BRPI0807981A2 - Heparinas de baixo peso molecular, compreendendo pelo menos uma ligação covalente com a biotina ou um derivado da biotina, o respectivo processo de preparo e o respectivo uso - Google Patents
Heparinas de baixo peso molecular, compreendendo pelo menos uma ligação covalente com a biotina ou um derivado da biotina, o respectivo processo de preparo e o respectivo usoInfo
- Publication number
- BRPI0807981A2 BRPI0807981A2 BRPI0807981-1A2A BRPI0807981A BRPI0807981A2 BR PI0807981 A2 BRPI0807981 A2 BR PI0807981A2 BR PI0807981 A BRPI0807981 A BR PI0807981A BR PI0807981 A2 BRPI0807981 A2 BR PI0807981A2
- Authority
- BR
- Brazil
- Prior art keywords
- biotine
- biotin
- derivative
- understanding
- molecular weight
- Prior art date
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title 3
- 235000020958 biotin Nutrition 0.000 title 1
- 239000011616 biotin Substances 0.000 title 1
- 229960002685 biotin Drugs 0.000 title 1
- 229940127215 low-molecular weight heparin Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0701055A FR2912409B1 (fr) | 2007-02-14 | 2007-02-14 | Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation |
PCT/FR2008/000173 WO2008113919A1 (fr) | 2007-02-14 | 2008-02-12 | Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine, leur procede de preparation et leur utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0807981A2 true BRPI0807981A2 (pt) | 2014-06-24 |
Family
ID=38461986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0807981-1A2A BRPI0807981A2 (pt) | 2007-02-14 | 2008-02-12 | Heparinas de baixo peso molecular, compreendendo pelo menos uma ligação covalente com a biotina ou um derivado da biotina, o respectivo processo de preparo e o respectivo uso |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100081629A1 (pt) |
EP (1) | EP2121769A1 (pt) |
JP (1) | JP5351770B2 (pt) |
KR (1) | KR20090109104A (pt) |
CN (1) | CN101636417A (pt) |
AR (1) | AR065323A1 (pt) |
AU (1) | AU2008228162A1 (pt) |
BR (1) | BRPI0807981A2 (pt) |
CA (1) | CA2678168A1 (pt) |
FR (1) | FR2912409B1 (pt) |
IL (1) | IL200111A0 (pt) |
MX (1) | MX2009008752A (pt) |
RU (1) | RU2009134188A (pt) |
TW (1) | TW200846014A (pt) |
WO (1) | WO2008113919A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008314505C1 (en) | 2007-10-16 | 2020-11-05 | Progen Pg500 Series Pty Ltd | Novel sulfated oligosaccharide derivatives |
US8592393B2 (en) | 2007-11-02 | 2013-11-26 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
US9351992B2 (en) | 2007-11-02 | 2016-05-31 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
US8569262B2 (en) | 2007-11-02 | 2013-10-29 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
JP5982361B2 (ja) | 2010-04-16 | 2016-08-31 | モメンタ ファーマシューティカルズ インコーポレイテッド | 組織標的化方法 |
WO2011159770A2 (en) | 2010-06-17 | 2011-12-22 | Momenta Pharmaceuticals, Inc. | Methods and compositions for modulating hair growth |
US10016449B2 (en) | 2013-05-28 | 2018-07-10 | Momenta Pharmaceuticals, Inc. | Pharmaceutical compositions |
CN103421128B (zh) * | 2013-07-31 | 2015-08-12 | 山东辰中生物制药有限公司 | 一种高品质低分子帕那肝素的制备方法 |
EP3388439A1 (en) * | 2017-04-11 | 2018-10-17 | Leadiant Biosciences SA | Biotin-conjugated n-acetyl glycol split heparin |
CN111333664A (zh) * | 2020-03-27 | 2020-06-26 | 苏州昊帆生物股份有限公司 | 生物素交联剂、应用及其制备方法 |
CN117777216A (zh) * | 2022-09-21 | 2024-03-29 | 中国科学院上海药物研究所 | 可中和的生物素化肝素五糖的制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE38743E1 (en) * | 1990-06-26 | 2005-06-14 | Aventis Pharma S.A. | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
FR2663639B1 (fr) * | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation. |
FR2814463B1 (fr) * | 2000-09-22 | 2002-11-15 | Sanofi Synthelabo | Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine |
US20040229778A1 (en) * | 2003-05-13 | 2004-11-18 | Elmaleh David R. | Pharmaceutical compositions of antithrombin III for the treatment of retroviral diseases |
FR2874924B1 (fr) * | 2004-09-09 | 2006-12-01 | Sanofi Aventis Sa | Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique |
-
2007
- 2007-02-14 FR FR0701055A patent/FR2912409B1/fr not_active Expired - Fee Related
-
2008
- 2008-02-04 TW TW097104302A patent/TW200846014A/zh unknown
- 2008-02-12 CN CN200880005216A patent/CN101636417A/zh active Pending
- 2008-02-12 EP EP08761873A patent/EP2121769A1/fr not_active Withdrawn
- 2008-02-12 CA CA002678168A patent/CA2678168A1/fr not_active Abandoned
- 2008-02-12 AU AU2008228162A patent/AU2008228162A1/en not_active Abandoned
- 2008-02-12 JP JP2009549440A patent/JP5351770B2/ja not_active Expired - Fee Related
- 2008-02-12 KR KR1020097016908A patent/KR20090109104A/ko not_active Application Discontinuation
- 2008-02-12 BR BRPI0807981-1A2A patent/BRPI0807981A2/pt not_active IP Right Cessation
- 2008-02-12 WO PCT/FR2008/000173 patent/WO2008113919A1/fr active Application Filing
- 2008-02-12 RU RU2009134188/04A patent/RU2009134188A/ru not_active Application Discontinuation
- 2008-02-12 MX MX2009008752A patent/MX2009008752A/es not_active Application Discontinuation
- 2008-02-13 AR ARP080100609A patent/AR065323A1/es unknown
-
2009
- 2009-07-28 IL IL200111A patent/IL200111A0/en unknown
- 2009-08-11 US US12/539,224 patent/US20100081629A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2010518238A (ja) | 2010-05-27 |
WO2008113919A1 (fr) | 2008-09-25 |
AU2008228162A1 (en) | 2008-09-25 |
MX2009008752A (es) | 2009-08-27 |
CN101636417A (zh) | 2010-01-27 |
EP2121769A1 (fr) | 2009-11-25 |
JP5351770B2 (ja) | 2013-11-27 |
CA2678168A1 (fr) | 2008-09-25 |
IL200111A0 (en) | 2010-04-15 |
TW200846014A (en) | 2008-12-01 |
US20100081629A1 (en) | 2010-04-01 |
FR2912409A1 (fr) | 2008-08-15 |
RU2009134188A (ru) | 2011-03-20 |
KR20090109104A (ko) | 2009-10-19 |
FR2912409B1 (fr) | 2012-08-24 |
AR065323A1 (es) | 2009-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 5A E 6A ANUIDADES. |
|
B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A, 7A, 8A, 9A, 10A, 11A E 12A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |