MX2010001135A - Nuevos derivados de 1,2,3-triazol, utiles como modulares de receptores de acetilcolina nicotinicos. - Google Patents
Nuevos derivados de 1,2,3-triazol, utiles como modulares de receptores de acetilcolina nicotinicos.Info
- Publication number
- MX2010001135A MX2010001135A MX2010001135A MX2010001135A MX2010001135A MX 2010001135 A MX2010001135 A MX 2010001135A MX 2010001135 A MX2010001135 A MX 2010001135A MX 2010001135 A MX2010001135 A MX 2010001135A MX 2010001135 A MX2010001135 A MX 2010001135A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- modulators
- disorders
- novel
- nicotinic acetylcholine
- Prior art date
Links
- 125000001399 1,2,3-triazolyl group Chemical class N1N=NC(=C1)* 0.000 title abstract 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title abstract 2
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 8
- 201000010099 disease Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 4
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 2
- 208000017701 Endocrine disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000030172 endocrine system disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000016160 smooth muscle contraction Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/34—Tobacco-abuse
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200701134 | 2007-08-08 | ||
| US95508107P | 2007-08-10 | 2007-08-10 | |
| PCT/EP2008/060307 WO2009019278A1 (en) | 2007-08-08 | 2008-08-06 | Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001135A true MX2010001135A (es) | 2010-03-09 |
Family
ID=39870242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001135A MX2010001135A (es) | 2007-08-08 | 2008-08-06 | Nuevos derivados de 1,2,3-triazol, utiles como modulares de receptores de acetilcolina nicotinicos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8110588B2 (https=) |
| EP (1) | EP2185529A1 (https=) |
| JP (1) | JP2010535738A (https=) |
| KR (1) | KR20100046179A (https=) |
| CN (1) | CN101796034A (https=) |
| AU (1) | AU2008285644A1 (https=) |
| CA (1) | CA2695812A1 (https=) |
| MX (1) | MX2010001135A (https=) |
| NZ (1) | NZ582520A (https=) |
| RU (1) | RU2010102994A (https=) |
| WO (1) | WO2009019278A1 (https=) |
| ZA (1) | ZA201000127B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009112459A1 (en) * | 2008-03-11 | 2009-09-17 | Neurosearch A/S | Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
| JP2011530495A (ja) * | 2008-08-08 | 2011-12-22 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体のモジュレーターとして有用な新規のジフェニル１，２，３−トリアゾール誘導体 |
| CA2735773A1 (en) * | 2008-09-02 | 2010-03-11 | Neurosearch A/S | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators |
| TW201124406A (en) | 2009-10-07 | 2011-07-16 | Karobio Ab | Novel estrogen receptor ligands |
| KR20140041442A (ko) | 2011-02-03 | 2014-04-04 | 루핀 리미티드 | 알파 7 ｎａｃｈｒ의 조절자로 사용된 피롤 유도체 |
| EA024170B1 (ru) | 2011-02-23 | 2016-08-31 | Люпин Лимитед | ГЕТЕРОАРИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ nAChR АЛЬФА7 |
| EP2691368A1 (en) | 2011-03-31 | 2014-02-05 | Lupin Limited | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease |
| FR2974365B1 (fr) * | 2011-04-20 | 2017-08-25 | Centre Nat De La Rech Scient (C N R S) | 1,2,3-triazoles 1,4-disubstituees, leurs procedes de preparation et leurs utilisations diagnostiques et therapeutiques |
| EP2729455B1 (en) | 2011-07-05 | 2016-09-14 | Lupin Limited | Biaryl derivatives as nachr modulators |
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| EP2822946A1 (en) | 2012-03-06 | 2015-01-14 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| US20150299178A1 (en) | 2012-11-12 | 2015-10-22 | Lupin Limited | Thiazole Derivatives as Alpha 7 NACHR Modulators |
| US9617211B2 (en) | 2013-01-16 | 2017-04-11 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
| AU2014229300A1 (en) | 2013-03-13 | 2015-06-11 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
| TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
| AU2014282886A1 (en) | 2013-06-17 | 2015-12-17 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
| US20210163425A1 (en) | 2017-12-20 | 2021-06-03 | Gyeonggido Business & Science Accelerator | Triazole derivative and use thereof |
| CN113045507B (zh) * | 2021-03-04 | 2022-10-25 | 中山大学南方学院 | 一种3,4-二羟基苯甲酸甲酯衍生物及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1242216B (de) | 1963-12-27 | 1967-06-15 | Union Carbide Corp | Verfahren zur Herstellung von Inaminsalzen |
| DE60222698T2 (de) * | 2001-12-18 | 2008-06-19 | Merck & Co., Inc. | Heteroarylsubstituierte triazolmodulatoren des metabotropen glutamatarezeptors 5 |
| AU2003230829B8 (en) | 2002-04-26 | 2008-12-11 | Eli Lilly And Company | Triazole derivatives as tachykinin receptor antagonists |
| RU2006142896A (ru) | 2004-05-06 | 2008-06-20 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния (Us) | Замещенные енаминоны, их производные и их применение |
| WO2006071184A1 (en) | 2004-12-28 | 2006-07-06 | Astrazeneca Ab | Aryl sulphonamide modulators |
| WO2009112459A1 (en) | 2008-03-11 | 2009-09-17 | Neurosearch A/S | Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
| JP2011530495A (ja) | 2008-08-08 | 2011-12-22 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体のモジュレーターとして有用な新規のジフェニル１，２，３−トリアゾール誘導体 |
-
2008
- 2008-08-06 WO PCT/EP2008/060307 patent/WO2009019278A1/en not_active Ceased
- 2008-08-06 CN CN200880102108A patent/CN101796034A/zh active Pending
- 2008-08-06 JP JP2010519457A patent/JP2010535738A/ja not_active Abandoned
- 2008-08-06 CA CA2695812A patent/CA2695812A1/en not_active Abandoned
- 2008-08-06 MX MX2010001135A patent/MX2010001135A/es not_active Application Discontinuation
- 2008-08-06 NZ NZ582520A patent/NZ582520A/en not_active IP Right Cessation
- 2008-08-06 KR KR1020107002808A patent/KR20100046179A/ko not_active Withdrawn
- 2008-08-06 AU AU2008285644A patent/AU2008285644A1/en not_active Abandoned
- 2008-08-06 US US12/672,252 patent/US8110588B2/en not_active Expired - Fee Related
- 2008-08-06 EP EP08786915A patent/EP2185529A1/en not_active Withdrawn
- 2008-08-06 RU RU2010102994/04A patent/RU2010102994A/ru not_active Application Discontinuation
-
2010
- 2010-01-07 ZA ZA2010/00127A patent/ZA201000127B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008285644A1 (en) | 2009-02-12 |
| KR20100046179A (ko) | 2010-05-06 |
| RU2010102994A (ru) | 2011-09-20 |
| ZA201000127B (en) | 2011-03-30 |
| US8110588B2 (en) | 2012-02-07 |
| WO2009019278A1 (en) | 2009-02-12 |
| US20100222398A1 (en) | 2010-09-02 |
| EP2185529A1 (en) | 2010-05-19 |
| CA2695812A1 (en) | 2009-02-12 |
| CN101796034A (zh) | 2010-08-04 |
| JP2010535738A (ja) | 2010-11-25 |
| NZ582520A (en) | 2011-10-28 |
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