MX2013010997A - Ensayo para clasificacion de compuestos que disminuyen selectivamente el numero de celulas madre de cance. - Google Patents
Ensayo para clasificacion de compuestos que disminuyen selectivamente el numero de celulas madre de cance.Info
- Publication number
- MX2013010997A MX2013010997A MX2013010997A MX2013010997A MX2013010997A MX 2013010997 A MX2013010997 A MX 2013010997A MX 2013010997 A MX2013010997 A MX 2013010997A MX 2013010997 A MX2013010997 A MX 2013010997A MX 2013010997 A MX2013010997 A MX 2013010997A
- Authority
- MX
- Mexico
- Prior art keywords
- stem cells
- cancer stem
- csc
- assay
- screening compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Abstract
La presente invención proporciona, entre otras cosas, un método para identificar un agente que disminuye selectivamente el número de células madre de cáncer (CSCs). Este método incluye (a) contactar una CSC de una población de células con un agente candidato; y (b) determinar si el agente candidato reduce la supervivencia o crecimiento de la CSC o incrementa la diferenciación de la CSC en una forma relativa a una CSC que no ha sido contactada con el agente candidato. El método se puede utilizar como una clasificación de alto rendimiento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161467265P | 2011-03-24 | 2011-03-24 | |
PCT/US2012/030103 WO2012129393A1 (en) | 2011-03-24 | 2012-03-22 | Assay for screening compounds that selectively decrease the number of cancer stem cells |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013010997A true MX2013010997A (es) | 2014-06-23 |
MX345893B MX345893B (es) | 2017-02-22 |
Family
ID=46879743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013010997A MX345893B (es) | 2011-03-24 | 2012-03-22 | Ensayo para clasificación de compuestos que disminuyen selectivamente el número de células madre de cáncer. |
Country Status (18)
Country | Link |
---|---|
US (2) | US20140364402A1 (es) |
EP (1) | EP2689249B1 (es) |
JP (1) | JP6002748B2 (es) |
KR (1) | KR101945065B1 (es) |
CN (1) | CN103688175B (es) |
AU (1) | AU2012230850B2 (es) |
BR (1) | BR112013024476B1 (es) |
CA (1) | CA2830613A1 (es) |
DK (1) | DK2689249T3 (es) |
ES (1) | ES2586599T3 (es) |
HK (1) | HK1191693A1 (es) |
HU (1) | HUE030159T2 (es) |
IL (1) | IL228171A (es) |
MX (1) | MX345893B (es) |
PL (1) | PL2689249T3 (es) |
PT (1) | PT2689249T (es) |
RU (1) | RU2013146849A (es) |
WO (1) | WO2012129393A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6187980B2 (ja) * | 2014-12-03 | 2017-08-30 | 国立大学法人 大分大学 | Dna傷害型物質のスクリーニング方法 |
RU2702910C2 (ru) * | 2018-12-20 | 2019-10-14 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ снижения количества стволовых клеток рака молочной железы |
KR102353109B1 (ko) * | 2020-02-24 | 2022-01-19 | 부산대학교 산학협력단 | 상피성장인자-유사도메인 8 또는 이의 활성화제를 유효성분으로 함유하는 암줄기세포 마커 발현 암질환 예방 또는 치료용 약학조성물 |
CN111363821A (zh) * | 2020-03-19 | 2020-07-03 | 宁波晶点医药研究开发有限公司 | Ifi16作为抗肿瘤耐药增效及逆转的药物靶点的应用 |
CN112843238B (zh) * | 2021-02-26 | 2023-03-10 | 中国科学技术大学 | 包含微管蛋白抑制剂和Notch抑制剂的药物组合物及其应用 |
CN116609525B (zh) * | 2023-05-26 | 2023-10-27 | 杭州圣域生物医药科技有限公司 | 基于细胞内aldh3b1蛋白水平以筛选染色质重塑复合体抑制剂的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006009860A2 (en) * | 2004-06-17 | 2006-01-26 | Massachusetts Institute Of Technology | Methods for identifying stem cells based on nuclear morphotypes |
CA3218940A1 (en) * | 2004-11-12 | 2006-05-18 | Cambridge University Technical Services Ltd. | Methods and means related to cancer stem cells |
GB0515305D0 (en) * | 2005-07-26 | 2005-08-31 | Procure Therapeutics Ltd | Stem cell markers 1 |
EP2526969A1 (en) * | 2006-09-07 | 2012-11-28 | Stemline Therapeutics, Inc. | Monitoring cancer stem cells |
EP2109668A4 (en) * | 2007-01-22 | 2011-10-05 | Macrogenics West Inc | HUMAN CANCER STEM CELLS |
WO2009126310A2 (en) * | 2008-04-10 | 2009-10-15 | Massachusetts Institute Of Technology | Methods for identification and use of agents targeting cancer stem cells |
US20110020221A1 (en) * | 2009-04-09 | 2011-01-27 | The Johns Hopkins University | Cancer stem cell expression patterns and compounds to target cancer stem cells |
WO2011038300A1 (en) * | 2009-09-24 | 2011-03-31 | The Trustees Of Columbia University In The City Of New York | Cancer stem cells, kits, and methods |
-
2012
- 2012-03-22 BR BR112013024476-3A patent/BR112013024476B1/pt not_active IP Right Cessation
- 2012-03-22 HU HUE12760950A patent/HUE030159T2/en unknown
- 2012-03-22 DK DK12760950.1T patent/DK2689249T3/en active
- 2012-03-22 ES ES12760950.1T patent/ES2586599T3/es active Active
- 2012-03-22 CA CA2830613A patent/CA2830613A1/en not_active Abandoned
- 2012-03-22 WO PCT/US2012/030103 patent/WO2012129393A1/en active Application Filing
- 2012-03-22 KR KR1020137028153A patent/KR101945065B1/ko active IP Right Grant
- 2012-03-22 RU RU2013146849/15A patent/RU2013146849A/ru not_active Application Discontinuation
- 2012-03-22 US US14/005,058 patent/US20140364402A1/en not_active Abandoned
- 2012-03-22 PL PL12760950T patent/PL2689249T3/pl unknown
- 2012-03-22 JP JP2014501240A patent/JP6002748B2/ja active Active
- 2012-03-22 MX MX2013010997A patent/MX345893B/es active IP Right Grant
- 2012-03-22 CN CN201280021396.7A patent/CN103688175B/zh not_active Expired - Fee Related
- 2012-03-22 AU AU2012230850A patent/AU2012230850B2/en not_active Ceased
- 2012-03-22 PT PT127609501T patent/PT2689249T/pt unknown
- 2012-03-22 EP EP12760950.1A patent/EP2689249B1/en active Active
-
2013
- 2013-08-29 IL IL228171A patent/IL228171A/en active IP Right Grant
-
2014
- 2014-05-28 HK HK14105011.8A patent/HK1191693A1/zh not_active IP Right Cessation
-
2015
- 2015-07-24 US US14/808,514 patent/US20160187320A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2012230850A1 (en) | 2013-04-18 |
KR20140016348A (ko) | 2014-02-07 |
EP2689249A1 (en) | 2014-01-29 |
PL2689249T3 (pl) | 2017-09-29 |
PT2689249T (pt) | 2016-09-20 |
CA2830613A1 (en) | 2012-09-27 |
BR112013024476B1 (pt) | 2022-06-14 |
WO2012129393A1 (en) | 2012-09-27 |
CN103688175A (zh) | 2014-03-26 |
JP6002748B2 (ja) | 2016-10-05 |
US20160187320A1 (en) | 2016-06-30 |
IL228171A (en) | 2017-09-28 |
BR112013024476A2 (pt) | 2017-02-14 |
MX345893B (es) | 2017-02-22 |
CN103688175B (zh) | 2015-09-09 |
DK2689249T3 (en) | 2016-08-29 |
US20140364402A1 (en) | 2014-12-11 |
HK1191693A1 (zh) | 2014-08-01 |
EP2689249A4 (en) | 2014-12-31 |
ES2586599T3 (es) | 2016-10-17 |
RU2013146849A (ru) | 2015-04-27 |
KR101945065B1 (ko) | 2019-02-01 |
HUE030159T2 (en) | 2017-05-29 |
JP2014509867A (ja) | 2014-04-24 |
NZ615669A (en) | 2015-08-28 |
EP2689249B1 (en) | 2016-05-25 |
AU2012230850B2 (en) | 2015-08-27 |
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