MX2009009541A - Inhibidores de metaloproteasa que contienen una porcion heterociclica. - Google Patents
Inhibidores de metaloproteasa que contienen una porcion heterociclica.Info
- Publication number
- MX2009009541A MX2009009541A MX2009009541A MX2009009541A MX2009009541A MX 2009009541 A MX2009009541 A MX 2009009541A MX 2009009541 A MX2009009541 A MX 2009009541A MX 2009009541 A MX2009009541 A MX 2009009541A MX 2009009541 A MX2009009541 A MX 2009009541A
- Authority
- MX
- Mexico
- Prior art keywords
- heterocyclic
- heterocyclic moiety
- metalloprotease inhibitors
- inhibitors containing
- moiety
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- A—HUMAN NECESSITIES
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
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Abstract
La presente invención se refiere generalmente a agentes farmacéuticos que contienen una porción heterocíclica, y en particular, a compuestos que inhiben la metaloproteasa heterocíclicos. Más particularmente, la presente invención proporciona una nueva clase de compuestos que inhiben MMP-13 heterocíclicos con una porción de benzoxazina modificada, que exhibe una potencia y selectividad aumentada en relación con los inhibidores MMP-13 actualmente conocidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90556507P | 2007-03-07 | 2007-03-07 | |
PCT/US2008/003191 WO2008109177A2 (en) | 2007-03-07 | 2008-03-07 | Metalloprotease inhibitors containing a heterocyclic moiety |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009009541A true MX2009009541A (es) | 2009-09-16 |
Family
ID=39551667
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009009552A MX2009009552A (es) | 2007-03-07 | 2008-03-07 | Inhibidores de metaloproteasa que contienen una porcion heterociclica. |
MX2009009541A MX2009009541A (es) | 2007-03-07 | 2008-03-07 | Inhibidores de metaloproteasa que contienen una porcion heterociclica. |
MX2009009540A MX2009009540A (es) | 2007-03-07 | 2008-03-07 | Inhibidores de metaloproteasa que contienen una porcion heterociclica. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009009552A MX2009009552A (es) | 2007-03-07 | 2008-03-07 | Inhibidores de metaloproteasa que contienen una porcion heterociclica. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009009540A MX2009009540A (es) | 2007-03-07 | 2008-03-07 | Inhibidores de metaloproteasa que contienen una porcion heterociclica. |
Country Status (7)
Country | Link |
---|---|
US (5) | US20080221095A1 (es) |
EP (3) | EP2134693A2 (es) |
JP (3) | JP2010520294A (es) |
AU (3) | AU2008223352A1 (es) |
CA (3) | CA2680312A1 (es) |
MX (3) | MX2009009552A (es) |
WO (5) | WO2008109180A2 (es) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7728031B2 (en) * | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
EP2099792A1 (en) * | 2006-11-20 | 2009-09-16 | Alantos Pharmaceuticals Holding, Inc. | Heterotricyclic metalloprotease inhibitors |
WO2009036132A1 (en) * | 2007-09-11 | 2009-03-19 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole n-oxides |
JP5432982B2 (ja) | 2008-03-31 | 2014-03-05 | 武田薬品工業株式会社 | アポトーシスシグナル調節キナーゼ1阻害剤 |
AU2009276403B2 (en) | 2008-08-01 | 2016-03-10 | Ventirx Pharmaceuticals, Inc. | Toll-like receptor agonist formulations and their use |
EP2358683B1 (en) | 2008-11-06 | 2015-04-01 | VentiRx Pharmaceuticals, Inc. | Methods of synthesis of benzazepine derivatives |
WO2010111626A2 (en) * | 2009-03-27 | 2010-09-30 | Takeda Pharmaceutical Company Limited | Poly (adp-ribose) polymerase (parp) inhibitors |
JP2012527474A (ja) * | 2009-05-22 | 2012-11-08 | エクセリクシス, インク. | 増殖性疾患に対するベンゾキサゼピンベースのpi3k/mt0r阻害剤 |
DK2467380T3 (en) | 2009-08-18 | 2017-03-13 | Ventirx Pharmaceuticals Inc | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS |
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EP2125816A2 (en) | 2009-12-02 |
AU2008223351A1 (en) | 2008-09-12 |
AU2008223348A1 (en) | 2008-09-12 |
WO2008109177A3 (en) | 2009-01-22 |
CA2680312A1 (en) | 2008-09-12 |
MX2009009552A (es) | 2009-09-28 |
JP2010520294A (ja) | 2010-06-10 |
WO2008109180A3 (en) | 2009-07-09 |
WO2008109181A3 (en) | 2008-12-11 |
CA2680173A1 (en) | 2008-09-12 |
JP2010520293A (ja) | 2010-06-10 |
AU2008223352A1 (en) | 2008-09-12 |
EP2139887A2 (en) | 2010-01-06 |
WO2008109181A2 (en) | 2008-09-12 |
US7691851B2 (en) | 2010-04-06 |
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