MX2011002706A - Tornillo radiolucido con marcador radiopaco. - Google Patents
Tornillo radiolucido con marcador radiopaco.Info
- Publication number
- MX2011002706A MX2011002706A MX2011002706A MX2011002706A MX2011002706A MX 2011002706 A MX2011002706 A MX 2011002706A MX 2011002706 A MX2011002706 A MX 2011002706A MX 2011002706 A MX2011002706 A MX 2011002706A MX 2011002706 A MX2011002706 A MX 2011002706A
- Authority
- MX
- Mexico
- Prior art keywords
- seq
- expression
- sequences
- vector
- fusion protein
- Prior art date
Links
- 239000003550 marker Substances 0.000 title description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 83
- 230000014509 gene expression Effects 0.000 claims description 81
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 71
- 210000004027 cell Anatomy 0.000 claims description 68
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 68
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 claims description 58
- 102000004169 proteins and genes Human genes 0.000 claims description 53
- 239000013604 expression vector Substances 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 37
- 239000013598 vector Substances 0.000 claims description 31
- 102000037865 fusion proteins Human genes 0.000 claims description 29
- 108020001507 fusion proteins Proteins 0.000 claims description 29
- 150000007523 nucleic acids Chemical class 0.000 claims description 29
- 102000039446 nucleic acids Human genes 0.000 claims description 25
- 108020004707 nucleic acids Proteins 0.000 claims description 25
- 210000004962 mammalian cell Anatomy 0.000 claims description 23
- 102000005962 receptors Human genes 0.000 claims description 19
- 108020003175 receptors Proteins 0.000 claims description 19
- 239000013612 plasmid Substances 0.000 claims description 17
- 239000012634 fragment Substances 0.000 claims description 16
- 230000002103 transcriptional effect Effects 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 13
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 12
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 12
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 12
- 239000002773 nucleotide Substances 0.000 claims description 11
- 125000003729 nucleotide group Chemical group 0.000 claims description 11
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 230000002068 genetic effect Effects 0.000 claims description 8
- 230000002759 chromosomal effect Effects 0.000 claims description 7
- 239000003623 enhancer Substances 0.000 claims description 7
- 230000010076 replication Effects 0.000 claims description 6
- 238000013519 translation Methods 0.000 claims description 6
- 238000011144 upstream manufacturing Methods 0.000 claims description 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 3
- 230000001973 epigenetic effect Effects 0.000 claims description 3
- 230000008488 polyadenylation Effects 0.000 claims description 3
- 238000003259 recombinant expression Methods 0.000 claims description 3
- 230000014621 translational initiation Effects 0.000 claims description 3
- 108091006107 transcriptional repressors Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims 3
- 102100025169 Max-binding protein MNT Human genes 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 206010054094 Tumour necrosis Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000013602 bacteriophage vector Substances 0.000 claims 1
- 230000012743 protein tagging Effects 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 5
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 description 31
- 108010077544 Chromatin Proteins 0.000 description 20
- 210000003483 chromatin Anatomy 0.000 description 20
- 239000011159 matrix material Substances 0.000 description 10
- 206010039073 rheumatoid arthritis Diseases 0.000 description 10
- 230000010354 integration Effects 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 238000013518 transcription Methods 0.000 description 9
- 108010008165 Etanercept Proteins 0.000 description 8
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 description 8
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 description 8
- 210000000349 chromosome Anatomy 0.000 description 8
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 230000035897 transcription Effects 0.000 description 8
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 108700019146 Transgenes Proteins 0.000 description 7
- 208000019069 chronic childhood arthritis Diseases 0.000 description 7
- 229940073621 enbrel Drugs 0.000 description 7
- 239000013600 plasmid vector Substances 0.000 description 7
- 229920001184 polypeptide Polymers 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 7
- 238000001890 transfection Methods 0.000 description 6
- 208000003456 Juvenile Arthritis Diseases 0.000 description 5
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 5
- 101150084935 PTER gene Proteins 0.000 description 5
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 5
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 5
- 102000040430 polynucleotide Human genes 0.000 description 5
- 108091033319 polynucleotide Proteins 0.000 description 5
- 239000002157 polynucleotide Substances 0.000 description 5
- 230000004481 post-translational protein modification Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000012250 transgenic expression Methods 0.000 description 5
- 108091026890 Coding region Proteins 0.000 description 4
- 241000699800 Cricetinae Species 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000030279 gene silencing Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 3
- 230000004544 DNA amplification Effects 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 201000004681 Psoriasis Diseases 0.000 description 3
- 201000001263 Psoriatic Arthritis Diseases 0.000 description 3
- 208000036824 Psoriatic arthropathy Diseases 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 210000003292 kidney cell Anatomy 0.000 description 3
- 210000000299 nuclear matrix Anatomy 0.000 description 3
- 210000001672 ovary Anatomy 0.000 description 3
- 108091008146 restriction endonucleases Proteins 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- 241000699802 Cricetulus griseus Species 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 230000007067 DNA methylation Effects 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 2
- 108091092195 Intron Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 102000008297 Nuclear Matrix-Associated Proteins Human genes 0.000 description 2
- 108010035916 Nuclear Matrix-Associated Proteins Proteins 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 102100029131 Retrotransposon Gag-like protein 4 Human genes 0.000 description 2
- 108010022394 Threonine synthase Proteins 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- CREXVNNSNOKDHW-UHFFFAOYSA-N azaniumylideneazanide Chemical group N[N] CREXVNNSNOKDHW-UHFFFAOYSA-N 0.000 description 2
- 238000012761 co-transfection Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000005547 deoxyribonucleotide Substances 0.000 description 2
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 2
- 102000004419 dihydrofolate reductase Human genes 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000002864 sequence alignment Methods 0.000 description 2
- 230000010473 stable expression Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000001179 synovial fluid Anatomy 0.000 description 2
- 230000005026 transcription initiation Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000010474 transient expression Effects 0.000 description 2
- 102100033647 Activity-regulated cytoskeleton-associated protein Human genes 0.000 description 1
- 241000726103 Atta Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108700031361 Brachyury Proteins 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
- 102000016911 Deoxyribonucleases Human genes 0.000 description 1
- 108010053770 Deoxyribonucleases Proteins 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
- 241000255601 Drosophila melanogaster Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- OOFLZRMKTMLSMH-UHFFFAOYSA-N H4atta Chemical compound OC(=O)CN(CC(O)=O)CC1=CC=CC(C=2N=C(C=C(C=2)C=2C3=CC=CC=C3C=C3C=CC=CC3=2)C=2N=C(CN(CC(O)=O)CC(O)=O)C=CC=2)=N1 OOFLZRMKTMLSMH-UHFFFAOYSA-N 0.000 description 1
- 108010034791 Heterochromatin Proteins 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 101001094537 Homo sapiens Retrotransposon Gag-like protein 3 Proteins 0.000 description 1
- 101000699781 Homo sapiens Retrotransposon Gag-like protein 4 Proteins 0.000 description 1
- 101000699777 Homo sapiens Retrotransposon Gag-like protein 5 Proteins 0.000 description 1
- 101000699774 Homo sapiens Retrotransposon Gag-like protein 6 Proteins 0.000 description 1
- 101001073409 Homo sapiens Retrotransposon-derived protein PEG10 Proteins 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- 101000801232 Homo sapiens Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108090000157 Metallothionein Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 108091093105 Nuclear DNA Proteins 0.000 description 1
- 108010047956 Nucleosomes Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 101000945964 Rattus norvegicus CCAAT/enhancer-binding protein beta Proteins 0.000 description 1
- 101000924396 Rattus norvegicus Cytosol aminopeptidase Proteins 0.000 description 1
- 101001001280 Rattus norvegicus Lysosomal acid phosphatase Proteins 0.000 description 1
- 102100029146 Retrotransposon Gag-like protein 5 Human genes 0.000 description 1
- 102100029147 Retrotransposon Gag-like protein 6 Human genes 0.000 description 1
- 102100035844 Retrotransposon-derived protein PEG10 Human genes 0.000 description 1
- 108700005078 Synthetic Genes Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
- 241000219873 Vicia Species 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 241000269370 Xenopus <genus> Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 210000002230 centromere Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000006957 competitive inhibition Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 229960000403 etanercept Drugs 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000012226 gene silencing method Methods 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000004458 heterochromatin Anatomy 0.000 description 1
- 229920000140 heteropolymer Polymers 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 102000057041 human TNF Human genes 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000031864 metaphase Effects 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 238000009343 monoculture Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000001623 nucleosome Anatomy 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011165 process development Methods 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000009465 prokaryotic expression Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8685—Pins or screws or threaded wires; nuts therefor comprising multiple separate parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7032—Screws or hooks with U-shaped head or back through which longitudinal rods pass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7035—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other
- A61B17/7037—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other wherein pivoting is blocked when the rod is clamped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/866—Material or manufacture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8625—Shanks, i.e. parts contacting bone tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/0088—Material properties ceramic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/00902—Material properties transparent or translucent
- A61B2017/00915—Material properties transparent or translucent for radioactive radiation
- A61B2017/0092—Material properties transparent or translucent for radioactive radiation for X-rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/00955—Material properties thermoplastic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3966—Radiopaque markers visible in an X-ray image
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/208,986 US9408649B2 (en) | 2008-09-11 | 2008-09-11 | Radiolucent screw with radiopaque marker |
| PCT/US2009/056508 WO2010030774A1 (en) | 2008-09-11 | 2009-09-10 | Radiolucent screw with radiopaque marker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011002706A true MX2011002706A (es) | 2011-07-20 |
Family
ID=41354042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011002706A MX2011002706A (es) | 2008-09-11 | 2009-09-10 | Tornillo radiolucido con marcador radiopaco. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9408649B2 (enExample) |
| EP (1) | EP2326270B1 (enExample) |
| JP (1) | JP5600107B2 (enExample) |
| CN (1) | CN102209501A (enExample) |
| AU (1) | AU2009291800B2 (enExample) |
| BR (1) | BRPI0918450A2 (enExample) |
| CA (1) | CA2736891C (enExample) |
| MX (1) | MX2011002706A (enExample) |
| WO (1) | WO2010030774A1 (enExample) |
Families Citing this family (172)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7833250B2 (en) | 2004-11-10 | 2010-11-16 | Jackson Roger P | Polyaxial bone screw with helically wound capture connection |
| US7862587B2 (en) * | 2004-02-27 | 2011-01-04 | Jackson Roger P | Dynamic stabilization assemblies, tool set and method |
| US8876868B2 (en) | 2002-09-06 | 2014-11-04 | Roger P. Jackson | Helical guide and advancement flange with radially loaded lip |
| US7621918B2 (en) | 2004-11-23 | 2009-11-24 | Jackson Roger P | Spinal fixation tool set and method |
| US7377923B2 (en) | 2003-05-22 | 2008-05-27 | Alphatec Spine, Inc. | Variable angle spinal screw assembly |
| US7766915B2 (en) | 2004-02-27 | 2010-08-03 | Jackson Roger P | Dynamic fixation assemblies with inner core and outer coil-like member |
| US7776067B2 (en) | 2005-05-27 | 2010-08-17 | Jackson Roger P | Polyaxial bone screw with shank articulation pressure insert and method |
| US8936623B2 (en) | 2003-06-18 | 2015-01-20 | Roger P. Jackson | Polyaxial bone screw assembly |
| US7179261B2 (en) | 2003-12-16 | 2007-02-20 | Depuy Spine, Inc. | Percutaneous access devices and bone anchor assemblies |
| US11419642B2 (en) | 2003-12-16 | 2022-08-23 | Medos International Sarl | Percutaneous access devices and bone anchor assemblies |
| US7527638B2 (en) | 2003-12-16 | 2009-05-05 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
| US7160300B2 (en) | 2004-02-27 | 2007-01-09 | Jackson Roger P | Orthopedic implant rod reduction tool set and method |
| US11241261B2 (en) | 2005-09-30 | 2022-02-08 | Roger P Jackson | Apparatus and method for soft spinal stabilization using a tensionable cord and releasable end structure |
| US9050148B2 (en) | 2004-02-27 | 2015-06-09 | Roger P. Jackson | Spinal fixation tool attachment structure |
| CA2555868C (en) | 2004-02-27 | 2011-09-06 | Roger P. Jackson | Orthopedic implant rod reduction tool set and method |
| US8152810B2 (en) | 2004-11-23 | 2012-04-10 | Jackson Roger P | Spinal fixation tool set and method |
| US8926672B2 (en) | 2004-11-10 | 2015-01-06 | Roger P. Jackson | Splay control closure for open bone anchor |
| US8444681B2 (en) | 2009-06-15 | 2013-05-21 | Roger P. Jackson | Polyaxial bone anchor with pop-on shank, friction fit retainer and winged insert |
| US9980753B2 (en) | 2009-06-15 | 2018-05-29 | Roger P Jackson | pivotal anchor with snap-in-place insert having rotation blocking extensions |
| US8308782B2 (en) | 2004-11-23 | 2012-11-13 | Jackson Roger P | Bone anchors with longitudinal connecting member engaging inserts and closures for fixation and optional angulation |
| US9168069B2 (en) | 2009-06-15 | 2015-10-27 | Roger P. Jackson | Polyaxial bone anchor with pop-on shank and winged insert with lower skirt for engaging a friction fit retainer |
| US20100331887A1 (en) | 2006-01-09 | 2010-12-30 | Jackson Roger P | Longitudinal connecting member with sleeved tensioned cords |
| US7901437B2 (en) | 2007-01-26 | 2011-03-08 | Jackson Roger P | Dynamic stabilization member with molded connection |
| US8608797B2 (en) | 2005-03-17 | 2013-12-17 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
| US8951285B2 (en) | 2005-07-05 | 2015-02-10 | Mitralign, Inc. | Tissue anchor, anchoring system and methods of using the same |
| US9974653B2 (en) | 2006-12-05 | 2018-05-22 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
| CA2670988C (en) | 2006-12-08 | 2014-03-25 | Roger P. Jackson | Tool system for dynamic spinal implants |
| US10792074B2 (en) | 2007-01-22 | 2020-10-06 | Roger P. Jackson | Pivotal bone anchor assemly with twist-in-place friction fit insert |
| US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
| US9668775B2 (en) * | 2008-06-03 | 2017-06-06 | Jeffrey Scott Smith | Pedicle screw |
| US8986318B2 (en) | 2008-06-03 | 2015-03-24 | Jeffrey Scott Smith | Pedicle depth measuring apparatus |
| US8382829B1 (en) | 2008-03-10 | 2013-02-26 | Mitralign, Inc. | Method to reduce mitral regurgitation by cinching the commissure of the mitral valve |
| EP2296744B1 (en) | 2008-06-16 | 2019-07-31 | Valtech Cardio, Ltd. | Annuloplasty devices |
| US9408649B2 (en) * | 2008-09-11 | 2016-08-09 | Innovasis, Inc. | Radiolucent screw with radiopaque marker |
| CN102245115B (zh) * | 2008-10-15 | 2016-08-24 | 史密夫和内修有限公司 | 复合内部固定架 |
| US8241351B2 (en) | 2008-12-22 | 2012-08-14 | Valtech Cardio, Ltd. | Adjustable partial annuloplasty ring and mechanism therefor |
| US8715342B2 (en) | 2009-05-07 | 2014-05-06 | Valtech Cardio, Ltd. | Annuloplasty ring with intra-ring anchoring |
| US10517719B2 (en) | 2008-12-22 | 2019-12-31 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| ES2873182T3 (es) | 2008-12-22 | 2021-11-03 | Valtech Cardio Ltd | Dispositivos de anuloplastia ajustables |
| US9011530B2 (en) | 2008-12-22 | 2015-04-21 | Valtech Cardio, Ltd. | Partially-adjustable annuloplasty structure |
| US8911494B2 (en) | 2009-05-04 | 2014-12-16 | Valtech Cardio, Ltd. | Deployment techniques for annuloplasty ring |
| US8353956B2 (en) | 2009-02-17 | 2013-01-15 | Valtech Cardio, Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
| US9968452B2 (en) | 2009-05-04 | 2018-05-15 | Valtech Cardio, Ltd. | Annuloplasty ring delivery cathethers |
| US12485010B2 (en) | 2009-05-07 | 2025-12-02 | Edwards Lifesciences Innovation (Israel) Ltd. | Multiple anchor delivery tool |
| WO2013043218A1 (en) | 2009-06-15 | 2013-03-28 | Jackson Roger P | Polyaxial bone anchor with pop-on shank and winged insert with friction fit compressive collet |
| US11229457B2 (en) | 2009-06-15 | 2022-01-25 | Roger P. Jackson | Pivotal bone anchor assembly with insert tool deployment |
| US8998959B2 (en) | 2009-06-15 | 2015-04-07 | Roger P Jackson | Polyaxial bone anchors with pop-on shank, fully constrained friction fit retainer and lock and release insert |
| US9668771B2 (en) | 2009-06-15 | 2017-06-06 | Roger P Jackson | Soft stabilization assemblies with off-set connector |
| CN103917181A (zh) | 2009-06-15 | 2014-07-09 | 罗杰.P.杰克逊 | 包括套接杆和具有低外形边缘锁的摩擦配合保持件的多轴骨锚 |
| US8574273B2 (en) | 2009-09-09 | 2013-11-05 | Innovision, Inc. | Bone screws and methods of use thereof |
| US9433439B2 (en) | 2009-09-10 | 2016-09-06 | Innovasis, Inc. | Radiolucent stabilizing rod with radiopaque marker |
| WO2011043805A1 (en) | 2009-10-05 | 2011-04-14 | Roger Jackson P | Polyaxial bone anchor with non-pivotable retainer and pop-on shank, some with friction fit |
| US9180007B2 (en) | 2009-10-29 | 2015-11-10 | Valtech Cardio, Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
| US10098737B2 (en) | 2009-10-29 | 2018-10-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
| US9011520B2 (en) | 2009-10-29 | 2015-04-21 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
| WO2011067770A1 (en) | 2009-12-02 | 2011-06-09 | Valtech Cardio, Ltd. | Delivery tool for implantation of spool assembly coupled to a helical anchor |
| US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
| US8801712B2 (en) * | 2010-03-08 | 2014-08-12 | Innovasis, Inc. | Radiolucent bone plate with radiopaque marker |
| US20110264151A1 (en) * | 2010-04-26 | 2011-10-27 | Timothy Davis | Bone fixation device and method of validating its proper placement |
| US12383311B2 (en) | 2010-05-14 | 2025-08-12 | Roger P. Jackson | Pivotal bone anchor assembly and method for use thereof |
| US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
| EP2608726A4 (en) * | 2010-08-25 | 2014-04-02 | Halifax Biomedical Inc | Method for detecting movements between an implant and a bone |
| US8903473B2 (en) * | 2010-09-15 | 2014-12-02 | Medtronic, Inc. | Radiopaque markers for implantable medical devices |
| DE112011104028A1 (de) | 2010-11-02 | 2013-12-12 | Roger P. Jackson | Polyaxialer Knochenanker mit Schnellsteck-Schaft und drehbarer Halterung |
| CN102551856B (zh) * | 2011-01-24 | 2014-07-09 | 上海锐植医疗器械有限公司 | 自旋转撑开脊柱创伤内固定系统 |
| US8740949B2 (en) | 2011-02-24 | 2014-06-03 | Spinal Elements, Inc. | Methods and apparatus for stabilizing bone |
| WO2012128825A1 (en) | 2011-03-24 | 2012-09-27 | Jackson Roger P | Polyaxial bone anchor with compound articulation and pop-on shank |
| US9017409B2 (en) * | 2011-04-22 | 2015-04-28 | K2M, Inc. | Spinal interbody spacer with semi-constrained screws |
| US9649490B2 (en) | 2011-06-16 | 2017-05-16 | Cook Medical Technologies Llc | Tip for lead extraction device |
| US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
| EP3725269A1 (en) | 2011-06-23 | 2020-10-21 | Valtech Cardio, Ltd. | Closure element for use with annuloplasty structure |
| ES2418604T3 (es) * | 2011-08-18 | 2013-08-14 | Biedermann Technologies Gmbh & Co. Kg | Dispositivo de anclaje óseo poliaxial |
| US9173683B2 (en) | 2011-08-31 | 2015-11-03 | DePuy Synthes Products, Inc. | Revisable orthopedic anchor and methods of use |
| US9060818B2 (en) | 2011-09-01 | 2015-06-23 | DePuy Synthes Products, Inc. | Bone implants |
| USD739935S1 (en) | 2011-10-26 | 2015-09-29 | Spinal Elements, Inc. | Interbody bone implant |
| US9622788B2 (en) * | 2011-11-02 | 2017-04-18 | Warsaw Orthopedic, Inc. | Implant assembly with a rigid interface |
| US8858623B2 (en) | 2011-11-04 | 2014-10-14 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
| EP3970627B1 (en) | 2011-11-08 | 2023-12-20 | Edwards Lifesciences Innovation (Israel) Ltd. | Controlled steering functionality for implant-delivery tool |
| EP2886084B1 (en) | 2011-12-12 | 2018-02-14 | David Alon | Heart valve repair device |
| WO2013106217A1 (en) | 2012-01-10 | 2013-07-18 | Jackson, Roger, P. | Multi-start closures for open implants |
| EP2667352B1 (en) * | 2012-05-23 | 2020-01-01 | Stryker European Holdings I, LLC | Virtual 3D overlay as reduction aid for complex fractures |
| US9572598B2 (en) * | 2012-08-09 | 2017-02-21 | Spine Craft, LLC | Uniplanar surgical screw assembly |
| CA2885354A1 (en) | 2012-09-29 | 2014-04-03 | Mitralign, Inc. | Plication lock delivery system and method of use thereof |
| EP2911593B1 (en) | 2012-10-23 | 2020-03-25 | Valtech Cardio, Ltd. | Percutaneous tissue anchor techniques |
| US9949828B2 (en) | 2012-10-23 | 2018-04-24 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
| US8911478B2 (en) | 2012-11-21 | 2014-12-16 | Roger P. Jackson | Splay control closure for open bone anchor |
| EP2740427B1 (en) * | 2012-12-05 | 2020-03-11 | Biedermann Technologies GmbH & Co. KG | Dynamic bone anchor and method of manufacturing the same |
| US9730793B2 (en) | 2012-12-06 | 2017-08-15 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of a tool |
| EP2948103B1 (en) | 2013-01-24 | 2022-12-07 | Cardiovalve Ltd | Ventricularly-anchored prosthetic valves |
| US10058354B2 (en) | 2013-01-28 | 2018-08-28 | Roger P. Jackson | Pivotal bone anchor assembly with frictional shank head seating surfaces |
| US8852239B2 (en) | 2013-02-15 | 2014-10-07 | Roger P Jackson | Sagittal angle screw with integral shank and receiver |
| WO2014134183A1 (en) | 2013-02-26 | 2014-09-04 | Mitralign, Inc. | Devices and methods for percutaneous tricuspid valve repair |
| US10449333B2 (en) | 2013-03-14 | 2019-10-22 | Valtech Cardio, Ltd. | Guidewire feeder |
| US9421044B2 (en) | 2013-03-14 | 2016-08-23 | Spinal Elements, Inc. | Apparatus for bone stabilization and distraction and methods of use |
| JP6411446B2 (ja) | 2013-03-15 | 2018-10-24 | インノビシオン， インコーポレーティッド | 骨ねじ及びその使用方法 |
| US9724195B2 (en) | 2013-03-15 | 2017-08-08 | Mitralign, Inc. | Translation catheters and systems |
| JP2014210082A (ja) * | 2013-04-19 | 2014-11-13 | サンエー精工株式会社 | 骨固定用スクリューセット |
| EP3777734B1 (en) * | 2013-05-13 | 2025-08-13 | Neo Medical SA | Orthopedic implant kit |
| DE102013107170A1 (de) * | 2013-07-08 | 2015-01-22 | Aesculap Ag | Knochenschraube |
| US10070857B2 (en) | 2013-08-31 | 2018-09-11 | Mitralign, Inc. | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
| CN105682583B (zh) | 2013-09-01 | 2019-01-04 | 碳固定因骨科有限责任公司 | 复合材料脊椎植入物 |
| US9839450B2 (en) | 2013-09-27 | 2017-12-12 | Spinal Elements, Inc. | Device and method for reinforcement of a facet |
| US9456855B2 (en) | 2013-09-27 | 2016-10-04 | Spinal Elements, Inc. | Method of placing an implant between bone portions |
| WO2015059699A2 (en) | 2013-10-23 | 2015-04-30 | Valtech Cardio, Ltd. | Anchor magazine |
| US9566092B2 (en) | 2013-10-29 | 2017-02-14 | Roger P. Jackson | Cervical bone anchor with collet retainer and outer locking sleeve |
| US9717533B2 (en) | 2013-12-12 | 2017-08-01 | Roger P. Jackson | Bone anchor closure pivot-splay control flange form guide and advancement structure |
| US9610162B2 (en) | 2013-12-26 | 2017-04-04 | Valtech Cardio, Ltd. | Implantation of flexible implant |
| US9451993B2 (en) | 2014-01-09 | 2016-09-27 | Roger P. Jackson | Bi-radial pop-on cervical bone anchor |
| CN103961169A (zh) * | 2014-06-04 | 2014-08-06 | 池永龙 | 一种具有定位功能经皮关节突动态内固定器 |
| US9597119B2 (en) | 2014-06-04 | 2017-03-21 | Roger P. Jackson | Polyaxial bone anchor with polymer sleeve |
| US10064658B2 (en) | 2014-06-04 | 2018-09-04 | Roger P. Jackson | Polyaxial bone anchor with insert guides |
| WO2016014911A1 (en) * | 2014-07-25 | 2016-01-28 | The Grneral Hospital Corporation | System and method for an external hip fixator |
| ES2557955B1 (es) * | 2014-07-29 | 2016-11-10 | Inael Electrical Sytems, S.A. | Cortacircuitos fusible de expulsión |
| US10524910B2 (en) | 2014-07-30 | 2020-01-07 | Mitraltech Ltd. 3 Ariel Sharon Avenue | Articulatable prosthetic valve |
| US9883898B2 (en) | 2014-08-07 | 2018-02-06 | Jeffrey Scott Smith | Pedicle screw with electro-conductive coating or portion |
| US10470890B2 (en) | 2014-08-12 | 2019-11-12 | Neutin Orthopedics, LLC | Titanium plasma coated medical grade thermoplastic or polymer proximal and distal interphalangeal toe implant |
| US20160045324A1 (en) * | 2014-08-12 | 2016-02-18 | Neutin Orthopedics, LLC | Titanium plasma coated medical grade thermoplastic or polymer proximal and distal interphalangeal toe implant |
| WO2016044432A1 (en) | 2014-09-17 | 2016-03-24 | Spinal Elements, Inc. | Flexible fastening band connector |
| EP4331503A3 (en) | 2014-10-14 | 2024-06-05 | Edwards Lifesciences Innovation (Israel) Ltd. | Leaflet-restraining techniques |
| CN110141399B (zh) | 2015-02-05 | 2021-07-27 | 卡迪尔维尔福股份有限公司 | 带有轴向滑动框架的人工瓣膜 |
| US20160256269A1 (en) | 2015-03-05 | 2016-09-08 | Mitralign, Inc. | Devices for treating paravalvular leakage and methods use thereof |
| SG11201708397PA (en) | 2015-04-30 | 2017-11-29 | Valtech Cardio Ltd | Annuloplasty technologies |
| EP3115008B1 (de) * | 2015-07-09 | 2019-06-19 | Silony Medical International AG | Knochenverankerungselement |
| US10492838B2 (en) * | 2015-07-13 | 2019-12-03 | IntraFuse, LLC | Flexible bone implant |
| EP3184063B1 (en) * | 2015-12-21 | 2019-07-10 | Biedermann Technologies GmbH & Co. KG | Polyaxial bone anchoring device |
| WO2017117370A2 (en) | 2015-12-30 | 2017-07-06 | Mitralign, Inc. | System and method for reducing tricuspid regurgitation |
| US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
| US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
| US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
| GB201611910D0 (en) | 2016-07-08 | 2016-08-24 | Valtech Cardio Ltd | Adjustable annuloplasty device with alternating peaks and troughs |
| GB201613219D0 (en) | 2016-08-01 | 2016-09-14 | Mitraltech Ltd | Minimally-invasive delivery systems |
| EP4523659A3 (en) | 2016-08-10 | 2025-06-04 | Cardiovalve Ltd. | Prosthetic valve with concentric frames |
| US12296133B2 (en) * | 2017-03-14 | 2025-05-13 | Spinal Generations, Llc | Fluid delivery device and bone screw |
| US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
| WO2018200495A1 (en) * | 2017-04-25 | 2018-11-01 | Shaun Tanner | Tissue fixation systems |
| US12064347B2 (en) | 2017-08-03 | 2024-08-20 | Cardiovalve Ltd. | Prosthetic heart valve |
| US11793633B2 (en) | 2017-08-03 | 2023-10-24 | Cardiovalve Ltd. | Prosthetic heart valve |
| US12458493B2 (en) | 2017-09-19 | 2025-11-04 | Cardiovalve Ltd. | Prosthetic heart valve and delivery systems and methods |
| US10507043B1 (en) | 2017-10-11 | 2019-12-17 | Seaspine Orthopedics Corporation | Collet for a polyaxial screw assembly |
| US10835221B2 (en) | 2017-11-02 | 2020-11-17 | Valtech Cardio, Ltd. | Implant-cinching devices and systems |
| US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
| US11534219B2 (en) | 2017-11-21 | 2022-12-27 | Esp Medical Solutions, Llc | Hybrid radiolucent screw with radiopaque components and radiolucent components and method of manufacture |
| CN111655200B (zh) | 2018-01-24 | 2023-07-14 | 爱德华兹生命科学创新(以色列)有限公司 | 瓣环成形术结构的收缩 |
| EP3743014B1 (en) | 2018-01-26 | 2023-07-19 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
| WO2019152502A2 (en) * | 2018-01-30 | 2019-08-08 | Orthopediatrics Corp. | Vertebral body tethering with suture loops |
| CN111970991B (zh) * | 2018-05-02 | 2022-02-08 | 大多和德人 | 扫描用夹具、对种植物等的空间上的位置进行确定的方法及系统 |
| US10966736B2 (en) * | 2018-05-21 | 2021-04-06 | Warsaw Orthopedic, Inc. | Spinal implant system and methods of use |
| ES2974082T3 (es) | 2018-07-12 | 2024-06-25 | Edwards Lifesciences Innovation Israel Ltd | Sistemas de anuloplastia y herramientas de bloqueo para los mismos |
| BR112021019026A2 (pt) | 2019-03-26 | 2021-11-30 | Neo Medical Sa | Sistema para apertar um parafuso de fixação ortopédico em dois níveis de torque diferentes |
| JP2022535698A (ja) | 2019-05-22 | 2022-08-10 | スパイナル・エレメンツ・インコーポレーテッド | 骨タイおよび骨タイ・インサータ |
| US11457959B2 (en) | 2019-05-22 | 2022-10-04 | Spinal Elements, Inc. | Bone tie and bone tie inserter |
| CN120531524A (zh) | 2019-05-29 | 2025-08-26 | 爱德华兹生命科学创新(以色列)有限公司 | 组织锚固器存取系统和方法 |
| JP7562582B2 (ja) | 2019-07-02 | 2024-10-07 | ネオ・メディカル・ソシエテ・アノニム | ねじ回しおよびねじエクステンダによって引き起こされる軸線外力から生じる骨構造上の横方向応力を防止するための方法、装置、およびシステム |
| US12364606B2 (en) | 2019-07-23 | 2025-07-22 | Edwards Lifesciences Innovation (Israel) Ltd. | Fluoroscopic visualization of heart valve anatomy |
| CN114258313A (zh) | 2019-08-28 | 2022-03-29 | 瓦尔泰克卡迪欧有限公司 | 低剖面可转向导管 |
| EP4555942A3 (en) | 2019-08-30 | 2025-07-30 | Edwards Lifesciences Innovation (Israel) Ltd. | Anchor channel tip |
| WO2021061945A1 (en) | 2019-09-25 | 2021-04-01 | Cardiac Implants Llc | Cardiac valve annulus reduction system |
| CA3142906A1 (en) | 2019-10-29 | 2021-05-06 | Valtech Cardio, Ltd. | Annuloplasty and tissue anchor technologies |
| US11304733B2 (en) | 2020-02-14 | 2022-04-19 | Spinal Elements, Inc. | Bone tie methods |
| US20210346065A1 (en) * | 2020-04-09 | 2021-11-11 | Globus Medical, Inc. | Spinal screw |
| CA3183115A1 (en) | 2020-05-20 | 2021-11-25 | Cardiac Implants Llc | Reducing the diameter of a cardiac valve annulus with independent control over each of the anchors that are launched into the annulus |
| EP4167869B1 (en) | 2020-06-19 | 2025-03-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Self-stopping tissue anchors |
| JP7446965B2 (ja) * | 2020-09-29 | 2024-03-11 | グローブライド株式会社 | 脊椎固定具用ロッド |
| US12357459B2 (en) | 2020-12-03 | 2025-07-15 | Cardiovalve Ltd. | Transluminal delivery system |
| KR20240028969A (ko) * | 2020-12-28 | 2024-03-05 | 유니버시티 오브 메릴랜드 메디컬 센터 | 역나사산 골 나사 |
| US11861822B2 (en) * | 2021-06-24 | 2024-01-02 | Saudi Arabian Oil Company | Image recognition device and method for retrieving information on a marker |
| EP4111992B1 (en) | 2021-07-01 | 2024-01-31 | Biedermann Technologies GmbH & Co. KG | Bone anchoring device |
| US12318124B2 (en) * | 2021-11-29 | 2025-06-03 | Warsaw Orthopedic, Inc. | Continuous fiber bone screw and method of manufacture |
| US12369952B2 (en) | 2021-12-10 | 2025-07-29 | Spinal Elements, Inc. | Bone tie and portal |
| US20230363808A1 (en) * | 2022-05-12 | 2023-11-16 | Glw, Inc. | Orthopedic Screw with Radiolucent and Radiopaque Thread Portions |
| US11871967B1 (en) | 2023-02-28 | 2024-01-16 | Vertrae Medical Consulting, LLC | Pedicle screw device and method of use |
Family Cites Families (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1828287A (en) * | 1928-03-09 | 1931-10-20 | Weldbuilt Corp | Method of making bolts and similar connecting devices |
| US2405909A (en) * | 1942-08-22 | 1946-08-13 | Hercules Powder Co Ltd | Method of producing threaded spiral tubes |
| US2680442A (en) * | 1952-04-04 | 1954-06-08 | Frank L Linzmayer | Disposable suppository casing |
| US3455360A (en) * | 1967-07-12 | 1969-07-15 | Leon Simons | Vibration-resistant screw |
| US4063838A (en) * | 1976-05-07 | 1977-12-20 | Fiber Glass Systems, Inc. | Rod construction and method of forming the same |
| GB1595358A (en) * | 1977-05-17 | 1981-08-12 | Commw Scient Ind Res Org | Impact-resisting composites |
| US4307979A (en) * | 1978-12-14 | 1981-12-29 | Ppg Industries, Inc. | Mine roof bolt and end cap |
| US4512038A (en) * | 1979-04-27 | 1985-04-23 | University Of Medicine And Dentistry Of New Jersey | Bio-absorbable composite tissue scaffold |
| US4329743A (en) * | 1979-04-27 | 1982-05-18 | College Of Medicine And Dentistry Of New Jersey | Bio-absorbable composite tissue scaffold |
| US4403606A (en) * | 1980-05-09 | 1983-09-13 | The Regents Of The University Of California | Compatible internal bone fixation plate |
| FR2541621B1 (fr) * | 1983-02-28 | 1988-01-08 | Asahi Chemical Ind | Element en matiere plastique renforcee par des fibres et filete exterieurement et son procede de fabrication |
| US4778637A (en) * | 1984-06-18 | 1988-10-18 | Tiodize Company, Inc, | Method of forming a composite fastener |
| US4863470A (en) * | 1985-03-19 | 1989-09-05 | Medical Engineering Corporation | Identification marker for a breast prosthesis |
| FI80605C (fi) * | 1986-11-03 | 1990-07-10 | Biocon Oy | Benkirurgisk biokompositmaterial. |
| US4863330A (en) * | 1987-07-15 | 1989-09-05 | Northrop Corporation | Composite fastener and method of manufacture |
| US5209888A (en) * | 1988-12-16 | 1993-05-11 | Fukuvi Chemical Industry Co., Ltd. | Method for producing frp screw-like fastening elements |
| US5127783A (en) * | 1989-05-25 | 1992-07-07 | The B.F. Goodrich Company | Carbon/carbon composite fasteners |
| US5360431A (en) | 1990-04-26 | 1994-11-01 | Cross Medical Products | Transpedicular screw system and method of use |
| US5246655A (en) * | 1991-04-30 | 1993-09-21 | The Young Industries, Inc. | Method of making thermoplastic valve rotors |
| US5437899A (en) * | 1992-07-14 | 1995-08-01 | Composite Development Corporation | Structural element formed of a fiber reinforced thermoplastic material and method of manufacture |
| BR9306919A (pt) | 1992-08-20 | 1999-01-12 | Lipomatrix Inc | Implante peniano |
| US5366773A (en) * | 1992-12-21 | 1994-11-22 | Xerox Corporation | Tubular pultruded member having uniform wall thickness |
| US5466237A (en) | 1993-11-19 | 1995-11-14 | Cross Medical Products, Inc. | Variable locking stabilizer anchor seat and screw |
| US5609627A (en) | 1994-02-09 | 1997-03-11 | Boston Scientific Technology, Inc. | Method for delivering a bifurcated endoluminal prosthesis |
| FR2726171B1 (fr) | 1994-10-28 | 1997-01-24 | Jbs Sa | Dispositif de vis de liaison rehabitable pour articulation osseuse, destine notamment a la stabilisation d'au moins deux vertebres |
| DE4443051A1 (de) | 1994-12-05 | 1996-10-02 | Friedrich Schmitt | Implantat |
| US5807051A (en) * | 1995-09-18 | 1998-09-15 | United Industries Corporation | Dielectric adhesive insert anchor |
| DE19545612C2 (de) * | 1995-12-07 | 2001-08-30 | Aesculap Ag & Co Kg | Orthopädisches Haltesystem |
| US5824042A (en) * | 1996-04-05 | 1998-10-20 | Medtronic, Inc. | Endoluminal prostheses having position indicating markers |
| IT1289103B1 (it) * | 1996-05-15 | 1998-09-25 | Orthofix Srl | Fissatore esterno compatto |
| US6174329B1 (en) * | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
| US5676146B1 (en) * | 1996-09-13 | 2000-04-18 | Osteotech Inc | Surgical implant containing a resorbable radiopaque marker and method of locating such within a body |
| AU732351B2 (en) * | 1996-12-12 | 2001-04-26 | Synthes Gmbh | Device for the connection of a longitudinal support with a pedicle screw |
| US6485494B1 (en) * | 1996-12-20 | 2002-11-26 | Thomas T. Haider | Pedicle screw system for osteosynthesis |
| EP0954247B1 (de) * | 1997-01-22 | 2005-11-23 | Synthes Ag Chur | Vorrichtung zur verbindung eines langsträgers mit einer pedikelschraube |
| US6248105B1 (en) * | 1997-05-17 | 2001-06-19 | Synthes (U.S.A.) | Device for connecting a longitudinal support with a pedicle screw |
| FR2763832B1 (fr) * | 1997-05-29 | 1999-10-01 | Materiel Orthopedique En Abreg | Tige vertebrale pour instrumentation d'osteosynthese rachidienne, et instrumentation d'osteosynthese comportant cette tige |
| US6340367B1 (en) * | 1997-08-01 | 2002-01-22 | Boston Scientific Scimed, Inc. | Radiopaque markers and methods of using the same |
| JP3901299B2 (ja) * | 1997-10-02 | 2007-04-04 | 双和化成株式会社 | Ｕボルトの製法 |
| US6059769A (en) * | 1998-10-02 | 2000-05-09 | Medtronic, Inc. | Medical catheter with grooved soft distal segment |
| US6342055B1 (en) * | 1999-04-29 | 2002-01-29 | Theken Surgical Llc | Bone fixation system |
| US6423067B1 (en) * | 1999-04-29 | 2002-07-23 | Theken Surgical Llc | Nonlinear lag screw with captive driving device |
| US6214921B1 (en) * | 1999-07-22 | 2001-04-10 | Xerox Corporation | Electrical component |
| DE19936286C2 (de) * | 1999-08-02 | 2002-01-17 | Lutz Biedermann | Knochenschraube |
| US6280442B1 (en) | 1999-09-01 | 2001-08-28 | Sdgi Holdings, Inc. | Multi-axial bone screw assembly |
| US6302630B1 (en) * | 2000-04-18 | 2001-10-16 | Lockheed Martin | Fastener with recessed head and head insert |
| US6235033B1 (en) * | 2000-04-19 | 2001-05-22 | Synthes (Usa) | Bone fixation assembly |
| US6733531B1 (en) * | 2000-10-20 | 2004-05-11 | Sdgi Holdings, Inc. | Anchoring devices and implants for intervertebral disc augmentation |
| DE10065799C1 (de) | 2000-12-30 | 2002-04-25 | Rehau Ag & Co | Schädelschraube |
| US6652585B2 (en) * | 2001-02-28 | 2003-11-25 | Sdgi Holdings, Inc. | Flexible spine stabilization system |
| US6666868B2 (en) * | 2001-03-02 | 2003-12-23 | Medicinelodge, Inc. | Two-part orthopedic fastener |
| FR2822052B1 (fr) * | 2001-03-15 | 2003-09-19 | Stryker Spine Sa | Organe d'ancrage avec cale pour systeme d'osteosynthese rachidien |
| US6599290B2 (en) * | 2001-04-17 | 2003-07-29 | Ebi, L.P. | Anterior cervical plating system and associated method |
| US7235079B2 (en) * | 2004-11-18 | 2007-06-26 | Acumed Llc | Composite bone fasteners |
| US6974480B2 (en) | 2001-05-03 | 2005-12-13 | Synthes (Usa) | Intervertebral implant for transforaminal posterior lumbar interbody fusion procedure |
| ATE404155T1 (de) * | 2001-06-12 | 2008-08-15 | Stick Tech Oy | Prepreg, verbundmaterial und ihre anwendungen |
| DE10152094C2 (de) * | 2001-10-23 | 2003-11-27 | Biedermann Motech Gmbh | Fixationseinrichtung für Knochen |
| US6679883B2 (en) * | 2001-10-31 | 2004-01-20 | Ortho Development Corporation | Cervical plate for stabilizing the human spine |
| US20050228479A1 (en) | 2001-11-29 | 2005-10-13 | Cook Incorporated | Medical device delivery system |
| US20040019353A1 (en) * | 2002-02-01 | 2004-01-29 | Freid James M. | Spinal plate system for stabilizing a portion of a spine |
| US6641586B2 (en) | 2002-02-01 | 2003-11-04 | Depuy Acromed, Inc. | Closure system for spinal fixation instrumentation |
| US6955513B2 (en) * | 2002-03-21 | 2005-10-18 | California Polytechnic State University Foundation | Flexible fastener |
| US6740086B2 (en) * | 2002-04-18 | 2004-05-25 | Spinal Innovations, Llc | Screw and rod fixation assembly and device |
| US7674297B2 (en) * | 2002-06-14 | 2010-03-09 | U.S. Spinal Technologies, Llc | Anatomic vertebral cage |
| FR2844180B1 (fr) * | 2002-09-11 | 2005-08-05 | Spinevision | Element de liaison pour la stabilisation dynamique d'un systeme de fixation rachidien et systeme de fixation rachidien comportant un tel element |
| US6837905B1 (en) * | 2002-09-26 | 2005-01-04 | Daniel M. Lieberman | Spinal vertebral fusion implant and method |
| US6712852B1 (en) * | 2002-09-30 | 2004-03-30 | Depuy Spine, Inc. | Laminoplasty cage |
| US7273481B2 (en) * | 2002-10-28 | 2007-09-25 | Blackstone Medical, Inc. | Bone plate assembly provided with screw locking mechanisms |
| JP4633622B2 (ja) * | 2002-10-30 | 2011-02-16 | ツィマー スパイン インコーポレイテッド | 脊椎安定化システム |
| US7192447B2 (en) * | 2002-12-19 | 2007-03-20 | Synthes (Usa) | Intervertebral implant |
| US7048739B2 (en) * | 2002-12-31 | 2006-05-23 | Depuy Spine, Inc. | Bone plate and resilient screw system allowing bi-directional assembly |
| US8172885B2 (en) * | 2003-02-05 | 2012-05-08 | Pioneer Surgical Technology, Inc. | Bone plate system |
| US7326251B2 (en) * | 2003-04-01 | 2008-02-05 | Sdgi Holdings, Inc. | Interbody fusion device |
| US7938861B2 (en) * | 2003-04-15 | 2011-05-10 | Depuy Products, Inc. | Implantable orthopaedic device and method for making the same |
| US9278009B2 (en) | 2003-04-21 | 2016-03-08 | Rsb Spine Llc | Spine implants |
| US7169150B2 (en) * | 2003-04-25 | 2007-01-30 | Warsaw Orthopedic, Inc. | Non-metallic orthopedic plate |
| WO2004105577A2 (en) * | 2003-05-23 | 2004-12-09 | Globus Medical, Inc. | Spine stabilization system |
| US20040243129A1 (en) | 2003-05-28 | 2004-12-02 | Missoum Moumene | Double helical threaded bone screw |
| DE10326517A1 (de) * | 2003-06-12 | 2005-01-05 | Stratec Medical | Vorrichtung zur dynamischen Stabilisierung von Knochen oder Knochenfragmenten, insbesondere Rückenwirbelkörpern |
| US20050065516A1 (en) * | 2003-09-24 | 2005-03-24 | Tae-Ahn Jahng | Method and apparatus for flexible fixation of a spine |
| US20050203513A1 (en) * | 2003-09-24 | 2005-09-15 | Tae-Ahn Jahng | Spinal stabilization device |
| CA2548469A1 (en) * | 2003-12-01 | 2005-06-16 | Smith & Nephew, Inc. | Humeral nail with insert for fixing a screw |
| US8182518B2 (en) * | 2003-12-22 | 2012-05-22 | Life Spine, Inc. | Static and dynamic cervical plates and cervical plate constructs |
| DE102004009429A1 (de) * | 2004-02-24 | 2005-09-22 | Biedermann Motech Gmbh | Knochenverankerungselement |
| DE102004010380A1 (de) * | 2004-03-03 | 2005-09-22 | Biedermann Motech Gmbh | Verankerungselement und Stabilisierungseinrichtung zur dynamischen Stabilisierung von Wirbeln bzw. Knochen mit einem solchen Verankerungselement |
| DE102004011685A1 (de) * | 2004-03-09 | 2005-09-29 | Biedermann Motech Gmbh | Stabförmiges Element für die Anwendung in der Wirbelsäulen- oder Unfallchirurgie und Stabilisierungseinrichtung mit einem solchen stabförmigen Element |
| US7150594B2 (en) * | 2004-03-09 | 2006-12-19 | The Boeing Company | Hybrid fastener apparatus and method for fastening |
| JP2005270250A (ja) | 2004-03-24 | 2005-10-06 | Kawasumi Lab Inc | 医療用チューブ |
| US8070816B2 (en) * | 2004-03-29 | 2011-12-06 | 3Hbfm, Llc | Arthroplasty spinal prosthesis and insertion device |
| US20050228388A1 (en) * | 2004-03-30 | 2005-10-13 | Darrel Brodke | Double lead bone screw |
| US7833256B2 (en) | 2004-04-16 | 2010-11-16 | Biedermann Motech Gmbh | Elastic element for the use in a stabilization device for bones and vertebrae and method for the manufacture of such elastic element |
| US7406775B2 (en) * | 2004-04-22 | 2008-08-05 | Archus Orthopedics, Inc. | Implantable orthopedic device component selection instrument and methods |
| US8298235B2 (en) * | 2004-09-30 | 2012-10-30 | Depuy Spine, Inc. | Instrument and method for the insertion and alignment of an intervertebral implant |
| US7691129B2 (en) | 2004-10-27 | 2010-04-06 | Felix Brent A | Spinal stabilizing system |
| EP1841375A1 (en) * | 2005-01-26 | 2007-10-10 | AESCULAP AG & Co. KG | Self-contouring spinal rod |
| US8128670B2 (en) | 2005-04-15 | 2012-03-06 | Biodynamics Llc | Surgical expansion fasteners |
| US20060247638A1 (en) * | 2005-04-29 | 2006-11-02 | Sdgi Holdings, Inc. | Composite spinal fixation systems |
| US20060276788A1 (en) | 2005-05-26 | 2006-12-07 | Amedica Corporation | Osteoconductive spinal fixation system |
| US20090093844A1 (en) * | 2005-09-30 | 2009-04-09 | Jackson Roger P | Elastic covered dynamic stabilization connector and assembly |
| US20070156145A1 (en) * | 2005-12-30 | 2007-07-05 | Kentomia, Llc | Therapeutic constructions, spinal plates, cervical plates, hooks and screws |
| US7524190B2 (en) * | 2006-01-30 | 2009-04-28 | K1C2 | Fabric-wrapped craft wire and process for manufacturing same |
| US7850717B2 (en) | 2006-03-01 | 2010-12-14 | Warsaw Orthopedic, Inc. | Bone anchors having two or more portions exhibiting different performance characteristics and method of forming the same |
| US20070233073A1 (en) | 2006-03-02 | 2007-10-04 | Sdgi Holdings, Inc. | Spinal rod characterized by a time-varying stiffness |
| FR2899787B1 (fr) | 2006-04-12 | 2008-06-20 | Neuro France Implants Sarl | Vis pour la reduction d'une fracture de l'apophyse odontoire |
| US7998180B2 (en) | 2006-04-28 | 2011-08-16 | Warsaw Orthopedic, Inc. | Radiolucent bone plate systems and methods of use |
| EP2308402A3 (en) | 2006-05-15 | 2011-04-27 | Biomet Spain Orthopaedics S.L. | Surgical screw system |
| JP5210305B2 (ja) * | 2006-06-16 | 2013-06-12 | アルファテック スパイン， インコーポレイテッド | 脊椎ネジアセンブリシステム、脊椎ネジアセンブリを移植するためのシステム |
| US7766942B2 (en) * | 2006-08-31 | 2010-08-03 | Warsaw Orthopedic, Inc. | Polymer rods for spinal applications |
| US8267978B2 (en) * | 2006-09-14 | 2012-09-18 | Warsaw Orthopedic, Inc. | Hybrid bone fixation apparatus |
| US8114080B2 (en) * | 2006-09-27 | 2012-02-14 | Depuy Products, Inc. | Flexible bone fixation device |
| US8016862B2 (en) | 2006-09-27 | 2011-09-13 | Innovasis, Inc. | Spinal stabilizing system |
| US7842037B2 (en) * | 2006-09-27 | 2010-11-30 | Dupuy Products, Inc. | Flexible bone fixation device |
| US8066750B2 (en) * | 2006-10-06 | 2011-11-29 | Warsaw Orthopedic, Inc | Port structures for non-rigid bone plates |
| US7927348B2 (en) * | 2006-10-10 | 2011-04-19 | Codman & Shurtleff, Inc. | Stretch resistant coil device |
| US20080125777A1 (en) * | 2006-11-27 | 2008-05-29 | Warsaw Orthopedic, Inc. | Vertebral Stabilizer Having Adjustable Rigidity |
| US8663328B2 (en) * | 2006-12-21 | 2014-03-04 | Warsaw Orthopedic, Inc. | Methods for positioning a load-bearing component of an orthopedic implant device by inserting a malleable device that hardens in vivo |
| US7789895B2 (en) | 2006-12-26 | 2010-09-07 | Warsaw Orthopedic, Inc. | Sacral reconstruction fixation device |
| US8257395B2 (en) | 2007-09-21 | 2012-09-04 | Jmea Corporation | Spinal fixation with selectively applied bone growth promoting agent |
| US8292925B2 (en) | 2007-06-19 | 2012-10-23 | Zimmer Spine, Inc. | Flexible member with variable flexibility for providing dynamic stability to a spine |
| US7966711B2 (en) * | 2007-08-14 | 2011-06-28 | The Boeing Company | Method and apparatus for fastening components using a composite two-piece fastening system |
| JP5369540B2 (ja) * | 2007-08-29 | 2013-12-18 | 住友化学株式会社 | アルカリ金属フッ化物分散液およびそれを用いる含フッ素有機化合物の製造方法 |
| US20090093819A1 (en) * | 2007-10-05 | 2009-04-09 | Abhijeet Joshi | Anisotropic spinal stabilization rod |
| US8043339B2 (en) * | 2007-10-24 | 2011-10-25 | Zimmer Spine, Inc. | Flexible member for use in a spinal column and method for making |
| US9232968B2 (en) | 2007-12-19 | 2016-01-12 | DePuy Synthes Products, Inc. | Polymeric pedicle rods and methods of manufacturing |
| US20090234388A1 (en) | 2008-03-15 | 2009-09-17 | Warsaw Orthopedic, Inc. | Spinal Stabilization Connecting Element and System |
| US20090240284A1 (en) * | 2008-03-24 | 2009-09-24 | David Scott Randol | Stabilization rods |
| US20090248083A1 (en) | 2008-03-26 | 2009-10-01 | Warsaw Orthopedic, Inc. | Elongated connecting element with varying modulus of elasticity |
| US20090326582A1 (en) | 2008-04-10 | 2009-12-31 | Marcus Songer | Dynamic Rod |
| US8430912B2 (en) | 2008-05-05 | 2013-04-30 | Warsaw Orthopedic, Inc. | Dynamic stabilization rod |
| AU2009246848B2 (en) | 2008-05-13 | 2014-10-02 | Stryker European Holdings I, Llc | Composite spinal rod |
| US8475505B2 (en) * | 2008-08-13 | 2013-07-02 | Smed-Ta/Td, Llc | Orthopaedic screws |
| EP2341852B1 (en) * | 2008-08-29 | 2018-08-15 | SMed-TA/TD, LLC | Orthopaedic implant |
| EP2160988B1 (en) | 2008-09-04 | 2012-12-26 | Biedermann Technologies GmbH & Co. KG | Rod-shaped implant in particular for stabilizing the spinal column and stabilization device including such a rod-shaped implant |
| US9408649B2 (en) | 2008-09-11 | 2016-08-09 | Innovasis, Inc. | Radiolucent screw with radiopaque marker |
| US20100082064A1 (en) | 2008-09-30 | 2010-04-01 | Iksoo Chun | Method for coating metallic surfaces of medical devices with an anti-infective agent |
| US20100114167A1 (en) * | 2008-10-31 | 2010-05-06 | Warsaw Orthopedic, Inc. | Transition rod |
| WO2010075400A1 (en) * | 2008-12-22 | 2010-07-01 | Synthes Usa, Llc | Variable tension spine fixation rod |
| US8641734B2 (en) | 2009-02-13 | 2014-02-04 | DePuy Synthes Products, LLC | Dual spring posterior dynamic stabilization device with elongation limiting elastomers |
| US20100211105A1 (en) | 2009-02-13 | 2010-08-19 | Missoum Moumene | Telescopic Rod For Posterior Dynamic Stabilization |
| US8801712B2 (en) | 2010-03-08 | 2014-08-12 | Innovasis, Inc. | Radiolucent bone plate with radiopaque marker |
| US20120109207A1 (en) * | 2010-10-29 | 2012-05-03 | Warsaw Orthopedic, Inc. | Enhanced Interfacial Conformance for a Composite Rod for Spinal Implant Systems with Higher Modulus Core and Lower Modulus Polymeric Sleeve |
-
2008
- 2008-09-11 US US12/208,986 patent/US9408649B2/en active Active
-
2009
- 2009-09-10 BR BRPI0918450A patent/BRPI0918450A2/pt not_active Application Discontinuation
- 2009-09-10 WO PCT/US2009/056508 patent/WO2010030774A1/en not_active Ceased
- 2009-09-10 CA CA2736891A patent/CA2736891C/en not_active Expired - Fee Related
- 2009-09-10 JP JP2011526971A patent/JP5600107B2/ja not_active Expired - Fee Related
- 2009-09-10 MX MX2011002706A patent/MX2011002706A/es active IP Right Grant
- 2009-09-10 CN CN2009801449250A patent/CN102209501A/zh active Pending
- 2009-09-10 EP EP09792417A patent/EP2326270B1/en not_active Not-in-force
- 2009-09-10 AU AU2009291800A patent/AU2009291800B2/en not_active Ceased
- 2009-09-10 US US13/063,605 patent/US10194950B2/en active Active
-
2019
- 2019-02-04 US US16/267,198 patent/US20190167310A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2736891A1 (en) | 2010-03-18 |
| BRPI0918450A2 (pt) | 2015-12-01 |
| AU2009291800B2 (en) | 2015-04-23 |
| JP2012501804A (ja) | 2012-01-26 |
| WO2010030774A1 (en) | 2010-03-18 |
| CN102209501A (zh) | 2011-10-05 |
| US20190167310A1 (en) | 2019-06-06 |
| US20110172718A1 (en) | 2011-07-14 |
| AU2009291800A1 (en) | 2010-03-18 |
| US20100063550A1 (en) | 2010-03-11 |
| EP2326270A1 (en) | 2011-06-01 |
| CA2736891C (en) | 2017-09-19 |
| US10194950B2 (en) | 2019-02-05 |
| US9408649B2 (en) | 2016-08-09 |
| EP2326270B1 (en) | 2012-10-24 |
| JP5600107B2 (ja) | 2014-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2011002706A (es) | Tornillo radiolucido con marcador radiopaco. | |
| MX2011001644A (es) | Un vector de expresion y un metodo del mismo. | |
| US20160194660A1 (en) | Expression vectors for recombinant protein production in mammalian cells | |
| AU2019236586A1 (en) | Expression constructs and methods for expressing polypeptides in eukaryotic cells | |
| US9062326B2 (en) | Expression vector for animal cells | |
| JPH05503015A (ja) | 哺乳類発現ベクター | |
| WO2008091276A2 (en) | Use of chick beta actin gene intron-1 | |
| KR20100097123A (ko) | 신규한 재조합 서열 | |
| CA2611946C (en) | Expression vector and methods of producing high levels of proteins | |
| Reik et al. | Enhanced protein production by engineered zinc finger proteins | |
| JPH02500161A (ja) | 異種遺伝子の高水準誘導発現 | |
| US20140248660A1 (en) | Heterologous intron within a signal peptide | |
| AU606049B2 (en) | Inducible heat shock and amplification system | |
| WO2011015916A2 (en) | Vectors and compounds for expression of recombinant infliximab | |
| CN116555310A (zh) | 一种高通量筛选异源组成型启动子的方法及其应用 | |
| JPWO2005090562A1 (ja) | 軽度の低温により遺伝子の発現を促進させる配列 | |
| RU2500818C1 (ru) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК рАР227, КОДИРУЮЩАЯ ПОЛИПЕПТИД РЕКОМБИНАНТНОГО ФАКТОРА VIII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА, ЛИНИЯ КЛЕТОК Cricetulus griseus CHO 2H5 - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ФАКТОРА VIII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА И СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА, ОБЛАДАЮЩЕГО АКТИВНОСТЬЮ ФАКТОРА VIII | |
| HK1134687A (en) | Matrix attachment regions (mars) for increasing transcription and uses thereof | |
| HK1156663B (en) | Novel regulatory elements | |
| HK1156663A1 (en) | Novel regulatory elements |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |