AR065328A1 - Heparinas que comprenden por lo menos un enlace covalente con la biotina o un derivado de la biotina , su procedimiento de preparacion y su utilizacion - Google Patents

Heparinas que comprenden por lo menos un enlace covalente con la biotina o un derivado de la biotina , su procedimiento de preparacion y su utilizacion

Info

Publication number
AR065328A1
AR065328A1 ARP080100610A ARP080100610A AR065328A1 AR 065328 A1 AR065328 A1 AR 065328A1 AR P080100610 A ARP080100610 A AR P080100610A AR P080100610 A ARP080100610 A AR P080100610A AR 065328 A1 AR065328 A1 AR 065328A1
Authority
AR
Argentina
Prior art keywords
biotine
preparation procedure
heparinas
derivative
understand
Prior art date
Application number
ARP080100610A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR065328A1 publication Critical patent/AR065328A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Heparinas biotiniladas, caracterizadas porque los polisacáridos constitutivos de dichas heparinas poseen en su extremo reductor un enlace covalente con un grupo -(R1)i-Biot y responden a la formula general (1) en la que i es igual 0 o 1, R1representa una cadena de formula -CO-(CH2)j-NH- o -CO-(CH2)j-NH-CO-(CH2)k-NH, en las que j y k son numeros enteros que pueden tener cualquier valor de 1 a 10, Biot representa un grupo biotina o derivado de biotina, n representa un numero entero quetiene un valor medio de alrededor de 25 para una heparina de masa molecular media de 15.000 Da, X representa H o SO3Na, Y representa COCH3 o SO3Na, el trazo ondulado designa un enlace situado ya sea por debajo, ya sea por encima del plano del ciclopiranosico al que está unido. Su procedimiento de preparacion y su utilizacion en terapéutica.
ARP080100610A 2007-02-14 2008-02-13 Heparinas que comprenden por lo menos un enlace covalente con la biotina o un derivado de la biotina , su procedimiento de preparacion y su utilizacion AR065328A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0701053A FR2912408A1 (fr) 2007-02-14 2007-02-14 Heparine comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine,leur procede de preparation,leur utilisation

Publications (1)

Publication Number Publication Date
AR065328A1 true AR065328A1 (es) 2009-06-03

Family

ID=38470146

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100610A AR065328A1 (es) 2007-02-14 2008-02-13 Heparinas que comprenden por lo menos un enlace covalente con la biotina o un derivado de la biotina , su procedimiento de preparacion y su utilizacion

Country Status (15)

Country Link
US (1) US20100075922A1 (es)
EP (1) EP2120970A1 (es)
JP (1) JP2010518251A (es)
KR (1) KR20090109105A (es)
CN (1) CN101605549A (es)
AR (1) AR065328A1 (es)
AU (1) AU2008228161A1 (es)
BR (1) BRPI0808070A2 (es)
CA (1) CA2678166A1 (es)
FR (1) FR2912408A1 (es)
IL (1) IL199880A0 (es)
MX (1) MX2009008025A (es)
RU (1) RU2009134160A (es)
TW (1) TW200902036A (es)
WO (1) WO2008113918A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2012036152A1 (ja) * 2010-09-14 2014-02-03 国立大学法人 宮崎大学 高純度ヘパリンおよびその製造方法
CN103087218B (zh) * 2011-12-30 2016-01-20 北京大学 直链形肝素修饰的生物型人造血管
GB201415062D0 (en) * 2014-08-26 2014-10-08 Aplagon Oy Therapeutic
WO2018175464A1 (en) * 2017-03-20 2018-09-27 Rensselaer Polytechnic Institute Enzymatic preparation of increased anticoagulant bovine sourced heparin
KR102138366B1 (ko) 2017-12-11 2020-07-28 이강수 이중관 선단보강부를 이용하여 제작된 선단보강파일 및 그 시공방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2874924B1 (fr) * 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique

Also Published As

Publication number Publication date
FR2912408A1 (fr) 2008-08-15
KR20090109105A (ko) 2009-10-19
CA2678166A1 (fr) 2008-09-25
TW200902036A (en) 2009-01-16
RU2009134160A (ru) 2011-03-20
IL199880A0 (en) 2010-04-15
WO2008113918A1 (fr) 2008-09-25
CN101605549A (zh) 2009-12-16
JP2010518251A (ja) 2010-05-27
BRPI0808070A2 (pt) 2014-08-05
AU2008228161A1 (en) 2008-09-25
MX2009008025A (es) 2009-08-07
EP2120970A1 (fr) 2009-11-25
US20100075922A1 (en) 2010-03-25

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