BR112013024476A2 - método para identificar um agente que diminui seletivamente o número de células-tronco com câncer, método de classificação de resultado máximo para identificação de agentes, agente para matar seletivamente cscs e composição farmacêutica - Google Patents
método para identificar um agente que diminui seletivamente o número de células-tronco com câncer, método de classificação de resultado máximo para identificação de agentes, agente para matar seletivamente cscs e composição farmacêuticaInfo
- Publication number
- BR112013024476A2 BR112013024476A2 BR112013024476A BR112013024476A BR112013024476A2 BR 112013024476 A2 BR112013024476 A2 BR 112013024476A2 BR 112013024476 A BR112013024476 A BR 112013024476A BR 112013024476 A BR112013024476 A BR 112013024476A BR 112013024476 A2 BR112013024476 A2 BR 112013024476A2
- Authority
- BR
- Brazil
- Prior art keywords
- agent
- selectively
- identifying
- pharmaceutical composition
- stem cells
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000007423 decrease Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161467265P | 2011-03-24 | 2011-03-24 | |
| US61/467,265 | 2011-03-24 | ||
| PCT/US2012/030103 WO2012129393A1 (en) | 2011-03-24 | 2012-03-22 | Assay for screening compounds that selectively decrease the number of cancer stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013024476A2 true BR112013024476A2 (pt) | 2017-02-14 |
| BR112013024476B1 BR112013024476B1 (pt) | 2022-06-14 |
Family
ID=46879743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013024476-3A BR112013024476B1 (pt) | 2011-03-24 | 2012-03-22 | Método para identificar um agente que diminui seletivamente o número de células-tronco com câncer e método de classificação de resultado máximo para identificação de agentes |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20140364402A1 (pt) |
| EP (1) | EP2689249B1 (pt) |
| JP (1) | JP6002748B2 (pt) |
| KR (1) | KR101945065B1 (pt) |
| CN (1) | CN103688175B (pt) |
| AU (1) | AU2012230850B2 (pt) |
| BR (1) | BR112013024476B1 (pt) |
| CA (1) | CA2830613A1 (pt) |
| DK (1) | DK2689249T3 (pt) |
| ES (1) | ES2586599T3 (pt) |
| HK (1) | HK1191693A1 (pt) |
| HU (1) | HUE030159T2 (pt) |
| IL (1) | IL228171A (pt) |
| MX (1) | MX345893B (pt) |
| PL (1) | PL2689249T3 (pt) |
| PT (1) | PT2689249T (pt) |
| RU (1) | RU2013146849A (pt) |
| WO (1) | WO2012129393A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6187980B2 (ja) * | 2014-12-03 | 2017-08-30 | 国立大学法人 大分大学 | Ｄｎａ傷害型物質のスクリーニング方法 |
| RU2702910C2 (ru) * | 2018-12-20 | 2019-10-14 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ снижения количества стволовых клеток рака молочной железы |
| KR102353109B1 (ko) * | 2020-02-24 | 2022-01-19 | 부산대학교 산학협력단 | 상피성장인자-유사도메인 8 또는 이의 활성화제를 유효성분으로 함유하는 암줄기세포 마커 발현 암질환 예방 또는 치료용 약학조성물 |
| CN111363821A (zh) * | 2020-03-19 | 2020-07-03 | 宁波晶点医药研究开发有限公司 | Ifi16作为抗肿瘤耐药增效及逆转的药物靶点的应用 |
| CN112843238B (zh) * | 2021-02-26 | 2023-03-10 | 中国科学技术大学 | 包含微管蛋白抑制剂和Notch抑制剂的药物组合物及其应用 |
| CN116609525B (zh) * | 2023-05-26 | 2023-10-27 | 杭州圣域生物医药科技有限公司 | 基于细胞内aldh3b1蛋白水平以筛选染色质重塑复合体抑制剂的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1774325B1 (en) * | 2004-06-17 | 2016-02-24 | Massachusetts Institute of Technology | Methods for identifying stem cells based on nuclear morphotypes |
| CA2629330C (en) * | 2004-11-12 | 2018-05-22 | Cambridge University Technical Services Ltd. | Methods and means related to cancer stem cells |
| GB0515305D0 (en) * | 2005-07-26 | 2005-08-31 | Procure Therapeutics Ltd | Stem cell markers 1 |
| CA2698597A1 (en) * | 2006-09-07 | 2008-03-13 | Stemline Therapeutics, Inc. | Monitoring cancer stem cells |
| AU2008207945A1 (en) * | 2007-01-22 | 2008-07-31 | Macrogenics West, Inc. | Human cancer stem cells |
| CA2723648A1 (en) * | 2008-04-10 | 2009-10-15 | Piyush Gupta | Methods for identification and use of agents targeting cancer stem cells |
| US20110020221A1 (en) * | 2009-04-09 | 2011-01-27 | The Johns Hopkins University | Cancer stem cell expression patterns and compounds to target cancer stem cells |
| WO2011038300A1 (en) * | 2009-09-24 | 2011-03-31 | The Trustees Of Columbia University In The City Of New York | Cancer stem cells, kits, and methods |
-
2012
- 2012-03-22 CA CA2830613A patent/CA2830613A1/en not_active Abandoned
- 2012-03-22 HU HUE12760950A patent/HUE030159T2/en unknown
- 2012-03-22 EP EP12760950.1A patent/EP2689249B1/en active Active
- 2012-03-22 JP JP2014501240A patent/JP6002748B2/ja active Active
- 2012-03-22 RU RU2013146849/15A patent/RU2013146849A/ru not_active Application Discontinuation
- 2012-03-22 ES ES12760950.1T patent/ES2586599T3/es active Active
- 2012-03-22 PT PT127609501T patent/PT2689249T/pt unknown
- 2012-03-22 PL PL12760950T patent/PL2689249T3/pl unknown
- 2012-03-22 BR BR112013024476-3A patent/BR112013024476B1/pt not_active IP Right Cessation
- 2012-03-22 MX MX2013010997A patent/MX345893B/es active IP Right Grant
- 2012-03-22 KR KR1020137028153A patent/KR101945065B1/ko active IP Right Grant
- 2012-03-22 US US14/005,058 patent/US20140364402A1/en not_active Abandoned
- 2012-03-22 WO PCT/US2012/030103 patent/WO2012129393A1/en active Application Filing
- 2012-03-22 CN CN201280021396.7A patent/CN103688175B/zh not_active Expired - Fee Related
- 2012-03-22 AU AU2012230850A patent/AU2012230850B2/en not_active Ceased
- 2012-03-22 DK DK12760950.1T patent/DK2689249T3/en active
-
2013
- 2013-08-29 IL IL228171A patent/IL228171A/en active IP Right Grant
-
2014
- 2014-05-28 HK HK14105011.8A patent/HK1191693A1/zh not_active IP Right Cessation
-
2015
- 2015-07-24 US US14/808,514 patent/US20160187320A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2689249A1 (en) | 2014-01-29 |
| NZ615669A (en) | 2015-08-28 |
| EP2689249B1 (en) | 2016-05-25 |
| CN103688175B (zh) | 2015-09-09 |
| CA2830613A1 (en) | 2012-09-27 |
| EP2689249A4 (en) | 2014-12-31 |
| WO2012129393A1 (en) | 2012-09-27 |
| IL228171A (en) | 2017-09-28 |
| JP6002748B2 (ja) | 2016-10-05 |
| AU2012230850A1 (en) | 2013-04-18 |
| DK2689249T3 (en) | 2016-08-29 |
| BR112013024476B1 (pt) | 2022-06-14 |
| US20140364402A1 (en) | 2014-12-11 |
| MX345893B (es) | 2017-02-22 |
| JP2014509867A (ja) | 2014-04-24 |
| HUE030159T2 (en) | 2017-05-29 |
| AU2012230850B2 (en) | 2015-08-27 |
| PL2689249T3 (pl) | 2017-09-29 |
| KR101945065B1 (ko) | 2019-02-01 |
| PT2689249T (pt) | 2016-09-20 |
| MX2013010997A (es) | 2014-06-23 |
| US20160187320A1 (en) | 2016-06-30 |
| ES2586599T3 (es) | 2016-10-17 |
| HK1191693A1 (zh) | 2014-08-01 |
| KR20140016348A (ko) | 2014-02-07 |
| RU2013146849A (ru) | 2015-04-27 |
| CN103688175A (zh) | 2014-03-26 |
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