MX364498B - Conjugados de oligosacáridos-protenías. - Google Patents

Conjugados de oligosacáridos-protenías.

Info

Publication number
MX364498B
MX364498B MX2015002855A MX2015002855A MX364498B MX 364498 B MX364498 B MX 364498B MX 2015002855 A MX2015002855 A MX 2015002855A MX 2015002855 A MX2015002855 A MX 2015002855A MX 364498 B MX364498 B MX 364498B
Authority
MX
Mexico
Prior art keywords
oligosaccharide
protein conjugates
conjugates
protein
formulae
Prior art date
Application number
MX2015002855A
Other languages
English (en)
Inventor
Robert J Miller
Clark Pan
Paul A Konowicz
Luis Z Avila
James E Stefano
Michael R Reardon
John Harrahy
Qun Zhou
Lauren Young
Patrick Finn
Xiaoyang Zheng
Joseph Kutzko
Zhu Yunxiang
Patterson Duncan
Peer Andreas
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX364498B publication Critical patent/MX364498B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

La presente invención se refiere a conjugados que comprenden una proteína y un oligosacárido de una de las fórmulas I-VI. También se proporcionan composiciones farmacéuticas que comprenden estos conjugados. Además, se proporcionan procedimientos para tratar un trastorno por depósito lisosomal en un mamífero con la administración de un conjugado de oligosacáridos-glicoproteínas.
MX2015002855A 2008-12-16 2009-12-11 Conjugados de oligosacáridos-protenías. MX364498B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12285108P 2008-12-16 2008-12-16
PCT/US2009/067775 WO2010075010A2 (en) 2008-12-16 2009-12-11 Oligosaccharide-protein conjugates

Publications (1)

Publication Number Publication Date
MX364498B true MX364498B (es) 2019-04-29

Family

ID=42138937

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2011006347A MX2011006347A (es) 2008-12-16 2009-12-11 Conjugados de oligosacaridos-proteinas.
MX2015002855A MX364498B (es) 2008-12-16 2009-12-11 Conjugados de oligosacáridos-protenías.
MX2019004905A MX2019004905A (es) 2008-12-16 2011-06-14 Conjugados de oligosacaridos-proteinas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2011006347A MX2011006347A (es) 2008-12-16 2009-12-11 Conjugados de oligosacaridos-proteinas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019004905A MX2019004905A (es) 2008-12-16 2011-06-14 Conjugados de oligosacaridos-proteinas.

Country Status (20)

Country Link
US (5) US8835614B2 (es)
EP (5) EP2889043B1 (es)
JP (6) JP5658167B2 (es)
CN (5) CN112220930A (es)
BR (2) BRPI0923047B8 (es)
CA (2) CA3040973A1 (es)
CY (1) CY1121860T1 (es)
DK (3) DK3608330T3 (es)
ES (3) ES2735023T3 (es)
HR (2) HRP20150340T1 (es)
HU (2) HUE044381T2 (es)
IL (5) IL213595B (es)
LT (1) LT2889043T (es)
MX (3) MX2011006347A (es)
PL (2) PL2465542T3 (es)
PT (2) PT2889043T (es)
SI (2) SI2889043T1 (es)
SM (2) SMT201900375T1 (es)
TR (1) TR201909909T4 (es)
WO (1) WO2010075010A2 (es)

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