POSITIVE ELECTRODE ACTIVE MATERIAL, AND CELL
TWD178855S (zh) 電連接器
EP3521325A4 (en) POLYMER, SOLID POLYMER ELECTROLYTE MEMBRANE AND MEMBRANE ELECTRODE ARRANGEMENT
EP3098885A4 (en) Titanium material or titanium alloy material that have surface conductivity, fuel cell separator using same, and fuel cell
EP3333960A4 (en) Composition for gel polymer electrolyte, gel polymer electrolyte produced therefrom, and electrochemical element comprising same
EP3235858A4 (en) Polymer-ion-permeable membrane, composite-ion-permeable membrane, battery electrolyte membrane, and electrode composite
EP3309882A4 (en) Cathode composition, cathode and fuel cell including same
WO2018049401A8 (en) PRIMARY LYMPHOCYTE B RESULTING FROM GENETIC EDITION AND METHODS OF PREPARATION AND USE
EP3282507A4 (en) Hydrogen-occlusion alloy, negative electrode including said hydrogen-occlusion alloy, and nickel-hydrogen secondary battery including said negative electrode