MX2013007295A - Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2. - Google Patents
Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2.Info
- Publication number
- MX2013007295A MX2013007295A MX2013007295A MX2013007295A MX2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A
- Authority
- MX
- Mexico
- Prior art keywords
- quinoxalines
- aza
- receptor modulators
- crth2 receptor
- compounds
- Prior art date
Links
- 150000003252 quinoxalines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000009389 Prostaglandin D receptors Human genes 0.000 abstract 1
- 108050000258 Prostaglandin D receptors Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426886P | 2010-12-23 | 2010-12-23 | |
| PCT/US2011/065716 WO2012087861A1 (en) | 2010-12-23 | 2011-12-19 | Quinoxalines and aza-quinoxalines as crth2 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013007295A true MX2013007295A (es) | 2013-08-26 |
Family
ID=46314391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013007295A MX2013007295A (es) | 2010-12-23 | 2011-12-19 | Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9469615B2 (OSRAM) |
| EP (1) | EP2661428B1 (OSRAM) |
| JP (1) | JP5952829B2 (OSRAM) |
| KR (1) | KR20130133219A (OSRAM) |
| CN (1) | CN103702985B (OSRAM) |
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| RU (1) | RU2589709C2 (OSRAM) |
| TW (1) | TW201307302A (OSRAM) |
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| EP2661265B1 (en) | 2010-12-23 | 2017-03-08 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as crth2 receptor modulators |
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| JP5629403B2 (ja) | 2011-06-17 | 2014-11-19 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Crth2受容体モジュレータとしてのシクロアルキル縮合テトラヒドロキノリン |
| CN104011021B (zh) | 2011-12-21 | 2016-08-24 | 埃科特莱茵药品有限公司 | 杂环衍生物及其作为前列腺素d2受体调节剂的用途 |
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| WO2015153554A1 (en) * | 2014-03-31 | 2015-10-08 | The Trustees Of The University Of Pennsylvania | Novel antiviral compounds and methods using same |
| TW201625578A (zh) | 2014-04-18 | 2016-07-16 | 千禧製藥公司 | 喹啉化合物及其用途 |
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| CA3068623A1 (en) * | 2017-06-30 | 2019-01-03 | Quixgen, Inc. | Novel spirolactone compounds |
| EP3643711A1 (en) | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| EP4076460B1 (en) | 2019-12-17 | 2026-01-21 | Merck Sharp & Dohme LLC | 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine derivatives as prmt5 inhibitors for the treatment of cancer |
| BR112022012015A2 (pt) * | 2019-12-17 | 2022-08-30 | Merck Sharp & Dohme Llc | Inibidores de prmt5 |
| CA3160153A1 (en) | 2019-12-17 | 2021-06-24 | Michelle Machacek | Prmt5 inhibitors |
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2011
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- 2011-12-19 KR KR1020137016245A patent/KR20130133219A/ko not_active Ceased
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- 2011-12-19 AU AU2011349524A patent/AU2011349524B2/en not_active Ceased
- 2011-12-19 WO PCT/US2011/065716 patent/WO2012087861A1/en not_active Ceased
- 2011-12-19 RU RU2013134334/04A patent/RU2589709C2/ru not_active IP Right Cessation
- 2011-12-19 BR BR112013015397A patent/BR112013015397A2/pt not_active Application Discontinuation
- 2011-12-19 CA CA2818597A patent/CA2818597A1/en not_active Abandoned
- 2011-12-19 EP EP11851281.3A patent/EP2661428B1/en active Active
- 2011-12-21 TW TW100147844A patent/TW201307302A/zh unknown
- 2011-12-22 AR ARP110104895A patent/AR084573A1/es unknown
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| EP2661428A1 (en) | 2013-11-13 |
| CN103702985B (zh) | 2016-02-17 |
| BR112013015397A2 (pt) | 2016-09-20 |
| US9469615B2 (en) | 2016-10-18 |
| AU2011349524B2 (en) | 2016-06-02 |
| RU2589709C2 (ru) | 2016-07-10 |
| AR084573A1 (es) | 2013-05-29 |
| CA2818597A1 (en) | 2012-06-28 |
| US20130303517A1 (en) | 2013-11-14 |
| CN103702985A (zh) | 2014-04-02 |
| TW201307302A (zh) | 2013-02-16 |
| EP2661428A4 (en) | 2014-12-17 |
| KR20130133219A (ko) | 2013-12-06 |
| AU2011349524A1 (en) | 2013-05-30 |
| RU2013134334A (ru) | 2015-01-27 |
| JP5952829B2 (ja) | 2016-07-13 |
| JP2014500323A (ja) | 2014-01-09 |
| ES2635030T3 (es) | 2017-10-02 |
| EP2661428B1 (en) | 2017-06-07 |
| WO2012087861A1 (en) | 2012-06-28 |
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