BR112015022819A8 - método para a preparação de um taxano lipossomal, composição compreendendo um lipossoma e taxano lipossomal - Google Patents
método para a preparação de um taxano lipossomal, composição compreendendo um lipossoma e taxano lipossomal Download PDFInfo
- Publication number
- BR112015022819A8 BR112015022819A8 BR112015022819A BR112015022819A BR112015022819A8 BR 112015022819 A8 BR112015022819 A8 BR 112015022819A8 BR 112015022819 A BR112015022819 A BR 112015022819A BR 112015022819 A BR112015022819 A BR 112015022819A BR 112015022819 A8 BR112015022819 A8 BR 112015022819A8
- Authority
- BR
- Brazil
- Prior art keywords
- liposome
- taxane
- lipid
- preparation
- composition
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 8
- 229940123237 Taxane Drugs 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 4
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 229930182558 Sterol Natural products 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960003668 docetaxel Drugs 0.000 abstract 1
- 150000004625 docetaxel anhydrous derivatives Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- -1 phosphatidyl choline lipid Chemical class 0.000 abstract 1
- 150000003432 sterols Chemical class 0.000 abstract 1
- 235000003702 sterols Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779902P | 2013-03-13 | 2013-03-13 | |
| PCT/US2014/026483 WO2014160392A1 (en) | 2013-03-13 | 2014-03-13 | Modified docetaxel liposome formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015022819A2 BR112015022819A2 (pt) | 2017-07-18 |
| BR112015022819A8 true BR112015022819A8 (pt) | 2019-11-26 |
Family
ID=50686145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015022819A BR112015022819A8 (pt) | 2013-03-13 | 2014-03-13 | método para a preparação de um taxano lipossomal, composição compreendendo um lipossoma e taxano lipossomal |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140271822A1 (enExample) |
| EP (1) | EP2968145A1 (enExample) |
| JP (3) | JP6294456B2 (enExample) |
| CN (1) | CN105188675A (enExample) |
| BR (1) | BR112015022819A8 (enExample) |
| CA (1) | CA2903255C (enExample) |
| MX (1) | MX2015012201A (enExample) |
| WO (1) | WO2014160392A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015022819A8 (pt) * | 2013-03-13 | 2019-11-26 | Mallinckrodt Llc | método para a preparação de um taxano lipossomal, composição compreendendo um lipossoma e taxano lipossomal |
| CN104622810B (zh) * | 2015-02-15 | 2018-06-08 | 中国药科大学 | 一种稳定型难溶性抗肿瘤药物脂质体及其制备方法 |
| US20160250177A1 (en) * | 2015-02-17 | 2016-09-01 | Mallinckrodt Llc | Modified docetaxel liposome formulations and uses thereof |
| EP3277264A4 (en) * | 2015-04-02 | 2018-07-18 | The Research Foundation for the State University of New York | Serum-stable compositions and methods for light-triggered release of materials |
| EP3352733A1 (en) * | 2015-09-21 | 2018-08-01 | Mallinckrodt LLC | Improved stability of liposome formulations and uses thereof |
| AU2017205337B2 (en) * | 2016-01-07 | 2022-09-08 | Tesorx Pharma, Llc | Formulations for treating bladder cancer |
| AU2017232636A1 (en) * | 2016-03-16 | 2018-09-13 | Merrimack Pharmaceuticals, Inc | Treating ephrin receptor A2 (EphA2) positive cancer with targeted docetaxel-generating nano-liposome compositions |
| WO2017161069A1 (en) * | 2016-03-16 | 2017-09-21 | Merrimack Pharmaceuticals, Inc | Nanoliposomal targeting of ephrin receptor a2 (epha2) and related diagnosticss |
| AU2017232632A1 (en) * | 2016-03-16 | 2018-09-13 | Merrimack Pharmaceuticals, Inc | Ephrin receptor A2 (EphA2)-targeted docetaxel-generating nano-liposome compositions |
| IL264842B (en) * | 2016-08-18 | 2022-08-01 | Troy Bremer | Delivery of urea to cells of the macula and retina using liposome constructs |
| CN107951861B (zh) * | 2016-10-17 | 2020-12-01 | 南京绿叶制药有限公司 | 一种脂质纳米粒膜材料组合物 |
| WO2018106980A1 (en) * | 2016-12-08 | 2018-06-14 | Mallinckrodt Llc | Liposomal elinafide formulations and uses thereof |
| WO2019010418A1 (en) | 2017-07-07 | 2019-01-10 | Drexel University | THERAPEUTIC, DIAGNOSTIC AND / OR THERANOSTIC CONSTRUCTS ACTIVATED BY VOLTAGE |
| CN110496103B (zh) * | 2018-05-18 | 2022-05-10 | 上海维洱生物医药科技有限公司 | 一种多西他赛棕榈酸酯脂质体及其制备方法 |
| US20220054455A1 (en) * | 2018-09-13 | 2022-02-24 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising of a sedative drug and uses thereof |
| JP7477844B2 (ja) * | 2018-10-17 | 2024-05-02 | タイワン リポソーム カンパニー リミテッド | 免疫調節剤を含む徐放性医薬組成物およびその使用 |
| AR122300A1 (es) * | 2019-08-09 | 2022-08-31 | Tesorxpharma Llc | Formulaciones proliposomales de testosterona undecanoato |
| CN110571005B (zh) * | 2019-09-27 | 2021-01-01 | 广西科技大学 | 一种固定化金属离子-磁性脂质体及其制备方法和应用 |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
| CN114588279B (zh) * | 2022-03-31 | 2023-10-20 | 重庆医科大学附属第二医院 | 一种多功能纳米分子探针及其制备方法和其作为视网膜母细胞瘤诊疗制剂的应用 |
| TW202527957A (zh) * | 2023-12-13 | 2025-07-16 | 大陸商上海艾力斯醫藥科技股份有限公司 | 一種含氮雜環化合物的脂質體及其應用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994005282A1 (en) | 1992-09-04 | 1994-03-17 | The Scripps Research Institute | Water soluble taxol derivatives |
| US5824701A (en) | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
| US6107332A (en) | 1995-09-12 | 2000-08-22 | The Liposome Company, Inc. | Hydrolysis-promoting hydrophobic taxane derivatives |
| TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| US6541508B2 (en) | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
| CA2383259A1 (en) * | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| WO2005079185A2 (en) * | 2003-09-02 | 2005-09-01 | Board Of Regents, The University Of Texas System | Neutral liposome-encapsulated compounds and methods of making and using thereof |
| DE602005008270D1 (de) * | 2004-10-08 | 2008-08-28 | Alza Corp | Verfahren zur einführung eines lipid-verknüpften teils in eine vorgeformte lipidanordnung mit mikrowellen |
| EP1871424A2 (en) * | 2005-04-22 | 2008-01-02 | Alza Corporation | Immunoliposome composition for targeting to a her2 cell receptor |
| CN101485629B (zh) * | 2008-01-16 | 2013-01-23 | 沈阳药科大学 | 一种给药系统及其制备方法 |
| ES2694481T3 (es) * | 2008-05-23 | 2018-12-21 | The University Of British Columbia | Fármacos modificados para su uso en nanopartículas liposomales |
| CN102038641B (zh) * | 2009-10-26 | 2013-04-17 | 石药集团中奇制药技术（石家庄）有限公司 | 一种外层经亲水聚合物修饰的脂质体药物的制备方法 |
| US20120231066A1 (en) * | 2011-01-24 | 2012-09-13 | Henry John Smith | Multi-drug liposomes to treat tumors |
| EP2667848A1 (en) * | 2011-01-28 | 2013-12-04 | Koninklijke Philips N.V. | Carriers for the local release of hydrophilic prodrugs |
| CN102188713A (zh) * | 2011-05-09 | 2011-09-21 | 中山大学 | 一种肝靶向药物组合物及其制备方法 |
| BR112015022819A8 (pt) * | 2013-03-13 | 2019-11-26 | Mallinckrodt Llc | método para a preparação de um taxano lipossomal, composição compreendendo um lipossoma e taxano lipossomal |
-
2014
- 2014-03-13 BR BR112015022819A patent/BR112015022819A8/pt not_active IP Right Cessation
- 2014-03-13 US US14/208,324 patent/US20140271822A1/en not_active Abandoned
- 2014-03-13 EP EP14722857.1A patent/EP2968145A1/en not_active Withdrawn
- 2014-03-13 JP JP2016502155A patent/JP6294456B2/ja not_active Expired - Fee Related
- 2014-03-13 CA CA2903255A patent/CA2903255C/en not_active Expired - Fee Related
- 2014-03-13 CN CN201480026436.6A patent/CN105188675A/zh active Pending
- 2014-03-13 MX MX2015012201A patent/MX2015012201A/es unknown
- 2014-03-13 WO PCT/US2014/026483 patent/WO2014160392A1/en not_active Ceased
-
2017
- 2017-09-15 JP JP2017177620A patent/JP2017214433A/ja active Pending
-
2018
- 2018-09-18 JP JP2018173770A patent/JP2019006815A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2903255C (en) | 2018-08-28 |
| CA2903255A1 (en) | 2014-10-02 |
| EP2968145A1 (en) | 2016-01-20 |
| BR112015022819A2 (pt) | 2017-07-18 |
| US20140271822A1 (en) | 2014-09-18 |
| MX2015012201A (es) | 2015-11-30 |
| JP6294456B2 (ja) | 2018-03-14 |
| JP2017214433A (ja) | 2017-12-07 |
| CN105188675A (zh) | 2015-12-23 |
| JP2019006815A (ja) | 2019-01-17 |
| WO2014160392A1 (en) | 2014-10-02 |
| JP2016513655A (ja) | 2016-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2623 DE 13/04/2021. |