MX2009007868A - Proceso para la preparacion de monoclorhidrato de 8-hidroxi-5-[(1r)-1-hidroxi-2[[(1r)-2-(4-metoxifenil)-1-metiletil ]amino]-etil]-2(1h)-quinolinona. - Google Patents

Proceso para la preparacion de monoclorhidrato de 8-hidroxi-5-[(1r)-1-hidroxi-2[[(1r)-2-(4-metoxifenil)-1-metiletil ]amino]-etil]-2(1h)-quinolinona.

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Publication number
MX2009007868A
MX2009007868A MX2009007868A MX2009007868A MX2009007868A MX 2009007868 A MX2009007868 A MX 2009007868A MX 2009007868 A MX2009007868 A MX 2009007868A MX 2009007868 A MX2009007868 A MX 2009007868A MX 2009007868 A MX2009007868 A MX 2009007868A
Authority
MX
Mexico
Prior art keywords
hydroxy
methylethyl
methoxyphenyl
ethyl
amino
Prior art date
Application number
MX2009007868A
Other languages
English (en)
Inventor
Maurizio Delcanale
Fausto Pivetti
Monica Bocchi
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of MX2009007868A publication Critical patent/MX2009007868A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se relaciona con un proceso para la preparación de monoclorhidrato de 8-hidroxi-5-[(1R)-1-hidroxi-2[[(1R)-2-(4-metoxi fenil)-1-metiletil]amino]etil]-2(1H)-quinolinona de la fórmula (I). También se describen los intermediarios útiles en el proceso.
MX2009007868A 2007-01-30 2008-01-22 Proceso para la preparacion de monoclorhidrato de 8-hidroxi-5-[(1r)-1-hidroxi-2[[(1r)-2-(4-metoxifenil)-1-metiletil ]amino]-etil]-2(1h)-quinolinona. MX2009007868A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07001950A EP1953143A1 (en) 2007-01-30 2007-01-30 Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride
PCT/IB2008/000134 WO2008093188A1 (en) 2007-01-30 2008-01-22 Process for the preparation of 8-hydroxy-5-[(1r)-1-hydroxy-2[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]-ethyl]-2(1h)-quinolinone monohydrochloride

Publications (1)

Publication Number Publication Date
MX2009007868A true MX2009007868A (es) 2009-07-31

Family

ID=38055152

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007868A MX2009007868A (es) 2007-01-30 2008-01-22 Proceso para la preparacion de monoclorhidrato de 8-hidroxi-5-[(1r)-1-hidroxi-2[[(1r)-2-(4-metoxifenil)-1-metiletil ]amino]-etil]-2(1h)-quinolinona.

Country Status (14)

Country Link
US (1) US8163922B2 (es)
EP (2) EP1953143A1 (es)
JP (1) JP2010516803A (es)
KR (1) KR101404263B1 (es)
CN (1) CN101611010B (es)
AU (1) AU2008211655B2 (es)
BR (1) BRPI0806411B8 (es)
CA (1) CA2676849C (es)
EA (1) EA018170B1 (es)
ES (1) ES2409740T3 (es)
HK (1) HK1135093A1 (es)
MX (1) MX2009007868A (es)
WO (1) WO2008093188A1 (es)
ZA (1) ZA200905291B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR048339A1 (es) * 2004-03-24 2006-04-19 Chiesi Farma Spa Monoclorhidrato de 8- hidroxi-5-((1r)) -1- hidroxi-2- (((1r)-2 ( 4-metoxifenil) -1- metiletil) amino ) eti l) -2 (1h) - quinolinona en form acristalina y el proceso para su preparacion
EP2116537A1 (en) * 2008-05-07 2009-11-11 CHIESI FARMACEUTICI S.p.A. Polymorph of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride
EP2578570A1 (en) * 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
ES2815123T3 (es) 2014-01-09 2021-03-29 Davuluri Ramamohan Rao Proceso novedoso para la preparación de indacaterol o sus sales aceptables farmacéuticamente

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
EP1452179A1 (en) * 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid
AR048339A1 (es) 2004-03-24 2006-04-19 Chiesi Farma Spa Monoclorhidrato de 8- hidroxi-5-((1r)) -1- hidroxi-2- (((1r)-2 ( 4-metoxifenil) -1- metiletil) amino ) eti l) -2 (1h) - quinolinona en form acristalina y el proceso para su preparacion

Also Published As

Publication number Publication date
EA018170B1 (ru) 2013-06-28
KR101404263B1 (ko) 2014-06-05
US8163922B2 (en) 2012-04-24
HK1135093A1 (es) 2010-05-28
CN101611010B (zh) 2012-03-21
EP2109603B1 (en) 2013-04-03
CA2676849C (en) 2015-12-15
EP2109603A1 (en) 2009-10-21
BRPI0806411B8 (pt) 2021-05-25
CN101611010A (zh) 2009-12-23
BRPI0806411A2 (pt) 2011-09-06
KR20090104820A (ko) 2009-10-06
BRPI0806411B1 (pt) 2020-10-13
EP1953143A1 (en) 2008-08-06
AU2008211655A1 (en) 2008-08-07
CA2676849A1 (en) 2008-08-07
EA200900926A1 (ru) 2010-02-26
ES2409740T3 (es) 2013-06-27
AU2008211655B2 (en) 2013-04-04
WO2008093188A1 (en) 2008-08-07
JP2010516803A (ja) 2010-05-20
US20090326231A1 (en) 2009-12-31
ZA200905291B (en) 2010-10-27

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