MX2010014125A - Derivados de tiofeno o tiazol y su uso como inhibidores de p13k. - Google Patents
Derivados de tiofeno o tiazol y su uso como inhibidores de p13k.Info
- Publication number
- MX2010014125A MX2010014125A MX2010014125A MX2010014125A MX2010014125A MX 2010014125 A MX2010014125 A MX 2010014125A MX 2010014125 A MX2010014125 A MX 2010014125A MX 2010014125 A MX2010014125 A MX 2010014125A MX 2010014125 A MX2010014125 A MX 2010014125A
- Authority
- MX
- Mexico
- Prior art keywords
- elements
- optionally substituted
- independently
- sulfur
- oxygen
- Prior art date
Links
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Classifications
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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| US13248408P | 2008-06-19 | 2008-06-19 | |
| PCT/US2009/003607 WO2009154741A1 (en) | 2008-06-19 | 2009-06-17 | Thiophene or thiazole derivatives and their use as pi3k inhibitors |
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| MX2010014125A true MX2010014125A (es) | 2011-02-24 |
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| MX2010014125A MX2010014125A (es) | 2008-06-19 | 2009-06-17 | Derivados de tiofeno o tiazol y su uso como inhibidores de p13k. |
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| WO2009094224A1 (en) | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
| CN102066365A (zh) * | 2008-06-19 | 2011-05-18 | 米伦纽姆医药公司 | 噻吩或噻唑衍生物和其作为pi3k抑制剂的用途 |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| JP2012516329A (ja) * | 2009-01-30 | 2012-07-19 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｐｉ３ｋ阻害剤としてのヘテロアリールおよびその使用 |
| US9062038B2 (en) | 2010-08-11 | 2015-06-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US8859768B2 (en) | 2010-08-11 | 2014-10-14 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| EP2603214A4 (en) * | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | HETEROARYLE AND USES THEREOF |
| JP5726635B2 (ja) | 2010-08-25 | 2015-06-03 | 株式会社Ｎｔｔドコモ | マルチモードフロントエンド回路 |
| MX2013004003A (es) | 2010-10-13 | 2013-10-01 | Millenium Pharmaceuticals Inc | Heteroarilos y usos de los mismos. |
| CN102503930B (zh) * | 2011-10-28 | 2014-07-02 | 浙江大学 | 3,4,5,-三取代氨基噻吩类化合物及其制备和用途 |
| ES2661510T3 (es) | 2011-12-15 | 2018-04-02 | Novartis Ag | Uso de inhibidores de la actividad o función de PI3K |
| TW201331194A (zh) * | 2011-12-23 | 2013-08-01 | Millennium Pharm Inc | 雜芳基化合物及其用途 |
| CA2865642C (en) * | 2012-03-14 | 2021-10-26 | Salk Institute For Biological Studies | Adenoviral tumor diagnostics |
| SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
| HK1214533A1 (zh) | 2013-03-15 | 2016-07-29 | 基因泰克公司 | 治疗癌症和预防癌症耐药性的方法 |
| KR20160115999A (ko) * | 2014-02-14 | 2016-10-06 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 치료제로서의 인간 안드로겐 수용체 dna-결합 도메인(dbd) 화합물 및 그의 사용 방법 |
| ES2899913T3 (es) | 2014-09-24 | 2022-03-15 | Salk Inst For Biological Studi | Virus tumorales oncolíticos y métodos de uso |
| WO2017147265A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| EP3390645B1 (en) | 2016-02-23 | 2022-09-14 | Salk Institute for Biological Studies | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
| AU2017375633C1 (en) | 2016-12-12 | 2023-04-27 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
| BR112020019942A2 (pt) | 2018-04-09 | 2021-01-26 | Salk Institute For Biological Studies | composições de adenovírus oncolítico com propriedades de replicação aprimoradas |
| JP7498199B2 (ja) * | 2019-06-28 | 2024-06-11 | ファイザー・インク | 種々の疾患を処置するために有用なｂｃｋｄｋ阻害剤としての５－（チオフェン－２－イル）－１ｈ－テトラゾール誘導体 |
| CN110759900B (zh) * | 2019-10-25 | 2021-07-30 | 沈阳药科大学 | 噻吩类化合物的制备方法和用途 |
| CN115103840B (zh) | 2019-12-20 | 2025-07-22 | 拜耳公司 | 取代的噻吩甲酰胺、噻吩甲酸及其衍生物 |
| CN113527281B (zh) * | 2020-04-20 | 2023-12-22 | 昆山彭济凯丰生物科技有限公司 | 杂环化合物及其制备方法和应用 |
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| DD275870A1 (de) | 1988-09-27 | 1990-02-07 | Univ Leipzig | Verfahren zur herstellung von in 5-position verschiedenartig substituierten 3-aminothiophen-4-carbonitrilen |
| JP2008503446A (ja) | 2004-05-06 | 2008-02-07 | プレキシコン，インコーポレーテッド | Ｐｄｅ４ｂ阻害剤及びその使用 |
| GB0508472D0 (en) * | 2005-04-26 | 2005-06-01 | Glaxo Group Ltd | Compounds |
| KR101533461B1 (ko) | 2006-04-26 | 2015-07-02 | 에프. 호프만-라 로슈 아게 | Ｐｉ３ｋ저해제로 유용한 티에노［3,2-ｄ］피리미딘 유도체 |
| JP2009535386A (ja) * | 2006-05-03 | 2009-10-01 | アストラゼネカ アクチボラグ | チアゾール誘導体および抗腫瘍剤としてのその使用 |
| WO2008023159A1 (en) | 2006-08-24 | 2008-02-28 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| CN101932587A (zh) * | 2007-09-24 | 2010-12-29 | 吉宁特有限公司 | 噻唑并嘧啶pi3k抑制剂化合物及使用方法 |
| WO2009094224A1 (en) * | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
| CN102066365A (zh) * | 2008-06-19 | 2011-05-18 | 米伦纽姆医药公司 | 噻吩或噻唑衍生物和其作为pi3k抑制剂的用途 |
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- 2009-06-17 JP JP2011514600A patent/JP5596026B2/ja active Active
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2011
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2012
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Also Published As
| Publication number | Publication date |
|---|---|
| NZ589844A (en) | 2012-11-30 |
| US20100075951A1 (en) | 2010-03-25 |
| US20120202812A1 (en) | 2012-08-09 |
| ES2491522T3 (es) | 2014-09-08 |
| US20130217689A1 (en) | 2013-08-22 |
| JP5596026B2 (ja) | 2014-09-24 |
| CR20110032A (es) | 2011-03-14 |
| CL2010001474A1 (es) | 2011-04-29 |
| AU2009260782A1 (en) | 2009-12-23 |
| CA2727069A1 (en) | 2009-12-23 |
| CO6331431A2 (es) | 2011-10-20 |
| GEP20125650B (en) | 2012-09-25 |
| US8440664B2 (en) | 2013-05-14 |
| AU2009260782B2 (en) | 2014-12-11 |
| IL210055A0 (en) | 2011-02-28 |
| BRPI0914223A2 (pt) | 2019-09-24 |
| US8183240B2 (en) | 2012-05-22 |
| EA201170052A1 (ru) | 2011-06-30 |
| UA106206C2 (ru) | 2014-08-11 |
| CN102066365A (zh) | 2011-05-18 |
| MA32468B1 (fr) | 2011-07-03 |
| WO2009154741A8 (en) | 2010-03-25 |
| ZA201008875B (en) | 2012-02-29 |
| WO2009154741A1 (en) | 2009-12-23 |
| KR20110018451A (ko) | 2011-02-23 |
| JP2011524904A (ja) | 2011-09-08 |
| EP2313399A1 (en) | 2011-04-27 |
| EP2313399B1 (en) | 2014-05-28 |
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