MX2015012201A - Formulaciones modificadas de liposomas de docetaxel. - Google Patents
Formulaciones modificadas de liposomas de docetaxel.Info
- Publication number
- MX2015012201A MX2015012201A MX2015012201A MX2015012201A MX2015012201A MX 2015012201 A MX2015012201 A MX 2015012201A MX 2015012201 A MX2015012201 A MX 2015012201A MX 2015012201 A MX2015012201 A MX 2015012201A MX 2015012201 A MX2015012201 A MX 2015012201A
- Authority
- MX
- Mexico
- Prior art keywords
- liposome formulations
- lipid
- docetaxel liposome
- taxane
- peg
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 150000004625 docetaxel anhydrous derivatives Chemical class 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 229940123237 Taxane Drugs 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 229930182558 Sterol Natural products 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960003668 docetaxel Drugs 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 phosphatidylcholine lipid Chemical class 0.000 abstract 1
- 150000003432 sterols Chemical class 0.000 abstract 1
- 235000003702 sterols Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779902P | 2013-03-13 | 2013-03-13 | |
| PCT/US2014/026483 WO2014160392A1 (en) | 2013-03-13 | 2014-03-13 | Modified docetaxel liposome formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015012201A true MX2015012201A (es) | 2015-11-30 |
Family
ID=50686145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015012201A MX2015012201A (es) | 2013-03-13 | 2014-03-13 | Formulaciones modificadas de liposomas de docetaxel. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140271822A1 (enExample) |
| EP (1) | EP2968145A1 (enExample) |
| JP (3) | JP6294456B2 (enExample) |
| CN (1) | CN105188675A (enExample) |
| BR (1) | BR112015022819A8 (enExample) |
| CA (1) | CA2903255C (enExample) |
| MX (1) | MX2015012201A (enExample) |
| WO (1) | WO2014160392A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2968145A1 (en) * | 2013-03-13 | 2016-01-20 | Mallinckrodt LLC | Modified docetaxel liposome formulations |
| CN104622810B (zh) * | 2015-02-15 | 2018-06-08 | 中国药科大学 | 一种稳定型难溶性抗肿瘤药物脂质体及其制备方法 |
| EP3258913A1 (en) * | 2015-02-17 | 2017-12-27 | Mallinckrodt Nuclear Medicine LLC | Modified docetaxel liposome formulations and uses thereof |
| WO2016161428A1 (en) * | 2015-04-02 | 2016-10-06 | The Research Foundation For The State University Of New York | Serum-stable compositions and methods for light-triggered release of materials |
| US20180344644A1 (en) * | 2015-09-21 | 2018-12-06 | Mallinckrodt Llc | Improved stability of liposome formulations and uses thereof |
| PH12022550592A1 (en) * | 2016-01-07 | 2023-07-17 | Tesorx Pharma Llc | Formulations for treating bladder cancer |
| BR112018068000A2 (pt) * | 2016-03-16 | 2019-02-05 | Merrimack Pharmaceuticals Inc | composições de nanolipossomas de geração de docetaxel direcionados ao receptor a2 de efrina (epha2) |
| EP3429631A1 (en) * | 2016-03-16 | 2019-01-23 | Merrimack Pharmaceuticals, Inc. | Treating ephrin receptor a2 (epha2) positive cancer with targeted docetaxel-generating nano-liposome compositions |
| JP2019512477A (ja) * | 2016-03-16 | 2019-05-16 | メリマック ファーマシューティカルズ インコーポレーティッド | エフリン受容体ａ２（ｅｐｈａ２）のナノリポソーム標的化及び関連する診断 |
| KR102509892B1 (ko) * | 2016-08-18 | 2023-03-13 | 트로이 브레머 | 리포솜 작제물을 사용한 황반 및 망막의 세포에의 우레아의 전달 |
| CN107951861B (zh) * | 2016-10-17 | 2020-12-01 | 南京绿叶制药有限公司 | 一种脂质纳米粒膜材料组合物 |
| US20210290537A1 (en) * | 2016-12-08 | 2021-09-23 | Mallinckrodt Llc | Liposomal elinafide formulations and uses thereof |
| CA3069125A1 (en) | 2017-07-07 | 2019-01-10 | Drexel University | Voltage-activated therapeutic, diagnostic, and/or theranostic constructs |
| CN110496103B (zh) * | 2018-05-18 | 2022-05-10 | 上海维洱生物医药科技有限公司 | 一种多西他赛棕榈酸酯脂质体及其制备方法 |
| TWI755629B (zh) * | 2018-09-13 | 2022-02-21 | 台灣微脂體股份有限公司 | 含鎮靜藥物之緩釋藥物組合物及其用途 |
| EP3866764A4 (en) * | 2018-10-17 | 2022-07-13 | Taiwan Liposome Company, Ltd. | DELAYED RELEASE PHARMACEUTICAL COMPOSITIONS WITH AN IMMUNOMODULATING AGENT AND USES THEREOF |
| AR122300A1 (es) * | 2019-08-09 | 2022-08-31 | Tesorxpharma Llc | Formulaciones proliposomales de testosterona undecanoato |
| CN110571005B (zh) * | 2019-09-27 | 2021-01-01 | 广西科技大学 | 一种固定化金属离子-磁性脂质体及其制备方法和应用 |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
| CN114588279B (zh) * | 2022-03-31 | 2023-10-20 | 重庆医科大学附属第二医院 | 一种多功能纳米分子探针及其制备方法和其作为视网膜母细胞瘤诊疗制剂的应用 |
| WO2025124498A1 (zh) * | 2023-12-13 | 2025-06-19 | 上海艾力斯医药科技股份有限公司 | 一种含氮杂环化合物的脂质体及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994005282A1 (en) | 1992-09-04 | 1994-03-17 | The Scripps Research Institute | Water soluble taxol derivatives |
| US5824701A (en) | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
| US6107332A (en) | 1995-09-12 | 2000-08-22 | The Liposome Company, Inc. | Hydrolysis-promoting hydrophobic taxane derivatives |
| TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| US6541508B2 (en) | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
| CA2383259A1 (en) * | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| JP2006508126A (ja) * | 2002-11-06 | 2006-03-09 | アザヤ セラピューティクス インコーポレイティッド | 薬学的製剤のタンパク質安定化されたリポソーム製剤 |
| US20070003607A1 (en) * | 2003-09-02 | 2007-01-04 | Vibhudutta Awasthi | Neutral liposome-encapsulated compounds and methods of making and using thereof |
| US7985417B2 (en) * | 2004-10-08 | 2011-07-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of lipid structure preparation |
| MX2007013200A (es) * | 2005-04-22 | 2008-03-24 | Johnson & Johnson | Composicion de inmunoliposoma para el direccionamiento hacia un receptor de la celula her2. |
| CN101485629B (zh) * | 2008-01-16 | 2013-01-23 | 沈阳药科大学 | 一种给药系统及其制备方法 |
| JP5542804B2 (ja) * | 2008-05-23 | 2014-07-09 | ザ ユニヴァーシティ オブ ブリティッシュ コロンビア | リポソームナノ粒子中で使用するための修飾薬物 |
| CN102038641B (zh) * | 2009-10-26 | 2013-04-17 | 石药集团中奇制药技术（石家庄）有限公司 | 一种外层经亲水聚合物修饰的脂质体药物的制备方法 |
| US20120231066A1 (en) * | 2011-01-24 | 2012-09-13 | Henry John Smith | Multi-drug liposomes to treat tumors |
| EP2667848A1 (en) * | 2011-01-28 | 2013-12-04 | Koninklijke Philips N.V. | Carriers for the local release of hydrophilic prodrugs |
| CN102188713A (zh) * | 2011-05-09 | 2011-09-21 | 中山大学 | 一种肝靶向药物组合物及其制备方法 |
| EP2968145A1 (en) * | 2013-03-13 | 2016-01-20 | Mallinckrodt LLC | Modified docetaxel liposome formulations |
-
2014
- 2014-03-13 EP EP14722857.1A patent/EP2968145A1/en not_active Withdrawn
- 2014-03-13 CN CN201480026436.6A patent/CN105188675A/zh active Pending
- 2014-03-13 US US14/208,324 patent/US20140271822A1/en not_active Abandoned
- 2014-03-13 JP JP2016502155A patent/JP6294456B2/ja not_active Expired - Fee Related
- 2014-03-13 CA CA2903255A patent/CA2903255C/en not_active Expired - Fee Related
- 2014-03-13 BR BR112015022819A patent/BR112015022819A8/pt not_active IP Right Cessation
- 2014-03-13 MX MX2015012201A patent/MX2015012201A/es unknown
- 2014-03-13 WO PCT/US2014/026483 patent/WO2014160392A1/en not_active Ceased
-
2017
- 2017-09-15 JP JP2017177620A patent/JP2017214433A/ja active Pending
-
2018
- 2018-09-18 JP JP2018173770A patent/JP2019006815A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20140271822A1 (en) | 2014-09-18 |
| JP2019006815A (ja) | 2019-01-17 |
| JP6294456B2 (ja) | 2018-03-14 |
| JP2016513655A (ja) | 2016-05-16 |
| WO2014160392A1 (en) | 2014-10-02 |
| BR112015022819A8 (pt) | 2019-11-26 |
| EP2968145A1 (en) | 2016-01-20 |
| CN105188675A (zh) | 2015-12-23 |
| CA2903255C (en) | 2018-08-28 |
| JP2017214433A (ja) | 2017-12-07 |
| BR112015022819A2 (pt) | 2017-07-18 |
| CA2903255A1 (en) | 2014-10-02 |
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