MX2009007248A - Peptidos bio-activos cortos para modulacion celular e inmunologica. - Google Patents
Peptidos bio-activos cortos para modulacion celular e inmunologica.Info
- Publication number
- MX2009007248A MX2009007248A MX2009007248A MX2009007248A MX2009007248A MX 2009007248 A MX2009007248 A MX 2009007248A MX 2009007248 A MX2009007248 A MX 2009007248A MX 2009007248 A MX2009007248 A MX 2009007248A MX 2009007248 A MX2009007248 A MX 2009007248A
- Authority
- MX
- Mexico
- Prior art keywords
- peptides
- disclosed
- peptide
- cellular
- active peptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 230000000975 bioactive effect Effects 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
- 230000001900 immune effect Effects 0.000 title 1
- 230000006378 damage Effects 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 210000003491 skin Anatomy 0.000 abstract 2
- 206010056340 Diabetic ulcer Diseases 0.000 abstract 1
- 108700022013 Insecta cecropin B Proteins 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 210000002510 keratinocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001617 migratory effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Insects & Arthropods (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Péptidos teniendo de cuatro a catorce residuos se divulgan que poseen actividad biológica constituyen fragmentos cortos del péptido HB-107 (SEQ ID NO : 1), el cual por sí mismo es un fragmento de la proteína anti-microbiana cecropina b, y exhibe propiedades celulares estimulatorias, migratorias y anti-inflamatorias. Como los queratinocitos son especialmente sensibles a estos efectos, los péptidos divulgados comprenden un agente útil para el tratamiento médico de lesión a la piel, tal como de úlceras diabéticas. Los péptidos también son efectivos para prevenir y revertir daño superficial a la piel resultante de varios insultos ambientales. De manera importante, los efectos terapéuticos de los péptidos se manifiestan a concentraciones iguales o mayores que aquellas de los péptidos HB-107, y por ende representan medios menos costos, más versátiles para desarrollar terapias efectivas. Métodos para la producción y uso de estos péptidos también se divulgan.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87884907P | 2007-01-05 | 2007-01-05 | |
| PCT/US2007/026368 WO2008085494A1 (en) | 2007-01-05 | 2007-12-27 | Short bio-active peptides for cellular and immunological modulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009007248A true MX2009007248A (es) | 2009-08-17 |
Family
ID=39345537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009007248A MX2009007248A (es) | 2007-01-05 | 2007-12-27 | Peptidos bio-activos cortos para modulacion celular e inmunologica. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7696174B2 (es) |
| EP (1) | EP2125878B1 (es) |
| JP (1) | JP5342455B2 (es) |
| CN (1) | CN101679495B (es) |
| AU (1) | AU2007342353B2 (es) |
| BR (1) | BRPI0720874C1 (es) |
| CA (1) | CA2673791C (es) |
| CY (1) | CY1114002T1 (es) |
| DK (1) | DK2125878T3 (es) |
| ES (1) | ES2404669T3 (es) |
| HK (1) | HK1137463A1 (es) |
| MX (1) | MX2009007248A (es) |
| PL (1) | PL2125878T3 (es) |
| RU (1) | RU2458069C2 (es) |
| SI (1) | SI2125878T1 (es) |
| WO (1) | WO2008085494A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2065029B1 (en) * | 2007-11-30 | 2013-04-17 | Evonik Goldschmidt GmbH | Personal care and cosmetic composition containing tetrapeptides with the motifs GX1X2G, PX1X2P, or PX1X2K |
| IT1393348B1 (it) * | 2009-03-13 | 2012-04-20 | Prevete | Peptide per rigenerare tessuti lesionati |
| DE102009046780A1 (de) | 2009-11-17 | 2011-05-19 | Evonik Goldschmidt Gmbh | Tetrapeptide zur Aufhellung der Haut |
| AU2014216730B2 (en) * | 2013-02-14 | 2015-12-17 | Helix Biomedix, Inc. | Short bio-active peptides for promoting wound healing |
| WO2014200651A1 (en) * | 2013-06-14 | 2014-12-18 | Helix Biomedix Inc. | Tetrapeptides derived from human c-x-c chemokines useful for treatment of various skin conditions |
| CN112759653B (zh) * | 2019-11-06 | 2023-06-23 | 珠海联邦制药股份有限公司 | 一种pkek融合蛋白及其制备方法与应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6360939A (ja) * | 1986-08-29 | 1988-03-17 | Shin Etsu Chem Co Ltd | 抗菌物質 |
| KR970006154B1 (ko) | 1987-07-06 | 1997-04-24 | 루이지아나 스테이트 유니버시티 아그리컬춰럴 앤드 메카니칼 컬리지 | 용해성 펩티드에 의한 진핵 병원체와 신생물의 억제 및 섬유아세포와 임파구의 자극 |
| US5861478A (en) | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| EP0365655B1 (en) | 1988-04-21 | 1994-09-21 | Uab Research Foundation | Bioelastomeric materials suitable for the protection of wound repair sites from the occurrence of adhesions |
| WO1990008771A1 (en) * | 1989-01-31 | 1990-08-09 | Rubin Jeffrey S | Dna encoding a growth factor specific for epithelial cells |
| ATE189231T1 (de) * | 1989-04-10 | 2000-02-15 | Helix Biomedix Inc | Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs |
| US5561107A (en) * | 1993-06-04 | 1996-10-01 | Demeter Biotechnologies, Ltd. | Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides |
| US5763576A (en) | 1995-10-06 | 1998-06-09 | Georgia Tech Research Corp. | Tetrapeptide α-ketoamides |
| EP0858808B1 (en) | 1997-01-17 | 2003-04-02 | Johnson & Johnson Medical Ltd. | Peptides for use in wound treatment |
| US6492326B1 (en) | 1999-04-19 | 2002-12-10 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
| CA2276542C (en) | 1999-06-28 | 2013-07-30 | Vladislav I. Deigin | Novel peptide, a method for its preparation and a pharmaceutical composition containing the peptide |
| KR100385293B1 (ko) * | 2000-05-13 | 2003-05-23 | 주식회사 리젠 바이오텍 | βｉｇ-ｈ3의 일부 도메인을 이용한 세포 부착 및 창상치유 방법 |
| GB0029777D0 (en) | 2000-12-06 | 2001-01-17 | Regen Therapeutics Plc | Peptides |
| US7381704B2 (en) * | 2001-03-28 | 2008-06-03 | Helix Biomedix, Inc. | Methods for use of short bioactive peptides |
| US6875744B2 (en) * | 2001-03-28 | 2005-04-05 | Helix Biomedix, Inc. | Short bioactive peptides |
| US7041506B2 (en) | 2001-11-19 | 2006-05-09 | Becton Dickinson And Company | Peptides promoting cell adherence, growth and secretion |
| CA2468187A1 (en) | 2001-11-28 | 2003-06-05 | Becton, Dickinson And Company | Peptides with growth inhibitory action |
| AU2003225540A1 (en) | 2002-01-31 | 2003-09-02 | Irm, Llc | Hepsin substrates and prodrugs |
| JP2006502971A (ja) | 2002-05-03 | 2006-01-26 | ミレニアム バイオロジックス インコーポレーテッド | 結合組織刺激ペプチド |
| US7541440B2 (en) | 2002-09-30 | 2009-06-02 | Immunomedics, Inc. | Chimeric, human and humanized anti-granulocyte antibodies and methods of use |
| ATE548022T1 (de) | 2003-11-17 | 2012-03-15 | Sederma Sa | Zusammensetzungen mit einer kombination von tetrapeptiden und tripeptiden |
| DE102004050563A1 (de) | 2004-10-15 | 2006-04-20 | Henkel Kgaa | Kosmetische und der dermatologische Zusammensetzungen mit Wirkstoffen für einen verbesserten Hautkomfort |
| DE202004012807U1 (de) | 2004-08-13 | 2004-10-21 | Henkel Kgaa | Kosmetische und dermatologische Zusammensetzungen mit DNA-Reparaturenzymen und Oligopeptiden |
| DE102005000868A1 (de) | 2004-10-15 | 2006-04-20 | Henkel Kgaa | Zusammensetzungen mit Inhibitoren der Prostaglandin- und/oder Leukotrien-Synthese in Kombination mit Stimulatoren der Freisetzung kutaner Neuromediatoren |
| DE102004055541A1 (de) | 2004-11-17 | 2006-05-18 | Henkel Kgaa | Kosmetische und dermatologische Zusammensetzungen zur Behandlung reifer Haut |
| WO2006028993A2 (en) | 2004-09-02 | 2006-03-16 | Vanderbilt University | Assessment of cancer susceptibility to molecular targeted therapy by use of recombinant peptides |
| US20070224150A1 (en) | 2005-03-24 | 2007-09-27 | Yongji Chung | Growth factor for hair and skin treatment |
| FR2884418B1 (fr) | 2005-04-15 | 2008-11-21 | Soc Extraction Principes Actif | Utilisation d'un peptide comme principe actif amincissant |
| WO2007004869A2 (en) | 2005-07-05 | 2007-01-11 | Biotempt B.V. | Treatment of tumors |
| DE102005063062A1 (de) | 2005-12-29 | 2007-07-05 | Henkel Kgaa | Synergistische Proteinhydrolysat-Kombinationen zur Behandlung reifer Haut |
| US7807625B2 (en) | 2006-01-18 | 2010-10-05 | Grant Industries, Inc | Anti-wrinkle composition |
-
2007
- 2007-12-27 AU AU2007342353A patent/AU2007342353B2/en active Active
- 2007-12-27 CN CN200780051983XA patent/CN101679495B/zh active Active
- 2007-12-27 RU RU2009129950/10A patent/RU2458069C2/ru active
- 2007-12-27 ES ES07868047T patent/ES2404669T3/es active Active
- 2007-12-27 JP JP2009544855A patent/JP5342455B2/ja active Active
- 2007-12-27 BR BRPI0720874A patent/BRPI0720874C1/pt active IP Right Grant
- 2007-12-27 PL PL07868047T patent/PL2125878T3/pl unknown
- 2007-12-27 WO PCT/US2007/026368 patent/WO2008085494A1/en active Application Filing
- 2007-12-27 SI SI200731182T patent/SI2125878T1/sl unknown
- 2007-12-27 MX MX2009007248A patent/MX2009007248A/es active IP Right Grant
- 2007-12-27 DK DK07868047.7T patent/DK2125878T3/da active
- 2007-12-27 CA CA2673791A patent/CA2673791C/en active Active
- 2007-12-27 EP EP07868047A patent/EP2125878B1/en active Active
- 2007-12-27 US US12/005,653 patent/US7696174B2/en active Active
-
2010
- 2010-04-30 HK HK10104284.5A patent/HK1137463A1/xx unknown
-
2013
- 2013-05-20 CY CY20131100406T patent/CY1114002T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2404669T3 (es) | 2013-05-28 |
| BRPI0720874A2 (pt) | 2014-03-04 |
| EP2125878B1 (en) | 2013-02-20 |
| CA2673791C (en) | 2014-11-25 |
| US7696174B2 (en) | 2010-04-13 |
| CN101679495B (zh) | 2013-07-17 |
| DK2125878T3 (da) | 2013-05-27 |
| SI2125878T1 (sl) | 2013-06-28 |
| WO2008085494A1 (en) | 2008-07-17 |
| AU2007342353B2 (en) | 2012-06-28 |
| EP2125878A1 (en) | 2009-12-02 |
| JP5342455B2 (ja) | 2013-11-13 |
| JP2010515679A (ja) | 2010-05-13 |
| RU2458069C2 (ru) | 2012-08-10 |
| CN101679495A (zh) | 2010-03-24 |
| US20080206160A1 (en) | 2008-08-28 |
| CA2673791A1 (en) | 2008-07-17 |
| CY1114002T1 (el) | 2016-07-27 |
| PL2125878T3 (pl) | 2013-08-30 |
| HK1137463A1 (en) | 2010-07-30 |
| AU2007342353A1 (en) | 2008-07-17 |
| BRPI0720874C1 (pt) | 2021-05-25 |
| BRPI0720874B1 (pt) | 2018-11-21 |
| RU2009129950A (ru) | 2011-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |