MX2016002492A - Composiciones bioactivas derivables de concentrados de plaquetas, y metodos para prepararlas y usarlas. - Google Patents

Composiciones bioactivas derivables de concentrados de plaquetas, y metodos para prepararlas y usarlas.

Info

Publication number
MX2016002492A
MX2016002492A MX2016002492A MX2016002492A MX2016002492A MX 2016002492 A MX2016002492 A MX 2016002492A MX 2016002492 A MX2016002492 A MX 2016002492A MX 2016002492 A MX2016002492 A MX 2016002492A MX 2016002492 A MX2016002492 A MX 2016002492A
Authority
MX
Mexico
Prior art keywords
methods
preparing
same
bioactive
platelet concentrates
Prior art date
Application number
MX2016002492A
Other languages
English (en)
Spanish (es)
Inventor
John Woods Erik
Gregory Taylor Christopher
Original Assignee
Cook General Biotechnology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook General Biotechnology Llc filed Critical Cook General Biotechnology Llc
Publication of MX2016002492A publication Critical patent/MX2016002492A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/135—Platelet-derived growth factor [PDGF]
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    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115—Platelets, megakaryocytes

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MX2016002492A 2013-08-27 2014-08-27 Composiciones bioactivas derivables de concentrados de plaquetas, y metodos para prepararlas y usarlas. MX2016002492A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361870686P 2013-08-27 2013-08-27
PCT/US2014/052885 WO2015031465A1 (en) 2013-08-27 2014-08-27 Bioactive compositions derivable from platelet concentrates, and methods for preparing and using same

Publications (1)

Publication Number Publication Date
MX2016002492A true MX2016002492A (es) 2016-12-09

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MX2016002492A MX2016002492A (es) 2013-08-27 2014-08-27 Composiciones bioactivas derivables de concentrados de plaquetas, y metodos para prepararlas y usarlas.

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Country Link
US (2) US9757430B2 (https=)
EP (1) EP3038628B1 (https=)
JP (1) JP6649257B2 (https=)
KR (1) KR102313054B1 (https=)
CN (2) CN105636599A (https=)
AU (1) AU2014312421A1 (https=)
BR (1) BR112016004510A2 (https=)
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2840568C (en) * 2011-06-27 2021-05-04 Emory University Compositions, uses, and preparation of platelet lysates
DE102015205293A1 (de) * 2015-03-24 2016-09-29 Marc Schrott Verfahren zur Herstellung von Augentropfen
FR3036707B1 (fr) * 2015-05-29 2019-05-17 Maco Pharma Procede de sterilisation d'un lysat plaquettaire
KR102925966B1 (ko) 2015-05-29 2026-02-10 자디 셀 엘엘씨 미립자 동결건조된 혈소판 용해물 조성물
ES2633815B1 (es) * 2016-03-23 2018-07-06 Biotechnology Institute I Mas D, S.L. Formulación de aplicación tópica, rica en plaquetas y/o factores de crecimiento y un método de preparación de la misma
IL266723B2 (en) * 2016-11-18 2023-10-01 Power Of Platelets Pte Ltd A method for preparing platelet lysate containing growth factors
IL271436B2 (en) * 2017-06-16 2024-02-01 Centre Hospitalier Regional Et Univ De Lille Chru Process for preparing a pooled human platelet lysate, pooled human platelet lysate and its use for treating neurological disorders
EP3920944A4 (en) * 2019-02-07 2023-03-29 Biobridge Global METHODS AND COMPOSITIONS RELATED TO PLATELET RELEASTAT AND PLATELET-RICH FIBRIN
EP4190892A4 (en) * 2020-07-31 2024-10-30 Rainbow Inc. Platelet lysate derived from autologous platelets
JP7313098B2 (ja) * 2021-02-26 2023-07-24 株式会社同仁がん免疫研究所 成長因子混合物を調整する方法
KR102656373B1 (ko) * 2021-06-25 2024-04-12 서울대학교병원 난소 조직 이식용 하이드로겔
EP4276173A1 (en) * 2022-05-10 2023-11-15 Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. Stable human platelet lysate composition, methods and uses thereof
CN115125191B (zh) * 2022-08-22 2023-10-13 浙江绿蔻生物技术有限公司 成纤维细胞转化培养基及其应用、成纤维细胞的制备方法
CN119454910B (zh) * 2023-08-10 2025-10-28 四川大学华西医院 一种仿血小板凝胶修复制剂及其制备方法和促进伤口愈合的用途
WO2025085793A1 (en) * 2023-10-20 2025-04-24 Ossium Health, Inc. Compositions and methods comprising tissue implants
WO2025184489A1 (en) 2024-02-29 2025-09-04 Consano Bio, Inc. Allogeneic human plasma and platelet derived products and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520107A (en) * 1982-09-28 1985-05-28 Polydex Chemicals Ltd. Tissue culture and cell growth-promoting material and its method of manufacture
SE8801537D0 (sv) * 1988-04-26 1988-04-26 Ellco Food Ab Cellodlingsmedium samt forfarande for dess framstellning
SE0501462L (sv) * 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
WO2008034803A1 (en) 2006-09-18 2008-03-27 Medizinische Universität Graz Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
EP2077118A1 (en) 2008-01-07 2009-07-08 Gwo Rei Biomedical Technology Corp. Clottable concentrate of platelet growth factors and preparation method thereof
IT1392897B1 (it) * 2008-07-18 2012-04-02 Fond Ircss Ca' Granda - Ospedale Maggiore Policlinico Frazione piastrinica derivante da sangue placentare
EP2334785B2 (en) 2008-09-16 2019-08-14 Mayo Foundation For Medical Education And Research Compositions containing platelet contents
US20130017180A1 (en) * 2010-04-05 2013-01-17 Allan Mishra Platelet rich plasma formulations
PT2611906T (pt) 2010-08-31 2024-04-16 Gallant Pet Inc Terapias sistémicas com células estaminais alogénicas para tratamento de doenças em gatos e cães
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
CA2840568C (en) * 2011-06-27 2021-05-04 Emory University Compositions, uses, and preparation of platelet lysates
US8430521B2 (en) * 2011-07-02 2013-04-30 Jet Motor Limited Pool lighting assembly
EP2733200A1 (en) 2012-11-15 2014-05-21 Biorigen International SA Cell culture supplements
CA2900971C (en) * 2013-02-12 2023-08-08 Lacerta Technologies Inc. Serum fraction of platelet-rich fibrin

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CN105636599A (zh) 2016-06-01
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CA2922205A1 (en) 2015-03-05
US20150064133A1 (en) 2015-03-05
CA2922205C (en) 2021-08-17
US20170319622A1 (en) 2017-11-09
ES2837854T3 (es) 2021-07-01
US9757430B2 (en) 2017-09-12
JP6649257B2 (ja) 2020-02-19
BR112016004510A2 (pt) 2017-09-12
KR102313054B1 (ko) 2021-10-18
EP3038628B1 (en) 2020-09-23
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