MX2011006347A - Conjugados de oligosacaridos-proteinas. - Google Patents
Conjugados de oligosacaridos-proteinas.Info
- Publication number
- MX2011006347A MX2011006347A MX2011006347A MX2011006347A MX2011006347A MX 2011006347 A MX2011006347 A MX 2011006347A MX 2011006347 A MX2011006347 A MX 2011006347A MX 2011006347 A MX2011006347 A MX 2011006347A MX 2011006347 A MX2011006347 A MX 2011006347A
- Authority
- MX
- Mexico
- Prior art keywords
- oligosaccharide
- protein conjugates
- conjugates
- protein
- formulae
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 208000015439 Lysosomal storage disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
- 150000002482 oligosaccharides Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12285108P | 2008-12-16 | 2008-12-16 | |
| PCT/US2009/067775 WO2010075010A2 (en) | 2008-12-16 | 2009-12-11 | Oligosaccharide-protein conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011006347A true MX2011006347A (es) | 2011-09-06 |
Family
ID=42138937
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011006347A MX2011006347A (es) | 2008-12-16 | 2009-12-11 | Conjugados de oligosacaridos-proteinas. |
| MX2015002855A MX364498B (es) | 2008-12-16 | 2009-12-11 | Conjugados de oligosacáridos-protenías. |
| MX2019004905A MX2019004905A (es) | 2008-12-16 | 2011-06-14 | Conjugados de oligosacaridos-proteinas. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015002855A MX364498B (es) | 2008-12-16 | 2009-12-11 | Conjugados de oligosacáridos-protenías. |
| MX2019004905A MX2019004905A (es) | 2008-12-16 | 2011-06-14 | Conjugados de oligosacaridos-proteinas. |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US8835614B2 (enExample) |
| EP (5) | EP2889043B1 (enExample) |
| JP (6) | JP5658167B2 (enExample) |
| CN (5) | CN112220930A (enExample) |
| BR (2) | BRPI0923047B8 (enExample) |
| CA (2) | CA3040973A1 (enExample) |
| CY (1) | CY1121860T1 (enExample) |
| DK (3) | DK3608330T3 (enExample) |
| ES (3) | ES2735023T3 (enExample) |
| HR (2) | HRP20150340T1 (enExample) |
| HU (2) | HUE044381T2 (enExample) |
| IL (5) | IL213595B (enExample) |
| LT (1) | LT2889043T (enExample) |
| MX (3) | MX2011006347A (enExample) |
| PL (2) | PL2465542T3 (enExample) |
| PT (2) | PT2889043T (enExample) |
| SI (2) | SI2889043T1 (enExample) |
| SM (2) | SMT201900375T1 (enExample) |
| TR (1) | TR201909909T4 (enExample) |
| WO (1) | WO2010075010A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| CA2675968C (en) | 2007-01-18 | 2019-05-21 | Genzyme Corporation | Oligosaccharides comprising an aminooxy group and conjugates thereof |
| SI2889043T1 (sl) * | 2008-12-16 | 2019-08-30 | Genzyme Corporation | Sintetične vmesne spojine za pripravo konjugatov oligosaharid-protein |
| CN102596232A (zh) | 2009-08-28 | 2012-07-18 | 西奈山医学院 | 用于治疗酸性鞘磷脂酶缺乏的剂量递增酶替代疗法 |
| EP2699676A1 (en) | 2011-04-22 | 2014-02-26 | Genzyme Corporation | Modified acid alpha glucosidase with accelerated processing |
| WO2013096899A2 (en) * | 2011-12-23 | 2013-06-27 | Shire Human Genetic Therapies, Inc. | Stable formulations for cns delivery of arylsulfatase a |
| JP6055466B2 (ja) * | 2012-05-24 | 2016-12-27 | 国立大学法人 東京大学 | 酸化オリゴ糖で架橋したゲル材料 |
| FI3201320T3 (fi) * | 2014-09-30 | 2024-01-08 | Amicus Therapeutics Inc | Erittäin tehokas hapan alfa-glukosidaasi parannetuilla hiilihydraateilla |
| CN107429257B (zh) | 2015-03-17 | 2022-02-15 | 艾丽法有限责任公司 | 糖基化溶酶体蛋白、生产方法和用途 |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| CA3010205A1 (en) | 2015-12-30 | 2017-07-06 | Amicus Therapeutics, Inc. | Augmented acid alpha-glucosidase for the treatment of pompe disease |
| WO2017170896A1 (ja) * | 2016-03-30 | 2017-10-05 | 国立大学法人徳島大学 | マンノース－６－リン酸基含有糖蛋白質の製造方法、及び蛍光基結合型マンノース－６－リン酸基含有糖蛋白質の細胞内分布を検出する方法 |
| KR20250050123A (ko) | 2016-03-30 | 2025-04-14 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 고 m6p 재조합 단백질의 선택 방법 |
| AU2017239641A1 (en) * | 2016-03-30 | 2018-10-18 | Amicus Therapeutics, Inc. | Formulations comprising recombinant acid alpha-glucosidase |
| WO2017175082A1 (en) * | 2016-04-05 | 2017-10-12 | Gsk Vaccines S.R.L. | Immunogenic compositions |
| CN106366163A (zh) * | 2016-10-31 | 2017-02-01 | 中国人民解放军第二军医大学 | 一种β‑1,2‑D‑寡聚甘露糖肽‑蛋白缀合物及其制备方法和应用 |
| CN106432371A (zh) * | 2016-10-31 | 2017-02-22 | 中国人民解放军第二军医大学 | β‑1,2‑D‑寡聚甘露糖蛋白缀合物及其制备方法和应用 |
| PT3624831T (pt) | 2017-05-15 | 2023-07-04 | Amicus Therapeutics Inc | Alfa-glucosidase ácida humana recombinante |
| MX2021000278A (es) | 2018-07-09 | 2021-03-31 | Merck Sharp & Dohme Llc | Sintesis enzimatica de analogos de nucleosido de 4'-etinilo. |
| AU2019316103B2 (en) | 2018-08-02 | 2026-02-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US20220023434A1 (en) * | 2018-12-19 | 2022-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional Molecules for Lysosomal Targeting and Related Compositions and Methods |
| WO2021159092A1 (en) * | 2020-02-08 | 2021-08-12 | Genzyme Corporation | Compositions and methods for treating pompe disease |
| KR20230025874A (ko) | 2020-06-14 | 2023-02-23 | 젠자임 코포레이션 | 후기 발병형 폼페병을 치료하기 위한 조성물 및 방법 |
| JP2024524614A (ja) | 2021-07-14 | 2024-07-05 | ライシア セラピューティクス， インコーポレイテッド | Ａｓｇｐｒ細胞表面受容体結合化合物及びコンジュゲート |
Family Cites Families (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4701521A (en) | 1978-07-17 | 1987-10-20 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
| US4749570A (en) | 1981-12-31 | 1988-06-07 | The Governors Of The University Of Alberta | Targeting conjugates of albumin and therapeutic agents |
| US4867973A (en) | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| JPS5936691A (ja) * | 1982-08-24 | 1984-02-28 | Rikagaku Kenkyusho | 新規オリゴマンノシド及びその製造法 |
| US5851991A (en) | 1987-08-31 | 1998-12-22 | The Regents Of The University Of California | Therapeutic use of the retinoblastoma susceptibility gene product |
| US5066789A (en) | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
| US5236838A (en) | 1988-12-23 | 1993-08-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
| US5549892A (en) | 1988-12-23 | 1996-08-27 | Genzyme Corporation | Enhanced in vivo uptake of glucocerebrosidase |
| IL93432A (en) | 1989-02-24 | 1994-02-27 | Johnson Mathey Inc | Hydrazines and hydrazides, their conjugates with macromolecules, and such conjugates labeled with metallic ions |
| US5206370A (en) | 1989-02-24 | 1993-04-27 | Johnson Matthey, Inc. | Certain pyridyl hydrazines and hydrazides useful for protein labeling |
| US5179023A (en) | 1989-03-24 | 1993-01-12 | Research Corporation Technologies, Inc. | Recombinant α-galactosidase a therapy for Fabry disease |
| US5212298A (en) | 1989-08-16 | 1993-05-18 | Monsanto Company | Method for producing synthetic N-linked glycoconjugates |
| US5280113A (en) | 1989-08-16 | 1994-01-18 | Monsanto Company | Method for producing synthetic N-linked glycoconjugates |
| US5324663A (en) | 1990-02-14 | 1994-06-28 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| US5583042A (en) | 1990-04-16 | 1996-12-10 | Neose Pharmaceuticals, Inc. | Apparatus for the synthesis of saccharide compositions |
| US5312903A (en) * | 1990-06-01 | 1994-05-17 | E. I. Du Pont De Nemours And Company | Lysine-glycosylated recombinant interleukin-2 |
| US5677440A (en) | 1990-07-16 | 1997-10-14 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| CA2073511A1 (en) | 1990-11-14 | 1992-05-29 | Matthew R. Callstrom | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
| JPH06506217A (ja) | 1991-03-18 | 1994-07-14 | エンゾン，インコーポレーテッド | ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体 |
| US5733761A (en) | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| DE69233704T2 (de) * | 1991-12-20 | 2008-05-21 | Novo Nordisk A/S | Stabilisierte pharmazeutische Formulierung, umfassend Wachstumshormon und Histidin |
| US5834266A (en) | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
| US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| FR2721612B1 (fr) | 1994-06-23 | 1996-08-09 | Idm | Nouveaux dérivés d'oligosides, leur procédé de préparation et leurs applications. |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US5719131A (en) | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
| US5767099A (en) | 1994-12-09 | 1998-06-16 | Genzyme Corporation | Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules |
| US5948767A (en) | 1994-12-09 | 1999-09-07 | Genzyme Corporation | Cationic amphiphile/DNA complexes |
| US5747471A (en) | 1994-12-09 | 1998-05-05 | Genzyme Corporation | Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules |
| US5939401A (en) | 1994-12-09 | 1999-08-17 | Genzyme Corporation | Cationic amphiphile compositions for intracellular delivery of therapeutic molecules |
| US5910487A (en) | 1994-12-09 | 1999-06-08 | Genzyme Corporation | Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules |
| US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| US5840710A (en) | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
| US5650096A (en) | 1994-12-09 | 1997-07-22 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
| US6492332B1 (en) | 1995-12-12 | 2002-12-10 | Omeros Corporation | Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation |
| US5811510A (en) | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
| US6118045A (en) | 1995-08-02 | 2000-09-12 | Pharming B.V. | Lysosomal proteins produced in the milk of transgenic animals |
| CA2230758A1 (en) | 1995-09-08 | 1997-03-13 | Genzyme Corporation | Improved aav vectors for gene therapy |
| US5916911A (en) | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
| US7141676B1 (en) | 1996-02-08 | 2006-11-28 | University Of Washington | Water soluble multi-biotin-containing compounds |
| AU2341197A (en) * | 1996-03-21 | 1997-10-10 | Intercardia, Inc. | Solid phase lipoglycopeptide library, compositions and methods |
| US5840702A (en) | 1996-03-22 | 1998-11-24 | Uab Research Foundation | Cystic fibrosis treatment |
| US5935936A (en) | 1996-06-03 | 1999-08-10 | Genzyme Corporation | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
| AUPO190596A0 (en) | 1996-08-26 | 1996-09-19 | Alchemia Pty Ltd | Oligosaccharide synthesis |
| HU227189B1 (en) | 1996-09-13 | 2010-10-28 | Transkaryotic Therapies | Therapy for alpha-galactosidase a deficiency |
| US5861397A (en) | 1996-10-03 | 1999-01-19 | Vical Incorporated | Piperazine based cytofectins |
| ATE451124T1 (de) | 1997-01-21 | 2009-12-15 | Sanofi Pasteur | Polysaccharid-peptid-konjugate |
| US5925628A (en) | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
| US5912239A (en) | 1997-04-04 | 1999-06-15 | Genzyme Corporation | Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules |
| US5948925A (en) | 1997-05-06 | 1999-09-07 | Genzyme Corporation | Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids |
| US5952516A (en) | 1997-05-08 | 1999-09-14 | Genzyme Corporation | Cationic amphiphiles containing multiplesteroid lipophilic groups |
| US5942634A (en) | 1997-05-09 | 1999-08-24 | Genzyme Corporation | Cationic amphiphiles for cell transfections |
| WO2000009153A1 (en) | 1997-10-29 | 2000-02-24 | Genzyme Corporation | Compositions and methods for treating lysosomal storage disease |
| SE513149C2 (sv) | 1997-12-05 | 2000-07-17 | Katarina Edwards | Läkemedelsdistributionssystem med tvåstegsmålsökning, till specifika celler eller vävnad och till dess cellkärna |
| US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| US6703488B1 (en) | 1998-01-15 | 2004-03-09 | Center For Molecular Medicine And Immunology | Antibody/receptor targeting moiety for enhanced delivery of armed ligand |
| US6287857B1 (en) | 1998-02-09 | 2001-09-11 | Genzyme Corporation | Nucleic acid delivery vehicles |
| WO1999041400A1 (en) | 1998-02-17 | 1999-08-19 | Genzyme Corporation | Methods for pseudoadenoviral vector production |
| EP1056880A1 (en) | 1998-02-17 | 2000-12-06 | Genzyme Corporation | Methods for purified aav vector production |
| US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| WO1999057296A1 (en) | 1998-05-01 | 1999-11-11 | Genzyme Corporation | Partially deleted adenoviral vectors |
| US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| US6538117B1 (en) | 1999-08-10 | 2003-03-25 | The Scripps Research Institute | Programmable one-pot oligosaccharide synthesis |
| US6399575B1 (en) | 1998-11-10 | 2002-06-04 | Auburn University | Methods and compositions for targeting compounds to the central nervous system |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| GB9909066D0 (en) | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| GB9909064D0 (en) | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| AU6050600A (en) | 1999-07-26 | 2001-02-13 | G.D. Searle & Co. | Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases |
| US6770468B1 (en) | 1999-09-14 | 2004-08-03 | Genzyme Glycobiology Research Institute, Inc. | Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway |
| US6534300B1 (en) | 1999-09-14 | 2003-03-18 | Genzyme Glycobiology Research Institute, Inc. | Methods for producing highly phosphorylated lysosomal hydrolases |
| ATE360082T1 (de) | 1999-11-16 | 2007-05-15 | Genzyme Corp | Vektoren und transgene mit regulatorischen elementen zur genverabreichung in leber |
| US6749865B2 (en) | 2000-02-15 | 2004-06-15 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
| AU2001238346A1 (en) | 2000-02-15 | 2001-08-27 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
| WO2001060377A2 (en) | 2000-02-17 | 2001-08-23 | Genzyme Corporation | Methods for treatment of lysosomal storage diseases using biphosphonates |
| US7943129B2 (en) | 2000-05-26 | 2011-05-17 | National Research Council Of Canada | Single-domain brain-targeting antibody fragments derived from llama antibodies |
| US20040014652A1 (en) | 2000-06-01 | 2004-01-22 | Andre Trouet | Tumor activated prodrug compounds and methods of making and using the same |
| US20040204379A1 (en) | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| WO2001097829A2 (en) | 2000-06-19 | 2001-12-27 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| WO2002007671A2 (en) | 2000-07-26 | 2002-01-31 | Ramot-University Authority For Applied Research And Industrial Development Ltd. | Intracellular delivery system for protein phosphatases and other polypeptides |
| CA2420183C (en) | 2000-08-18 | 2009-11-24 | Massachusetts Institute Of Technology | Apparatus and methods for the automated synthesis of oligosaccharides |
| US6676963B1 (en) | 2000-10-27 | 2004-01-13 | Barnes-Jewish Hospital | Ligand-targeted emulsions carrying bioactive agents |
| US7001994B2 (en) | 2001-01-18 | 2006-02-21 | Genzyme Corporation | Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| US7629309B2 (en) | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| AU2002256423B2 (en) | 2001-04-30 | 2008-07-24 | Zystor Therapeutics, Inc. | Subcellular targeting of therapeutic proteins |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| JP2004514410A (ja) | 2001-05-07 | 2004-05-20 | スプラテック ファーマ インコーポレイティド | 生物剤の経口およびｃｎｓ供給を強化するためのリガンド |
| EP2266968B1 (en) | 2001-07-16 | 2013-01-09 | Genzyme Corporation | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| EP2305312B1 (en) | 2001-10-10 | 2015-03-04 | ratiopharm GmbH | Remodelling and glycoconjugation of follicle-stimulating hormone (FSH) |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| AU2002348261A1 (en) | 2001-11-26 | 2003-06-10 | Genzyme Corporation | Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors |
| WO2003046150A2 (en) | 2001-11-28 | 2003-06-05 | Neose Technologies, Inc. | Glycoprotein remodeling using endoglycanases |
| US6905856B2 (en) | 2001-12-21 | 2005-06-14 | Genzyme Glycobiology Research Institute, Inc. | Soluble GlcNAc phosphotransferase |
| US6800472B2 (en) | 2001-12-21 | 2004-10-05 | Genzyme Glycobiology Research Institute, Inc. | Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase |
| JP2006506317A (ja) | 2002-01-11 | 2006-02-23 | バイオマリン ファーマシューティカル インコーポレイテッド | 治療用リソソーム酵素の送達のための酵素送達系としてのｐ９７の使用 |
| EP1585817B1 (en) | 2002-02-20 | 2009-09-02 | The General Hospital Corporation | Conjugates comprising a biodegradable polymer and uses therefor |
| US6916802B2 (en) | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| CN102586205A (zh) | 2003-01-31 | 2012-07-18 | 纽约大学西奈山医学院 | 酶和酶的活性部位特异性陪伴分子的组合 |
| WO2005002515A2 (en) | 2003-06-20 | 2005-01-13 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| US20050026823A1 (en) | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
| JP2007501811A (ja) | 2003-08-08 | 2007-02-01 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 治療的な関心対象のタンパク質に対する遅延分子の選択的な化学物質接合のためのガラクトースオキシダーゼの使用。 |
| ATE374788T1 (de) | 2003-08-12 | 2007-10-15 | Lipoxen Technologies Ltd | Polysialinsäurederivate |
| US7442372B2 (en) | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| US7232805B2 (en) | 2003-09-10 | 2007-06-19 | Inflabloc Pharmaceuticals, Inc. | Cobalamin conjugates for anti-tumor therapy |
| EP1525890A1 (en) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Protein-Proteophore complexes |
| US7176185B2 (en) | 2003-11-25 | 2007-02-13 | Tsrl, Inc. | Short peptide carrier system for cellular delivery of agent |
| EP1713508A2 (en) | 2004-01-29 | 2006-10-25 | Biosynexus Incorporated | Use of amino-oxy functional groups in the preparation of vaccine conjugates |
| EP1720405A4 (en) | 2004-02-06 | 2008-08-27 | Biomarin Pharm Inc | PREPARATION OF STRONG PHOSPHORYLATED LYSOSOMAL ENZYMES AND THEIR USE |
| DK1740204T3 (en) | 2004-04-01 | 2018-05-22 | Chiesi Farm Spa | MEDICAL USE OF ALFA MANNOSIDASE |
| US8017151B2 (en) | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
| US7341720B2 (en) | 2005-04-06 | 2008-03-11 | Genzyme Corporation | Targeting of glycoprotein therapeutics |
| AR059089A1 (es) * | 2006-01-20 | 2008-03-12 | Genzyme Corp | Administracion intraventricular de una enzima para enfermedades de almacenamiento lisosomal |
| EP1987068B1 (en) * | 2006-02-10 | 2018-08-08 | Life Technologies Corporation | Oligosaccharide modification and labeling of proteins |
| CA2675968C (en) | 2007-01-18 | 2019-05-21 | Genzyme Corporation | Oligosaccharides comprising an aminooxy group and conjugates thereof |
| WO2008089339A2 (en) | 2007-01-18 | 2008-07-24 | Genzyme Corporation | Oligosaccharide conjugates for cellular targeting |
| SI2889043T1 (sl) | 2008-12-16 | 2019-08-30 | Genzyme Corporation | Sintetične vmesne spojine za pripravo konjugatov oligosaharid-protein |
| US12285108B1 (en) | 2024-08-08 | 2025-04-29 | Frank R. Connors | Shelf device with interchangeable faceplate |
-
2009
- 2009-12-11 SI SI200931981T patent/SI2889043T1/sl unknown
- 2009-12-11 LT LTEP14194176.5T patent/LT2889043T/lt unknown
- 2009-12-11 DK DK19167964.6T patent/DK3608330T3/da active
- 2009-12-11 WO PCT/US2009/067775 patent/WO2010075010A2/en not_active Ceased
- 2009-12-11 CA CA3040973A patent/CA3040973A1/en not_active Abandoned
- 2009-12-11 CN CN202011052459.8A patent/CN112220930A/zh active Pending
- 2009-12-11 ES ES14194176T patent/ES2735023T3/es active Active
- 2009-12-11 MX MX2011006347A patent/MX2011006347A/es active IP Right Grant
- 2009-12-11 TR TR2019/09909T patent/TR201909909T4/tr unknown
- 2009-12-11 CN CN202011434866.5A patent/CN112618724A/zh active Pending
- 2009-12-11 PL PL12160009T patent/PL2465542T3/pl unknown
- 2009-12-11 BR BRPI0923047A patent/BRPI0923047B8/pt active IP Right Grant
- 2009-12-11 DK DK12160009.2T patent/DK2465542T3/en active
- 2009-12-11 CN CN200980156896XA patent/CN102369023A/zh active Pending
- 2009-12-11 US US13/140,272 patent/US8835614B2/en active Active
- 2009-12-11 JP JP2011542288A patent/JP5658167B2/ja active Active
- 2009-12-11 CN CN201610298866.4A patent/CN105879047A/zh active Pending
- 2009-12-11 ES ES19167964T patent/ES2937017T3/es active Active
- 2009-12-11 PT PT14194176T patent/PT2889043T/pt unknown
- 2009-12-11 EP EP14194176.5A patent/EP2889043B1/en active Active
- 2009-12-11 EP EP19167964.6A patent/EP3608330B1/en active Active
- 2009-12-11 SI SI200931162T patent/SI2465542T1/sl unknown
- 2009-12-11 SM SM20190375T patent/SMT201900375T1/it unknown
- 2009-12-11 HU HUE14194176 patent/HUE044381T2/hu unknown
- 2009-12-11 HU HUE19167964A patent/HUE060974T2/hu unknown
- 2009-12-11 EP EP22205652.5A patent/EP4212541A1/en active Pending
- 2009-12-11 BR BR122020010601A patent/BR122020010601B8/pt active IP Right Grant
- 2009-12-11 DK DK14194176.5T patent/DK2889043T3/da active
- 2009-12-11 ES ES12160009.2T patent/ES2534056T3/es active Active
- 2009-12-11 PT PT121600092T patent/PT2465542E/pt unknown
- 2009-12-11 EP EP12160009.2A patent/EP2465542B1/en active Active
- 2009-12-11 PL PL14194176T patent/PL2889043T3/pl unknown
- 2009-12-11 MX MX2015002855A patent/MX364498B/es unknown
- 2009-12-11 CA CA2747230A patent/CA2747230C/en not_active Expired - Fee Related
- 2009-12-11 CN CN2013103303923A patent/CN103432566A/zh not_active Withdrawn
- 2009-12-11 EP EP09771640A patent/EP2376123A2/en not_active Withdrawn
-
2011
- 2011-06-14 MX MX2019004905A patent/MX2019004905A/es unknown
- 2011-06-16 IL IL213595A patent/IL213595B/en active IP Right Grant
-
2014
- 2014-03-07 JP JP2014045356A patent/JP2014139204A/ja not_active Withdrawn
- 2014-07-29 US US14/445,941 patent/US9493498B2/en active Active
-
2015
- 2015-03-25 HR HRP20150340TT patent/HRP20150340T1/hr unknown
- 2015-03-25 IL IL237932A patent/IL237932B/en active IP Right Grant
- 2015-03-25 IL IL237933A patent/IL237933A0/en unknown
- 2015-03-30 SM SM201500082T patent/SMT201500082B/xx unknown
-
2016
- 2016-09-20 JP JP2016182748A patent/JP6659503B2/ja active Active
- 2016-10-07 US US15/288,486 patent/US10464962B2/en active Active
-
2019
- 2019-03-13 JP JP2019046041A patent/JP2019112444A/ja not_active Withdrawn
- 2019-06-18 HR HRP20191102TT patent/HRP20191102T1/hr unknown
- 2019-07-10 CY CY20191100730T patent/CY1121860T1/el unknown
- 2019-09-24 US US16/581,148 patent/US11279725B2/en active Active
- 2019-11-26 IL IL270930A patent/IL270930B/en unknown
-
2021
- 2021-06-20 IL IL284184A patent/IL284184B2/en unknown
- 2021-07-02 JP JP2021110649A patent/JP2021169467A/ja active Pending
-
2022
- 2022-02-14 US US17/671,249 patent/US12252504B2/en active Active
-
2023
- 2023-08-24 JP JP2023136066A patent/JP7590515B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2011006347A (es) | Conjugados de oligosacaridos-proteinas. | |
| EP4293112A3 (en) | Oligosaccharides comprising an aminooxy group and conjugates thereof | |
| MX391454B (es) | Compuesto de engarce-fármaco para conjugación a una unidad de ligando. | |
| MX2010003977A (es) | Terapia de combinacion con conjugados de anticuerpo-farmaco. | |
| MX349749B (es) | Suministro enzimatico intraventricular para enfermedades de almacenamiento lisosomico. | |
| IN2012DN04908A (enExample) | ||
| EP2170054A4 (en) | TARGETING CONJUGATES WITH ACTIVE SUBSTANCES ENCAPLED IN CYCLODEXTRIN POLYMERS | |
| EP2350273A4 (en) | COMPOSITIONS OF MANIPULATED HUMAN ARGINAS AND METHOD FOR THE TREATMENT OF CANCER | |
| MX2018013333A (es) | Composiciones de nucleasas terapeuticas y metodos. | |
| BRPI0917000A2 (pt) | proteínas conjugadas com eficácia in vivo prolongada | |
| WO2010059253A3 (en) | Methods and compositions for localized agent delivery | |
| MX2009013982A (es) | Composiciones que comprenden inhibidores de triptofano hidroxilasa. | |
| MX2010004110A (es) | Formulacion para mejorar la funcion gastrointestinal. | |
| WO2008089339A3 (en) | Oligosaccharide conjugates for cellular targeting | |
| AR061155A1 (es) | Preparaciones liofilizadas de pantoprazol sodico para inyeccion | |
| CY1116394T1 (el) | Συζευγματα ολιγοσακχαριτη-πρωτεϊνης | |
| BRPI0917819B8 (pt) | compostos derivados poliméricos de benzil carbonato, conjugado de droga, formulação farmacêutica, e, uso de um conjugado | |
| MX2010006170A (es) | Composicion farmaceutica para la limpieza del intestino. | |
| CY1114320T1 (el) | Ολιγοσακχαριτες που περιλαμβανουν αμινοοξυ-ομαδα και συζευγματα αυτων | |
| IL202849A0 (en) | Targeting conjugates comprising active agent encapsulated in cyclodextrin-containing polymers | |
| SI2121713T1 (sl) | Oligosaharidi, ki obsegajo aminooksi skupino, in njihovi konjugati |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |