MX2009012666A - Composicion para el tratamiento de enfermedades isquemicas de las extremidades que se componen de celulas madre derivadas de tejido adiposo. - Google Patents
Composicion para el tratamiento de enfermedades isquemicas de las extremidades que se componen de celulas madre derivadas de tejido adiposo.Info
- Publication number
- MX2009012666A MX2009012666A MX2009012666A MX2009012666A MX2009012666A MX 2009012666 A MX2009012666 A MX 2009012666A MX 2009012666 A MX2009012666 A MX 2009012666A MX 2009012666 A MX2009012666 A MX 2009012666A MX 2009012666 A MX2009012666 A MX 2009012666A
- Authority
- MX
- Mexico
- Prior art keywords
- composition
- stem cells
- adipose tissue
- treating ischemic
- ischemic limb
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000000302 ischemic effect Effects 0.000 title abstract 3
- 210000000577 adipose tissue Anatomy 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 210000000130 stem cell Anatomy 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 208000023589 ischemic disease Diseases 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Dispersion Chemistry (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Se divulgó en este documento una composición terapéutica celular para el tratamiento de enfermedades isquémicas en las extremidades inferiores, más específicamente, se divulgó una composición terapéutica celular para el tratamiento de enfermedades isquémicas que contienen células madre mesenquimatosas derivadas de tejido adiposo y sacarosa o manosa como un excipiente. La composición induce la angiogénesis alrededor de los vasos sanguíneos en las lesiones isquémicas de las extremidades inferiores, y de este modo es útil para tratar enfermedades isquémicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070050624A KR20080103637A (ko) | 2007-05-25 | 2007-05-25 | 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물 |
PCT/KR2008/002614 WO2008147057A1 (en) | 2007-05-25 | 2008-05-09 | Composition for treating ischemic limb disease comprising stem cells derived from adipose tissue |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009012666A true MX2009012666A (es) | 2010-02-18 |
Family
ID=40075249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009012666A MX2009012666A (es) | 2007-05-25 | 2008-05-09 | Composicion para el tratamiento de enfermedades isquemicas de las extremidades que se componen de celulas madre derivadas de tejido adiposo. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20100196329A1 (es) |
EP (1) | EP2162141B1 (es) |
JP (1) | JP5290281B2 (es) |
KR (1) | KR20080103637A (es) |
CN (1) | CN101711160B (es) |
ES (1) | ES2431816T3 (es) |
MX (1) | MX2009012666A (es) |
WO (1) | WO2008147057A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010000394A (es) | 2007-11-30 | 2010-05-13 | Rnl Bio Co Ltd | Agente celular terapeutico para la incontinencia de la orina, que comprende celulas madres originadas de decidua o tejido adiposo. |
CA2762584A1 (en) | 2009-05-20 | 2010-11-25 | Cardio3 Biosciences S.A. | Pharmaceutical composition for the treatment of heart diseases |
GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
CN102920735A (zh) * | 2012-11-14 | 2013-02-13 | 青岛奥克生物开发有限公司 | 一种间充质干细胞注射液及其制备方法和在制备治疗糖尿病药物中的应用 |
WO2014112607A1 (ja) * | 2013-01-21 | 2014-07-24 | 国立大学法人名古屋大学 | 細胞製剤及び細胞の活性を高める方法 |
KR101583569B1 (ko) * | 2013-05-15 | 2016-01-08 | 라정찬 | 정맥 투여용 줄기세포 조성물 |
JP2016008198A (ja) * | 2014-06-24 | 2016-01-18 | 国立大学法人名古屋大学 | 間質性膀胱炎の治療 |
CN107072189B (zh) * | 2014-07-08 | 2021-07-20 | 罗廷灿 | 用于改善干细胞稳定性的组合物 |
KR101613478B1 (ko) * | 2014-09-22 | 2016-04-19 | (주)안트로젠 | 중간엽줄기세포-하이드로겔을 함유하는 조성물 및 이의 제조방법 |
EP3271396B1 (en) | 2015-03-20 | 2022-03-16 | Orbsen Therapeutics Limited | Modulators of syndecan-2 and uses thereof |
EP3922253A1 (en) | 2016-01-15 | 2021-12-15 | Orbsen Therapeutics Limited | Sdc-2 exosome compositions and methods of isolation and use |
MY176088A (en) * | 2016-07-26 | 2020-07-24 | Cytopeutics Sdn Bhd | A cell-based composition and use thereof for treatment of psoriasis and systemic lupus erythematosus |
KR101980562B1 (ko) * | 2017-01-16 | 2019-05-21 | 사회복지법인 삼성생명공익재단 | 옥살산염을 이용한 줄기세포능 향상 방법 |
GB2560933A (en) * | 2017-03-28 | 2018-10-03 | Glaxosmithkline Ip Dev Ltd | Transduced cell formulation |
JP6256786B1 (ja) * | 2017-04-12 | 2018-01-10 | 学校法人福岡大学 | 不妊症の処置に用いられる医薬組成物およびその製造方法 |
EP3652305A2 (en) | 2017-07-14 | 2020-05-20 | Orbsen Therapeutics Limited | Cd39 stromal stem cells methods of isolation and use |
EP3677287B1 (en) | 2017-08-30 | 2024-05-29 | FUJIFILM Corporation | Cell transplantation device and method for manufacturing same |
JP6854904B2 (ja) | 2017-08-30 | 2021-04-07 | 富士フイルム株式会社 | 血管新生剤およびその製造方法 |
CN112546070A (zh) * | 2020-07-01 | 2021-03-26 | 陕西佰傲干细胞再生医学有限公司 | 间充质干细胞制剂及其制备方法和应用 |
JP7018527B1 (ja) | 2020-12-16 | 2022-02-10 | アニコム先進医療研究所株式会社 | 細胞の保存方法および細胞懸濁液 |
WO2023182609A1 (ko) * | 2022-03-22 | 2023-09-28 | 가톨릭관동대학교산학협력단 | 지방 조직 유래 중간엽 줄기세포 및 인간 기질 혈관 분획을 포함하는 혈관신생 촉진용 조성물 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5045446A (en) * | 1988-08-26 | 1991-09-03 | Cryopharm Corporation | Lyophilization of cells |
US6972125B2 (en) * | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
US6436704B1 (en) * | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
AU2001286221B2 (en) | 2000-09-13 | 2006-09-28 | Chugai Seiyaku Kabushiki Kaisha | Remedies for ischemic diseases |
WO2003059272A2 (en) * | 2002-01-14 | 2003-07-24 | Henry Ford Health System | Materials from bone marrow stromal cells for use in forming blood vessels and producing angiogenic and trophic factors |
CN100402654C (zh) | 2003-02-19 | 2008-07-16 | 株式会社载体研究所 | 缺血疾病的治疗方法 |
MXPA06003088A (es) * | 2003-09-17 | 2006-06-20 | Macropore Biosurgery Inc | Metodos para usar celulas regenerativas en el tratamiento de enfermedades vasculares perifericas y trastornos relacionados. |
US20060045872A1 (en) * | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
JPWO2006134951A1 (ja) * | 2005-06-13 | 2009-01-08 | 株式会社バイオマスター | 脂肪由来幹細胞の長期培養増殖法 |
DE602005012081D1 (de) * | 2005-07-29 | 2009-02-12 | Univ Bonn | Verfahren zur Isolierung von Stammzellen aus ein kissenformiges Gewebe der Zähne |
-
2007
- 2007-05-25 KR KR1020070050624A patent/KR20080103637A/ko not_active Application Discontinuation
-
2008
- 2008-05-09 JP JP2010510198A patent/JP5290281B2/ja active Active
- 2008-05-09 EP EP08753410.3A patent/EP2162141B1/en not_active Not-in-force
- 2008-05-09 MX MX2009012666A patent/MX2009012666A/es active IP Right Grant
- 2008-05-09 CN CN2008800174909A patent/CN101711160B/zh not_active Expired - Fee Related
- 2008-05-09 US US12/601,809 patent/US20100196329A1/en not_active Abandoned
- 2008-05-09 ES ES08753410T patent/ES2431816T3/es active Active
- 2008-05-09 WO PCT/KR2008/002614 patent/WO2008147057A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN101711160A (zh) | 2010-05-19 |
KR20080103637A (ko) | 2008-11-28 |
CN101711160B (zh) | 2013-04-24 |
WO2008147057A1 (en) | 2008-12-04 |
JP2010528107A (ja) | 2010-08-19 |
EP2162141A1 (en) | 2010-03-17 |
US20100196329A1 (en) | 2010-08-05 |
ES2431816T3 (es) | 2013-11-28 |
EP2162141B1 (en) | 2013-09-11 |
EP2162141A4 (en) | 2011-01-26 |
JP5290281B2 (ja) | 2013-09-18 |
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