ZA201000127B - Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors - Google Patents

Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors

Info

Publication number
ZA201000127B
ZA201000127B ZA2010/00127A ZA201000127A ZA201000127B ZA 201000127 B ZA201000127 B ZA 201000127B ZA 2010/00127 A ZA2010/00127 A ZA 2010/00127A ZA 201000127 A ZA201000127 A ZA 201000127A ZA 201000127 B ZA201000127 B ZA 201000127B
Authority
ZA
South Africa
Prior art keywords
modulators
novel
nicotinic acetylcholine
triazole derivatives
acetylcholine receptors
Prior art date
Application number
ZA2010/00127A
Other languages
English (en)
Inventor
Jeppe Kejser Christensen
Antonio Nardi
Tino Dyhring
Dan Peters
Gunnar M Olsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of ZA201000127B publication Critical patent/ZA201000127B/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Psychiatry (AREA)
  • Endocrinology (AREA)
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  • Gynecology & Obstetrics (AREA)
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ZA2010/00127A 2007-08-08 2010-01-07 Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors ZA201000127B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200701134 2007-08-08
PCT/EP2008/060307 WO2009019278A1 (en) 2007-08-08 2008-08-06 Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors

Publications (1)

Publication Number Publication Date
ZA201000127B true ZA201000127B (en) 2011-03-30

Family

ID=39870242

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2010/00127A ZA201000127B (en) 2007-08-08 2010-01-07 Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors

Country Status (12)

Country Link
US (1) US8110588B2 (https=)
EP (1) EP2185529A1 (https=)
JP (1) JP2010535738A (https=)
KR (1) KR20100046179A (https=)
CN (1) CN101796034A (https=)
AU (1) AU2008285644A1 (https=)
CA (1) CA2695812A1 (https=)
MX (1) MX2010001135A (https=)
NZ (1) NZ582520A (https=)
RU (1) RU2010102994A (https=)
WO (1) WO2009019278A1 (https=)
ZA (1) ZA201000127B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110060017A1 (en) * 2008-03-11 2011-03-10 Neurosearch A/S Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors
WO2010015583A1 (en) * 2008-08-08 2010-02-11 Neurosearch A/S Novel diphenyl 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors
BRPI0917693A2 (pt) * 2008-09-02 2016-05-17 Neurosearch As composto derivado de triazol, composição farmacêutica, e, uso de um derivado de triazol
ES2737429T3 (es) 2009-10-07 2020-01-14 Karo Pharma Ab Pirazoles sustituidos como ligandos del receptor de estrógenos
SG192078A1 (en) 2011-02-03 2013-08-30 Lupin Ltd Pyrrole derivatives used as modulators of alpha7 nachr
ES2594409T3 (es) 2011-02-23 2016-12-20 Lupin Limited Derivados de heteroarilo como moduladores del nAChR á7
WO2012131576A1 (en) 2011-03-31 2012-10-04 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
FR2974365B1 (fr) * 2011-04-20 2017-08-25 Centre Nat De La Rech Scient (C N R S) 1,2,3-triazoles 1,4-disubstituees, leurs procedes de preparation et leurs utilisations diagnostiques et therapeutiques
EP2729455B1 (en) 2011-07-05 2016-09-14 Lupin Limited Biaryl derivatives as nachr modulators
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
NZ629453A (en) 2012-03-06 2016-04-29 Lupin Ltd Thiazole derivatives as alpha 7 nachr modulators
US20150299178A1 (en) 2012-11-12 2015-10-22 Lupin Limited Thiazole Derivatives as Alpha 7 NACHR Modulators
US9617211B2 (en) 2013-01-16 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
US9617210B2 (en) 2013-03-13 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 NACHR modulators
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
AU2014282886A1 (en) 2013-06-17 2015-12-17 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
WO2019124577A1 (ko) * 2017-12-20 2019-06-27 재단법인 경기도경제과학진흥원 트리아졸 유도체 및 이의 용도
CN113045507B (zh) * 2021-03-04 2022-10-25 中山大学南方学院 一种3,4-二羟基苯甲酸甲酯衍生物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1242216B (de) * 1963-12-27 1967-06-15 Union Carbide Corp Verfahren zur Herstellung von Inaminsalzen
CA2469821C (en) * 2001-12-18 2009-10-20 Merck & Co., Inc. Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
KR100755577B1 (ko) * 2002-04-26 2007-09-12 일라이 릴리 앤드 캄파니 타키키닌 수용체 길항제로서의 트리아졸 유도체
WO2005108347A2 (en) 2004-05-06 2005-11-17 The Regents Of The University Of California Substituted enaminones, their derivatives and uses thereof
WO2006071184A1 (en) 2004-12-28 2006-07-06 Astrazeneca Ab Aryl sulphonamide modulators
US20110060017A1 (en) 2008-03-11 2011-03-10 Neurosearch A/S Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors
WO2010015583A1 (en) 2008-08-08 2010-02-11 Neurosearch A/S Novel diphenyl 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors

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Publication number Publication date
JP2010535738A (ja) 2010-11-25
WO2009019278A1 (en) 2009-02-12
NZ582520A (en) 2011-10-28
RU2010102994A (ru) 2011-09-20
KR20100046179A (ko) 2010-05-06
EP2185529A1 (en) 2010-05-19
CA2695812A1 (en) 2009-02-12
US20100222398A1 (en) 2010-09-02
CN101796034A (zh) 2010-08-04
US8110588B2 (en) 2012-02-07
AU2008285644A1 (en) 2009-02-12
MX2010001135A (es) 2010-03-09

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