MX2016012008A - Inhibidores de diacilglicerol acil transferasa 2 para utilizarlos en el tratamiento de enfermedades metabolicas y relacionadas. - Google Patents

Inhibidores de diacilglicerol acil transferasa 2 para utilizarlos en el tratamiento de enfermedades metabolicas y relacionadas.

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Publication number
MX2016012008A
MX2016012008A MX2016012008A MX2016012008A MX2016012008A MX 2016012008 A MX2016012008 A MX 2016012008A MX 2016012008 A MX2016012008 A MX 2016012008A MX 2016012008 A MX2016012008 A MX 2016012008A MX 2016012008 A MX2016012008 A MX 2016012008A
Authority
MX
Mexico
Prior art keywords
treatment
metabolic
inhibitors
diacylglycerol acyltransferase
related disorders
Prior art date
Application number
MX2016012008A
Other languages
English (en)
Inventor
Cabral Shawn
Futatsugi Kentaro
Hepworth David
Huard Kim
Wei- Shung Kung Daniel
Song Kun
Tuula Marjukka Orr Suvi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2016012008A publication Critical patent/MX2016012008A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Abstract

En la presente se describen compuestos de la Fórmula I que inhiben la actividad de la diacilglicerol aciltransferasa 2 (DGAT2) y sus usos en el tratamiento de enfermedades relacionadas con estos en animales.
MX2016012008A 2014-03-17 2015-03-03 Inhibidores de diacilglicerol acil transferasa 2 para utilizarlos en el tratamiento de enfermedades metabolicas y relacionadas. MX2016012008A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461954351P 2014-03-17 2014-03-17
PCT/IB2015/051560 WO2015140658A1 (en) 2014-03-17 2015-03-03 Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders

Publications (1)

Publication Number Publication Date
MX2016012008A true MX2016012008A (es) 2016-12-07

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MX2016012008A MX2016012008A (es) 2014-03-17 2015-03-03 Inhibidores de diacilglicerol acil transferasa 2 para utilizarlos en el tratamiento de enfermedades metabolicas y relacionadas.

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US (3) US9440949B2 (es)
EP (1) EP3119757B1 (es)
JP (1) JP6152229B2 (es)
KR (1) KR101772836B1 (es)
CN (1) CN106103425A (es)
AP (1) AP2016009407A0 (es)
AR (1) AR099768A1 (es)
AU (1) AU2015233094B2 (es)
CA (1) CA2942759C (es)
CL (1) CL2016002169A1 (es)
CR (1) CR20160405A (es)
CU (1) CU24395B1 (es)
CY (1) CY1120354T1 (es)
DK (1) DK3119757T3 (es)
DO (1) DOP2016000248A (es)
EA (1) EA032356B1 (es)
EC (1) ECSP16072034A (es)
ES (1) ES2674240T3 (es)
GE (1) GEP20186864B (es)
HR (1) HRP20180992T1 (es)
HU (1) HUE039446T2 (es)
IL (1) IL247809A0 (es)
LT (1) LT3119757T (es)
MA (1) MA39753B1 (es)
MD (1) MD20160099A2 (es)
MX (1) MX2016012008A (es)
NI (1) NI201600129A (es)
PE (1) PE20161368A1 (es)
PH (1) PH12016501654A1 (es)
PL (1) PL3119757T3 (es)
PT (1) PT3119757T (es)
RS (1) RS57384B1 (es)
SG (1) SG11201606779RA (es)
SI (1) SI3119757T1 (es)
SV (1) SV2016005279A (es)
TR (1) TR201809388T4 (es)
TW (1) TWI551596B (es)
UY (1) UY36033A (es)
WO (1) WO2015140658A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3119757B1 (en) 2014-03-17 2018-05-16 Pfizer Inc Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders
AR109179A1 (es) * 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
JP6811489B2 (ja) * 2016-10-17 2021-01-13 学校法人慶應義塾 未分化幹細胞除去剤、及び未分化幹細胞除去方法
EP3538088A1 (en) * 2016-11-11 2019-09-18 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
CN110305966B (zh) * 2019-06-18 2023-03-28 广西壮族自治区水产科学研究院 一种罗非鱼肝脏dgat2基因表达的调控方法
TWI771766B (zh) * 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
IL294139A (en) 2019-12-23 2022-08-01 Lg Chemical Ltd A new aryl amino derivative useful as a diarylglycerol acyltransferase 2 inhibitor and its use
KR102557329B1 (ko) * 2019-12-23 2023-07-19 주식회사 엘지화학 디아실글리세롤 아실트랜스퍼라제 2 억제제로서 유용한 신규 아미드 유도체 및 이의 용도
WO2021161222A1 (en) * 2020-02-11 2021-08-19 Inorbit Therapeutics Ab Compounds useful in inhibiting diacylglycerol o-acyltransferase and methods of making and using the same
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
WO2021236401A1 (en) 2020-05-18 2021-11-25 Merck Sharp & Dohme Corp. Novel diacylglyceride o-acyltransferase 2 inhibitors
TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
KR20230084258A (ko) 2020-10-08 2023-06-12 머크 샤프 앤드 돔 엘엘씨 신규 디아실글리세리드 o-아실트랜스퍼라제 2 억제제로서의 벤즈이미다졸론 유도체의 제조
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1146866A (en) 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
EP0028489B1 (en) 1979-11-05 1983-10-05 Beecham Group Plc Enzyme derivatives, and their preparation
DE3438830A1 (de) 1984-10-23 1986-04-30 Rentschler Arzneimittel Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung
EP0580860B2 (en) 1991-04-16 2004-12-15 Nippon Shinyaku Company, Limited Method of manufacturing solid dispersion
US5340591A (en) 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
JP3265680B2 (ja) 1992-03-12 2002-03-11 大正製薬株式会社 経口製剤用組成物
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
DE19504832A1 (de) 1995-02-14 1996-08-22 Basf Ag Feste Wirkstoff-Zubereitungen
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
ES2287971T3 (es) 1997-08-11 2007-12-16 Pfizer Products Inc. Dispersiones farmaceuticas solidas con biodisponibilidad incrementada.
AU767456B2 (en) 1998-07-06 2003-11-13 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
BR0207658A (pt) 2001-02-28 2005-10-25 Merck & Co Inc Métodos para o tratamento ou a prevenção de distúrbios, doenças ou condições responsivas à ativação do receptor de melanocortina-4, de obesidade, de diabetes melito, de disfunção sexual masculina ou feminina, e de disfunção erétil em um mamìfero que disto necessita, e, composição farmacêutica
CN1642599A (zh) 2002-02-27 2005-07-20 辉瑞产品公司 Acc抑制剂
AR044152A1 (es) 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
US7320992B2 (en) 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
US7241773B2 (en) 2003-12-22 2007-07-10 Abbott Laboratories 3-quinuclidinyl heteroatom bridged biaryl derivatives
EP1747206A1 (en) 2004-04-29 2007-01-31 Abbott Laboratories Amino-tetrazoles analogues and methods of use
RS51106B (sr) 2004-05-12 2010-10-31 Pfizer Products Inc. Derivati prolina i njihova upotreba kao inhibitora dipeptidil peptidaze iv
GEP20094723B (en) 2004-05-25 2009-07-10 Pfizer Prod Inc Tetraazabenzo [e] azulene derivatives and analogs thereof
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
CA2648852C (en) 2006-04-20 2012-12-11 Pfizer Products Inc. Fused phenyl amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases
EP2097420B1 (en) 2006-11-29 2012-04-04 Pfizer Products Inc. Spiroketone inhibitors of acetyl-coa carboxylase
AR070301A1 (es) 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
US8299051B2 (en) 2008-05-13 2012-10-30 Southern Methodist University Beta-lactamase inhibitory compounds
US20110009443A1 (en) 2008-05-28 2011-01-13 Kevin Daniel Freeman-Cook Pyrazolospiroketone Acetyl-Coa Carboxylase Inhibitors
EP2297163B1 (en) 2008-05-28 2015-07-08 Pfizer Inc. Pyrazolospiroketone acetyl-CoA carboxylase inhibitors
WO2010013161A1 (en) 2008-07-29 2010-02-04 Pfizer Inc. Fluorinated heteroaryls
WO2010022055A2 (en) * 2008-08-20 2010-02-25 Amgen Inc. Inhibitors of voltage-gated sodium channels
BRPI0918841B8 (pt) 2008-08-28 2021-05-25 Pfizer derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol, seus cristais, composições farmacêuticas e usos
PE20110854A1 (es) 2008-09-26 2011-12-23 Boehringer Ingelheim Int DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1
DE102008053240A1 (de) 2008-10-25 2010-04-29 Saltigo Gmbh Herstellung von (N-Heterozyklyl)-Arylethern
US8324385B2 (en) 2008-10-30 2012-12-04 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
WO2010086820A1 (en) 2009-02-02 2010-08-05 Pfizer Inc. 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof
WO2010100050A1 (en) 2009-03-05 2010-09-10 F. Hoffmann-La Roche Ag Pyridine-2-yl-carboxylic acid amides
BRPI1013246B1 (pt) 2009-03-11 2019-10-01 Pfizer, Inc. Derivados de benzofuranila, suas composições farmacêuticas e seus usos
CA2754685A1 (en) 2009-03-11 2010-09-16 Pfizer Inc. Substituted indazole amides
CA2754523A1 (en) 2009-03-20 2010-09-23 Pfizer Inc. 3-oxa-7-azabicyclo[3.3.1]nonanes
WO2010128414A1 (en) 2009-05-08 2010-11-11 Pfizer Inc. Gpr 119 modulators
EP2427450A1 (en) 2009-05-08 2012-03-14 Pfizer Inc. Gpr 119 modulators
WO2010140092A1 (en) 2009-06-05 2010-12-09 Pfizer Inc. L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators
JP2012529535A (ja) * 2009-06-12 2012-11-22 ブリストル−マイヤーズ スクイブ カンパニー キナーゼモジュレーターとして有用なニコチンアミド化合物
WO2011005611A1 (en) 2009-07-09 2011-01-13 Merck Sharp & Dohme Corp. Neuromedin u receptor agonists and uses thereof
WO2012024179A1 (en) * 2010-08-18 2012-02-23 Merck Sharp & Dohme Corp. Substituted amide derivatives as dgat-1 inhibitors
EP2714678A1 (en) * 2011-06-02 2014-04-09 Intervet International B.V. Imidazole derivatives
WO2013068328A1 (en) 2011-11-07 2013-05-16 Intervet International B.V. Bicyclo [2.2.2] octan-1-ylcarboxylic acid compounds as dgat-1 inhibitors
CN104334557A (zh) * 2012-04-06 2015-02-04 辉瑞公司 二酰基甘油酰基转移酶2抑制剂
EP3119757B1 (en) * 2014-03-17 2018-05-16 Pfizer Inc Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders

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