MX2011007024A - Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal. - Google Patents

Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal.

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Publication number
MX2011007024A
MX2011007024A MX2011007024A MX2011007024A MX2011007024A MX 2011007024 A MX2011007024 A MX 2011007024A MX 2011007024 A MX2011007024 A MX 2011007024A MX 2011007024 A MX2011007024 A MX 2011007024A MX 2011007024 A MX2011007024 A MX 2011007024A
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Mexico
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compound
treatment
methods
compounds
tract
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MX2011007024A
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English (en)
Inventor
Jeffrey W Jacobs
Dominique Charmot
Michael Robert Leadbetter
Marc Navre
Chris Carreras
Noah Bell
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Aedelyx Inc
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Publication of MX2011007024A publication Critical patent/MX2011007024A/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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Abstract

La presente descripción se refiere a compuestos y métodos para el tratamiento de trastornos asociados con retención de fluido o sobrecarga de sal, tal como falla cardiaca (en particular, falla cardiaca congestiva), enfermedad renal crónica, enfermedad renal de etapa terminal, enfermedad hepática, y retención de fluido inducida por agonista de receptor gamma activado por proliferador de peroxisoma (PPAR). La presente descripción también se refiere a compuestos y métodos para el tratamiento de hipertensión. La presente descripción también se refiere a compuestos y métodos para el tratamiento de trastornos del tracto gastrointestinal, incluyendo el tratamiento o reducción de dolor asociado con trastornos del tracto gastrointestinal. Los métodos comprenden en general administrar a un mamífero en necesidad de esto una cantidad farmacéuticamente efectiva de un compuesto, o una composición farmacéutica que comprende este compuesto, que se diseña para ser sustancialmente activo en el tracto gastrointestinal (GI) o para inhibir el antiporte mediado por NHE de iones de sodio y de iones de hidrógeno en el mismo. De manera más particular, el método comprende administrar a un mamífero en necesidad de esto una cantidad farmacéuticamente efectiva de un compuesto o composición farmacéutica que comprende este compuesto, que inhibe el antiporte mediado por NHE-3, -2 y/o -8 de iones de sodio y/o hidrógeno en el tracto GI y se diseña para ser sustancialmente impermeable a la capa de células epiteliales, o de manera más específica al epitelio del tracto GI. Como resultado de que el compuesto sea sustancialmente impermeable, no se absorbe y de esta manera es esencialmente no biodisponible de manera sistémica, para limitar la exposición de otros árganos internos por ejemplo, hígado, corazón, cerebro, etc) a esto. La presente descripción se refiere aún además a un método en donde se administra a un mamífero con este compuesto con un polímero absorbedor de fluido, tal que la combinación actúe como se describe anteriormente y proporcione además la capacidad de secuestrar el fluido y/o sal presentes en el tracto GI.
MX2011007024A 2008-12-31 2009-12-30 Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal. MX2011007024A (es)

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Application Number Priority Date Filing Date Title
US14185308P 2008-12-31 2008-12-31
US16950909P 2009-04-15 2009-04-15
US23784209P 2009-08-28 2009-08-28
PCT/US2009/069852 WO2010078449A2 (en) 2008-12-31 2009-12-30 Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders

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MX2011007024A true MX2011007024A (es) 2011-09-27

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MX2011007024A MX2011007024A (es) 2008-12-31 2009-12-30 Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal.
MX2015004407A MX345283B (es) 2008-12-31 2009-12-30 Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal.

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