MX2016015642A - Derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arisulfonil)f enil)urea como inhibidores de cxcr2. - Google Patents

Derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arisulfonil)f enil)urea como inhibidores de cxcr2.

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Publication number
MX2016015642A
MX2016015642A MX2016015642A MX2016015642A MX2016015642A MX 2016015642 A MX2016015642 A MX 2016015642A MX 2016015642 A MX2016015642 A MX 2016015642A MX 2016015642 A MX2016015642 A MX 2016015642A MX 2016015642 A MX2016015642 A MX 2016015642A
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Mexico
Prior art keywords
derivatives
cyclopent
arylsulfonyl
ure
hydroxy
Prior art date
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MX2016015642A
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English (en)
Inventor
Xichen Lin
Ren Feng
Chen Weichun
F Igboko Ebere
Lu Hongfu
Xu Zhongmiao
Yang Ting
Zhu Lingdong
Bryan Wren Paul
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Glaxosmithkline Ip Dev Ltd
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Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of MX2016015642A publication Critical patent/MX2016015642A/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
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Abstract

La invención se refiere a derivados de 1-(3-sulfonilfenil)-3-(cicl opent-2-en-1-il)urea, y a su uso en el tratamiento o prevención de enfermedades y afecciones mediadas por el receptor CXCR2; además, la invención se refiere a composiciones que contienen los derivados y a procedimientos para su preparación. (ver Fórmula).
MX2016015642A 2014-05-29 2015-05-27 Derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arisulfonil)f enil)urea como inhibidores de cxcr2. MX2016015642A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2014000545 2014-05-29
CN2014083380 2014-07-31
CN2015077947 2015-04-30
PCT/EP2015/061618 WO2015181186A1 (en) 2014-05-29 2015-05-27 1 -(cyclopent-2-en-1 -yl)-3-(2-hydroxy-3-(arylsulfonyl)phenyl)urea derivatives as cxcr2 inhibitors

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MX2016015642A true MX2016015642A (es) 2017-03-15

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US (2) US10106515B2 (es)
EP (1) EP3148963B1 (es)
JP (1) JP6580598B2 (es)
KR (1) KR20170007481A (es)
CN (1) CN107027306B (es)
AU (1) AU2015265993B2 (es)
BR (1) BR112016028037A2 (es)
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UY36141A (es) 2016-02-29
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CA2950466A1 (en) 2015-12-03
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