MX2015008606A - Composiciones y metodos para tratamiento de cancer usando bacterias. - Google Patents
Composiciones y metodos para tratamiento de cancer usando bacterias.Info
- Publication number
- MX2015008606A MX2015008606A MX2015008606A MX2015008606A MX2015008606A MX 2015008606 A MX2015008606 A MX 2015008606A MX 2015008606 A MX2015008606 A MX 2015008606A MX 2015008606 A MX2015008606 A MX 2015008606A MX 2015008606 A MX2015008606 A MX 2015008606A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- methods
- bacteria
- pyrogenicity
- gram
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 5
- 241000894006 Bacteria Species 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000007893 endotoxin activity Effects 0.000 abstract 3
- 239000002510 pyrogen Substances 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 108010040201 Polymyxins Proteins 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 230000009395 genetic defect Effects 0.000 abstract 1
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se proporcionan en la presente composiciones que comprenden sustancialmente organismos bacterianos Gramnegativos no viables que tienen una reducción sustancial en la actividad y/o pirogenicidad de endotoxina y métodos para tratar un cáncer usando los mismos. También se proporcionan métodos para tratar cáncer proporcionados en la presente, que comprenden administrar a un mamífero diagnosticado con cáncer, bacterias Gram-negativas sustancialmente no viables que tienen una reducción sustancial en la actividad y/o pirogenicidad de endotoxina en una cantidad suficiente para inhibir el crecimiento o metástasis del cáncer. Se proporciona un método adicional que comprende administrar organismos bacterianos Gram-negativos viables o no viables que tienen un defecto genético que da por resultado una pérdida sustancial de lipopolisacárido dentro de la membrana exterior de las bacterias. Se proporciona adicionalmente métodos para reducir la actividad y/o pirogenicidad de endotoxina en bacterias Gram-negativas, que comprenden el tratamiento con polimixina y glutaraldehído.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361748369P | 2013-01-02 | 2013-01-02 | |
PCT/US2013/077441 WO2014107365A1 (en) | 2013-01-02 | 2013-12-23 | Compositions and methods for treatment of cancer using bacteria |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015008606A true MX2015008606A (es) | 2016-01-14 |
MX368210B MX368210B (es) | 2019-09-24 |
Family
ID=49943600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015008606A MX368210B (es) | 2013-01-02 | 2013-12-23 | Composiciones que comprenden bacterias y usos de las mismas en el tratamiento del cáncer. |
Country Status (17)
Country | Link |
---|---|
US (5) | US10195259B2 (es) |
EP (1) | EP2941258B1 (es) |
JP (1) | JP6125041B2 (es) |
KR (1) | KR102214794B1 (es) |
CN (1) | CN104884073B (es) |
AU (1) | AU2013371454B2 (es) |
CA (1) | CA2896858C (es) |
DK (1) | DK2941258T3 (es) |
EA (1) | EA030573B1 (es) |
ES (1) | ES2759854T3 (es) |
HK (1) | HK1217289A1 (es) |
IL (1) | IL239453B (es) |
MX (1) | MX368210B (es) |
PL (1) | PL2941258T3 (es) |
PT (1) | PT2941258T (es) |
TW (1) | TWI664976B (es) |
WO (1) | WO2014107365A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2759854T3 (es) | 2013-01-02 | 2020-05-12 | Decoy Biosystems Inc | Composiciones y métodos para el tratamiento del cáncer utilizando bacterias |
WO2015153820A1 (en) * | 2014-04-02 | 2015-10-08 | Felder Mitchell S | Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer |
AU2015304448B2 (en) * | 2014-08-19 | 2020-04-30 | National University Corporation Okayama University | Method for enhancing immune cell function and method for assessing immune cell multifunctionality |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
JP2020524145A (ja) * | 2017-06-16 | 2020-08-13 | ナントバイオ,インコーポレイテッド | 細菌性ワクチン |
US11168326B2 (en) | 2017-07-11 | 2021-11-09 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
CA3082589A1 (en) | 2017-11-20 | 2019-05-23 | Codex Dna, Inc. | Vibrio sp. organisms with modified lipopolysaccharide |
CA3088343A1 (en) * | 2018-01-19 | 2019-07-25 | 4D Pharma Research Limited | Combination therapy for treating or preventing cancer |
CA3176812A1 (en) | 2018-07-11 | 2020-01-16 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
US11242528B2 (en) | 2018-08-28 | 2022-02-08 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
KR20210068462A (ko) | 2018-09-27 | 2021-06-09 | 디코이 바이오시스템즈 인코퍼레이티드 | 박테리아를 사용하는 감염 치료 방법 |
US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
WO2020232389A1 (en) * | 2019-05-16 | 2020-11-19 | City Of Hope | Compositions and methods for targeting tumor-associated extracellular matrix components to improve drug delivery |
CN114302729A (zh) * | 2019-08-29 | 2022-04-08 | 生物医学研究集团有限公司 | 癌化学疗法支持剂、食品及药品 |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
WO2022098213A1 (ko) * | 2020-11-09 | 2022-05-12 | 전남대학교 산학협력단 | 암의 예방 및 치료용 살모넬라 균주 및 이의 용도 |
FI129784B (en) * | 2021-04-27 | 2022-08-31 | Solar Foods Oy | METHODS OF PRODUCING MICROPRODUCTS |
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US6264952B1 (en) * | 1993-11-05 | 2001-07-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method for protecting a mammalian host against infection by Brucella |
JPH11506424A (ja) * | 1995-03-24 | 1999-06-08 | オフィディアン ファーマシューティカルズ インコーポレーテッド | ベロ毒素産生大腸菌に対する治療 |
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ES2759854T3 (es) | 2013-01-02 | 2020-05-12 | Decoy Biosystems Inc | Composiciones y métodos para el tratamiento del cáncer utilizando bacterias |
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2013
- 2013-12-23 ES ES13818965T patent/ES2759854T3/es active Active
- 2013-12-23 CN CN201380069002.XA patent/CN104884073B/zh active Active
- 2013-12-23 CA CA2896858A patent/CA2896858C/en active Active
- 2013-12-23 DK DK13818965.9T patent/DK2941258T3/da active
- 2013-12-23 US US14/377,693 patent/US10195259B2/en active Active
- 2013-12-23 TW TW102147759A patent/TWI664976B/zh active
- 2013-12-23 PL PL13818965T patent/PL2941258T3/pl unknown
- 2013-12-23 AU AU2013371454A patent/AU2013371454B2/en active Active
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- 2013-12-23 MX MX2015008606A patent/MX368210B/es active IP Right Grant
- 2013-12-23 US US14/139,063 patent/US9265804B2/en active Active
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2015
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2016
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