MX2017000698A - Uso terapeutico de la proteina de union a neurotrofina p75ntr. - Google Patents
Uso terapeutico de la proteina de union a neurotrofina p75ntr.Info
- Publication number
- MX2017000698A MX2017000698A MX2017000698A MX2017000698A MX2017000698A MX 2017000698 A MX2017000698 A MX 2017000698A MX 2017000698 A MX2017000698 A MX 2017000698A MX 2017000698 A MX2017000698 A MX 2017000698A MX 2017000698 A MX2017000698 A MX 2017000698A
- Authority
- MX
- Mexico
- Prior art keywords
- binding protein
- therapeutic use
- neurotrophin binding
- p75ntr neurotrophin
- p75ntr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención está relacionada a un nuevo uso terapéutico de una proteína de unión a neurotrofina p75NTR y moléculas relacionadas en el tratamiento de osteoartritis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1412748.4A GB201412748D0 (en) | 2014-07-17 | 2014-07-17 | Therapeutic use of P75NTR neurotrophin binding protein |
PCT/GB2015/052083 WO2016009222A1 (en) | 2014-07-17 | 2015-07-17 | Therapeutic use of p75ntr neurotrophin binding protein |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017000698A true MX2017000698A (es) | 2017-04-27 |
Family
ID=51494769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017000698A MX2017000698A (es) | 2014-07-17 | 2015-07-17 | Uso terapeutico de la proteina de union a neurotrofina p75ntr. |
Country Status (17)
Country | Link |
---|---|
US (2) | US11339202B2 (es) |
EP (1) | EP3169347A1 (es) |
JP (2) | JP2017527303A (es) |
KR (2) | KR20170062442A (es) |
CN (1) | CN108137668A (es) |
AU (2) | AU2015288918B2 (es) |
BR (1) | BR112017000833A2 (es) |
CA (1) | CA2953061A1 (es) |
EA (1) | EA201700057A1 (es) |
GB (1) | GB201412748D0 (es) |
HK (1) | HK1256712A1 (es) |
IL (1) | IL249535B (es) |
MX (1) | MX2017000698A (es) |
NZ (1) | NZ727446A (es) |
SG (1) | SG11201700056RA (es) |
WO (1) | WO2016009222A1 (es) |
ZA (1) | ZA201608675B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2825208T1 (sl) | 2012-03-14 | 2017-10-30 | Levicept Ltd. | P75ntr nevrotrofin vezavni protein za terapevtsko rabo |
GB201316592D0 (en) * | 2013-09-18 | 2013-10-30 | Levicept Ltd | Fusion protein |
GB201412748D0 (en) | 2014-07-17 | 2014-09-03 | Levicept Ltd | Therapeutic use of P75NTR neurotrophin binding protein |
GB201504691D0 (en) | 2015-03-19 | 2015-05-06 | Levicept Ltd | Fusion protein |
US11608371B1 (en) | 2021-10-21 | 2023-03-21 | Petmedix Ltd | Therapeutic molecules |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9022648D0 (en) | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
FR2686900B1 (fr) * | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant. |
US9498530B2 (en) * | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
JP2007531707A (ja) | 2003-10-15 | 2007-11-08 | ピーディーエル バイオファーマ, インコーポレイテッド | IGの重鎖定常領域の位置250、314および/または428の変異誘発によるFc融合タンパク質血清半減期の改変 |
DE602005021811D1 (de) * | 2004-09-13 | 2010-07-22 | Genzyme Corp | Multimere konstrukte |
CN101160322A (zh) * | 2005-01-28 | 2008-04-09 | 阿波罗生命科学有限公司 | 分子及其嵌合分子 |
EP1844069A4 (en) * | 2005-01-28 | 2009-05-20 | Apollo Life Sciences Ltd | MOLECULES AND CHIMESE MOLECULES THEREOF |
WO2007026567A1 (ja) | 2005-08-30 | 2007-03-08 | National University Corporation Chiba University | p75NTR阻害剤を有効成分として含有する鎮痛剤 |
WO2007070983A1 (en) | 2005-12-22 | 2007-06-28 | Apollo Life Sciences Limited | Transdermal delivery of pharmaceutical agents |
US8309088B2 (en) * | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
US20100061981A1 (en) * | 2008-08-15 | 2010-03-11 | The Salk Institute For Biological Studies | p75NTR MEDIATES EPHRIN-A REVERSE SIGNALING |
EP2413962A1 (en) * | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Influenza virus vaccines and uses thereof |
SG175436A1 (en) * | 2009-05-04 | 2011-12-29 | Abbott Res Bv | Antibodies against nerve growth factor (ngf) with enhanced in vivo stability |
CN102233128B (zh) | 2010-11-26 | 2013-04-17 | 王延江 | 一种p75NTR-ECD在防治阿尔茨海默病药物中应用 |
ITRM20110024A1 (it) | 2011-01-24 | 2012-07-25 | Consiglio Nazionale Ricerche | Uso di antagonisti del recettore p75ntr e/o di agonisti del recettore trka per il trattamento delle malattie infiammatorie croniche. |
TWI476001B (zh) | 2011-12-26 | 2015-03-11 | Ind Tech Res Inst | 三倍體Fc融合蛋白及其用途 |
CN102586313A (zh) | 2012-03-05 | 2012-07-18 | 中国人民解放军第三军医大学野战外科研究所 | p75NTR-ED-Fc融合蛋白的制备方法及其在损伤中枢神经再生与功能恢复中的应用 |
SI2825208T1 (sl) | 2012-03-14 | 2017-10-30 | Levicept Ltd. | P75ntr nevrotrofin vezavni protein za terapevtsko rabo |
EP2674439B1 (en) * | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
GB201316592D0 (en) | 2013-09-18 | 2013-10-30 | Levicept Ltd | Fusion protein |
GB201412748D0 (en) | 2014-07-17 | 2014-09-03 | Levicept Ltd | Therapeutic use of P75NTR neurotrophin binding protein |
GB201504691D0 (en) | 2015-03-19 | 2015-05-06 | Levicept Ltd | Fusion protein |
-
2014
- 2014-07-17 GB GBGB1412748.4A patent/GB201412748D0/en not_active Ceased
-
2015
- 2015-07-17 KR KR1020177004518A patent/KR20170062442A/ko not_active Application Discontinuation
- 2015-07-17 WO PCT/GB2015/052083 patent/WO2016009222A1/en active Application Filing
- 2015-07-17 US US15/326,936 patent/US11339202B2/en active Active
- 2015-07-17 CA CA2953061A patent/CA2953061A1/en active Pending
- 2015-07-17 KR KR1020227045862A patent/KR20230004967A/ko not_active Application Discontinuation
- 2015-07-17 EP EP15741288.3A patent/EP3169347A1/en active Pending
- 2015-07-17 EA EA201700057A patent/EA201700057A1/ru unknown
- 2015-07-17 BR BR112017000833-5A patent/BR112017000833A2/pt not_active Application Discontinuation
- 2015-07-17 AU AU2015288918A patent/AU2015288918B2/en active Active
- 2015-07-17 JP JP2017522743A patent/JP2017527303A/ja not_active Withdrawn
- 2015-07-17 SG SG11201700056RA patent/SG11201700056RA/en unknown
- 2015-07-17 NZ NZ727446A patent/NZ727446A/en unknown
- 2015-07-17 CN CN201580038782.0A patent/CN108137668A/zh active Pending
- 2015-07-17 MX MX2017000698A patent/MX2017000698A/es unknown
-
2016
- 2016-12-13 IL IL249535A patent/IL249535B/en active IP Right Grant
- 2016-12-15 ZA ZA201608675A patent/ZA201608675B/en unknown
-
2018
- 2018-12-07 HK HK18115709.0A patent/HK1256712A1/zh unknown
-
2021
- 2021-03-15 AU AU2021201611A patent/AU2021201611A1/en active Pending
- 2021-07-14 JP JP2021116160A patent/JP7365378B2/ja active Active
-
2022
- 2022-04-20 US US17/659,991 patent/US20230093211A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA201608675B (en) | 2019-11-27 |
BR112017000833A2 (pt) | 2020-07-07 |
US11339202B2 (en) | 2022-05-24 |
AU2021201611A1 (en) | 2021-04-01 |
JP2017527303A (ja) | 2017-09-21 |
WO2016009222A1 (en) | 2016-01-21 |
CN108137668A (zh) | 2018-06-08 |
AU2015288918A1 (en) | 2017-01-12 |
EP3169347A1 (en) | 2017-05-24 |
GB201412748D0 (en) | 2014-09-03 |
IL249535B (en) | 2021-01-31 |
KR20170062442A (ko) | 2017-06-07 |
JP7365378B2 (ja) | 2023-10-19 |
NZ727446A (en) | 2022-02-25 |
SG11201700056RA (en) | 2017-02-27 |
KR20230004967A (ko) | 2023-01-06 |
US20170204156A1 (en) | 2017-07-20 |
CA2953061A1 (en) | 2016-01-21 |
AU2015288918B2 (en) | 2021-02-25 |
IL249535A0 (en) | 2017-02-28 |
JP2021177766A (ja) | 2021-11-18 |
EA201700057A1 (ru) | 2017-06-30 |
US20230093211A1 (en) | 2023-03-23 |
HK1256712A1 (zh) | 2019-10-04 |
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