MX2016014911A - Acidos hidroxamicos heterociclicos como inhibidores de proteina desacetilasa e inhibidores dobles de proteina desacetilasa-proteina cinasa, y metodos de uso de los mismos. - Google Patents
Acidos hidroxamicos heterociclicos como inhibidores de proteina desacetilasa e inhibidores dobles de proteina desacetilasa-proteina cinasa, y metodos de uso de los mismos.Info
- Publication number
- MX2016014911A MX2016014911A MX2016014911A MX2016014911A MX2016014911A MX 2016014911 A MX2016014911 A MX 2016014911A MX 2016014911 A MX2016014911 A MX 2016014911A MX 2016014911 A MX2016014911 A MX 2016014911A MX 2016014911 A MX2016014911 A MX 2016014911A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- inhibitors
- deacetylase
- hydroxamic acids
- methods
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title abstract 4
- 108090000353 Histone deacetylase Proteins 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 Heterocyclic hydroxamic acids Chemical class 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461996702P | 2014-05-14 | 2014-05-14 | |
| US201461996691P | 2014-05-14 | 2014-05-14 | |
| PCT/US2015/030842 WO2015175813A1 (en) | 2014-05-14 | 2015-05-14 | Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016014911A true MX2016014911A (es) | 2017-04-06 |
Family
ID=54480695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014911A MX2016014911A (es) | 2014-05-14 | 2015-05-14 | Acidos hidroxamicos heterociclicos como inhibidores de proteina desacetilasa e inhibidores dobles de proteina desacetilasa-proteina cinasa, y metodos de uso de los mismos. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | USRE47690E1 (enExample) |
| EP (1) | EP3142652B1 (enExample) |
| JP (1) | JP6803235B2 (enExample) |
| KR (1) | KR20170003688A (enExample) |
| CN (1) | CN106456580B (enExample) |
| BR (1) | BR112016026518A2 (enExample) |
| CA (1) | CA2949163A1 (enExample) |
| MX (1) | MX2016014911A (enExample) |
| RU (1) | RU2016148863A (enExample) |
| TW (1) | TW201625620A (enExample) |
| WO (1) | WO2015175813A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9550770B2 (en) | 2013-08-23 | 2017-01-24 | Neupharma, Inc. | Substituted quinazolines for inhibiting kinase activity |
| WO2015175813A1 (en) | 2014-05-14 | 2015-11-19 | The Regents Of The University Of Colorado, A Body Corporate | Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof |
| WO2016095881A1 (en) * | 2014-12-15 | 2016-06-23 | Univerzita Palackeho V Olomouci | Substituted 6-anilino-9-heterocyclylpurine derivatives for inhibition of plant stress |
| CA2976227C (en) * | 2015-02-17 | 2023-10-24 | Neupharma, Inc. | Quinazoline derivatives and their use in treatment of cancer |
| CN106831780A (zh) * | 2015-12-03 | 2017-06-13 | 南开大学 | 具有cdk4/6和hdac抑制活性的新型杂环衍生物 |
| EP3497087B1 (en) | 2016-08-15 | 2021-11-10 | Neupharma, Inc. | Pyrrolo[1,2-c]pyrimidine, imidazo[1,5-c]pyrimidine, quinazoline, purine and imidazo[1,5-a][1,3,5]triazine derivatives as tyrosine kinase inhibitors for the treatment of cancer |
| US10781215B2 (en) * | 2016-10-28 | 2020-09-22 | Bristol-Myers Squibb Company | Heterobicyclic compounds useful as modulators of IL-12, IL-23 and/or IFNα responses |
| IT201700041723A1 (it) * | 2017-04-14 | 2018-10-14 | Italfarmaco Spa | Nuovi inibitori selettivi di HDAC6 |
| CN107513064B (zh) * | 2017-09-27 | 2019-07-09 | 南昌大学 | 一种嘌呤异羟肟酸衍生物及其制备方法和应用 |
| JOP20180094A1 (ar) | 2017-10-18 | 2019-04-18 | Hk Inno N Corp | مركب حلقي غير متجانس كمثبط بروتين كيناز |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| KR102847312B1 (ko) * | 2021-12-30 | 2025-08-19 | 한국화학연구원 | 피라졸로피리미딘 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
| WO2023128708A1 (ko) * | 2021-12-30 | 2023-07-06 | 한국화학연구원 | 피라졸로피리미딘 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
| CN114685507B (zh) * | 2022-04-06 | 2024-01-12 | 山东大学 | 嘌呤胺衍生物类cdk2抑制剂及其制备方法和应用 |
| KR102792443B1 (ko) * | 2022-05-13 | 2025-04-08 | 서울대학교산학협력단 | Cdk를 저해하는 신규 피롤로피리미디논 카복사미드 화합물, 이의 입체이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암 치료용 약학적 조성물 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1254337A (zh) * | 1997-03-04 | 2000-05-24 | 孟山都公司 | N－羟基4－磺酰基丁酰胺化合物 |
| WO1998039315A1 (en) | 1997-03-04 | 1998-09-11 | Monsanto Company | Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds |
| WO1998039326A1 (en) * | 1997-03-04 | 1998-09-11 | Monsanto Company | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds |
| CN1279669A (zh) | 1997-11-14 | 2001-01-10 | G·D·瑟尔公司 | 芳族砜异羟肟酸金属蛋白酶抑制剂 |
| US20020049237A1 (en) | 1998-03-17 | 2002-04-25 | Newton Roger Schofield | Statin-MMP inhibitor combinations |
| EP1355648A2 (en) | 2001-01-11 | 2003-10-29 | Bristol-Myers Squibb Pharma Company | 1,2-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLORPROTEASES AND TNF-$g(a) |
| US20050119305A1 (en) * | 2001-03-21 | 2005-06-02 | Masao Naka | Il-6 production inhibitors |
| PE20030701A1 (es) * | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| AU2003900608A0 (en) | 2003-02-11 | 2003-02-27 | Fujisawa Pharmaceutical Co., Ltd. | Hdac inhibitor |
| WO2004092115A2 (en) * | 2003-04-07 | 2004-10-28 | Axys Pharmaceuticals Inc. | Hydroxamates as therapeutic agents |
| WO2005009958A1 (en) | 2003-07-17 | 2005-02-03 | Plexxikon, Inc. | Ppar active compounds |
| DK1981871T3 (da) * | 2006-01-19 | 2012-02-13 | Janssen Pharmaceutica Nv | Heterocyclylalkylderivater som hidtil ukendte inhibitorer af histondeacetylase |
| BRPI0622100A2 (pt) | 2006-10-30 | 2011-12-27 | Chroma Therapeutics Ltd | hidroxamatos como inibidores de desacetilase de histona |
| KR20090103897A (ko) * | 2006-12-28 | 2009-10-01 | 다이쇼 세이야꾸 가부시끼가이샤 | 피라졸로피리미딘 화합물 |
| WO2009036020A1 (en) | 2007-09-10 | 2009-03-19 | Curis, Inc. | Mek inhibitors containing a zinc binding moiety |
| WO2009036066A1 (en) * | 2007-09-10 | 2009-03-19 | Curis, Inc. | Vegfr inhibitors containing a zinc binding moiety |
| KR101168801B1 (ko) * | 2009-03-27 | 2012-07-25 | 주식회사종근당 | 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 |
| LT2526093T (lt) * | 2010-01-22 | 2016-10-10 | Acetylon Pharmaceuticals, Inc. | Grįžtamieji amido junginiai kaip baltymo deacetilazės inhibitoriai ir jų panaudojimo būdai |
| US8513421B2 (en) | 2010-05-19 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012170827A2 (en) * | 2011-06-08 | 2012-12-13 | Cylene Pharmaceuticals, Inc. | Pyrazolopyrimidines and related heterocycles as ck2 inhibitors |
| WO2013041407A1 (en) * | 2011-09-19 | 2013-03-28 | Cellzome Ag | Hydroxamic acids as hdac6 inhibitors |
| KR20140118575A (ko) | 2013-03-29 | 2014-10-08 | 한미약품 주식회사 | 신규한 하이드록사메이트 유도체 |
| WO2015175813A1 (en) | 2014-05-14 | 2015-11-19 | The Regents Of The University Of Colorado, A Body Corporate | Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof |
-
2015
- 2015-05-14 WO PCT/US2015/030842 patent/WO2015175813A1/en not_active Ceased
- 2015-05-14 BR BR112016026518A patent/BR112016026518A2/pt not_active IP Right Cessation
- 2015-05-14 US US15/968,188 patent/USRE47690E1/en active Active
- 2015-05-14 CN CN201580024748.8A patent/CN106456580B/zh active Active
- 2015-05-14 RU RU2016148863A patent/RU2016148863A/ru unknown
- 2015-05-14 EP EP15792349.1A patent/EP3142652B1/en active Active
- 2015-05-14 KR KR1020167035003A patent/KR20170003688A/ko not_active Withdrawn
- 2015-05-14 MX MX2016014911A patent/MX2016014911A/es unknown
- 2015-05-14 CA CA2949163A patent/CA2949163A1/en not_active Abandoned
- 2015-05-14 JP JP2016567524A patent/JP6803235B2/ja not_active Expired - Fee Related
- 2015-05-14 TW TW104115502A patent/TW201625620A/zh unknown
- 2015-05-14 US US15/310,743 patent/US9840520B2/en not_active Ceased
-
2017
- 2017-07-19 US US15/654,662 patent/US10508122B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10508122B2 (en) | 2019-12-17 |
| BR112016026518A2 (pt) | 2017-08-15 |
| KR20170003688A (ko) | 2017-01-09 |
| US20180044352A1 (en) | 2018-02-15 |
| US9840520B2 (en) | 2017-12-12 |
| US20170081343A1 (en) | 2017-03-23 |
| CN106456580B (zh) | 2020-09-04 |
| CN106456580A (zh) | 2017-02-22 |
| RU2016148863A3 (enExample) | 2018-12-17 |
| EP3142652A1 (en) | 2017-03-22 |
| TW201625620A (zh) | 2016-07-16 |
| RU2016148863A (ru) | 2018-06-18 |
| CA2949163A1 (en) | 2015-11-19 |
| USRE47690E1 (en) | 2019-11-05 |
| JP6803235B2 (ja) | 2020-12-23 |
| EP3142652A4 (en) | 2017-11-29 |
| EP3142652B1 (en) | 2021-08-25 |
| WO2015175813A1 (en) | 2015-11-19 |
| JP2017515848A (ja) | 2017-06-15 |
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