CN105636599A - 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法 - Google Patents
可来源于血小板浓缩液的生物活性组合物及其制备和使用方法 Download PDFInfo
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- CN105636599A CN105636599A CN201480056186.0A CN201480056186A CN105636599A CN 105636599 A CN105636599 A CN 105636599A CN 201480056186 A CN201480056186 A CN 201480056186A CN 105636599 A CN105636599 A CN 105636599A
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- A61K35/14—Blood; Artificial blood
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210028365.XA CN114392274A (zh) | 2013-08-27 | 2014-08-27 | 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361870686P | 2013-08-27 | 2013-08-27 | |
| US61/870,686 | 2013-08-27 | ||
| PCT/US2014/052885 WO2015031465A1 (en) | 2013-08-27 | 2014-08-27 | Bioactive compositions derivable from platelet concentrates, and methods for preparing and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210028365.XA Division CN114392274A (zh) | 2013-08-27 | 2014-08-27 | 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105636599A true CN105636599A (zh) | 2016-06-01 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480056186.0A Pending CN105636599A (zh) | 2013-08-27 | 2014-08-27 | 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法 |
| CN202210028365.XA Pending CN114392274A (zh) | 2013-08-27 | 2014-08-27 | 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210028365.XA Pending CN114392274A (zh) | 2013-08-27 | 2014-08-27 | 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法 |
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| EP (1) | EP3038628B1 (https=) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108671224A (zh) * | 2011-06-27 | 2018-10-19 | 爱默蕾大学 | 血小板裂解物的组合物、用途和制备 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015205293A1 (de) * | 2015-03-24 | 2016-09-29 | Marc Schrott | Verfahren zur Herstellung von Augentropfen |
| FR3036707B1 (fr) * | 2015-05-29 | 2019-05-17 | Maco Pharma | Procede de sterilisation d'un lysat plaquettaire |
| KR102925966B1 (ko) | 2015-05-29 | 2026-02-10 | 자디 셀 엘엘씨 | 미립자 동결건조된 혈소판 용해물 조성물 |
| ES2633815B1 (es) * | 2016-03-23 | 2018-07-06 | Biotechnology Institute I Mas D, S.L. | Formulación de aplicación tópica, rica en plaquetas y/o factores de crecimiento y un método de preparación de la misma |
| IL266723B2 (en) * | 2016-11-18 | 2023-10-01 | Power Of Platelets Pte Ltd | A method for preparing platelet lysate containing growth factors |
| IL271436B2 (en) * | 2017-06-16 | 2024-02-01 | Centre Hospitalier Regional Et Univ De Lille Chru | Process for preparing a pooled human platelet lysate, pooled human platelet lysate and its use for treating neurological disorders |
| EP3920944A4 (en) * | 2019-02-07 | 2023-03-29 | Biobridge Global | METHODS AND COMPOSITIONS RELATED TO PLATELET RELEASTAT AND PLATELET-RICH FIBRIN |
| EP4190892A4 (en) * | 2020-07-31 | 2024-10-30 | Rainbow Inc. | Platelet lysate derived from autologous platelets |
| JP7313098B2 (ja) * | 2021-02-26 | 2023-07-24 | 株式会社同仁がん免疫研究所 | 成長因子混合物を調整する方法 |
| KR102656373B1 (ko) * | 2021-06-25 | 2024-04-12 | 서울대학교병원 | 난소 조직 이식용 하이드로겔 |
| EP4276173A1 (en) * | 2022-05-10 | 2023-11-15 | Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. | Stable human platelet lysate composition, methods and uses thereof |
| CN115125191B (zh) * | 2022-08-22 | 2023-10-13 | 浙江绿蔻生物技术有限公司 | 成纤维细胞转化培养基及其应用、成纤维细胞的制备方法 |
| CN119454910B (zh) * | 2023-08-10 | 2025-10-28 | 四川大学华西医院 | 一种仿血小板凝胶修复制剂及其制备方法和促进伤口愈合的用途 |
| WO2025085793A1 (en) * | 2023-10-20 | 2025-04-24 | Ossium Health, Inc. | Compositions and methods comprising tissue implants |
| WO2025184489A1 (en) | 2024-02-29 | 2025-09-04 | Consano Bio, Inc. | Allogeneic human plasma and platelet derived products and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010007502A2 (en) * | 2008-07-18 | 2010-01-21 | Fondazione Irccs "Ospedale Maggiore Policlinico Mangiagalli E Regina Elena" | Platelet fraction deriving from placental blood |
| WO2013003356A1 (en) * | 2011-06-27 | 2013-01-03 | Emory University | Compositions, uses, and preparation of platelet lysates |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4520107A (en) * | 1982-09-28 | 1985-05-28 | Polydex Chemicals Ltd. | Tissue culture and cell growth-promoting material and its method of manufacture |
| SE8801537D0 (sv) * | 1988-04-26 | 1988-04-26 | Ellco Food Ab | Cellodlingsmedium samt forfarande for dess framstellning |
| SE0501462L (sv) * | 2005-06-23 | 2006-09-26 | Proliff Ab | Förfarande för framställning av blodplättslysat |
| WO2008034803A1 (en) | 2006-09-18 | 2008-03-27 | Medizinische Universität Graz | Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics |
| EP2077118A1 (en) | 2008-01-07 | 2009-07-08 | Gwo Rei Biomedical Technology Corp. | Clottable concentrate of platelet growth factors and preparation method thereof |
| EP2334785B2 (en) | 2008-09-16 | 2019-08-14 | Mayo Foundation For Medical Education And Research | Compositions containing platelet contents |
| US20130017180A1 (en) * | 2010-04-05 | 2013-01-17 | Allan Mishra | Platelet rich plasma formulations |
| PT2611906T (pt) | 2010-08-31 | 2024-04-16 | Gallant Pet Inc | Terapias sistémicas com células estaminais alogénicas para tratamento de doenças em gatos e cães |
| IL210162A0 (en) | 2010-12-21 | 2011-03-31 | Omrix Biopharmaceuticals | Viral inactivated platelet extract, use and preparation thereof |
| US8430521B2 (en) * | 2011-07-02 | 2013-04-30 | Jet Motor Limited | Pool lighting assembly |
| EP2733200A1 (en) | 2012-11-15 | 2014-05-21 | Biorigen International SA | Cell culture supplements |
| CA2900971C (en) * | 2013-02-12 | 2023-08-08 | Lacerta Technologies Inc. | Serum fraction of platelet-rich fibrin |
-
2014
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- 2014-08-27 BR BR112016004510A patent/BR112016004510A2/pt not_active Application Discontinuation
- 2014-08-27 KR KR1020167007410A patent/KR102313054B1/ko active Active
- 2014-08-27 AU AU2014312421A patent/AU2014312421A1/en not_active Abandoned
- 2014-08-27 US US14/469,963 patent/US9757430B2/en active Active
- 2014-08-27 JP JP2016537808A patent/JP6649257B2/ja active Active
- 2014-08-27 CN CN201480056186.0A patent/CN105636599A/zh active Pending
- 2014-08-27 EP EP14766283.7A patent/EP3038628B1/en active Active
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- 2014-08-27 ES ES14766283T patent/ES2837854T3/es active Active
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-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010007502A2 (en) * | 2008-07-18 | 2010-01-21 | Fondazione Irccs "Ospedale Maggiore Policlinico Mangiagalli E Regina Elena" | Platelet fraction deriving from placental blood |
| WO2013003356A1 (en) * | 2011-06-27 | 2013-01-03 | Emory University | Compositions, uses, and preparation of platelet lysates |
| CN103702674A (zh) * | 2011-06-27 | 2014-04-02 | 爱默蕾大学 | 血小板裂解物的组合物、用途和制备 |
Non-Patent Citations (4)
| Title |
|---|
| ANITUA E ET AL: "Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture", 《J ORTHOP RES》 * |
| COPLAND IB ET AL: "The effect of platelet lysate fibrinogen on the functionality of MSCs in mumunotherapy", 《BIOMATERIALS》 * |
| 中国医学创新杂志社编: "《实用临床诊疗技术 4 医学检验分册》", 30 June 2009 * |
| 马志华 等: "《实用实验诊断》", 31 March 1997 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108671224A (zh) * | 2011-06-27 | 2018-10-19 | 爱默蕾大学 | 血小板裂解物的组合物、用途和制备 |
| CN108671224B (zh) * | 2011-06-27 | 2022-12-13 | 爱默蕾大学 | 血小板裂解物的组合物、用途和制备 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160054496A (ko) | 2016-05-16 |
| WO2015031465A1 (en) | 2015-03-05 |
| JP2016529283A (ja) | 2016-09-23 |
| MX2016002492A (es) | 2016-12-09 |
| AU2014312421A1 (en) | 2016-04-14 |
| CN114392274A (zh) | 2022-04-26 |
| CA2922205A1 (en) | 2015-03-05 |
| US20150064133A1 (en) | 2015-03-05 |
| CA2922205C (en) | 2021-08-17 |
| US20170319622A1 (en) | 2017-11-09 |
| ES2837854T3 (es) | 2021-07-01 |
| US9757430B2 (en) | 2017-09-12 |
| JP6649257B2 (ja) | 2020-02-19 |
| BR112016004510A2 (pt) | 2017-09-12 |
| KR102313054B1 (ko) | 2021-10-18 |
| EP3038628B1 (en) | 2020-09-23 |
| EP3038628A1 (en) | 2016-07-06 |
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