MX2015016054A - Terapia de combinacion anti-quimiocina del ligando 2 del motif c-c y anti-lisil oxidasa-tipo 2 para el tratamiento de escleroderma. - Google Patents

Terapia de combinacion anti-quimiocina del ligando 2 del motif c-c y anti-lisil oxidasa-tipo 2 para el tratamiento de escleroderma.

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Publication number
MX2015016054A
MX2015016054A MX2015016054A MX2015016054A MX2015016054A MX 2015016054 A MX2015016054 A MX 2015016054A MX 2015016054 A MX2015016054 A MX 2015016054A MX 2015016054 A MX2015016054 A MX 2015016054A MX 2015016054 A MX2015016054 A MX 2015016054A
Authority
MX
Mexico
Prior art keywords
ccl2
scleroderma
loxl2
treatment
combination therapy
Prior art date
Application number
MX2015016054A
Other languages
English (en)
Other versions
MX371412B (es
Inventor
Paolo G V Martini
Madhusudan Natarajan
Patrick Anthony John Haslett
Albert Barnes Seymour
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of MX2015016054A publication Critical patent/MX2015016054A/es
Publication of MX371412B publication Critical patent/MX371412B/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/54—F(ab')2
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)

Abstract

La presente invención proporciona, entre otras cosas, moléculas biespecíficas que incluyen de modo no taxativo, anticuerpos, fynomers, aptámeros, proteínas de fusión y dominios de unión a la proteína que se unen a CCL2 y LOXL2 y usos de estos, en particular, para el tratamiento de esclerodermia y enfermedades, trastornos y afecciones fibróticos y/o inflamatorios relacionados; en algunas modalidades, la presente invención proporciona además métodos y composiciones para el tratamiento de esclerodermia y enfermedades, trastornos y afecciones fibróticas y/o inflamatorios relacionadas en función de la combinación de moléculas anti-CCL2 y anti-LOXL2 monoespecíficas.
MX2015016054A 2013-05-23 2014-05-23 ANTICUERPOS BIESPECÍFICOS QUE SE UNEN ESPECÍFICAMENTE A LOXL2 Y ccl.2, COMPOSICIONES DE LOS MISMOS, Y SU USO EN EL TRATAMIENTO DE ESCLERODERMIA. MX371412B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361826692P 2013-05-23 2013-05-23
PCT/US2014/039437 WO2014190316A1 (en) 2013-05-23 2014-05-23 Anti-ccl2 and anti-loxl2 combination therapy for treatment of scleroderma

Publications (2)

Publication Number Publication Date
MX2015016054A true MX2015016054A (es) 2016-08-03
MX371412B MX371412B (es) 2020-01-29

Family

ID=50983195

Family Applications (1)

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MX2015016054A MX371412B (es) 2013-05-23 2014-05-23 ANTICUERPOS BIESPECÍFICOS QUE SE UNEN ESPECÍFICAMENTE A LOXL2 Y ccl.2, COMPOSICIONES DE LOS MISMOS, Y SU USO EN EL TRATAMIENTO DE ESCLERODERMIA.

Country Status (11)

Country Link
US (1) US11059906B2 (es)
EP (1) EP2999484B1 (es)
JP (1) JP6587609B2 (es)
CN (1) CN105358175B (es)
AU (2) AU2014268316B2 (es)
BR (1) BR112015029300A2 (es)
CA (1) CA2912443A1 (es)
EA (1) EA201591993A1 (es)
HK (1) HK1224174A1 (es)
MX (1) MX371412B (es)
WO (1) WO2014190316A1 (es)

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CN110767262B (zh) * 2019-09-18 2021-02-26 复旦大学 一种基于结构的核酸适配体优化设计方法
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WO2023097111A2 (en) * 2021-11-29 2023-06-01 Riptide Bioscience, Inc. Methods and compositions for treating calcinosis associated conditions

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Also Published As

Publication number Publication date
US20160083482A1 (en) 2016-03-24
JP2016520594A (ja) 2016-07-14
CN105358175A (zh) 2016-02-24
US11059906B2 (en) 2021-07-13
AU2014268316B2 (en) 2019-10-10
JP6587609B2 (ja) 2019-10-09
AU2019236656A1 (en) 2019-10-17
AU2014268316A1 (en) 2015-12-03
EP2999484B1 (en) 2019-09-11
EP2999484A1 (en) 2016-03-30
BR112015029300A2 (pt) 2017-09-19
MX371412B (es) 2020-01-29
HK1224174A1 (zh) 2017-08-18
CN105358175B (zh) 2020-10-16
CA2912443A1 (en) 2014-11-27
EA201591993A1 (ru) 2016-05-31
WO2014190316A1 (en) 2014-11-27

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