MX2015006149A - Cromatografia de intercambio ionico de gradiente de ph mediada por concentracion ionica. - Google Patents
Cromatografia de intercambio ionico de gradiente de ph mediada por concentracion ionica.Info
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- MX2015006149A MX2015006149A MX2015006149A MX2015006149A MX2015006149A MX 2015006149 A MX2015006149 A MX 2015006149A MX 2015006149 A MX2015006149 A MX 2015006149A MX 2015006149 A MX2015006149 A MX 2015006149A MX 2015006149 A MX2015006149 A MX 2015006149A
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- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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| PCT/US2013/070415 WO2014078729A1 (en) | 2012-11-15 | 2013-11-15 | IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY |
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| ES2705700T3 (es) * | 2013-07-12 | 2019-03-26 | Hoffmann La Roche | Elucidación de la optimización de entrada en cromatografía de intercambio iónico |
| EP3280444B1 (en) * | 2015-04-10 | 2024-05-08 | Adimab, LLC | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| WO2017084738A1 (en) * | 2015-11-18 | 2017-05-26 | Merck Patent Gmbh | Opposite ph-salt gradients for improved protein separations |
| KR20180083409A (ko) * | 2015-11-18 | 2018-07-20 | 메르크 파텐트 게엠베하 | 이온 교환 크로마토그래피에서의 개선된 단백질 분리 |
| CN108333264A (zh) * | 2017-01-20 | 2018-07-27 | 湖北生物医药产业技术研究院有限公司 | 检测蛋白电荷变异体的方法及确定生物制品生产工艺的方法 |
| WO2019067637A1 (en) * | 2017-09-26 | 2019-04-04 | Waters Technologies Corporation | HIGH-PURITY CHROMATOGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER FOR RETENTION OF ACID ANALYTES |
| EP3791172B1 (en) | 2018-05-08 | 2023-06-28 | Waters Technologies Corporation | Methods, compositions and kits useful for ph gradient cation exchange chromatography |
| KR20200080748A (ko) * | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법 |
| TW202128264A (zh) * | 2019-09-25 | 2021-08-01 | 瑞士商赫孚孟拉羅股份公司 | 使用經預測之溶離緩衝鹽濃度的陽離子層析法 |
| CN111024883B (zh) * | 2019-12-31 | 2022-12-06 | 上海博威生物医药有限公司 | 一种奥马珠单抗的电荷异质体的分离方法 |
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| US20150285771A1 (en) | 2015-10-08 |
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| CN105051528A (zh) | 2015-11-11 |
| BR112015011011A2 (pt) | 2019-12-17 |
| WO2014078729A1 (en) | 2014-05-22 |
| EP2920586A1 (en) | 2015-09-23 |
| EP2920586A4 (en) | 2017-01-04 |
| US10712322B2 (en) | 2020-07-14 |
| KR20150084046A (ko) | 2015-07-21 |
| US20180120273A1 (en) | 2018-05-03 |
| US9810670B2 (en) | 2017-11-07 |
| JP2015537212A (ja) | 2015-12-24 |
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