MX2009012029A - Cepas genéticamente modificadas que producen metabolitos de antraciclina útiles como antineoplasicos. - Google Patents

Cepas genéticamente modificadas que producen metabolitos de antraciclina útiles como antineoplasicos.

Info

Publication number
MX2009012029A
MX2009012029A MX2009012029A MX2009012029A MX2009012029A MX 2009012029 A MX2009012029 A MX 2009012029A MX 2009012029 A MX2009012029 A MX 2009012029A MX 2009012029 A MX2009012029 A MX 2009012029A MX 2009012029 A MX2009012029 A MX 2009012029A
Authority
MX
Mexico
Prior art keywords
genetically modified
cancer drugs
strains producing
modified strains
metabolites useful
Prior art date
Application number
MX2009012029A
Other languages
English (en)
Inventor
Michael Lambert
Kristiina Ylihonko
Original Assignee
Heraeus Gmbh W C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Gmbh W C filed Critical Heraeus Gmbh W C
Publication of MX2009012029A publication Critical patent/MX2009012029A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La invención se refiere a una cepa microbiana, que produce metabolitos de antraciclina en una concentración de por lo menos 0.5 g/l en el caldo de fermenmtación.
MX2009012029A 2007-05-08 2008-04-29 Cepas genéticamente modificadas que producen metabolitos de antraciclina útiles como antineoplasicos. MX2009012029A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07009217.6A EP1990405B1 (en) 2007-05-08 2007-05-08 Genetically modified strains producing anthracycline metabolites useful as cancer drugs
PCT/EP2008/003447 WO2008135195A1 (en) 2007-05-08 2008-04-29 Genetically modified strains producing anthracycline metabolites useful as cancer drugs

Publications (1)

Publication Number Publication Date
MX2009012029A true MX2009012029A (es) 2010-01-25

Family

ID=38387557

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012029A MX2009012029A (es) 2007-05-08 2008-04-29 Cepas genéticamente modificadas que producen metabolitos de antraciclina útiles como antineoplasicos.

Country Status (12)

Country Link
US (1) US20100143977A1 (es)
EP (1) EP1990405B1 (es)
JP (1) JP2010525828A (es)
KR (1) KR101177175B1 (es)
CN (1) CN101978043B (es)
CA (1) CA2687034A1 (es)
DK (1) DK1990405T3 (es)
ES (1) ES2644422T3 (es)
MX (1) MX2009012029A (es)
PL (1) PL1990405T3 (es)
TW (1) TWI374187B (es)
WO (1) WO2008135195A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2301943B1 (en) 2009-09-08 2014-01-08 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCI
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
DE102014208194A1 (de) * 2014-04-30 2015-11-05 Heraeus Deutschland GmbH & Co. KG Aufreinigung von Epidaunorubicin
KR102155411B1 (ko) 2015-03-30 2020-09-11 메이지 세이카 파루마 가부시키가이샤 에피루비신 제조방법 및 그의 신규한 제조 중간체
CN105861455B (zh) 2016-05-16 2018-10-26 浙江海正药业股份有限公司 DoxA蛋白突变体及其编码基因与应用
CN107541481B (zh) * 2016-06-23 2021-07-02 上海医药工业研究院 一种产表阿霉素的基因工程菌及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3060472D1 (en) 1979-09-01 1982-07-15 Erba Farmitalia Anthracycline glycosides, processes for their preparation and pharmaceutical composition containing them
ES2151632T3 (es) 1996-12-16 2001-01-01 Pharmachemie Bv Un proceso para preparar epirubicina o sales de adicion de acidos de la misma a partir de daunorubicina.
US5955319A (en) 1997-07-28 1999-09-21 Pharmacia & Upjohn, S.P.A. Process for preparing doxorubicin
CA2256318A1 (en) 1997-03-06 1998-09-11 Pharmacia & Upjohn S.P.A. Process for preparing doxorubicin
US20020012979A1 (en) * 1998-06-08 2002-01-31 Alan Berry Vitamin c production in microorganisms and plants
FI107053B (fi) 1998-10-23 2001-05-31 Galilaeus Oy Nogalamysiinin biosynteesiin liittyvä geeniryhmittymä ja sen käyttö hybridiantibioottien tuotossa
DE10300719A1 (de) * 2003-01-11 2004-07-22 Basf Ag Verbessertes Verfahren zur Herstellung von Vitamin B12
WO2006111561A1 (en) 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins

Also Published As

Publication number Publication date
PL1990405T3 (pl) 2018-01-31
EP1990405B1 (en) 2017-07-26
KR101177175B1 (ko) 2012-08-24
JP2010525828A (ja) 2010-07-29
US20100143977A1 (en) 2010-06-10
CA2687034A1 (en) 2008-11-13
DK1990405T3 (da) 2017-11-06
ES2644422T3 (es) 2017-11-28
TWI374187B (en) 2012-10-11
CN101978043A (zh) 2011-02-16
TW201012923A (en) 2010-04-01
CN101978043B (zh) 2013-06-19
WO2008135195A1 (en) 2008-11-13
KR20100010503A (ko) 2010-02-01
EP1990405A1 (en) 2008-11-12

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