MX2016005050A - Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenarativos. - Google Patents

Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenarativos.

Info

Publication number
MX2016005050A
MX2016005050A MX2016005050A MX2016005050A MX2016005050A MX 2016005050 A MX2016005050 A MX 2016005050A MX 2016005050 A MX2016005050 A MX 2016005050A MX 2016005050 A MX2016005050 A MX 2016005050A MX 2016005050 A MX2016005050 A MX 2016005050A
Authority
MX
Mexico
Prior art keywords
semaphorin
binding molecules
neurodegenerative disorders
treating neurodegenerative
plexin
Prior art date
Application number
MX2016005050A
Other languages
English (en)
Inventor
S Smith Ernest
Zauderer Maurice
J Bowers William
Jonason Alan
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of MX2016005050A publication Critical patent/MX2016005050A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporcionan en la presente métodos para aliviar los síntomas en un sujeto que tiene un trastorno neurodegenerativo, que comprenden la administración al sujeto una cantidad efectiva de una molécula de unión aislada que específicamente se une a Semaforina-4D (SEMA4D) o a sus receptores de Plexina-B1 o Plexina-B2. Además, se proporciona una molécula de unión aislada que se une específicamente al mismo epítopo SEMA4D como un anticuerpo de referencia seleccionado del grupo que consiste de VX1572503 y 67.
MX2016005050A 2013-10-21 2014-10-21 Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenarativos. MX2016005050A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361893814P 2013-10-21 2013-10-21
US201461979384P 2014-04-14 2014-04-14
US201462012805P 2014-06-16 2014-06-16
PCT/US2014/061592 WO2015061330A1 (en) 2013-10-21 2014-10-21 Use of semaphorin-4d binding molecules for treating neurodegenerative disorders

Publications (1)

Publication Number Publication Date
MX2016005050A true MX2016005050A (es) 2016-08-17

Family

ID=52826380

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016005050A MX2016005050A (es) 2013-10-21 2014-10-21 Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenarativos.
MX2020009260A MX2020009260A (es) 2013-10-21 2016-04-19 Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenerativos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020009260A MX2020009260A (es) 2013-10-21 2016-04-19 Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenerativos.

Country Status (19)

Country Link
US (4) US9598495B2 (es)
EP (2) EP3060252B1 (es)
JP (2) JP6461944B2 (es)
KR (4) KR20210118246A (es)
CN (2) CN106029093B (es)
AU (3) AU2014340210B2 (es)
BR (1) BR112016009047B1 (es)
CA (2) CA2927841C (es)
DK (1) DK3060252T3 (es)
EA (1) EA033072B1 (es)
ES (1) ES2773961T3 (es)
IL (3) IL275720B (es)
MX (2) MX2016005050A (es)
NZ (1) NZ630892A (es)
PL (1) PL3060252T3 (es)
PT (1) PT3060252T (es)
SG (2) SG10201707786QA (es)
WO (1) WO2015061330A1 (es)
ZA (1) ZA201602686B (es)

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CA2927841A1 (en) 2015-04-30
JP6875363B2 (ja) 2021-05-26
CA3193983A1 (en) 2015-04-30
JP6461944B2 (ja) 2019-01-30
US20150110800A1 (en) 2015-04-23
AU2019257379A1 (en) 2019-11-14
US9249227B2 (en) 2016-02-02
KR102602502B1 (ko) 2023-11-14
PL3060252T3 (pl) 2020-05-18
IL275720A (en) 2020-08-31
KR20220110853A (ko) 2022-08-09
KR20230159633A (ko) 2023-11-21
AU2019257379B2 (en) 2021-04-01
US9598495B2 (en) 2017-03-21
IL295045B1 (en) 2023-12-01
IL295045A (en) 2022-09-01
AU2021202095B9 (en) 2023-11-09
AU2021202095A1 (en) 2021-05-06
ES2773961T3 (es) 2020-07-15
BR112016009047B1 (pt) 2024-02-06
AU2014340210A1 (en) 2016-05-05
SG10201707786QA (en) 2017-10-30
CN116966293A (zh) 2023-10-31
JP2017502920A (ja) 2017-01-26
IL275720B (en) 2022-09-01
JP2019059786A (ja) 2019-04-18
ZA201602686B (en) 2020-11-25
EP3060252B1 (en) 2019-12-11
DK3060252T3 (da) 2020-03-16
IL245089B (en) 2020-10-29
EA033072B1 (ru) 2019-08-30
KR20160065981A (ko) 2016-06-09
CN106029093B (zh) 2023-03-28
US20150353641A1 (en) 2015-12-10
MX2020009260A (es) 2020-10-01
PT3060252T (pt) 2020-03-04
KR20210118246A (ko) 2021-09-29
US20190322757A1 (en) 2019-10-24
SG11201603167YA (en) 2016-05-30
EP3060252A4 (en) 2017-06-07
US20170198053A1 (en) 2017-07-13
KR102308493B1 (ko) 2021-10-07
WO2015061330A1 (en) 2015-04-30
EP3639853A1 (en) 2020-04-22
AU2021202095B2 (en) 2023-11-02
IL295045B2 (en) 2024-04-01
US10385136B2 (en) 2019-08-20
CN106029093A (zh) 2016-10-12
AU2014340210B2 (en) 2019-08-08
CA2927841C (en) 2023-05-23
NZ630892A (en) 2016-03-31
IL245089A0 (en) 2016-06-30
EP3060252A1 (en) 2016-08-31
US10800853B2 (en) 2020-10-13
EA201690813A1 (ru) 2016-08-31
BR112016009047A2 (pt) 2017-09-19

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