MX2009008025A - Heparinas que incluyen al menos un enlace covalente con biotina o un derivado de biotina, método para prepararlas y su uso. - Google Patents
Heparinas que incluyen al menos un enlace covalente con biotina o un derivado de biotina, método para prepararlas y su uso.Info
- Publication number
- MX2009008025A MX2009008025A MX2009008025A MX2009008025A MX2009008025A MX 2009008025 A MX2009008025 A MX 2009008025A MX 2009008025 A MX2009008025 A MX 2009008025A MX 2009008025 A MX2009008025 A MX 2009008025A MX 2009008025 A MX2009008025 A MX 2009008025A
- Authority
- MX
- Mexico
- Prior art keywords
- biotin
- covalent bond
- heparins
- preparing same
- so3na
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Heparinas biotiniladas, caracterizadas porque los polisacáridos que constituyen dichas heparinas poseen en su extremo reductor, un enlace covalente con un grupo -(R1), -Biot y corresponden a la fórmula general (I): en la cual i es igual a 0 o 1, R1 representa una cadena de la fórmula -CO-(CH2)j-NH o -CO-(CH2)jNH-CO-(CH2)k-NH o j y k son enteros que pueden tener cualquier valor desde 1 hasta 10. Biot representa un grupo biotina o derivado de biotina, n representa un número entero que tiene un valor medio de aproximadamente 25 para una heparina de masa molecular media de 15 000 Da, X representa H o SO3Na, Y representa COCH3 o SO3Na, la línea ondulada representa una unión situada ya sea debajo o encima del ciclo piranósico al cual está unida. La invención también se refiere a un método para su preparación y a su uso en terapéutica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0701053A FR2912408A1 (fr) | 2007-02-14 | 2007-02-14 | Heparine comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine,leur procede de preparation,leur utilisation |
PCT/FR2008/000172 WO2008113918A1 (fr) | 2007-02-14 | 2008-02-12 | Heparines comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine, leur procede de preparation et leur utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009008025A true MX2009008025A (es) | 2009-08-07 |
Family
ID=38470146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009008025A MX2009008025A (es) | 2007-02-14 | 2008-02-12 | Heparinas que incluyen al menos un enlace covalente con biotina o un derivado de biotina, método para prepararlas y su uso. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100075922A1 (es) |
EP (1) | EP2120970A1 (es) |
JP (1) | JP2010518251A (es) |
KR (1) | KR20090109105A (es) |
CN (1) | CN101605549A (es) |
AR (1) | AR065328A1 (es) |
AU (1) | AU2008228161A1 (es) |
BR (1) | BRPI0808070A2 (es) |
CA (1) | CA2678166A1 (es) |
FR (1) | FR2912408A1 (es) |
IL (1) | IL199880A0 (es) |
MX (1) | MX2009008025A (es) |
RU (1) | RU2009134160A (es) |
TW (1) | TW200902036A (es) |
WO (1) | WO2008113918A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101794877B1 (ko) * | 2010-09-14 | 2017-11-07 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 고순도 헤파린 및 그 제조방법 |
CN103087218B (zh) * | 2011-12-30 | 2016-01-20 | 北京大学 | 直链形肝素修饰的生物型人造血管 |
GB201415062D0 (en) * | 2014-08-26 | 2014-10-08 | Aplagon Oy | Therapeutic |
WO2018175464A1 (en) * | 2017-03-20 | 2018-09-27 | Rensselaer Polytechnic Institute | Enzymatic preparation of increased anticoagulant bovine sourced heparin |
KR102138366B1 (ko) | 2017-12-11 | 2020-07-28 | 이강수 | 이중관 선단보강부를 이용하여 제작된 선단보강파일 및 그 시공방법 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2874924B1 (fr) * | 2004-09-09 | 2006-12-01 | Sanofi Aventis Sa | Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique |
-
2007
- 2007-02-14 FR FR0701053A patent/FR2912408A1/fr not_active Withdrawn
-
2008
- 2008-02-04 TW TW097104306A patent/TW200902036A/zh unknown
- 2008-02-12 EP EP08761872A patent/EP2120970A1/fr not_active Withdrawn
- 2008-02-12 WO PCT/FR2008/000172 patent/WO2008113918A1/fr active Application Filing
- 2008-02-12 BR BRPI0808070-4A patent/BRPI0808070A2/pt not_active IP Right Cessation
- 2008-02-12 CN CNA2008800048677A patent/CN101605549A/zh active Pending
- 2008-02-12 MX MX2009008025A patent/MX2009008025A/es not_active Application Discontinuation
- 2008-02-12 RU RU2009134160/15A patent/RU2009134160A/ru not_active Application Discontinuation
- 2008-02-12 KR KR1020097016909A patent/KR20090109105A/ko not_active Application Discontinuation
- 2008-02-12 AU AU2008228161A patent/AU2008228161A1/en not_active Abandoned
- 2008-02-12 JP JP2009549840A patent/JP2010518251A/ja not_active Withdrawn
- 2008-02-12 CA CA002678166A patent/CA2678166A1/fr not_active Abandoned
- 2008-02-13 AR ARP080100610A patent/AR065328A1/es unknown
-
2009
- 2009-07-15 IL IL199880A patent/IL199880A0/en unknown
- 2009-08-11 US US12/539,237 patent/US20100075922A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FR2912408A1 (fr) | 2008-08-15 |
AR065328A1 (es) | 2009-06-03 |
RU2009134160A (ru) | 2011-03-20 |
TW200902036A (en) | 2009-01-16 |
JP2010518251A (ja) | 2010-05-27 |
AU2008228161A1 (en) | 2008-09-25 |
IL199880A0 (en) | 2010-04-15 |
WO2008113918A1 (fr) | 2008-09-25 |
KR20090109105A (ko) | 2009-10-19 |
EP2120970A1 (fr) | 2009-11-25 |
US20100075922A1 (en) | 2010-03-25 |
CN101605549A (zh) | 2009-12-16 |
CA2678166A1 (fr) | 2008-09-25 |
BRPI0808070A2 (pt) | 2014-08-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |