MX2016009465A - Pirimidinas fusionadas como inhibidores del complejo p97. - Google Patents

Pirimidinas fusionadas como inhibidores del complejo p97.

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Publication number
MX2016009465A
MX2016009465A MX2016009465A MX2016009465A MX2016009465A MX 2016009465 A MX2016009465 A MX 2016009465A MX 2016009465 A MX2016009465 A MX 2016009465A MX 2016009465 A MX2016009465 A MX 2016009465A MX 2016009465 A MX2016009465 A MX 2016009465A
Authority
MX
Mexico
Prior art keywords
complex
ring
inhibitors
fused pyrimidines
pyrimidine
Prior art date
Application number
MX2016009465A
Other languages
English (en)
Inventor
Zhou Han-Jie
Wustrow David
Original Assignee
Cleave Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52478057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016009465(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cleave Biosciences Inc filed Critical Cleave Biosciences Inc
Publication of MX2016009465A publication Critical patent/MX2016009465A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D491/04—Ortho-condensed systems
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Abstract

La presente invención está dirigida a ciertas pirimidinas fusionadas que tienen un anillo homocíclico o heterocíclico de ciclopentilo, ciclohexilo o cicloheptilo como socio de fusión de la pirimidina; que tienen un grupo aminobencilo o aminobencilo sustituido en la posición 4 del anillo de pirimidina; y un anillo heterobicíclico 5:6 con al menos un N, O, o S en la posición 2 del anillo de pirimidina. Estos compuestos son útiles en el tratamiento del cáncer por inhibición del complejo p97.
MX2016009465A 2014-01-20 2015-01-19 Pirimidinas fusionadas como inhibidores del complejo p97. MX2016009465A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461929382P 2014-01-20 2014-01-20
PCT/US2015/011921 WO2015109285A1 (en) 2014-01-20 2015-01-19 FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

Publications (1)

Publication Number Publication Date
MX2016009465A true MX2016009465A (es) 2016-12-02

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ID=52478057

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MX2016009465A MX2016009465A (es) 2014-01-20 2015-01-19 Pirimidinas fusionadas como inhibidores del complejo p97.

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US (2) US9828363B2 (es)
EP (1) EP3097092B1 (es)
JP (1) JP6387111B2 (es)
KR (1) KR101922317B1 (es)
CN (1) CN106458996B (es)
AR (1) AR099138A1 (es)
AU (1) AU2015206292B2 (es)
BR (1) BR112016016421B1 (es)
CA (1) CA2936559C (es)
CL (1) CL2016001840A1 (es)
EA (1) EA031317B1 (es)
ES (1) ES2819867T3 (es)
IL (1) IL246692B (es)
MX (1) MX2016009465A (es)
NZ (1) NZ722624A (es)
SG (1) SG11201605699QA (es)
TW (1) TWI640516B (es)
WO (1) WO2015109285A1 (es)
ZA (1) ZA201605107B (es)

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EP3080101A1 (en) 2013-12-10 2016-10-19 Cleave Biosciences, Inc. Monocyclic pyrimidine/pyridine compounds as inhibitors of p97 complex
ES2819867T3 (es) 2014-01-20 2021-04-19 Cleave Biosciences Inc Pirimidinas condensadas como inhibidores del complejo p97
HUE056777T2 (hu) * 2016-12-22 2022-03-28 Amgen Inc Benzizotiazol-, izotiazolo[3,4-b]piridin-, kinazolin-, ftálazin-, pirido[2,3-d]piridazin- és pirido[2,3-d]pirimidin-származékok mint KRAS G12C inhibitorok tüdõ-, hasnyálmirigy- vagy vastagbélrák kezelésére
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
UY37870A (es) 2017-09-08 2019-03-29 Amgen Inc Inhibidores de kras g12c y métodos para utilizarlos campo de la invención
US20210230170A1 (en) * 2018-08-31 2021-07-29 Mirati Therapeutics, Inc. Kras g12c inhibitors
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
CA3140392A1 (en) 2019-05-21 2020-11-26 Amgen Inc. Solid state forms
CN110078749B (zh) * 2019-06-04 2021-01-01 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 3a，3a′-双呋喃[2,3-b]吲哚啉类化合物、制备方法、药物组合物及应用
CN110872291B (zh) * 2019-11-26 2021-06-25 五邑大学 一种四氢吡啶并嘧啶类化合物及其制备方法和应用
US20230172936A1 (en) * 2020-05-11 2023-06-08 Cleave Therapeutics, Inc. VCP/p97 INHIBITOR FOR THE TREATMENT OF CANCER
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