MX2013005857A - 5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo[1,2-a][1,4] benzodiazepinas sustituidas con derivados de fenilo antimicoticas. - Google Patents
5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo[1,2-a][1,4] benzodiazepinas sustituidas con derivados de fenilo antimicoticas.Info
- Publication number
- MX2013005857A MX2013005857A MX2013005857A MX2013005857A MX2013005857A MX 2013005857 A MX2013005857 A MX 2013005857A MX 2013005857 A MX2013005857 A MX 2013005857A MX 2013005857 A MX2013005857 A MX 2013005857A MX 2013005857 A MX2013005857 A MX 2013005857A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrrolo
- benzodiazepines
- dihydro
- antifungal
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a 5,6-dihidro-4H-pirrolo-[1,2-a][ 1,4]benzodiazepinas y 6H-pirrolo[1,2-a][1,4]benzodiazepinas antimicóticas novedosas de fórmula (I) en donde R1, R2, R3, R4, R5 y R6 tienen el significado definido en las reivindicaciones; los compuestos de acuerdo con la presente invención son activos principalmente contra dermatofitos e infecciones micóticas sistémicas; además, la invención se refiere a procedimientos para preparar estos compuestos novedosos, a composiciones farmacéuticas que comprenden dichos compuestos como ingrediente activo, y también al uso de dichos compuestos como medicamento (Ver Formula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10192321 | 2010-11-24 | ||
| PCT/EP2011/070458 WO2012069380A1 (en) | 2010-11-24 | 2011-11-18 | Antifungal 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]-benzodiazepines and 6h-pyrrolo[1,2-a][1,4]benzodiazepines substituted with phenyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013005857A true MX2013005857A (es) | 2013-07-03 |
Family
ID=43607927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013005857A MX2013005857A (es) | 2010-11-24 | 2011-11-18 | 5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo[1,2-a][1,4] benzodiazepinas sustituidas con derivados de fenilo antimicoticas. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9040523B2 (es) |
| EP (1) | EP2643324B1 (es) |
| JP (1) | JP5795076B2 (es) |
| KR (1) | KR101858630B1 (es) |
| CN (2) | CN107964013B (es) |
| AP (1) | AP3518A (es) |
| AU (1) | AU2011333918B2 (es) |
| BR (1) | BR112013012547A2 (es) |
| CA (1) | CA2816395C (es) |
| EA (1) | EA020837B1 (es) |
| ES (1) | ES2582313T3 (es) |
| HK (1) | HK1254681A1 (es) |
| IL (1) | IL226442A (es) |
| MX (1) | MX2013005857A (es) |
| MY (1) | MY162808A (es) |
| NZ (1) | NZ611892A (es) |
| SG (1) | SG190141A1 (es) |
| UA (1) | UA109676C2 (es) |
| WO (1) | WO2012069380A1 (es) |
| ZA (1) | ZA201303772B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2527032T3 (es) * | 2010-12-21 | 2015-01-19 | Janssen Pharmaceutica, N.V. | 5,6-dihidro-4H-pirrolo[1,2-a][1,4]-benzodiazepinas y 6H-pirrolo[1,2-a][1,4]benzodiazepinas sustituidas antifúngicas novedosas con derivados de benceno bicíclicos |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE431826T1 (de) * | 2000-10-23 | 2009-06-15 | Janssen Pharmaceutica Nv | In der 4-stellung substituierte 5,6-dihydro-4h- pyrroloä1,2-aü ä1,4ü benzodiazepine als fungizide |
| UA107963C2 (en) * | 2010-06-07 | 2015-03-10 | Janssen Pharmaceutica Nv | Antifungal derivatives of 5,6-dihydro-4 - [(difluoro ethyl) phenyl] -4h-pyrrolo [1,2-a] [1,4] benzodiazepine and 4- (diftoretil) phenyl-6h-pyrolyl [1,2- a] [1,4] benzodiazepine |
| ES2527032T3 (es) * | 2010-12-21 | 2015-01-19 | Janssen Pharmaceutica, N.V. | 5,6-dihidro-4H-pirrolo[1,2-a][1,4]-benzodiazepinas y 6H-pirrolo[1,2-a][1,4]benzodiazepinas sustituidas antifúngicas novedosas con derivados de benceno bicíclicos |
| UA110640C2 (uk) * | 2011-05-05 | 2016-01-25 | Янссен Фармацевтика Нв | ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ ТА 6Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ, ЯКІ ЗАМІЩЕНІ ГЕТЕРОЦИКЛІЧНИМИ ПОХІДНИМИ |
-
2011
- 2011-11-18 US US13/989,233 patent/US9040523B2/en active Active
- 2011-11-18 JP JP2013540307A patent/JP5795076B2/ja active Active
- 2011-11-18 EP EP11784506.5A patent/EP2643324B1/en active Active
- 2011-11-18 WO PCT/EP2011/070458 patent/WO2012069380A1/en active Application Filing
- 2011-11-18 UA UAA201305026A patent/UA109676C2/uk unknown
- 2011-11-18 AU AU2011333918A patent/AU2011333918B2/en active Active
- 2011-11-18 NZ NZ611892A patent/NZ611892A/en not_active IP Right Cessation
- 2011-11-18 CN CN201711416278.7A patent/CN107964013B/zh active Active
- 2011-11-18 SG SG2013034194A patent/SG190141A1/en unknown
- 2011-11-18 AP AP2013006868A patent/AP3518A/xx active
- 2011-11-18 CA CA2816395A patent/CA2816395C/en active Active
- 2011-11-18 MX MX2013005857A patent/MX2013005857A/es active IP Right Grant
- 2011-11-18 ES ES11784506.5T patent/ES2582313T3/es active Active
- 2011-11-18 KR KR1020137015739A patent/KR101858630B1/ko active IP Right Grant
- 2011-11-18 EA EA201390750A patent/EA020837B1/ru not_active IP Right Cessation
- 2011-11-18 CN CN201180056445.6A patent/CN103228659B/zh active Active
- 2011-11-18 MY MYPI2013001629A patent/MY162808A/en unknown
- 2011-11-18 BR BR112013012547A patent/BR112013012547A2/pt not_active Application Discontinuation
-
2013
- 2013-05-20 IL IL226442A patent/IL226442A/en active IP Right Grant
- 2013-05-23 ZA ZA2013/03772A patent/ZA201303772B/en unknown
-
2018
- 2018-10-25 HK HK18113662.0A patent/HK1254681A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1254681A1 (zh) | 2019-07-26 |
| CA2816395C (en) | 2019-03-12 |
| AU2011333918A1 (en) | 2013-05-23 |
| EP2643324B1 (en) | 2016-04-13 |
| KR20130115304A (ko) | 2013-10-21 |
| CA2816395A1 (en) | 2012-05-31 |
| EP2643324A1 (en) | 2013-10-02 |
| EA201390750A1 (ru) | 2013-09-30 |
| ZA201303772B (en) | 2017-06-28 |
| AP3518A (en) | 2016-01-11 |
| UA109676C2 (xx) | 2015-09-25 |
| US20130274250A1 (en) | 2013-10-17 |
| IL226442A0 (en) | 2013-07-31 |
| US9040523B2 (en) | 2015-05-26 |
| IL226442A (en) | 2015-10-29 |
| KR101858630B1 (ko) | 2018-05-16 |
| CN103228659A (zh) | 2013-07-31 |
| ES2582313T3 (es) | 2016-09-12 |
| CN107964013B (zh) | 2020-11-06 |
| CN103228659B (zh) | 2017-11-24 |
| AU2011333918B2 (en) | 2016-02-25 |
| JP5795076B2 (ja) | 2015-10-14 |
| EA020837B1 (ru) | 2015-02-27 |
| NZ611892A (en) | 2014-12-24 |
| SG190141A1 (en) | 2013-06-28 |
| MY162808A (en) | 2017-07-14 |
| JP2013543877A (ja) | 2013-12-09 |
| CN107964013A (zh) | 2018-04-27 |
| BR112013012547A2 (pt) | 2016-08-09 |
| AP2013006868A0 (en) | 2013-05-31 |
| WO2012069380A1 (en) | 2012-05-31 |
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