MX2013006840A - Inhibidores de la replicacion de los virus de la influenza. - Google Patents

Inhibidores de la replicacion de los virus de la influenza.

Info

Publication number
MX2013006840A
MX2013006840A MX2013006840A MX2013006840A MX2013006840A MX 2013006840 A MX2013006840 A MX 2013006840A MX 2013006840 A MX2013006840 A MX 2013006840A MX 2013006840 A MX2013006840 A MX 2013006840A MX 2013006840 A MX2013006840 A MX 2013006840A
Authority
MX
Mexico
Prior art keywords
alkyl
independently
group
optionally
ring
Prior art date
Application number
MX2013006840A
Other languages
English (en)
Spanish (es)
Inventor
John P Duffy
Marion W Wannamaker
Francesco G Salituro
Huai Gao
Emanuele Perola
Brian Ledford
Upul K Bandarage
Paul S Charifson
Hongbo Deng
Tiansheng Wang
Michael P Clark
Francois Maltais
Wenxin Gu
Joseph M Kennedy
Mark W Ledeboer
Luc J Farmer
Ioana Davies
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2013006840A publication Critical patent/MX2013006840A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX2013006840A 2010-12-16 2011-12-16 Inhibidores de la replicacion de los virus de la influenza. MX2013006840A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42393310P 2010-12-16 2010-12-16
US201161527277P 2011-08-25 2011-08-25
PCT/US2011/065389 WO2012083122A1 (en) 2010-12-16 2011-12-16 Inhibitors of influenza viruses replication

Publications (1)

Publication Number Publication Date
MX2013006840A true MX2013006840A (es) 2014-01-31

Family

ID=45464909

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006840A MX2013006840A (es) 2010-12-16 2011-12-16 Inhibidores de la replicacion de los virus de la influenza.

Country Status (10)

Country Link
US (1) US20130345218A1 (enExample)
EP (1) EP2651938A1 (enExample)
JP (1) JP2013545818A (enExample)
KR (1) KR20130128435A (enExample)
CN (1) CN103562205A (enExample)
AU (1) AU2011343647A1 (enExample)
CA (1) CA2822062A1 (enExample)
MX (1) MX2013006840A (enExample)
RU (1) RU2013132683A (enExample)
WO (1) WO2012083122A1 (enExample)

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TWI483941B (zh) 2009-06-17 2015-05-11 Vertex Pharma 流感病毒複製之抑制劑
MX2013006836A (es) 2010-12-16 2013-09-26 Vertex Pharma Inhibidores de la replicacion de los virus de la influenza.
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
MX2016006200A (es) 2013-11-13 2016-08-08 Vertex Pharma Metodos para preparar inhibidores de la replicacion de virus de influenza.
SMT201900450T1 (it) * 2013-11-13 2019-09-09 Vertex Pharma Inibitori della replicazione di virus dell’influenza
SG11201604821YA (en) 2013-12-20 2016-07-28 Signal Pharm Llc Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
SG11201700956VA (en) * 2014-08-08 2017-03-30 Janssen Sciences Ireland Uc Indoles for use in influenza virus infection
ES2860688T3 (es) * 2014-09-08 2021-10-05 Janssen Sciences Ireland Uc Pirrolopirimidinas para uso en la infección por el virus de la gripe
JP6892433B2 (ja) 2015-04-03 2021-06-23 ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts 十分に安定化された非対称sirna
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
CA2995110A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
AU2016359907B2 (en) * 2015-11-27 2021-04-01 Janssen Sciences Ireland Uc Heterocyclic indoles for use in influenza virus infection
AU2016368317B2 (en) 2015-12-09 2019-05-23 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
MX381314B (es) * 2016-01-20 2025-03-12 Janssen Sciences Ireland Uc Pirimidinas sustituidas con arilo para su uso en la infeccion por virus influenza
US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
WO2017133658A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 4, 7-diazaindole and 4, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza
WO2017133667A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof
WO2017133657A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza
WO2017133664A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Bicyclic pyridine and pyrimidine derivatives and their use in the treatment, amelioration or prevention of influenza
WO2017133670A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza
WO2017133665A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 6,7-diazaindazole and 6,7-diazaindole derivatives and use in treatment, amelioration or prevention of influenza thereof
US10501444B2 (en) 2016-08-16 2019-12-10 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
CN109641868B (zh) * 2016-08-30 2021-12-03 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
AU2017376541B2 (en) 2016-12-15 2021-08-05 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
CN108276401B (zh) 2017-01-05 2020-12-22 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
US10927118B2 (en) 2017-03-02 2021-02-23 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
CN108727369B (zh) * 2017-04-25 2023-06-09 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
EP3642341A4 (en) 2017-06-23 2021-06-16 University Of Massachusetts TWO-DAY SELF-RELEASING SIRNA AND RELATED PROCEDURES
MX2021000917A (es) * 2018-07-27 2021-06-23 Cocrystal Pharma Inc Derivados de pirrolo[2,3-b]piridina como inhibidores de la replicación del virus de la gripe.
JP7627042B2 (ja) 2018-08-23 2025-02-05 ユニバーシティー オブ マサチューセッツ O-メチルリッチ完全安定化オリゴヌクレオチド
CN109678738B (zh) * 2018-12-26 2021-11-30 深圳市华先医药科技有限公司 一种合成(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法
JP2022523467A (ja) 2019-01-18 2022-04-25 ユニバーシティ・オブ・マサチューセッツ 動的な薬物動態を修飾するアンカー
WO2020198509A2 (en) 2019-03-26 2020-10-01 University Of Massachusetts Modified oligonucleotides with increased stability
CA3149835A1 (en) 2019-08-09 2021-02-18 University Of Massachusetts Chemically modified oligonucleotides targeting snps
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
EP4126070A4 (en) 2020-03-26 2024-07-24 University Of Massachusetts Synthesis of modified oligonucleotides with increased stability
US20230159453A1 (en) * 2020-04-10 2023-05-25 Cocrystal Pharma, Inc. Inhibitors of norovirus and coronavirus replication
CN112063726A (zh) * 2020-09-21 2020-12-11 杭州市疾病预防控制中心 一种用于检测奥司他韦耐药突变的引物、探针及检测方法
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors

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AR045595A1 (es) * 2003-09-04 2005-11-02 Vertex Pharma Composiciones utiles como inhibidores de proteinas quinasas
UA87494C2 (en) * 2004-03-30 2009-07-27 Вертекс Фармасьютикалс Инкорпорейтед Azaindoles useful as inhibitors of jak and other protein kinases
KR101298967B1 (ko) * 2004-03-30 2013-09-02 버텍스 파마슈티칼스 인코포레이티드 Jak 및 기타 단백질 키나제의 억제제로서 유용한 아자인돌
US20060161001A1 (en) * 2004-12-20 2006-07-20 Amgen Inc. Substituted heterocyclic compounds and methods of use
KR20080016643A (ko) * 2005-05-16 2008-02-21 아이알엠 엘엘씨 단백질 키나제 억제제로서의 피롤로피리딘 유도체
JP2009513571A (ja) * 2005-09-30 2009-04-02 バーテックス ファーマシューティカルズ インコーポレイテッド ヤヌスキナーゼ阻害剤として有用なデアザプリン
RU2453548C2 (ru) 2006-01-17 2012-06-20 Вертекс Фармасьютикалз Инкорпорейтед Азаиндолы, полезные в качестве ингибиторов янус-киназ
AR064675A1 (es) * 2006-12-21 2009-04-15 Vertex Pharma Derivados heterociclicos de pirrolo- [2,3-b] piridina, inhibidores de proteinquinasas plk, composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos en trastornos hiperproliferativos
ES2389992T3 (es) 2007-11-02 2012-11-05 Vertex Pharmaceuticals Incorporated Derivados de [1H-pirazolo[3,4-b]piridin-4-il]-fenilo o -piridin-2-ilo como proteína cinasa c-theta
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TWI483941B (zh) * 2009-06-17 2015-05-11 Vertex Pharma 流感病毒複製之抑制劑
CN102471339A (zh) * 2009-07-15 2012-05-23 雅培制药有限公司 激酶的吡咯并吡啶抑制剂

Also Published As

Publication number Publication date
WO2012083122A1 (en) 2012-06-21
JP2013545818A (ja) 2013-12-26
EP2651938A1 (en) 2013-10-23
RU2013132683A (ru) 2015-01-27
CN103562205A (zh) 2014-02-05
US20130345218A1 (en) 2013-12-26
AU2011343647A1 (en) 2013-05-02
CA2822062A1 (en) 2012-06-21
KR20130128435A (ko) 2013-11-26
WO2012083122A8 (en) 2013-12-05

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Legal Events

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