WO2009050734A3 - An industrially feasible process for the manufacture of bisquinoline derivatives by using substantially pure n-monosubstituted piperazines - Google Patents

An industrially feasible process for the manufacture of bisquinoline derivatives by using substantially pure n-monosubstituted piperazines Download PDF

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Publication number
WO2009050734A3
WO2009050734A3 PCT/IN2008/000643 IN2008000643W WO2009050734A3 WO 2009050734 A3 WO2009050734 A3 WO 2009050734A3 IN 2008000643 W IN2008000643 W IN 2008000643W WO 2009050734 A3 WO2009050734 A3 WO 2009050734A3
Authority
WO
WIPO (PCT)
Prior art keywords
substantially pure
manufacture
feasible process
industrially feasible
monosubstituted piperazines
Prior art date
Application number
PCT/IN2008/000643
Other languages
French (fr)
Other versions
WO2009050734A9 (en
WO2009050734A2 (en
Inventor
Rajiv Sakhardande
Manmohan Nimbalkar
Subarao Patil
Santosh Bhalekar
Rajendra Patil
Rohidas Mhaske
Original Assignee
Elder Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elder Pharmaceuticals Ltd. filed Critical Elder Pharmaceuticals Ltd.
Priority to EP08839611A priority Critical patent/EP2212310A4/en
Publication of WO2009050734A2 publication Critical patent/WO2009050734A2/en
Publication of WO2009050734A3 publication Critical patent/WO2009050734A3/en
Publication of WO2009050734A9 publication Critical patent/WO2009050734A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A process for the preparation of substantially pure 7-chloro-4-(ρiρerazin-1-yl) quinoline of formula (II) free from dimer impurity of formula (III) and process for the preparation of substantially pure piperaquine and its acid salt by using pure 7- chloro-4-(piperazin-1-yl) quinoline.
PCT/IN2008/000643 2007-10-15 2008-10-06 An industrially feasible process for the manufacture of bisquinoline derivatives by using substantially pure n-monosubstituted piperazines WO2009050734A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08839611A EP2212310A4 (en) 2007-10-15 2008-10-06 An industrially feasible process for the manufacture of bisquinoline derivatives by using substantially pure n-monosubstituted piperazines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2053/MUM/2007 2007-10-15
IN2053MU2007 2007-10-15

Publications (3)

Publication Number Publication Date
WO2009050734A2 WO2009050734A2 (en) 2009-04-23
WO2009050734A3 true WO2009050734A3 (en) 2010-01-07
WO2009050734A9 WO2009050734A9 (en) 2010-03-11

Family

ID=40567906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000643 WO2009050734A2 (en) 2007-10-15 2008-10-06 An industrially feasible process for the manufacture of bisquinoline derivatives by using substantially pure n-monosubstituted piperazines

Country Status (2)

Country Link
EP (1) EP2212310A4 (en)
WO (1) WO2009050734A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011095885A1 (en) * 2010-02-08 2011-08-11 Matrix Laboratories Ltd. An improved process for the preparation of piperaquine
DE102010048476A1 (en) * 2010-10-14 2012-08-23 Julius-Maximilians-Universität Würzburg Hybrid compounds of 4- and 8-aminoquinolines for the prophylactic and therapeutic treatment of malaria and other parasitic diseases
CA2835344A1 (en) 2011-06-06 2012-12-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A Novel process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline
CN103058926B (en) * 2012-12-14 2014-12-10 重庆康乐制药有限公司 Preparation method of 7-chlorine-4-(piperazineyl-1-yl) quinoline
CN105330601A (en) * 2015-11-03 2016-02-17 重庆康乐制药有限公司 Preparation method of piperaquine derivative
CN110606830B (en) * 2018-06-14 2022-03-18 珠海润都制药股份有限公司 Method for producing piperaquine phosphate intermediate quinoline piperazine hydrochloride by applying piperazine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3173918A (en) * 1965-03-16 Bis(x-quwolyl-piperazinyjl) compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637271A (en) * 1963-04-04 1900-01-01
US20060270852A1 (en) * 2005-05-30 2006-11-30 Yadav Gyan C Preparation of bisquinoline compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3173918A (en) * 1965-03-16 Bis(x-quwolyl-piperazinyjl) compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 147:522286 *
See also references of EP2212310A4 *

Also Published As

Publication number Publication date
EP2212310A4 (en) 2011-04-20
EP2212310A2 (en) 2010-08-04
WO2009050734A9 (en) 2010-03-11
WO2009050734A2 (en) 2009-04-23

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