MX2016009491A - Dipeptidil peptidasa-4 (dpp4/cd26) como biomarcador periferico de activacion de interleucina 13 (il-13) en el pulmon asmatico. - Google Patents
Dipeptidil peptidasa-4 (dpp4/cd26) como biomarcador periferico de activacion de interleucina 13 (il-13) en el pulmon asmatico.Info
- Publication number
- MX2016009491A MX2016009491A MX2016009491A MX2016009491A MX2016009491A MX 2016009491 A MX2016009491 A MX 2016009491A MX 2016009491 A MX2016009491 A MX 2016009491A MX 2016009491 A MX2016009491 A MX 2016009491A MX 2016009491 A MX2016009491 A MX 2016009491A
- Authority
- MX
- Mexico
- Prior art keywords
- dpp4
- antagonist
- disorder
- specific
- biomarker
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
- C12Y304/14005—Dipeptidyl-peptidase IV (3.4.14.5)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5437—IL-13
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
- G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/20—Dermatological disorders
- G01N2800/202—Dermatitis
Abstract
La presente invención se refiere al uso de DPP4 (por ejemplo, niveles de expresión de proteína o génicos) como biomarcador para enfermedades o trastornos mediados por IL-13, por ejemplo, asma, FPI, EPOC o dermatitis atópica. Los niveles del biomarcador DPP4 por encima o por debajo de un nivel umbral predeterminado de DPP4 pueden usarse, por ejemplo, (i) para determinar la elegibilidad de un paciente para un determinado tratamiento con un antagonista de IL-13, (ii) para determinar si un determinado tratamiento de una enfermedad o trastorno mediado por IL-13 con un antagonista de IL-13 debería comenzar, suspenderse o modificarse, (iii) para diagnosticar si una afección o trastorno mediado por IL-13 es tratable con un antagonista específico de IL-13, (iv) para pronosticar el resultado de tratar una enfermedad o trastorno mediado por IL-13 con un antagonista específico de IL-13, etc. La descripción proporciona además kits de ensayo para la detección de DPP4, así como para métodos diagnóstico implementados por ordenador.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461931878P | 2014-01-27 | 2014-01-27 | |
US201461990932P | 2014-05-09 | 2014-05-09 | |
PCT/US2015/012885 WO2015112970A1 (en) | 2014-01-27 | 2015-01-26 | Dipeptidyl peptidase-4 (dpp4/cd26) as a peripheral biomarker of il-13 activation in asthmatic lung |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016009491A true MX2016009491A (es) | 2017-01-13 |
Family
ID=53682019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016009491A MX2016009491A (es) | 2014-01-27 | 2015-01-26 | Dipeptidil peptidasa-4 (dpp4/cd26) como biomarcador periferico de activacion de interleucina 13 (il-13) en el pulmon asmatico. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20160363591A1 (es) |
EP (2) | EP3099323A4 (es) |
JP (1) | JP2017509692A (es) |
KR (1) | KR20160113700A (es) |
CN (1) | CN105934254A (es) |
AU (1) | AU2015209124A1 (es) |
BR (1) | BR112016017192A2 (es) |
CA (1) | CA2937387A1 (es) |
MX (1) | MX2016009491A (es) |
RU (1) | RU2016134838A (es) |
SG (1) | SG11201606102UA (es) |
WO (1) | WO2015112970A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9862762B2 (en) * | 2014-02-07 | 2018-01-09 | Medimmune, Llc | Monoclonal antibodies which bind human periostin |
MX2017008748A (es) | 2015-01-09 | 2017-11-17 | Medimmune Llc | Ensayo para detectar dipeptidil peptidasa iv (dpp-4) humana. |
JP2018538249A (ja) * | 2015-11-04 | 2018-12-27 | アストラゼネカ アクチボラグ | 好酸球性疾患における好酸球標的化治療薬に対する臨床応答の予測変数としてのジペプチジルペプチダーゼ−4およびペリオスチン |
CN107474134B (zh) | 2016-06-08 | 2021-07-27 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
UA124269C2 (uk) * | 2016-09-23 | 2021-08-18 | Дженентек, Інк. | Застосування антагоністу il-13 для лікування атопічного дерматиту |
US10386368B2 (en) | 2017-02-24 | 2019-08-20 | Trustees Of Boston University | Isolation of human lung progenitors derived from pluripotent stem cells |
CN109055522A (zh) * | 2018-07-03 | 2018-12-21 | 吉林大学 | C4orf38在制备用于检测或治疗神经性疼痛的产品中的应用 |
CN113155996A (zh) * | 2021-03-23 | 2021-07-23 | 广州医科大学附属第一医院(广州呼吸中心) | 15(s)-羟基二十碳四烯酸在评估变应原特异性免疫治疗效果中的应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
EP1631680A2 (en) * | 2003-05-21 | 2006-03-08 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4) |
GB0407315D0 (en) | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
AU2005214286A1 (en) * | 2004-02-23 | 2005-09-01 | Erasmus University Medical Center Rotterdam | Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling |
US20090155784A1 (en) * | 2007-01-22 | 2009-06-18 | Wyeth | Assessment of asthma and allergen-dependent gene expression |
US20120005206A1 (en) * | 2007-02-09 | 2012-01-05 | Konstantinos Anagnostakis | Apparatus and method for analysis of data traffic |
CN102099485A (zh) * | 2007-10-23 | 2011-06-15 | 临床基因组学有限公司 | 诊断新生物的方法-ⅱ |
SG2014014138A (en) | 2008-03-31 | 2014-07-30 | Genentech Inc | Compositions and methods for treating and diagnosing asthma |
US20100221752A2 (en) | 2008-10-06 | 2010-09-02 | Somalogic, Inc. | Ovarian Cancer Biomarkers and Uses Thereof |
JP2013544235A (ja) * | 2010-10-15 | 2013-12-12 | メドイミューン・リミテッド | 肺機能を改善する治療法 |
NZ609493A (en) | 2010-12-16 | 2015-11-27 | Genentech Inc | Diagnosis and treatments relating to th2 inhibition |
EP2710370A4 (en) | 2011-05-18 | 2015-01-07 | Medimmune Llc | METHODS OF DIAGNOSING AND TREATING PULMONARY DISEASES OR DISORDERS |
-
2015
- 2015-01-26 JP JP2016566866A patent/JP2017509692A/ja active Pending
- 2015-01-26 SG SG11201606102UA patent/SG11201606102UA/en unknown
- 2015-01-26 BR BR112016017192A patent/BR112016017192A2/pt not_active IP Right Cessation
- 2015-01-26 KR KR1020167023637A patent/KR20160113700A/ko not_active Application Discontinuation
- 2015-01-26 CA CA2937387A patent/CA2937387A1/en not_active Abandoned
- 2015-01-26 EP EP15740660.4A patent/EP3099323A4/en not_active Withdrawn
- 2015-01-26 MX MX2016009491A patent/MX2016009491A/es unknown
- 2015-01-26 EP EP20158832.4A patent/EP3685857A1/en not_active Withdrawn
- 2015-01-26 AU AU2015209124A patent/AU2015209124A1/en not_active Abandoned
- 2015-01-26 WO PCT/US2015/012885 patent/WO2015112970A1/en active Application Filing
- 2015-01-26 US US15/114,467 patent/US20160363591A1/en not_active Abandoned
- 2015-01-26 RU RU2016134838A patent/RU2016134838A/ru not_active Application Discontinuation
- 2015-01-26 CN CN201580005884.2A patent/CN105934254A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3099323A1 (en) | 2016-12-07 |
US20160363591A1 (en) | 2016-12-15 |
JP2017509692A (ja) | 2017-04-06 |
EP3099323A4 (en) | 2017-10-04 |
EP3685857A1 (en) | 2020-07-29 |
SG11201606102UA (en) | 2016-08-30 |
CA2937387A1 (en) | 2015-07-30 |
RU2016134838A3 (es) | 2018-09-27 |
RU2016134838A (ru) | 2018-03-07 |
AU2015209124A1 (en) | 2016-08-18 |
KR20160113700A (ko) | 2016-09-30 |
WO2015112970A1 (en) | 2015-07-30 |
BR112016017192A2 (pt) | 2017-10-10 |
CN105934254A (zh) | 2016-09-07 |
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