MD20160099A2 - Inhibitori ai diacilglicerol aciltransferazei 2 pentru utilizare în tratamentul tulburărilor metabolice şi a celor asociate - Google Patents

Inhibitori ai diacilglicerol aciltransferazei 2 pentru utilizare în tratamentul tulburărilor metabolice şi a celor asociate Download PDF

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Publication number
MD20160099A2
MD20160099A2 MDA20160099A MD20160099A MD20160099A2 MD 20160099 A2 MD20160099 A2 MD 20160099A2 MD A20160099 A MDA20160099 A MD A20160099A MD 20160099 A MD20160099 A MD 20160099A MD 20160099 A2 MD20160099 A2 MD 20160099A2
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MD
Moldova
Prior art keywords
treatment
metabolic
inhibitors
diacylglycerol acyltransferase
associated disorders
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MDA20160099A
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English (en)
Russian (ru)
Inventor
Шон КАБРАЛ
Кентаро Футацуги
Дэвид Хепуорт
Ким ХАРД
Дэниел Вэй-Шун КУН
Суви Туула Марьюкка Орр
Кунь СУН
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Pfizer Inc.
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Publication of MD20160099A2 publication Critical patent/MD20160099A2/ro

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

Prezenta invenţie se referă la compuşi cu formula generală (I), care inhibă activitatea diacilglicerol aciltransferazei 2 (DGAT2) şi la utilizarea lor în tratamentul bolilor asociate la animale.(I)
MDA20160099A 2014-03-17 2015-03-03 Inhibitori ai diacilglicerol aciltransferazei 2 pentru utilizare în tratamentul tulburărilor metabolice şi a celor asociate MD20160099A2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461954351P 2014-03-17 2014-03-17
PCT/IB2015/051560 WO2015140658A1 (en) 2014-03-17 2015-03-03 Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders

Publications (1)

Publication Number Publication Date
MD20160099A2 true MD20160099A2 (ro) 2017-02-28

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MDA20160099A MD20160099A2 (ro) 2014-03-17 2015-03-03 Inhibitori ai diacilglicerol aciltransferazei 2 pentru utilizare în tratamentul tulburărilor metabolice şi a celor asociate

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US (3) US9440949B2 (ro)
EP (1) EP3119757B1 (ro)
JP (1) JP6152229B2 (ro)
KR (1) KR101772836B1 (ro)
CN (1) CN106103425A (ro)
AP (1) AP2016009407A0 (ro)
AR (1) AR099768A1 (ro)
AU (1) AU2015233094B2 (ro)
CA (1) CA2942759C (ro)
CL (1) CL2016002169A1 (ro)
CR (1) CR20160405A (ro)
CU (1) CU24395B1 (ro)
CY (1) CY1120354T1 (ro)
DK (1) DK3119757T3 (ro)
DO (1) DOP2016000248A (ro)
EA (1) EA032356B1 (ro)
EC (1) ECSP16072034A (ro)
ES (1) ES2674240T3 (ro)
GE (2) GEAP201814268A (ro)
HR (1) HRP20180992T1 (ro)
HU (1) HUE039446T2 (ro)
IL (1) IL247809A0 (ro)
LT (1) LT3119757T (ro)
MA (1) MA39753B1 (ro)
MD (1) MD20160099A2 (ro)
MX (1) MX2016012008A (ro)
NI (1) NI201600129A (ro)
PE (1) PE20161368A1 (ro)
PH (1) PH12016501654A1 (ro)
PL (1) PL3119757T3 (ro)
PT (1) PT3119757T (ro)
RS (1) RS57384B1 (ro)
SG (1) SG11201606779RA (ro)
SI (1) SI3119757T1 (ro)
SV (1) SV2016005279A (ro)
TR (1) TR201809388T4 (ro)
TW (1) TWI551596B (ro)
UY (1) UY36033A (ro)
WO (1) WO2015140658A1 (ro)

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AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
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WO2018089904A1 (en) * 2016-11-11 2018-05-17 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
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RS66416B1 (sr) 2019-01-18 2025-02-28 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene
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TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
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JP7451017B2 (ja) * 2019-12-23 2024-03-18 エルジー・ケム・リミテッド ジアシルグリセロールアシルトランスフェラーゼ２抑制剤として有用な新規アミド誘導体及びその使用
WO2021161222A1 (en) * 2020-02-11 2021-08-19 Inorbit Therapeutics Ab Compounds useful in inhibiting diacylglycerol o-acyltransferase and methods of making and using the same
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
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TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
EP4225739B1 (en) 2020-10-08 2026-01-21 Merck Sharp & Dohme LLC Preparation of benzimidazolone derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
CR20230160A (es) 2020-10-08 2023-06-02 Merck Sharp & Dohme Llc Preparación de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2
JP2024501520A (ja) 2020-12-22 2024-01-12 メルク・シャープ・アンド・ドーム・エルエルシー 新規ジアシルグリセリドｏ－アシルトランスフェラーゼ２阻害薬としてのテトラヒドロインダゾール誘導体の調製
US20250066337A1 (en) 2021-08-26 2025-02-27 Pfizer Inc. Amorphous Form of (S)-2-(5-((3-Ethoxypyridin-2-YL)Oxy)Pyridin-3-YL)-N-(Tetrahydrofuran-3-YL)Pyrimidine-5-Carboxamide
AU2023400409A1 (en) 2022-12-02 2025-06-26 Merck Sharp & Dohme Llc Preparation of fused azole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

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