UY36033A - “inhibidores de diacilglicerol aciltransferasa 2”. - Google Patents

“inhibidores de diacilglicerol aciltransferasa 2”.

Info

Publication number
UY36033A
UY36033A UY0001036033A UY36033A UY36033A UY 36033 A UY36033 A UY 36033A UY 0001036033 A UY0001036033 A UY 0001036033A UY 36033 A UY36033 A UY 36033A UY 36033 A UY36033 A UY 36033A
Authority
UY
Uruguay
Prior art keywords
diacilglicerol
aciltransferasa
inhibitors
dgat2
animals
Prior art date
Application number
UY0001036033A
Other languages
English (en)
Inventor
Futatsugi Kentaro
Cabral Shawn
Hepworth David
Huard Kim
Kung Daniel Wei-Shung
Orr Suvi Tuula Marjukka
Song Kun
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY36033A publication Critical patent/UY36033A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Child & Adolescent Psychology (AREA)
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Abstract

En la presente se describen compuestos de la Fórmula I que inhiben la actividad de la diacilglicerol aciltransferasa 2 (DGAT2) y sus usos en el tratamiento de enfermedades relacionadas con estos en animales.
UY0001036033A 2014-03-17 2015-03-16 “inhibidores de diacilglicerol aciltransferasa 2”. UY36033A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461954351P 2014-03-17 2014-03-17

Publications (1)

Publication Number Publication Date
UY36033A true UY36033A (es) 2015-10-30

Family

ID=52682788

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036033A UY36033A (es) 2014-03-17 2015-03-16 “inhibidores de diacilglicerol aciltransferasa 2”.

Country Status (39)

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US (3) US9440949B2 (es)
EP (1) EP3119757B1 (es)
JP (1) JP6152229B2 (es)
KR (1) KR101772836B1 (es)
CN (1) CN106103425A (es)
AP (1) AP2016009407A0 (es)
AR (1) AR099768A1 (es)
AU (1) AU2015233094B2 (es)
CA (1) CA2942759C (es)
CL (1) CL2016002169A1 (es)
CR (1) CR20160405A (es)
CU (1) CU24395B1 (es)
CY (1) CY1120354T1 (es)
DK (1) DK3119757T3 (es)
DO (1) DOP2016000248A (es)
EA (1) EA032356B1 (es)
EC (1) ECSP16072034A (es)
ES (1) ES2674240T3 (es)
GE (1) GEP20186864B (es)
HR (1) HRP20180992T1 (es)
HU (1) HUE039446T2 (es)
IL (1) IL247809A0 (es)
LT (1) LT3119757T (es)
MA (1) MA39753B1 (es)
MD (1) MD20160099A2 (es)
MX (1) MX2016012008A (es)
NI (1) NI201600129A (es)
PE (1) PE20161368A1 (es)
PH (1) PH12016501654A1 (es)
PL (1) PL3119757T3 (es)
PT (1) PT3119757T (es)
RS (1) RS57384B1 (es)
SG (1) SG11201606779RA (es)
SI (1) SI3119757T1 (es)
SV (1) SV2016005279A (es)
TR (1) TR201809388T4 (es)
TW (1) TWI551596B (es)
UY (1) UY36033A (es)
WO (1) WO2015140658A1 (es)

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DK3119757T3 (en) * 2014-03-17 2018-06-18 Pfizer DIACYLGYLERIC-ACYL TRANSFERASE-2 INHIBITORS TO USE IN THE TREATMENT OF METABOLIC AND RELATED DISEASES
AR109179A1 (es) * 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
US20190300857A1 (en) * 2016-10-17 2019-10-03 Keio University Undifferentiated stem cell-removing agent, and method for removing undifferentiated stem cells
JP2019533714A (ja) * 2016-11-11 2019-11-21 ３−ブイ・バイオサイエンシーズ・インコーポレイテッド３−Ｖ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 脂質合成の複素環式モジュレーター
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
CN110305966B (zh) * 2019-06-18 2023-03-28 广西壮族自治区水产科学研究院 一种罗非鱼肝脏dgat2基因表达的调控方法
TWI771766B (zh) * 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
EP4071147A4 (en) * 2019-12-23 2023-01-18 Lg Chem, Ltd. NEW AMINO-ARYL DERIVATIVE USEFUL AS A DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR AND THEIR USE
CN114901653A (zh) * 2019-12-23 2022-08-12 株式会社Lg化学 可用作二酰基甘油酰基转移酶2抑制剂的新的酰胺衍生物及其用途
WO2021161222A1 (en) * 2020-02-11 2021-08-19 Inorbit Therapeutics Ab Compounds useful in inhibiting diacylglycerol o-acyltransferase and methods of making and using the same
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
AR122092A1 (es) 2020-05-18 2022-08-10 Merck Sharp & Dohme Inhibidores de diacilglicerol o-aciltransferasa 2
TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
AR123700A1 (es) 2020-10-08 2023-01-04 Merck Sharp & Dohme Preparación de derivados de benzoimidazolona como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
US20240254114A1 (en) 2022-12-02 2024-08-01 Merck Sharp & Dohme Llc Preparation of fused azole derivatives as novel diacylglyceride 0-acyltransferase 2 inhibitors

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