MX2009003515A - Inhibidores de histona desacetilasa. - Google Patents

Inhibidores de histona desacetilasa.

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Publication number
MX2009003515A
MX2009003515A MX2009003515A MX2009003515A MX2009003515A MX 2009003515 A MX2009003515 A MX 2009003515A MX 2009003515 A MX2009003515 A MX 2009003515A MX 2009003515 A MX2009003515 A MX 2009003515A MX 2009003515 A MX2009003515 A MX 2009003515A
Authority
MX
Mexico
Prior art keywords
carboxylic acid
hdac inhibitors
natural
acid group
group
Prior art date
Application number
MX2009003515A
Other languages
English (en)
Inventor
Alan Hornsby Davidson
David Festus Charles Moffat
Alistair David Graham Donald
Francesca Ann Day
Original Assignee
Chroma Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chroma Therapeutics Ltd filed Critical Chroma Therapeutics Ltd
Publication of MX2009003515A publication Critical patent/MX2009003515A/es

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    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
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    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

Los compuesto de fórmula (I) inhiben la actividad de HDAC, en donde A, B y D representan independientemente =C- o =N-; W es un radical divalente -CH=CH- o CH2 CH2-; R1 es un grupo del ácido carboxílico (-COOH), o un grupo éster que es hidrolizable por una o más enzimas carboxiesterasa intracelulares a un grupo del ácido carboxílico; R2 es la cadena lateral de un aminoácido alfa natural o no-natural; z es 0 ó 1; e Y, L1 y X1 son como se define en las reivindicaciones.
MX2009003515A 2006-10-06 2007-09-14 Inhibidores de histona desacetilasa. MX2009003515A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0619753.7A GB0619753D0 (en) 2006-10-06 2006-10-06 Enzyme inhibitors
PCT/GB2007/003504 WO2008040934A1 (en) 2006-10-06 2007-09-14 Hdac inhibitors

Publications (1)

Publication Number Publication Date
MX2009003515A true MX2009003515A (es) 2009-04-16

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MX2009003515A MX2009003515A (es) 2006-10-06 2007-09-14 Inhibidores de histona desacetilasa.

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US (4) US8637547B2 (es)
EP (2) EP2069291B1 (es)
JP (1) JP5395668B2 (es)
KR (1) KR101570136B1 (es)
CN (2) CN104151200B (es)
AU (1) AU2007304022B2 (es)
BR (1) BRPI0719204A2 (es)
CA (1) CA2665428C (es)
CY (1) CY1118881T1 (es)
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GB (1) GB0619753D0 (es)
HU (1) HUE033229T2 (es)
IL (1) IL197752A0 (es)
LT (1) LT2295410T (es)
MX (1) MX2009003515A (es)
NZ (1) NZ576058A (es)
PL (1) PL2295410T3 (es)
PT (1) PT2295410T (es)
SI (1) SI2295410T1 (es)
WO (1) WO2008040934A1 (es)

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US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
CA2937005A1 (en) 2005-03-22 2006-09-28 President And Fellows Of Harvard College Treatment of protein degradation disorders
PL1877098T3 (pl) * 2005-05-05 2013-09-30 Glaxosmithkline Ip Dev Ltd Koniugaty estru alfa-aminokwasu z lekiem ulegające hydrolizie z udziałem karboksyloesterazy
GB0509225D0 (en) * 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of enzymatic activity
AU2007345292B2 (en) 2006-02-14 2013-10-31 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
US8304451B2 (en) 2006-05-03 2012-11-06 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
GB0619753D0 (en) * 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
BRPI0622100A2 (pt) * 2006-10-30 2011-12-27 Chroma Therapeutics Ltd hidroxamatos como inibidores de desacetilase de histona
GB0803747D0 (en) 2008-02-29 2008-04-09 Martin Enzyme and receptor modulation
CA2731730C (en) 2008-07-23 2017-06-13 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
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