MX2010005031A - Anticuerpos de axl. - Google Patents

Anticuerpos de axl.

Info

Publication number
MX2010005031A
MX2010005031A MX2010005031A MX2010005031A MX2010005031A MX 2010005031 A MX2010005031 A MX 2010005031A MX 2010005031 A MX2010005031 A MX 2010005031A MX 2010005031 A MX2010005031 A MX 2010005031A MX 2010005031 A MX2010005031 A MX 2010005031A
Authority
MX
Mexico
Prior art keywords
axl antibodies
antibodies
axl
bind
tyrosine kinase
Prior art date
Application number
MX2010005031A
Other languages
English (en)
Inventor
Peter Wirtz
Mike Rothe
Thore Hettmann
Esther Zwick-Wallasch
Jens Niewoehner
Jens Ruhe
Kerstin Selle
Original Assignee
U3 Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by U3 Pharma Gmbh filed Critical U3 Pharma Gmbh
Publication of MX2010005031A publication Critical patent/MX2010005031A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La presente invención se refiere a anticuerpos, particularmente a anticuerpos monoclonales, los cuales se enlazan al dominio extracelular del receptor AXL de tirosina quinasa y los cuales inhiben por lo menos parcialmente la actividad de AXL.
MX2010005031A 2007-11-12 2008-11-12 Anticuerpos de axl. MX2010005031A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07021931 2007-11-12
PCT/EP2008/009548 WO2009062690A1 (en) 2007-11-12 2008-11-12 Axl antibodies

Publications (1)

Publication Number Publication Date
MX2010005031A true MX2010005031A (es) 2010-06-25

Family

ID=40280763

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010005031A MX2010005031A (es) 2007-11-12 2008-11-12 Anticuerpos de axl.

Country Status (20)

Country Link
US (1) US8933202B2 (es)
EP (2) EP2220121B1 (es)
JP (2) JP5769969B2 (es)
KR (1) KR20100097684A (es)
CN (2) CN101939336B (es)
AU (1) AU2008323206B2 (es)
BR (1) BRPI0820073A2 (es)
CA (1) CA2705164A1 (es)
CO (1) CO6280499A2 (es)
DK (1) DK2220121T3 (es)
ES (1) ES2556214T3 (es)
HK (2) HK1147275A1 (es)
IL (1) IL205607A0 (es)
MX (1) MX2010005031A (es)
MY (1) MY155621A (es)
NZ (2) NZ599628A (es)
RU (1) RU2506276C2 (es)
SG (2) SG186000A1 (es)
WO (1) WO2009062690A1 (es)
ZA (1) ZA201003397B (es)

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RU2010123888A (ru) 2011-12-20
CO6280499A2 (es) 2011-05-20
SG186000A1 (en) 2012-12-28
AU2008323206B2 (en) 2014-08-14
KR20100097684A (ko) 2010-09-03
US8933202B2 (en) 2015-01-13
CN103275227A (zh) 2013-09-04
AU2008323206A1 (en) 2009-05-22
EP2220121A1 (en) 2010-08-25
HK1185622A1 (en) 2014-02-21
US20100330095A1 (en) 2010-12-30
HK1147275A1 (en) 2011-08-05
RU2506276C2 (ru) 2014-02-10
ZA201003397B (en) 2011-04-28
DK2220121T3 (en) 2015-12-07
NZ599628A (en) 2013-11-29
IL205607A0 (en) 2010-11-30
CN101939336A (zh) 2011-01-05
SG10201405835TA (en) 2014-10-30
EP2918605A1 (en) 2015-09-16
BRPI0820073A2 (pt) 2015-06-23
MY155621A (en) 2015-11-13
CN103275227B (zh) 2015-02-11
JP2011505120A (ja) 2011-02-24
JP5769969B2 (ja) 2015-08-26
NZ585465A (en) 2012-12-21
JP2015221804A (ja) 2015-12-10
ES2556214T3 (es) 2016-01-14
CA2705164A1 (en) 2009-05-22
EP2220121B1 (en) 2015-08-19
WO2009062690A1 (en) 2009-05-22

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